Oral branched-chain amino acid supplements that reduce brain serotonin during exercise in rats also lower brain catecholamines

Amino Acids

Volumn 45, Issue 5, 2013, Pages 1133-1142

  Choi, Sujean ^a   Disilvio, Briana ^b   Fernstrom, Madelyn H ^b   Fernstrom, John D ^b,c  

^a MARQUETTE UNIVERSITY   (United States)

^b UNIVERSITY OF PITTSBURGH SCHOOL OF MEDICINE   (United States)

^c UNIVERSITY OF PITTSBURGH   (United States)

Author keywords

Catecholamines; Exercise; Rat; Serotonin; Tryptophan; Tyrosine

Indexed keywords

BRANCHED CHAIN AMINO ACID; CATECHOLAMINE; SEROTONIN; TRYPTOPHAN; TYROSINE;

AMINO ACID BLOOD LEVEL; AMINO ACID BRAIN LEVEL; AMINO ACID SYNTHESIS; AMINO ACID TRANSPORT; ANIMAL EXPERIMENT; ARTICLE; BRAIN REGION; CATECHOLAMINE BRAIN LEVEL; CATECHOLAMINE RELEASE; CATECHOLAMINE SYNTHESIS; CONTROLLED STUDY; DYSTHYMIA; EXERCISE; HYPOTHALAMUS; MALE; MUSCLE MASS; NONHUMAN; PHYSICAL PERFORMANCE; PRIORITY JOURNAL; PROTEIN SYNTHESIS; RAT; SEROTONIN RELEASE; SITTING;

RATTUS;

AMINO ACIDS, BRANCHED-CHAIN; ANIMALS; BRAIN; CATECHOLAMINES; DIETARY SUPPLEMENTS; EXERCISE; HUMANS; RATS; RATS, SPRAGUE-DAWLEY; SEROTONIN;

EID: 84886284922     PISSN: 09394451     EISSN: 14382199     Source Type: Journal    
DOI: 10.1007/s00726-013-1566-1     Document Type: Article

References (45)

1. Bailey SP, Davis JM, Ahlborn EN (1992) Effect of increased brain serotonergic activity on endurance performance in the rat. Acta Physiol Scand 145:75-76
2. Bailey SP, Davis JM, Ahlborn EN (1993) Serotonergic agonists and antagonists affect endurance performance in the rat. Int J Sports Med 14:330-333 (Pubitemid 23260002)
3. Blomstrand E, Hassmen P, Ekblom B, Newsholme EA (1991) Administration of branched-chain amino acids during sustained exercise-effects on performance and on plasma concentration of some amino acids. Eur J Appl Physiol 63:83-88
4. Bongiovanni R, Yamamoto BK, Jaskiw GE (2001) Improved method for the measurement of large neutral amino acids in biological matrices. J Chromatog B 754:369-376 (Pubitemid 32261032)
5. Carlsson A, Lindqvist M (1978) Dependence of 5-HT and catecholamine synthesis on concentrations of precursor amino acids in rat brain. Naunyn Schmied Arch Pharmacol 303:157-164 (Pubitemid 8369123)
6. Choi S, DiSilvio B, Fernstrom MH, Fernstrom JD (2009) Meal ingestion, amino acids and brain neurotransmitters: effects of dietary protein source on serotonin and catecholamine synthesis rates. Physiol Behav 98:156-162
7. Davis JM, Alderson NL, Welsh RS (2000) Serotonin and central nervous system fatigue: nutritional considerations. Am J Clin Nutr 72:573S-578S (Pubitemid 30650057)
8. Fernstrom JD (1983) Role of precursor availability in the control of monoamine biosynthesis in brain. Physiol Rev 63:484-546 (Pubitemid 13134308)
9. Fernstrom JD, Faller DV (1978) Neutral amino acids in the brain: changes in response to food ingestion. J Neurochem 30:1531-1538 (Pubitemid 8377077)
10. Fernstrom MH, Fernstrom JD (1987) Protein consumption increases tyrosine concentration and in vivo tyrosine hydroxylation rate in the light-adapted rat retina. Brain Res 401:392-396 (Pubitemid 17221833)
11. Fernstrom MH, Fernstrom JD (1995a) Effect of chronic protein ingestion on rat central nervous system tyrosine levels and in vivo tyrosine hydroxylation rate. Brain Res 672:97-103
12. Fernstrom MH, Fernstrom JD (1995b) Acute tyrosine depletion reduces tyrosine hydroxylation rate in rat central nervous system. Life Sci 57:PL97-PL102
13. Fernstrom MH, Fernstrom JD (1995c) Brain tryptophan concentrations and serotonin synthesis remain responsive to food consumption after the ingestion of sequential meals. Am J Clin Nutr 61:312-319
14. Fernstrom JD, Wurtman RJ (1971) Brain serotonin content: physiological dependence on plasma tryptophan levels. Science 173:149-152
15. Fernstrom JD, Wurtman RJ (1972) Brain serotonin content: physiological regulation by plasma neutral amino acids. Science 178:414-416
16. Fernstrom MH, Volk EA, Fernstrom JD (1986) In vivo inhibition of tyrosine uptake into rat retina by large neutral but not acidic amino acids. Am J Physiol 251:E393-E399
17. Friedman PA, Kappelman AH, Kaufman S (1972) Partial purification and characterization of tryptophan hydroxylase from rabbit hindbrain. J Biol Chem 247:4165-4173
18. Gartside SE, Cowen PJ, Sharp T (1992) Evidence that the large neutral amino acid l-valine decreases electrically-evoked release of 5-HT in rat hippocampus in vivo. Psychopharmacology 109:251-253
19. Gijsman HJ, Scarna A, Harmer CJ, McTavish SB, Odontiadis J, Cowen PJ, Goodwin GM (2002) A dose-finding study on the effects of branch chain amino acids on surrogate markers of brain dopamine function. Psychopharmacology 160:192-197 (Pubitemid 34212245)
20. Hobson RM, Watson P, Maughan RJ (2013) Acute tryptophan depletion does not improve endurance cycling capacity in a warm environment. Amino Acids 44:983-991
21. Hundal HS, Rennie MJ, Watt PW (1989) Characteristics of acidic, basic and neutral amino acid transport in the perfused rat hindlimb. J Physiol Lond 408:93-114 (Pubitemid 19040011)
22. Kaufman S (1974) Properties of the pterin-dependent aromatic amino acid hydroxylases. In: Wolstenholme GEW, FitzSimons DW (eds) Aromatic amino acids in the brain (CIBA foundation symposium 22 [New Series]). Elsevier, Amsterdam, pp 85-115
23. Lieberman HR (2003) Nutrition, brain function and cognitive performance. Appetite 40:245-254 (Pubitemid 36687823)
24. McTavish SFB, Cowen PJ, Sharp T (1999) Effect of a tyrosine-free amino acid mixture on regional brain catecholamine synthesis and release. Psychopharmacology 141:182-188 (Pubitemid 29200170)
25. Meeusen R, Watson P, Hasegawa H, Roelands B, Piacentini MF (2006) Central fatigue: the serotonin hypothesis and beyond. Sports Med 36:881-909 (Pubitemid 44497464)
26. Moir ATB, Eccleston D (1968) The effects of precursor loading in the cerebral metabolism of 5-hydroxyindoles. J Neurochem 15:1093-1108
27. Newsholme EA, Blomstrand E (1996) The plasma level of some amino acids and physical and mental fatigue. Experientia 52:413-415 (Pubitemid 26158607)
28. Pardridge WM (1979) The role of blood-brain barrier transport of tryptophan and other neutral amino acids in the regulation of substrate-limited pathways of brain amino acid metabolism. J Neural Transm Suppl 15:43-54
29. Pardridge WM, Oldendorf WH (1975) Kinetic analysis of blood-brain barrier transport of amino acids. Biochim Biophys Acta 401:128-136
30. Paxinos G, Watson C (1982) The rat brain in stereotaxic coordinates. Academic Press, New York
31. Phillips SM (2004) Protein requirements and supplementation in strength sports. Nutrition 20:689-695 (Pubitemid 38798086)
32. Roelands B, Hasegawa H, Watson P, Piacentini MF, Buyse L, De Schutter G, Meeusen R (2008a) The effects of acute dopamine reuptake inhibition on performance. Med Sci Sports Exerc 40:879-885
33. Roelands B, Goekint M, Heyman E, Piacentini MF, Watson P, Hasegawa H, Buyse L, Pauwels F, De Schutter G, Meeusen R (2008b) Acute norepinephrine reuptake inhibition decreases performance in normal and high ambient temperature. J Appl Physiol 105:206-212
34. Rouch C, Meile MJ, Orosco M (2003) Extracellular hypothalamic serotonin and plasma amino acids in response to sequential carbohydrate and protein meals. Nutr Neurosci 6:117-124 (Pubitemid 36417043)
35. Smriga M, Kameishi M, Tanaka T, Kondoh T, Torii K (2002) Preference for a solution of branched-chain amino acids plus glutamine and arginine correlates with free running activity in rats: involvement of serotonergic-dependent processes of lateral hypothalamus. Nutr Neurosci 5:189-199 (Pubitemid 34568214)
36. Struder HK, Hollmann W, Platen P, Donike M, Gotzmann A, Weber K (1998) Influence of paroxetine, branched-chain amino acids and tyrosine on neuroendocrine system responses and fatigue in humans. Horm Metab Res 30:188-194 (Pubitemid 28201085)
37. Tarnopolsky M (2004) Protein requirements for endurance athletes. Nutrition 20:662-668 (Pubitemid 38798083)
38. Tipton KD, Wolfe RR (2004) Protein and amino acids for athletes. J Sports Sci 22:65-79 (Pubitemid 38173091)
39. Tipton KD, Ferrando AA, Phillips SM, Doyle D, Wolfe RR (1999) Postexercise net protein synthesis in human muscle from orally administered amino acids. Am J Physiol 276:E628-E634
40. Tumilty L, Davison G, Beckmann M, Thatcher R (2011) Oral tyrosine supplementation improves exercise capacity in the heat. Eur J Appl Physiol 111:2941-2950
41. US Department of Agriculture, Agricultural Research Service (2006) USDA national nutrient database for standard reference, Release 19. Nutrient database laboratory home page http://www.ars.usda.gov/nutrientdata. Accessed 15 Nov 2007
42. Watson P, Hasegawa H, Roelands B, Piacentini MF, Looverie R, Meeusen R (2005) Acute dopamine/noradrenaline reuptake inhibition enhances human exercise performance in warm, but not temperate conditions. J Physiol 565:873-883 (Pubitemid 40903299)
43. Watson P, Enever S, Page A, Stockwell J, Maughan RJ (2012) Tyrosine supplementation does not influence the capacity to perform prolonged exercise in a warm environment. Int J Sport Nutr Exerc Metab 22:363-373
44. Wilson WM, Maughan RJ (1992) Evidence for a possible role of 5-hydroxytryptamine in the genesis of fatigue in man: administration of paroxetine, a 5-HT re-uptake inhibitor, reduces the capacity to perform prolonged exercise. Exp Physiol 77:921-924
45. Wurtman RJ, Larin F, Mostafapour S, Fernstrom JD (1974) Brain catechol synthesis: control by brain tyrosine concentration. Science 185:183-184