Mean corpuscular volume is associated with endothelial dysfunction and predicts composite cardiovascular events in patients with chronic kidney disease

Nephrology

Volumn 18, Issue 11, 2013, Pages 728-735

  Solak, Yalcin ^a   Yilmaz, Mahmut Ilker ^b   Saglam, Mutlu ^b   Demirbas, Seref ^b   Verim, Samet ^b   Unal, Hilmi Umut ^b   Gaipov, Abduzhappar ^e   Oguz, Yusuf ^b   Kayrak, Mehmet ^c   Caglar, Kayser ^b   Vural, Abdulgaffar ^b   Turk, Suleyman ^c   Covic, Adrian ^f   Kanbay, Mehmet ^d  

^a Karaman State Hospital   (Turkey)

^b GULHANE SCHOOL OF MEDICINE   (Turkey)

^c SELCUK UNIVERSITY   (Turkey)

^d ISTANBUL MEDENIYET UNIVERSITY   (Turkey)

^e JSC National Scientific Medical Research Center   (Kazakhstan)

^f C I PARHON NATIONAL INSTITUTE OF ENDOCRINOLOGY   (Romania)

Author keywords

cardiovascular event; chronic kidney disease; flow mediated dilatation; mean corpuscular volume; prediction

Indexed keywords

C REACTIVE PROTEIN; HEMOGLOBIN;

ADULT; ANEMIA; ARTICLE; CARDIOVASCULAR DISEASE; CARDIOVASCULAR MORTALITY; CHRONIC KIDNEY DISEASE; DIABETES MELLITUS; DISEASE ASSOCIATION; ENDOTHELIAL DYSFUNCTION; FEMALE; GLOMERULUS FILTRATION RATE; HEMOGLOBIN BLOOD LEVEL; HUMAN; MAJOR CLINICAL STUDY; MALE; MEAN CORPUSCULAR VOLUME; MORBIDITY; PRIORITY JOURNAL; SURVIVAL; SYSTOLIC BLOOD PRESSURE; AGED; BLOOD; CARDIOVASCULAR DISEASES; CHRONIC KIDNEY FAILURE; COHORT ANALYSIS; COMPLICATION; MIDDLE AGED; MORTALITY; PATHOPHYSIOLOGY; PROPORTIONAL HAZARDS MODEL; RECEIVER OPERATING CHARACTERISTIC; VASCULAR ENDOTHELIUM; VASODILATATION;

ADULT; AGED; CARDIOVASCULAR DISEASES; COHORT STUDIES; ENDOTHELIUM, VASCULAR; ERYTHROCYTE INDICES; FEMALE; HUMANS; MALE; MIDDLE AGED; PROPORTIONAL HAZARDS MODELS; RENAL INSUFFICIENCY, CHRONIC; ROC CURVE; VASODILATION;

EID: 84886520942     PISSN: 13205358     EISSN: 14401797     Source Type: Journal    
DOI: 10.1111/nep.12130     Document Type: Article

References (24)

1. Voormolen N, Grootendorst DC, Urlings TA, et al. Prevalence of anemia and its impact on mortality and hospitalization rate in predialysis patients. Nephron Clin. Pract. 2010; 115: c133-141.
2. Astor BC, Muntner P, Levin A, Eustace JA, Coresh J,. Association of kidney function with anemia: The Third National Health and Nutrition Examination Survey (1988-1994). Arch. Intern. Med. 2002; 162: 1401-1408.
3. Toto RD,. Anemia of chronic disease: Past, present, and future. Kidney Int. Suppl. 2003; 64 (87): S20-23.
4. Yilmaz MI, Solak Y, Covic A, Goldsmith D, Kanbay M,. Renal anemia of inflammation: The name is self-explanatory. Blood Purif. 2011; 32: 220-225.
5. Zachee P, Vermylen J, Boogaerts MA,. Hematologic aspects of end-stage renal failure. Ann. Hematol. 1994; 69: 33-40.
6. Suega K, Bakta M, Dharmayudha TG, Lukman JS, Suwitra K,. Profile of anemia in chronic renal failure patients: Comparison between predialyzed and dialyzed patients at the Division of Nephrology, Department of Internal Medicine, Sanglah Hospital, Denpasar, Bali, Indonesia. Acta Med. Indones. 2005; 37: 190-194.
7. Pollak VE, Lorch JA, Means RT, Jr,. Unanticipated favorable effects of correcting iron deficiency in chronic hemodialysis patients. J. Investig. Med. 2001; 49: 173-183.
8. Hampers CL, Streiff R, Nathan DG, Snyder D, Merrill JP,. Megaloblastic hematopoiesis in uremia and in patients on long-term hemodialysis. N. Engl. J. Med. 1967; 276: 551-554.
9. Oh RC, Holt SN, Hitchcock K, Hoekzema G,. How do you evaluate macrocytosis without anemia? J. Fam. Pract. 2008; 57: 548-550.
10. Tennankore KK, Soroka SD, West KA, Kiberd BA,. Macrocytosis may be associated with mortality in chronic hemodialysis patients: A prospective study. BMC Nephrol. 2011; 12: 19.
11. Myojo M, Iwata H, Kohro T, et al. Prognostic implication of macrocytosis on adverse outcomes after coronary intervention. Atherosclerosis 2012; 221: 148-153.
12. K/DOQI clinical practice guidelines for bone metabolism and disease in chronic kidney disease. Am. J. Kidney Dis. 2003; 42 (4 Suppl 3): S1-201.
13. Levey AS, Bosch JP, Lewis JB, Greene T, Rogers N, Roth D,. A more accurate method to estimate glomerular filtration rate from serum creatinine: A new prediction equation. Modification of Diet in Renal Disease Study Group. Ann. Intern. Med. 1999; 130: 461-470.
14. Friedewald WT, Levy RI, Fredrickson DS,. Estimation of the concentration of low-density lipoprotein cholesterol in plasma, without use of the preparative ultracentrifuge. Clin. Chem. 1972; 18: 499-502.
15. Matthews DR, Hosker JP, Rudenski AS, Naylor BA, Treacher DF, Turner RC,. Homeostasis model assessment: Insulin resistance and beta-cell function from fasting plasma glucose and insulin concentrations in man. Diabetologia 1985; 28: 412-419.
16. Celermajer DS, Sorensen KE, Gooch VM, et al. Non-invasive detection of endothelial dysfunction in children and adults at risk of atherosclerosis. Lancet 1992; 340: 1111-1115.
17. Corretti MC, Anderson TJ, Benjamin EJ, et al. Guidelines for the ultrasound assessment of endothelial-dependent flow-mediated vasodilation of the brachial artery: A report of the International Brachial Artery Reactivity Task Force. J. Am. Coll. Cardiol. 2002; 39: 257-265.
18. Seward SJ, Safran C, Marton KI, Robinson SH,. Does the mean corpuscular volume help physicians evaluate hospitalized patients with anemia? J. Gen. Intern. Med. 1990; 5: 187-191.
19. Haltmayer M, Mueller T, Luft C, Poelz W, Haidinger D,. Erythrocyte mean corpuscular volume associated with severity of peripheral arterial disease: An angiographic evaluation. Ann. Vasc. Surg. 2002; 16: 474-479.
20. Thijssen DH, Black MA, Pyke KE, et al. Assessment of flow-mediated dilation in humans: A methodological and physiological guideline. Am. J. Physiol. Heart Circ. Physiol. 2011; 300 (1): H2-12.
21. Tsantes AE, Bonovas S, Travlou A, Sitaras NM,. Redox imbalance, macrocytosis, and RBC homeostasis. Antioxid. Redox Signal. 2006; 8 (7-8): 1205-1216.
22. Veeranna V, Zalawadiya SK, Niraj A, et al. Homocysteine and reclassification of cardiovascular disease risk. J. Am. Coll. Cardiol. 2011; 58: 1025-1033.
23. Pan Y, Guo LL, Cai LL, et al. Homocysteine-lowering therapy does not lead to reduction in cardiovascular outcomes in chronic kidney disease patients: A meta-analysis of randomised, controlled trials. Br. J. Nutr. 2012; 16: 1-8.
24. Singh AK, Szczech L, Tang KL, et al. Anaemia of CKD-the CHOIR study revisited. Nephrol. Dial. Transplant. 2007; 22: 1806-1810.