Are meningeal hemangiopericytoma and mesenchymal chondrosarcoma the same? A study of HEY1-NCOA2 fusion

American Journal of Clinical Pathology

Volumn 140, Issue 5, 2013, Pages 670-674

  Fritchie, Karen J ^a   Jin, Long ^a   Ruano, Ana ^b   Oliveira, Andre M ^a   Rubin, Brian P ^b  

^a MAYO CLINIC   (United States)

^b LERNER RESEARCH INSTITUTE   (United States)

Author keywords

HEY1 NCOA2; Meningeal hemangiopericytoma; Mesenchymal chondrosarcoma

Indexed keywords

HEY1 NCOA2 FUSION PROTEIN; HYBRID PROTEIN; TUMOR MARKER; UNCLASSIFIED DRUG;

ADULT; AGED; ARTICLE; CANCER DIAGNOSIS; CHONDROSARCOMA; CLINICAL ARTICLE; CONTROLLED STUDY; DIFFERENTIAL DIAGNOSIS; FEMALE; GENETIC TRANSCRIPTION; HEMANGIOPERICYTOMA; HISTOPATHOLOGY; HUMAN; HUMAN TISSUE; MALE; MENINGEAL HEMANGIOPERICYTOMA; MENINGIOMA; MESENCHYME CHONDROSARCOMA; PRIORITY JOURNAL; REVERSE TRANSCRIPTION POLYMERASE CHAIN REACTION;

HEY1-NCOA2; MENINGEAL HEMANGIOPERICYTOMA; MESENCHYMAL CHONDROSARCOMA;

ADULT; AGED; BASIC HELIX-LOOP-HELIX TRANSCRIPTION FACTORS; CELL CYCLE PROTEINS; CHONDROSARCOMA, MESENCHYMAL; DIAGNOSIS, DIFFERENTIAL; DNA, NEOPLASM; FEMALE; HEMANGIOPERICYTOMA; HUMANS; MALE; MENINGEAL NEOPLASMS; MIDDLE AGED; NEOPLASM RECURRENCE, LOCAL; NUCLEAR RECEPTOR COACTIVATOR 2; ONCOGENE PROTEINS, FUSION; REVERSE TRANSCRIPTASE POLYMERASE CHAIN REACTION; TUMOR MARKERS, BIOLOGICAL; YOUNG ADULT;

EID: 84886248170     PISSN: 00029173     EISSN: 19437722     Source Type: Journal    
DOI: 10.1309/AJCPGUNGP52ZSDNS     Document Type: Article

References (19)

1. Louis DN, Ohgaki H, Wiestler OD, et al, eds. WHO Classification of Tumours of the Central Nervous System. Lyons, France: IARC Press; 2007:178-180.
2. Weiss SW, Goldblum JR, eds. Enzinger and Weiss's Soft Tissue Tumors. Philadelphia, PA: Mosby Elsevier; 2008.
3. Wang L, Motoi T, Khanin R, et al. Identification of a novel, recurrent HEY1-NCOA2 fusion in mesenchymal chondrosarcoma based on a genome-wide screen of exon-level expression data. Genes Chromosomes Cancer. 2012;51:127-139.
4. Bailey P, Cushing H, Eisenhardt L. Angioblastic meningiomas. Arch Pathol. 1928;6:953-990.
5. Bailey P, Bucy PC. The origin and nature of meningeal tumors. Am J Cancer. 1931;15-54.
6. Bergstrand H, Olivecrona H. Angioblastic meningiomas. Am J Cancer. 1935;24:522.
7. Stout AP, Murray MR. Hemangiopericytoma: a vascular tumor featuring Zimmermann's pericytes. Ann Surg. 1942;116:26-33.
8. Begg CF, Garret R. Hemangiopericytoma occurring in the meninges: case report. Cancer. 1954;7:602-606.
9. Fisher ER, Davis JS, Lemmen LJ. Meningeal hemangiopericytoma. AMA Arch Neurol Psychiatry. 1958;79:40-45.
10. Simpson D. The recurrence of intracranial meningiomas after surgical treatment. J Neurol Neurosurg Psychiatry. 1957;20:22-39.
11. Perry A, Scheithauer BW, Nascimento AG. The immunophenotypic spectrum of meningeal hemangiopericytoma: a comparison with fibrous meningioma and solitary fibrous tumor of meninges. Am J Surg Pathol. 1997;21:1354-1360.
12. Tihan T, Viglione M, Rosenblum MK, et al. Solitary fibrous tumors in the central nervous system: a clinicopathologic review of 18 cases and comparison to meningeal hemangiopericytomas. Arch Pathol Lab Med. 2003;127:432-439.
13. Hayashi Y, Uchiyama N, Nakada M, et al. A reevaluation of the primary diagnosis of hemangiopericytoma and the clinical importance of differential diagnosis from solitary fibrous tumor of the central nervous system. Clin Neurol Neurosurg. 2009;111:34-38.
14. Lightenstein L, Bernstein D. Unusual benign and malignant chondroid tumors of bone: a survey of some mesenchymal cartilage tumors and malignant chondroblastic tumors, including a few multicentric ones, as well as many atypical benign chondroblastomas and chondromyxoid fibromas. Cancer. 1959;12:1142-1157.
15. Louis DN, Ohgaki H, Wiestler OD, et al. The 2007 WHO classification of tumours of the central nervous system. Acta Neuropathol. 2007;114:97-109.
16. Chmielecki J, Crago AM, Rosenberg M, et al. Whole-exome sequencing identifies a recurrent NAB2-STAT6 fusion in solitary fibrous tumors. Nat Genet. 2013;45:131-132.
17. Robinson DR, Wu YM, Kalyana-Sundaram S, et al. Identification of recurrent NAB2-STAT6 gene fusions in solitary fibrous tumor by integrative sequencing. Nat Genet. 2013;45:180-185.
18. Schweizer L, Koelsche C, Sahm F, et al. Meningeal hemangiopericytoma and solitary fibrous tumors carry the NAB2-STAT6 fusion and can be diagnosed by nuclear expression of STAT6 protein. Acta Neuropathol. 2013;125:651-658.
19. Kruse F Jr. Hemangiopericytoma of the meninges (angioblastic meningioma of Cushing and Eisenhardt): clinicopathologic aspects and follow-up studies in 8 cases. Neurology. 1961;11:771-777.