MACC1 is related to colorectal cancer initiation and early-stage invasive growth

American Journal of Clinical Pathology

Volumn 140, Issue 5, 2013, Pages 701-707

  Ren, Bing ^a   Zakharov, Vladislav ^a   Yang, Qi ^a   McMahon, Loralee ^a   Yu, JiangZhou ^a   Cao, Wenqing ^a  

^a UNIVERSITY OF ROCHESTER MEDICAL CENTER   (United States)

Author keywords

Early stage colorectal adenocarcinoma; MET; Metastasis associated in colon cancer 1; Neoplastic lesions

Indexed keywords

ANTIBODY; METASTASIS ASSOCIATED IN COLON CANCER 1; PARAFFIN; PROTEIN; SCATTER FACTOR RECEPTOR; UNCLASSIFIED DRUG;

ADULT; ADVANCED CANCER; AGED; ARTICLE; CANCER GROWTH; CANCER PROGNOSIS; CANCER STAGING; COLON ADENOCARCINOMA; COLON RESECTION; COLORECTAL ADENOMA; COLORECTAL POLYP; CONTROLLED STUDY; DISEASE ASSOCIATION; DISTANT METASTASIS; EARLY DIAGNOSIS; FEMALE; FOLLOW UP; HUMAN; IMMUNOHISTOCHEMISTRY; INVASIVE CARCINOMA; LIVER METASTASIS; MAJOR CLINICAL STUDY; MALE; MICROSURGERY; POLYPECTOMY; PRIORITY JOURNAL; PROTEIN EXPRESSION; TUMOR GROWTH;

EARLY-STAGE COLORECTAL ADENOCARCINOMA; MET; METASTASIS ASSOCIATED IN COLON CANCER 1; NEOPLASTIC LESIONS;

ADENOCARCINOMA; ADENOMA; ADULT; AGED; AGED, 80 AND OVER; CARCINOGENESIS; COLORECTAL NEOPLASMS; DISEASE PROGRESSION; EARLY DIAGNOSIS; FEMALE; GENE EXPRESSION REGULATION, NEOPLASTIC; HUMANS; LIVER NEOPLASMS; MALE; MIDDLE AGED; NEOPLASM INVASIVENESS; PROTO-ONCOGENE PROTEINS C-MET; TRANSCRIPTION FACTORS; TUMOR MARKERS, BIOLOGICAL; UP-REGULATION;

EID: 84886298150     PISSN: 00029173     EISSN: 19437722     Source Type: Journal    
DOI: 10.1309/AJCPRH1H5RWWSXRB     Document Type: Article

References (25)

1. Parkin DM, Ferlay J, Curado MP, et al. Fifty years of cancer incidence: CI5 I-IX. Int J Cancer. 2010;127:2918-2927.
2. Zeng ZS, Weiser MR, Kuntz E, et al. c-Met gene amplification is associated with advanced stage colorectal cancer and liver metastases. Cancer Lett. 2008;265:258-269.
3. Takeuchi H, Bilchik A, Saha S, et al. c-MET expression level in primary colon cancer: a predictor of tumor invasion and lymph node metastases. Clin Cancer Res. 2003;9:1480-1488.
4. Kammula US, Kuntz EJ, Francone TD, et al. Molecular co-expression of the c-Met oncogene and hepatocyte growth factor in primary colon cancer predicts tumor stage and clinical outcome. Cancer Lett. 2007;248:219-228.
5. Fazekas K, Csuka O, Koves I, et al. Experimental and clinicopathologic studies on the function of the HGF receptor in human colon cancer metastasis. Clin Exp Metastasis. 2000;18:639-649.
6. Stein U, Walther W, Arlt F, et al. MACC1, a newly identified key regulator of HGF-MET signaling, predicts colon cancer metastasis. Nat Med. 2009;15:59-67.
7. Stein U, Smith J, Walther W, et al. MACC1 controls Met: what a difference an Sp1 site makes. Cell Cycle. 2009;8:2467-2469.
8. Chundong G, Uramoto H, Onitsuka T, et al. Molecular diagnosis of MACC1 status in lung adenocarcinoma by immunohistochemical analysis. Anticancer Res. 2011;31:1141-1145.
9. Stein U, Dahlmann M, Walther W. MACC1-more than metastasis? Facts and predictions about a novel gene. J Mol Med (Berl). 2010;88:11-18.
10. Nitsche U, Rosenberg R, Balmert A, et al. Integrative marker analysis allows risk assessment for metastasis in stage II colon cancer. Ann Surg. 2012;256:763-771.
11. Arlt F, Stein U. Colon cancer metastasis: MACC1 and Met as metastatic pacemakers. Int J Biochem Cell Biol. 2009;41:2356-2359.
12. Zakharov V, Ren B, Ryan C, et al. Diagnostic value of HMGAs, p53 and beta-catenin in discriminating adenocarcinoma from adenoma or reactive atypia in ampulla and common bile duct biopsies. Histopathology. 2013;62:778-787.
13. Shu C, Cheng H, Wang A, et al. Thymidylate synthase expression and molecular alterations in adenosquamous carcinoma of the lung. Mod Pathol. 2013;26:239-246.
14. Kawamura M, Saigusa S, Toiyama Y, et al. Correlation of MACC1 and MET expression in rectal cancer after neoadjuvant chemoradiotherapy. Anticancer Res. 2012;32:1527-1531.
15. Qiu J, Huang P, Liu Q, et al. Identification of MACC1 as a novel prognostic marker in hepatocellular carcinoma. J Transl Med. 2011;9:166.
16. Shimokawa H, Uramoto H, Onitsuka T, et al. Overexpression of MACC1 mRNA in lung adenocarcinoma is associated with postoperative recurrence. J Thorac Cardiovasc Surg. 2011;141:895-898.
17. Rong S, Segal S, Anver M, et al. Invasiveness and metastasis of NIH 3T3 cells induced by Met-hepatocyte growth factor/scatter factor autocrine stimulation. Proc Natl Acad Sci U S A. 1994;91:4731-4735.
18. Meiners S, Brinkmann V, Naundorf H, et al. Role of morphogenetic factors in metastasis of mammary carcinoma cells. Oncogene. 1998;16(1):9-20.
19. Gallego MI, Bierie B, Hennighausen L. Targeted expression of HGF/SF in mouse mammary epithelium leads to metastatic adenosquamous carcinomas through the activation of multiple signal transduction pathways. Oncogene. 2003;22:8498-8508.
20. Moshitch-Moshkovitz S, Tsarfaty G, Kaufman DW, et al. In vivo direct molecular imaging of early tumorigenesis and malignant progression induced by transgenic expression of GFP-Met. Neoplasia. 2006;8:353-363.
21. Shirahata A, Shinmura K, Kitamura Y, et al. MACC1 as a marker for advanced colorectal carcinoma. Anticancer Res. 2010;30:2689-2692.
22. Stein U, Burock S, Herrmann P, et al. Circulating MACC1 transcripts in colorectal cancer patient plasma predict metastasis and prognosis. PLoS One. 2012;7:e49249.
23. Lang AH, Geller-Rhomberg S, Winder T, et al. A common variant of the MACC1 gene is significantly associated with overall survival in colorectal cancer patients. BMC Cancer. 2012;12:20.
24. Boardman LA. Overexpression of MACC1 leads to downstream activation of HGF/MET and potentiates metastasis and recurrence of colorectal cancer. Genome Med. 2009;1:36.
25. Galimi F, Torti D, Sassi F, Isella C, et al. Genetic and expression analysis of MET, MACC1, and HGF in metastatic colorectal cancer: response to Met inhibition in patient xenografts and pathologic correlations. Clin Cancer Res. 2011;17:3146-3156.