In silico oncology: Exploiting clinical studies to clinically adapt and validate multiscale oncosimulators

Proceedings of the Annual International Conference of the IEEE Engineering in Medicine and Biology Society, EMBS

Volumn , Issue , 2013, Pages 5545-5549

  Stamatakos, Georgios S ^a   Kolokotroni, Eleni ^a   Dionysiou, Dimitra ^a   Veith, Christian ^b   Kim, Yoo Jin ^b   Franz, Astrid ^c   Marias, Kostas ^d   Sabczynski, Joerg ^c   Bohle, Rainer ^b   Graf, Norbert ^b  

^a INSTITUTE OF COMMUNICATION AND COMPUTER SYSTEMS   (Greece)

^b SAARLAND UNIVERSITY   (Germany)

^c PHILIPS RESEARCH LABORATORIES   (Germany)

^d INSTITUTE OF COMPUTER SCIENCE   (Greece)

Author keywords

[No Author keywords available]

Indexed keywords

TUMORS;

ADAPTATION PROCESS; CHEMOTHERAPEUTIC AGENTS; CLINICAL VALIDATIONS; HIGH LEVEL DESCRIPTION; MULTI-SCALE DATUM; MULTI-SCALE MODELING; MULTI-SCALE SIMULATION; VALIDATION PROCESS;

DISCRETE EVENT SIMULATION;

EID: 84886502762     PISSN: 1557170X     EISSN: None     Source Type: Conference Proceeding    
DOI: 10.1109/EMBC.2013.6610806     Document Type: Conference Paper

References (15)

1. G.Stamatakos "In Silico Oncology Part I: Clinically Oriented Cancer Multilevel Modeling Based on Discrete Event Simulation" In T.Deisboeck and G. Stamatakos Eds " Cancer Multiscale Modeling, " CRC Press, pp. 407-436. Print ISBN: 978-1-4398-1440-6 eBook ISBN: 978-1-4398-1442-0 DOI: 10.1201/b10407-19 Boca Raton, Florida, USA, 2010.
2. G.S. Stamatakos, D.D. Dionysiou, E.I. Zacharaki, N.A. Mouravliansky, K.S.Nikita, N.K. Uzunoglu, "In silico radiation oncology: combining novel simulation algorithms with current visualization techniques, " Proceedings of IEEE - Special Issue on Bioinformatics: Advances and Challenges, 90(11), pp. 1764-1777, 2002.
3. D.D.Dionysiou, G.S. Stamatakos, N.K.Uzunoglu, K.S.Nikita, A. Marioli, "A Four Dimensional In Vivo Model of Tumour Response to Radiotherapy: Parametric Validation Considering Radiosensitivity, Genetic Profile and Fractionation, " J. Theor. Biol., 230, 1-20, 2004.
4. G.S.Stamatakos, D.D.Dionysiou, N.M.Graf, N.A.Sofra, C.Desmedt, A.Hoppe, N.Uzunoglu, M.Tsiknakis, "The Oncosimulator: A multilevel, clinically oriented simulation system of tumor growth and organism response to therapeutic schemes. Towards the clinical evaluation of in silico oncology, " in Proceedings of the 29th Annual Int. Conference of the IEEE EMBS, August 23-26, SuB07.1:pp. 6628-6631, Lyon, France, 2007.
5. T.S.Deisboeck and G. Stamatakos Eds "Multiscale Cancer Modeling, ", CRC Press 2011, Print ISBN: 978-1-4398-1440-6, eBook ISBN: 978-1- 4398-1442-0.
6. N. Graf, "In Silico Oncology Part II: Clinical Requirements Regarding In Silico Oncology, "In T.Deisboeck and G.Stamatakos Eds Multiscale Cancer Modeling, " CRC Press.pp. 437-446. Print ISBN: 978-1-4398-1440- 6, eBook ISBN: 978-1-4398-1442-0, DOI: 10.1201/b10407-20, 2010.
7. G.S. Stamatakos, E.A. Kolokotroni, D.D. Dionysiou, E.Ch. Georgiadi, C. Desmedt, "An advanced discrete state - discrete event multiscale simulation model of the response of a solid tumor to chemotherapy. Mimicking a clinical study, " J. Theor. Biology, vol. 266(1), pp. 124-139, 2010.
8. E.A. Kolokotroni, D.D. Dionysiou, N.K. Uzunoglu, and G.S. Stamatakos, "Studying the growth kinetics of untreated clinical tumors by using an advanced discrete simulation model, " Mathematical and Computer Modelling, vol. 54, pp. 1989-2006, Nov 2011.
9. G.S.Stamatakos, E.Ch.Georgiadi, N.Graf, E.A.Kolokotroni, and D.D.Dionysiou, "Exploiting Clinical Trial Data Drastically Narrows the Window of Possible Solutions to the Problem of Clinical Adaptation of a Multiscale Cancer Model", PLOS ONE 6(3), e17594 2011.
10. P. Boyle and B. Levin, Eds, World Cancer Report 2008, World Health Organization, International agency for research on Cancer, Lyon, 2008.
11. B.G. Katzung, Ed. Basic and Clinical Pharmacology, 8th ed., Lange Medical Books/McGraw-Hill: United States, 2001.
12. M.A. Fuertes, C. Alonso, and J.M. Pérez, "Biochemical modulation of cisplatin mechanisms of action: enhancement of antitumor activity and circumvention of drug resistance, " Chemical Reviews, vol. 103(3), pp. 645- 662, Mar 2003.
13. E. Mini, S. Nobili, B. Caciagli, I. Landini, and T. Mazzei, "Cellular pharmacology of gemcitabine, " Ann Oncol, vol. 17, Sup. 5, pp. v7-12, 2006.
14. L.E. Quint, J. Cheng, M. Schipper, A.C. Chang, and G. Kalemkerian, "Lung lesion doubling times: values and variability based on method of volume determination, " Clin Radiol, vol.63(1), pp. 41-48, Jan 2008.
15. P. Rudolph, J. Peters, D. Lorenz, D. Schmidt, and R. Parwaresch, "Correlation between mitotic and Ki-67 labeling indices in paraffinembedded carcinoma specimens, " Hum Pathol, vol. 29(11), pp. 1216-1222, Nov 1998.