HIV disease progression in the first year after delivery among african women followed in the HPTN 046 clinical trial

Journal of Acquired Immune Deficiency Syndromes

Volumn 64, Issue 3, 2013, Pages 299-306

  Watts, D Heather ^a,l   Brown, Elizabeth R ^b   Maldonado, Yvonne ^c   Herron, Casey ^b   Chipato, Tsungai ^d   Reddy, Leanne ^e   Moodley, Dhayendre ^e   Nakabiito, Clemensia ^f   Manji, Karim ^g   Fawzi, Wafaie ^h   George, Kathleen ⁱ   Richardson, Paul ^j   Zwerski, Sheryl ^k,l   Coovadia, Hoosen ^m   Fowler, Maryglenn ^j  

^a EUNICE KENNEDY SHRIVER NATIONAL INSTITUTE OF CHILD HEALTH AND HUMAN DEVELOPMENT   (United States)

^b Fred Hutchinson Cancer Research Center   (United States)

^c STANFORD UNIVERSITY SCHOOL OF MEDICINE   (United States)

^d UNIVERSITY OF ZIMBABWE   (Zimbabwe)

^e UNIVERSITY OF KWAZULU NATAL   (South Africa)

^f JOHNS HOPKINS UNIVERSITY   (United States)

^g Muhimbili University of Health and Allied Sciences   (India)

^h HARVARD SCHOOL OF PUBLIC HEALTH   (United States)

ⁱ FAMILY HEALTH INTERNATIONAL   (United States)

^j DEPARTMENT OF PATHOLOGY   (United States)

^k NATIONAL INSTITUTE OF ALLERGY AND INFECTIOUS DISEASES   (United States)

^l UNIVERSITY OF THE WITWATERSRAND   (South Africa)

^m Seattle WA 98109   (United States)

more..

Author keywords

disease progression; HIV; postpartum

Indexed keywords

NEVIRAPINE; ANTI HUMAN IMMUNODEFICIENCY VIRUS AGENT;

ADULT; ANTIVIRAL THERAPY; ARTICLE; BREAST FEEDING; CD4 LYMPHOCYTE COUNT; CONTROLLED STUDY; DISEASE COURSE; DOUBLE BLIND PROCEDURE; FEMALE; FOLLOW UP; HUMAN; HUMAN IMMUNODEFICIENCY VIRUS INFECTION; MAJOR CLINICAL STUDY; PRIORITY JOURNAL; PUERPERIUM; RANDOMIZED CONTROLLED TRIAL; SINGLE DRUG DOSE; ADOLESCENT; CLINICAL TRIAL; DRUG ADMINISTRATION; DRUG EFFECTS; EPIDEMIOLOGY; HIV INFECTIONS; IMMUNOLOGY; KAPLAN MEIER METHOD; MEDICATION COMPLIANCE; MIDDLE AGED; MORTALITY; MULTICENTER STUDY; NEWBORN; PREGNANCY; PREVENTION AND CONTROL; SOUTH AFRICA; STATISTICS AND NUMERICAL DATA; TANZANIA; TRANSMISSION; UGANDA; VERTICAL TRANSMISSION; VIRUS LOAD; ZIMBABWE;

ADOLESCENT; ADULT; ANTI-HIV AGENTS; BREAST FEEDING; CD4 LYMPHOCYTE COUNT; DISEASE PROGRESSION; DOUBLE-BLIND METHOD; DRUG ADMINISTRATION SCHEDULE; FEMALE; HIV INFECTIONS; HUMANS; INFANT, NEWBORN; INFECTIOUS DISEASE TRANSMISSION, VERTICAL; KAPLAN-MEIER ESTIMATE; MEDICATION ADHERENCE; MIDDLE AGED; NEVIRAPINE; POSTPARTUM PERIOD; PREGNANCY; SOUTH AFRICA; TANZANIA; UGANDA; VIRAL LOAD; ZIMBABWE;

EID: 84886386913     PISSN: 15254135     EISSN: 10779450     Source Type: Journal    
DOI: 10.1097/QAI.0b013e3182a2123a     Document Type: Article

References (21)

1. World Health Organization. Use of antiretroviral drugs for treating pregnant women and prevention HIV infection in infants: programmatic update. 2012. Available at: http://www.who.int/hiv/pub/mtct/programmatic-update2012/en/. Accessed June 7, 2013.
2. Kuhn L, Aldrovandi GM, Sinkala M, et al. Potential impact of new WHO criteria for antiretroviral treatment for prevention of mother-to-child HIV transmission. AIDS. 2010;24:1374-1377.
3. Cohen MS, Chen YQ, McCauley M, et al; for the HPTN 052 Study Team. Prevention of HV-1 infection with early antiretroviral therapy. N Engl J Med. 2011;365:493-505.
4. Nachega JB, Uthman OA, Anderson J, et al. Adherence to antiretroviral therapy during and after pregnancy in low-income, middle-income, and high-income countries: a systematic review and meta-analysis. AIDS. 2012;26:2039-2052.
5. Coovadia HM, Brown ER, Fowler MG, et al; for the HPNT046 protocol team. Efficacy and safety of an extended nevirapine regimen in infant children of breastfeeding mothers with HIV-1 infection for prevention of postnatal HIV-1 transmission (HPTN 046): a randomised, double-blind, placebo-controlled trial. Lancet. 2012;379:221-228.
6. World Health Organization. WHO case definitions of HIV for surveillance and revised clinical staging and immunological classification of HIVrelated disease in adults and children. 2007. Available at: http://www.who.int/hiv/pub/ guidelines/HIVstaging150307.pdf. Accessed June 7, 2013.
7. Fawzi WW, Msamanga GI, Hunter D, et al. Randomized trial of vitamin supplements in relation to transmission of HIV-1 through breastfeeding and early child mortality. AIDS. 2002;16:1935-1944.
8. Brown ER, Otieno P, Mbori-Ngacha DA, et al. Comparison of CD4 cell count, viral load, and other markers for the prediction of mortality among HIV-1-infected Kenyan pregnant women. J Infect Dis. 2009;199: 1292-1300.
9. World Health Organization. Rapid advice: antiretroviral therapy for HIV infection in adults and adolescents. 2009. Available at: http://www.who.int/hiv/ pub/arv/rapid-advice-art.pdf.
10. Ekouevi D, Abrams EJ, Schlesinger M, et al; for the MTCT-Plus Initiative. Maternal CD4+ cell count decline after interruption of antiretroviral prophylaxis for the prevention of mother-to-child transmission of HIV. PLoS One. 2012;7:e43750.
11. Coria A, Noel F, Bonhomme J, et al. Consideration of postpartum management in HIV-positive Haitian women: an analysis of CD4 decline, mortality, and follow-up after delivery. J Acquir Immune Defic Syndr. 2012;61:636-643.
12. Pilotto JH, Velasque LS, Friedman RK, et al. Maternal outcomes after HAART for the prevention of mother-to-child transmission in HIVinfected women in Brazil. Antivir Ther. 2011;16:349-356.
13. Manzi M, Zachariah R, Teck R, et al. High acceptability of voluntary counseling and HIV-testing but unacceptable loss to follow up in a prevention of mother-to-child HIV transmission programme in rural Malawi: scaling-up requires a different way of acting. Trop Med Int Health 2005; 10:1242-1250.
14. Wang B, Losina E, Stark R, et al. Loss to follow-up in a community clinic in South Africa-roles of gender, pregnancy and CD4 count. S Afr Med J. 2011;101:253-257.
15. Clouse K, Maskey M, Fox MP, et al. Delayed diagnosis of HIV and high rates of loss to follow-up among pregnant women receiving antenatal services at a primary healthcare clinic in Johannesburg, South Africa. Paper presented at: the 19th Conference on Retroviruses and Opportunistic Infections; Seattle, WA. March, 2012. Abstract 1004.
16. Ahoua L, Ayikoru H, Gnauck K, et al. Evaluation of a 5-year programme to prevent mother-to-child transmission of HIV infection in Northern Uganda. J Trop Pediatr. 2010;56:43-52.
17. Ekama SO, Herbertson EC, Addeh EJ, et al. Pattern and determinants of antiretroviral drug adherence among Nigerian pregnant women. J Pregnancy. 2012;2012:851810.
18. Nachega JB, Marconi VC, van Zyl GU, et al. HIV treatment adherence, drug resistance, virologic failure: evolving concepts. Infect Disord Drug Targets. 2011;11:167-174.
19. Chilongozi D, Wang L, Brown L, et al; for the HIVNET 024 Study Team. Morbidity and mortality among a cohort of human immunodeficiency virus type 1-infected and uninfected pregnant women and their infants from Malawi, Zambia, and Tanzania. Pediatr Infect Dis J. 2008; 27:808-814.
20. Landes M, van Lettow M, Bedell R, et al. Mortality and health outcomes in HIV-infected and HIV-uninfected mothers at 18-20 months postpartum in Zomba district, Malawi. PLoS One. 2012;7:e44396.
21. Richardson BA, Otieno PA, Mbori-Ngacha D, et al. Hormonal contraception and HIV-1 disease progression among postpartum Kenyan women. AIDS. 2007;21:749-753.