Proliferative Verrucous Leukoplakia (PVL): A review of an elusive pathologic entity!

Advances in Anatomic Pathology

Volumn 20, Issue 6, 2013, Pages 416-423

  Gillenwater, Ann M ^a   Vigneswaran, Nadarajah ^c   Fatani, Hanadi ^b   Saintigny, Pierre ^b   El Naggar, Adel K ^b  

^a Departments of Head and Neck Surgery   (United States)

^b UNIVERSITY OF TEXAS MD ANDERSON CANCER CENTER   (United States)

^c UNIVERSITY OF TEXAS DENTAL BRANCH AT HOUSTON   (United States)

Author keywords

lichen planus; oral leukoplakia; squamous dysplasia; squamous tumorigenesis; verrucous hyperplasia

Indexed keywords

TOPICAL AGENT;

CARBON DIOXIDE LASER; CLINICAL FEATURE; CRYOTHERAPY; DIFFERENTIAL DIAGNOSIS; HAIRY LEUKOPLAKIA; HISTOPATHOLOGY; HUMAN; HYPERPLASIA; LASER SURGERY; LEUKOPLAKIA; LICHEN PLANUS; MOUTH CARCINOMA; PHOTODYNAMIC THERAPY; PHOTOTHERAPY; PRIORITY JOURNAL; PROLIFERATIVE VERRUCOUS LEUKOPLAKIA; REVIEW; RISK FACTOR; VERRUCOUS HYPERPLASIA;

AGED; CARCINOMA, SQUAMOUS CELL; CELL TRANSFORMATION, NEOPLASTIC; DIAGNOSIS, DIFFERENTIAL; DISEASE PROGRESSION; FEMALE; HUMANS; LEUKOPLAKIA, HAIRY; LEUKOPLAKIA, ORAL; LICHEN PLANUS, ORAL; MALE; MIDDLE AGED; PRECANCEROUS CONDITIONS;

EID: 84886467608     PISSN: 10724109     EISSN: 15334031     Source Type: Journal    
DOI: 10.1097/PAP.0b013e3182a92df1     Document Type: Review

References (59)

1. van der Waal I. Potentially malignant disorders of the oral and oropharyngeal mucosa; terminology, classification and present concepts of management. Oral Oncol. 2009;45:317-323.
2. Warnakulasuriya S, Johnson NW, van der Waal I. Nomenclature and classification of potentially malignant disorders of the oral mucosa. J Oral Pathol Med. 2007;36:575-580. (Pubitemid 47609807)
3. Kramer IR, Lucas RB, Pindborg JJ, et al. Definition of leukoplakia and related lesions: an aid to studies on oral precancer. Oral Surg Oral Med Oral Pathol. 1978;46:518-539. (Pubitemid 9056118)
4. Lee JJ, Hong WK, Hittelman WN, et al. Predicting cancer development in oral leukoplakia: ten years of translational research. Clin Cancer Res. 2000;6:1702-1710. (Pubitemid 30305062)
5. Shopper TP, Brannon RB, Stalker WH. Proliferative verrucous leukoplakia: an aggressive form of oral leukoplakia. J Dent Hyg. 2004;78:1-6.
6. Cabay RJ, Morton TH Jr, Epstein JB. Proliferative verrucous leukoplakia and its progression to oral carcinoma: a review of the literature. J Oral Pathol Med. 2007;36:255-261. (Pubitemid 46632606)
7. van der Waal I, Reichart PA. Oral proliferative verrucous leukoplakia revisited. Oral Oncol. 2008;44:719-721. (Pubitemid 351992921)
8. Lopez-Jornet P, Alonso FC. Proliferative verrucous leukoplakia and malignant transformation. J Eur Acad Dermatol Venereol. 2008;22:1138-1139.
9. Bishen KA, Sethi A. Proliferative verrucous leukoplakia-diagnostic pitfalls and suggestions. Med Oral Patol Oral Cir Bucal. 2009;14:E263-E264.
10. Hansen LS, Olson JA, Silverman S Jr. Proliferative verrucous leukoplakia. A long-term study of thirty patients. Oral Surg Oral Med Oral Pathol. 1985;60:285-298. (Pubitemid 16110465)
11. Silverman S Jr, Gorsky M. Proliferative verrucous leukoplakia: a follow-up study of 54 cases. Oral Surg Oral Med Oral Pathol Oral Radiol Endod. 1997;84:154-157. (Pubitemid 127671955)
12. Vigliante CE, Quinn PD, Alawi F. Proliferative verrucous leukoplakia: report of a case with characteristic long-term progression. J Oral Maxillofac Surg. 2003;61:626-631. (Pubitemid 36532266)
13. Silverman S Jr, Gorsky M, Lozada F. Oral leukoplakia and malignant transformation. A follow-up study of 257 patients. Cancer. 1984;53:563-568. (Pubitemid 14182737)
14. Navarro CM, Sposto MR, Sgavioli-Massucato EM, et al. Transformation of proliferative verrucous leukoplakia to oral carcinoma: a ten years follow-up. Med Oral. 2004;9:229-233. (Pubitemid 38788568)
15. Haley JC, Hood AF, Mirowski GW. Proliferative verrucous leukoplakia with cutaneous involvement. J Am Acad Dermatol. 1999;41:481-483. (Pubitemid 29418521)
16. Batsakis JG, Suarez P, El-Naggar AK. Proliferative verrucous leukoplakia and its related lesions. Oral Oncol. 1999;35: 354-359. (Pubitemid 29276968)
17. Murrah VA, Batsakis JG. Proliferative verrucous leukoplakia and verrucous hyperplasia. Ann Otol Rhinol Laryngol. 1994; 103:660-663. (Pubitemid 24267418)
18. Fettig A, Pogrel MA, Silverman S Jr, et al. Proliferative verrucous leukoplakia of the gingiva. Oral Surg Oral Med Oral Pathol Oral Radiol Endod. 2000;90:723-730.
19. Bagan JV, Jimenez Y, Murillo J, et al. Lack of association between proliferative verrucous leukoplakia and human papillomavirus infection. J Oral Maxillofac Surg. 2007;65: 46-49. (Pubitemid 44914028)
20. Campisi G, Giovannelli L, Ammatuna P, et al. Proliferative verrucous vs. conventional leukoplakia: no significantly increased risk of HPV infection. Oral Oncol. 2004;40:835-840. (Pubitemid 39061101)
21. Gandolfo S, Castellani R, Pentenero M. Proliferative verrucous leukoplakia: a potentially malignant disorder involving periodontal sites. J Periodontol. 2009;80:274-281.
22. Bagan JV, Murillo J, Poveda R, et al. Proliferative verrucous leukoplakia: unusual locations of oral squamous cell carcinomas, and field cancerization as shown by the appearance of multiple OSCCs. Oral Oncol. 2004;40:440-443. (Pubitemid 38221392)
23. Bagan JV, Jimenez Y, Sanchis JM, et al. Proliferative verrucous leukoplakia: high incidence of gingival squamous cell carcinoma. J Oral Pathol Med. 2003;32:379-382. (Pubitemid 36885750)
24. Batsakis JG, Cleary KR, Cho KJ. Lichen planus and lichenoid lesions of the oral cavity. Ann Otol Rhinol Laryngol. 1994;103: 495-497. (Pubitemid 24192819)
25. Krutchkoff DJ, Eisenberg E. Lichenoid dysplasia: a distinct histopathologic entity. Oral Surg Oral Med Oral Pathol. 1985; 60:308-315. (Pubitemid 16110467)
26. Barnard NA, Scully C, Eveson JW, et al. Oral cancer development in patients with oral lichen planus. J Oral Pathol Med. 1993;22:421-424. (Pubitemid 2003139)
27. Eisen D. The clinical features, malignant potential, and systemic associations of oral lichen planus: a study of 723 patients. J Am Acad Dermatol. 2002;46:207-214. (Pubitemid 34118376)
28. Ingafou M, Leao JC, Porter SR, et al. Oral lichen planus: a retrospective study of 690 British patients. Oral Dis. 2006;12: 463-468. (Pubitemid 44252538)
29. Lovas JG, Harsanyi BB, ElGeneidy AK. Oral lichenoid dysplasia: a clinicopathologic analysis. Oral Surg Oral Med Oral Pathol. 1989;68:57-63. (Pubitemid 19176917)
30. Zhang L, Cheng X, Li Y, et al. High frequency of allelic loss in dysplastic lichenoid lesions. Lab Invest. 2000;80:233-237. (Pubitemid 30120975)
31. Greenspan JS, Barr CE, Sciubba JJ, et al. Oral manifestations of HIV infection. Definitions, diagnostic criteria, and principles of therapy. The USA Oral AIDS Collaborative Group. Oral Surg Oral Med Oral Pathol. 1992;73: 142-144.
32. Schiodt M, Norgaard T, Greenspan JS. Oral hairy leukoplakia in an HIV-negative woman with Behcet's syndrome. Oral Surg Oral Med Oral Pathol Oral Radiol Endod. 1995;79:53-56.
33. Gopalakrishnan R,Weghorst CM, Lehman TA, et al. Mutated and wild-type p53 expression and HPV integration in proliferative verrucous leukoplakia and oral squamous cell carcinoma. Oral Surg Oral Med Oral Pathol Oral Radiol Endod. 1997;83:471-477. (Pubitemid 127671863)
34. Rocco JW, Sidransky D. p16(MTS-1/CDKN2/INK4a) in cancer progression. Exp Cell Res. 2001;264:42-55. (Pubitemid 32989080)
35. Klanrit P, Sperandio M, Brown AL, et al. DNA ploidy in proliferative verrucous leukoplakia. Oral Oncol. 2007;43:310-316. (Pubitemid 46228017)
36. Epstein JB, Gorsky M, Wong FL, et al. Topical bleomycin for the treatment of dysplastic oral leukoplakia. Cancer. 1998;83: 629-634. (Pubitemid 28387683)
37. Kresty LA, Mallery SR, Knobloch TJ, et al. Frequent alterations of p16INK4a and p14ARF in oral proliferative verrucous leukoplakia. Cancer Epidemiol Biomarkers Prev. 2008;17:3179-3187.
38. Poi MJ, Yen T, Li J, et al. Somatic INK4a-ARF locus mutations: a significant mechanism of gene inactivation in squamous cell carcinomas of the head and neck. Mol Carcinog. 2001;30:26-36. (Pubitemid 32127347)
39. Shahnavaz SA, Bradley G, Regezi JA, et al. Patterns of CDKN2A gene loss in sequential oral epithelial dysplasias and carcinomas. Cancer Res. 2001;61:2371-2375. (Pubitemid 32685807)
40. Kresty LA, Mallery SR, Knobloch TJ, et al. Alterations of p16(INK4a) and p14(ARF) in patients with severe oral epithelial dysplasia. Cancer Res. 2002;62:5295-5300. (Pubitemid 35024605)
41. Bradley G, Irish J, MacMillan C, et al. Abnormalities of the ARF-p53 pathway in oral squamous cell carcinoma. Oncogene. 2001;20:654-658. (Pubitemid 32156190)
42. Viswanathan M, Tsuchida N, Shanmugam G. Selective deletion of p14(ARF) exon 1beta of the INK4a locus in oral squamous cell carcinomas of Indians. Oral Oncol. 2001;37:341-344. (Pubitemid 32391379)
43. Sciubba JJ. Oral cancer. The importance of early diagnosis and treatment. Am J Clin Dermatol. 2001;2:239-251. (Pubitemid 32738666)
44. Tabor MP, Brakenhoff RH, van Houten VM, et al. Persistence of genetically altered fields in head and neck cancer patients: biological and clinical implications. Clin Cancer Res. 2001;7:1523-1532. (Pubitemid 32708615)
45. Kelloff GJ, Sigman CC, Contag CH. Early detection of oral neoplasia: watching with new eyes. Cancer Prev Res (Phila). 2009;2:405-408.
46. Kapstad B, Bang G. Verrucous carcinoma of the oral cavity treated with bleomycin. Oral Surg Oral Med Oral Pathol. 1976; 42:588-590.
47. Schoelch ML, Sekandari N, Regezi JA, et al. Laser management of oral leukoplakias: a follow-up study of 70 patients. Laryngoscope. 1999;109:949-953. (Pubitemid 29269021)
48. Dilkes MG, Benjamin E, Ovaisi S, et al. Treatment of primary mucosal head and neck squamous cell carcinoma using photodynamic therapy: results after 25 treated cases. J Laryngol Otol. 2003;117:713-717. (Pubitemid 37281502)
49. Sieron A, Adamek M, Kawczyk-Krupka A, et al. Photodynamic therapy (PDT) using topically applied delta-aminolevulinic acid (ALA) for the treatment of oral leukoplakia. J Oral Pathol Med. 2003;32:330-336. (Pubitemid 36781531)
50. Femiano F, Gombos F, Scully C. Oral proliferative verrucous leukoplakia (PVL); open trial of surgery compared with combined therapy using surgery and methisoprinol in papillomavirus-related PVL. Int J Oral Maxillofac Surg. 2001;30:318-322. (Pubitemid 33114842)
51. Poveda-Roda R, Bagan JV, Jimenez-Soriano Y, et al. Retinoids and proliferative verrucous leukoplakia (PVL). A preliminary study. Med Oral Patol Oral Cir Bucal. 2010;15:e3-e9.
52. Vitale-Cross L, Czerninski R, Amornphimoltham P, et al. Chemical carcinogenesis models for evaluating molecular-targeted prevention and treatment of oral cancer. Cancer Prev Res (Phila). 2009;2:419-422.
53. Lingen MW. Screening for oral premalignancy and cancer: what platform and which biomarkers? Cancer Prev Res (Phila). 2010;3:1056-1059.
54. Vo QN, Geradts J, Gulley ML, et al. Epstein-Barr virus in gastric adenocarcinomas: association with ethnicity and CDKN2A promoter methylation. J Clin Pathol. 2002;55:669-675. (Pubitemid 34970088)
55. Wang LE, Hu Z, Sturgis EM, et al. Reduced DNA repair capacity for removing tobacco carcinogen-induced DNA adducts contributes to risk of head and neck cancer but not tumor characteristics. Clin Cancer Res. 2010;16:764-774.
56. Papadimitrakopoulou VA, Clayman GL, Shin DM, et al. Biochemoprevention for dysplastic lesions of the upper aerodigestive tract. Arch Otolaryngol Head Neck Surg. 1999; 125:1083-1089. (Pubitemid 29473370)
57. Kim J, Shin DM, El-Naggar A, et al. Chromosome polysomy and histological characteristics in oral premalignant lesions. Cancer Epidemiol Biomarkers Prev. 2001;10: 319-325. (Pubitemid 32703215)
58. Taoudi Benchekroun M, Saintigny P, Thomas SM, et al. Epidermal growth factor receptor expression and gene copy number in the risk of oral cancer. Cancer Prev Res (Phila). 2010;3:800-809.
59. Mao L, El-Naggar AK, Papadimitrakopoulou V, et al. Phenotype and genotype of advanced premalignant head and neck lesions after chemopreventive therapy. J Natl Cancer Inst. 1998;90:1545-1551. (Pubitemid 28535719)