Local administration of lactic acid and a low dose of the free radical scavenger, edaravone, alleviates myocardial reperfusion injury in rats

Journal of Cardiovascular Pharmacology

Volumn 62, Issue 4, 2013, Pages 369-378

  Zhang, Guoming ^a,b   Sun, Yuanyuan ^a   Wang, Yu ^b   Li, Xiaoyan ^a   Li, Tiande ^b   Su, Shaoping ^b   Xu, Lin ^a   Shen, Hong ^a  

^a JINAN MILITARY GENERAL HOSPITAL   (China)

^b CHINESE PLA GENERAL HOSPITAL   (China)

Author keywords

apoptosis; edaravone; ischemic reperfusion injury; lactic acid; mitochondrial permeability transition pore

Indexed keywords

CASPASE 9; CYTOCHROME C; LACTIC ACID; MALONALDEHYDE; MITOCHONDRIAL PERMEABILITY TRANSITION PORE; NORPHENAZONE; REACTIVE OXYGEN METABOLITE; SUPEROXIDE DISMUTASE;

ACUTE HEART INFARCTION; ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; APOPTOSIS; ARTICLE; BLOOD PH; CONTROLLED STUDY; ELECTROCARDIOGRAPHY; ENZYME ACTIVITY; HEART INFARCTION SIZE; HEART INJURY; HEART MUSCLE CELL; HEART MUSCLE INJURY; HEART PROTECTION; HEMODYNAMIC PARAMETERS; LEFT CORONARY ARTERY; LOW DRUG DOSE; MALE; MITOCHONDRION SWELLING; NONHUMAN; PRIORITY JOURNAL; RAT; REPERFUSION INJURY; WESTERN BLOTTING;

ANIMALS; ANTIPYRINE; APOPTOSIS; DOSE-RESPONSE RELATIONSHIP, DRUG; FREE RADICAL SCAVENGERS; ISCHEMIC POSTCONDITIONING; LACTIC ACID; MALE; MYOCARDIAL INFARCTION; MYOCARDIAL REPERFUSION INJURY; RATS; RATS, SPRAGUE-DAWLEY; REACTIVE OXYGEN SPECIES; TIME FACTORS;

EID: 84886391658     PISSN: 01602446     EISSN: 15334023     Source Type: Journal    
DOI: 10.1097/01.fjc.0000432860.48345.9d     Document Type: Article

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