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Volumn , Issue , 2012, Pages 169-183

The Clavulanic Acid Strain Improvement Program at DSM Anti-Infectives

Author keywords

Clavulanic acid by S. clavuligerus, biosynthetic pathway; Glutamate, clavulanic acid arginine biosynthesis; S. clavuligerus, targeted engineering approaches; Strains selected at DSM; The clavulanic acid strain improvement at DSM anti infectives

Indexed keywords


EID: 84886354594     PISSN: None     EISSN: None     Source Type: Book    
DOI: 10.1002/9781118433034.ch6     Document Type: Chapter
Times cited : (1)

References (13)
  • 3
    • 46949091082 scopus 로고    scopus 로고
    • Regulatory mechanisms controlling antibiotic production in Streptomyces clavuligerus
    • Liras, P., Gomez-Escribano, J.P., and Santamarta, I. (2008) Regulatory mechanisms controlling antibiotic production in Streptomyces clavuligerus. J Ind Microbiol Biotechnol, 35, 667-676.
    • (2008) J Ind Microbiol Biotechnol , vol.35 , pp. 667-676
    • Liras, P.1    Gomez-escribano, J.P.2    Santamarta, I.3
  • 4
    • 33646041617 scopus 로고    scopus 로고
    • Manipulation of the physiology of clavulanic acid biosynthesis with the aid of metabolic flux analysis
    • Bushell, M.E., Kirk, S., Zhao, H.-J., and Avignone-Rossa, C.A. (2006) Manipulation of the physiology of clavulanic acid biosynthesis with the aid of metabolic flux analysis. Enzyme Microb Technol, 39, 149-157.
    • (2006) Enzyme Microb Technol , vol.39 , pp. 149-157
    • Bushell, M.E.1    Kirk, S.2    Zhao, H.-J.3    Avignone-rossa, C.A.4
  • 5
    • 0021197255 scopus 로고
    • Industrial strain improvement: mutagenesis and random screening procedures
    • Rowlands, R.T. (1984) Industrial strain improvement: mutagenesis and random screening procedures. Enzyme Microb Technol, 6, 3-10.
    • (1984) Enzyme Microb Technol , vol.6 , pp. 3-10
    • Rowlands, R.T.1
  • 6
    • 0043156740 scopus 로고
    • Strain improvement and strain stability
    • In Finkelstein, D.B. and Ball, C. (eds.), Biotechnology of Filamentous Fungi. Butterworth-Heinemann, Boston
    • Rowlands, R.T. (1992) Strain improvement and strain stability. In Finkelstein, D.B. and Ball, C. (eds.), Biotechnology of Filamentous Fungi. Butterworth-Heinemann, Boston, pp. 41-64.
    • (1992) , pp. 41-64
    • Rowlands, R.T.1
  • 7
    • 0036260378 scopus 로고    scopus 로고
    • The clavulanic acid biosynthetic cluster of Streptomyces clavuligerus: genetic organization of the region upstream of the car gene
    • Mellado, E., Lorenzana, L.M., Rodríguez-Sáiz, M., Díez, B., Liras, P., and Barredo, J.L. (2002) The clavulanic acid biosynthetic cluster of Streptomyces clavuligerus: genetic organization of the region upstream of the car gene. Microbiology, 148, 1427-1438.
    • (2002) Microbiology , vol.148 , pp. 1427-1438
    • Mellado, E.1    Lorenzana, L.M.2    Rodríguez-sáiz, M.3    Díez, B.4    Liras, P.5    Barredo, J.L.6
  • 8
    • 0031891879 scopus 로고    scopus 로고
    • A pathway-specific transcriptional activator regulates late steps of clavulanic acid biosynthesis in Streptomyces clavuligerus
    • Paradkar, A.S., Aidoo, K.A., and Jensen, S.E. (1998) A pathway-specific transcriptional activator regulates late steps of clavulanic acid biosynthesis in Streptomyces clavuligerus. Mol Microbiol, 27, 831-843.
    • (1998) Mol Microbiol , vol.27 , pp. 831-843
    • Paradkar, A.S.1    Aidoo, K.A.2    Jensen, S.E.3
  • 11
    • 0031855642 scopus 로고    scopus 로고
    • Investigation of the Streptomyces clavuligerus cephamycin C gene cluster and its regulation by the CcaR protein
    • Alexander, D.C. and Jensen, S.E. (1998) Investigation of the Streptomyces clavuligerus cephamycin C gene cluster and its regulation by the CcaR protein. J Bacteriol, 180, 4068-4079.
    • (1998) J Bacteriol , vol.180 , pp. 4068-4079
    • Alexander, D.C.1    Jensen, S.E.2
  • 12
    • 33745438016 scopus 로고    scopus 로고
    • Amplification of the entire kanamycin biosynthetic cluster during empirical strain improvement of Streptomyces kanamyceticus
    • Yanai, K., Murakami, T., and Bibb, M. (2006) Amplification of the entire kanamycin biosynthetic cluster during empirical strain improvement of Streptomyces kanamyceticus. Proc Natl Acad Sci U S A, 103, 9661-9666.
    • (2006) Proc Natl Acad Sci U S A , vol.103 , pp. 9661-9666
    • Yanai, K.1    Murakami, T.2    Bibb, M.3
  • 13
    • 33646082272 scopus 로고    scopus 로고
    • Rational strain improvement for enhanced clavulanic acid production by genetic engineering of the glycolytic pathway in Streptomyces clavuligerus
    • Li, R. and Townsend, C.A. (2006) Rational strain improvement for enhanced clavulanic acid production by genetic engineering of the glycolytic pathway in Streptomyces clavuligerus. Metab Eng, 8, 240-252.
    • (2006) Metab Eng , vol.8 , pp. 240-252
    • Li, R.1    Townsend, C.A.2


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.