The OSIRIS Weight of Evidence approach: ITS mutagenicity and ITS carcinogenicity

Regulatory Toxicology and Pharmacology

Volumn 67, Issue 2, 2013, Pages 170-181

  Buist, Harrie ^a   Aldenberg, Tom ^b   Batke, Monika ^c   Escher, Sylvia ^c   Klein Entink, Rinke ^a   Kühne, Ralph ^d   Marquart, Hans ^e   Pauné, Eduard ^f   Rorije, Emiel ^b   Schüürmann, Gerrit ^d,g   Kroese, Dinant ^a  

^a TNO   (Netherlands)

^b NATIONAL INSTITUTE FOR PUBLIC HEALTH AND THE ENVIRONMENT   (Netherlands)

^c FRAUNHOFER INSTITUTE FOR TOXICOLOGY AND EXPERIMENTAL MEDICINE   (Germany)

^d HELMHOLTZ CENTRE FOR ENVIRONMENTAL RESEARCH UFZ   (Germany)

^e TNO Triskelion BV   (Netherlands)

^f SIMPPLE SL   (Spain)

^g TU BERGAKADEMIE FREIBERG   (Germany)

Author keywords

Bayes' theorem; Carcinogenicity; Decision theory; In vitro; In vivo; Mutagenicity; QSARs; Read across; Swing weighting; Testing strategies

Indexed keywords

ARTICLE; BAYES THEOREM; CARCINOGENICITY; CHROMOSOME ABERRATION; COMPUTER PROGRAM; DOCUMENTATION; GENE MUTATION; GENOTOXICITY; IN VITRO STUDY; IN VIVO STUDY; MUTAGENICITY; OSIRIS SOFTWARE; PRIORITY JOURNAL; QUALITY CONTROL; QUALITY OF LIFE; QUANTITATIVE ANALYSIS; QUANTITATIVE STRUCTURE ACTIVITY RELATION; RELIABILITY; RISK ASSESSMENT; RODENT; VALIDITY;

ANIMALIA; BACTERIA (MICROORGANISMS); MAMMALIA; RODENTIA;

BAYES' THEOREM; CARCINOGENICITY; DECISION THEORY; IN VITRO; IN VIVO; MUTAGENICITY; QSARS; READ-ACROSS; SWING WEIGHTING; TESTING STRATEGIES;

ANIMALS; CARCINOGENICITY TESTS; CARCINOGENS; MUTAGENICITY TESTS; MUTAGENS; RISK ASSESSMENT; SOFTWARE;

EID: 84886595662     PISSN: 02732300     EISSN: 10960295     Source Type: Journal    
DOI: 10.1016/j.yrtph.2013.01.002     Document Type: Article

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