The OSIRIS Weight of Evidence approach: ITS for the endpoints repeated-dose toxicity (RepDose ITS)

Regulatory Toxicology and Pharmacology

Volumn 67, Issue 2, 2013, Pages 157-169

  Tluczkiewicz, Inga ^a,f   Batke, Monika ^a   Kroese, Dinant ^b   Buist, Harrie ^b   Aldenberg, Tom ^c   Pauné, Eduard ^d   Grimm, Helvi ^a   Kühne, Ralph ^e   Schüürmann, Gerrit ^e,f   Mangelsdorf, Inge ^a   Escher, Sylvia E ^a  

^a FRAUNHOFER INSTITUTE FOR TOXICOLOGY AND EXPERIMENTAL MEDICINE   (Germany)

^b TNO   (Netherlands)

^c NATIONAL INSTITUTE FOR PUBLIC HEALTH AND THE ENVIRONMENT   (Netherlands)

^d Helmholtz Centre for Environmental Research ^*  (Spain)

^e HELMHOLTZ CENTRE FOR ENVIRONMENTAL RESEARCH UFZ   (Germany)

^f TU BERGAKADEMIE FREIBERG   (Germany)

Author keywords

3R principle; Alternative; Integrated Testing Strategy; ITS; Non testing method; OSIRIS; Repeated dose; Risk Assessment; TTC; Weighting

Indexed keywords

HEXACHLOROBENZENE;

ARTICLE; CARCINOGENICITY; CHRONIC TOXICITY; CONCENTRATION (PARAMETERS); EXPOSURE; IN VIVO STUDY; INTEGRATED TESTING STRATEGIES; NONHUMAN; PHYSICAL CHEMISTRY; PRIORITY JOURNAL; PROBABILITY; RELIABILITY; REPEATED DOSE TOXICITY INTEGRATED TESTING STRATEGIES; RISK ASSESSMENT; TOXICITY; TOXICITY TESTING; VALIDITY;

ANIMALIA;

3R PRINCIPLE; ALTERNATIVE; INTEGRATED TESTING STRATEGY; ITS; NON-TESTING METHOD; OSIRIS; REPEATED-DOSE; RISK ASSESSMENT; TTC; WEIGHTING;

ANIMALS; HAZARDOUS SUBSTANCES; RISK ASSESSMENT; SOFTWARE; TOXICITY TESTS;

EID: 84886589123     PISSN: 02732300     EISSN: 10960295     Source Type: Journal    
DOI: 10.1016/j.yrtph.2013.02.004     Document Type: Article

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