Lincosamide resistance mediated by lnu(C) (L phenotype) in a Streptococcus anginosus clinical isolate

Journal of Antimicrobial Chemotherapy

Volumn 68, Issue 11, 2013, Pages 2464-2467

  Gravey, François ^a   Galopin, Sébastien ^b   Grall, Nathalie ^c   Auzou, Michel ^a   Andremont, Antoine ^c   Leclercq, Roland ^a,b   Cattoir, Vincent ^a,b  

^a CAEN UNIVERSITY HOSPITAL   (France)

^b UNIVERSITÉ DE CAEN   (France)

^c BICHAT HOSPITAL   (France)

Author keywords

Lincomycin; Lnu(C); MLS resistance; S. Anginosus; Streptococcus milleri group

Indexed keywords

AMOXICILLIN; CLINDAMYCIN; COTRIMOXAZOLE; ERYTHROMYCIN; GENTAMICIN; LINCOMYCIN; LINCOSAMIDE; NUCLEOTIDYLTRANSFERASE; PENICILLIN G; PRISTINAMYCIN; RIFAMPICIN; TEICOPLANIN; TELITHROMYCIN; TETRACYCLINE; TRANSPOSASE; VANCOMYCIN;

ANTIBIOTIC RESISTANCE; ANTIBIOTIC SENSITIVITY; ARTICLE; BACTERIAL GENE; BACTERIAL STRAIN; BACTERIUM IDENTIFICATION; BACTERIUM ISOLATE; CONTROLLED STUDY; DISK DIFFUSION; IN VITRO STUDY; MINIMUM INHIBITORY CONCENTRATION; PHENOTYPE; STREPTOCOCCUS AGALACTIAE; STREPTOCOCCUS ANGINOSUS; STREPTOCOCCUS MILLERI; TRANSPOSON; VAGINA SMEAR;

LINCOMYCIN; LNU(C); MLS RESISTANCE; S. ANGINOSUS; STREPTOCOCCUS MILLERI GROUP;

ANTI-BACTERIAL AGENTS; BACTERIAL PROTEINS; CONJUGATION, GENETIC; DNA, BACTERIAL; DRUG RESISTANCE, BACTERIAL; GENE TRANSFER, HORIZONTAL; HUMANS; INFANT, NEWBORN; LINCOSAMIDES; MICROBIAL SENSITIVITY TESTS; MOTHERS; PHENOTYPE; POLYMERASE CHAIN REACTION; STREPTOCOCCAL INFECTIONS; STREPTOCOCCUS ANGINOSUS;

EID: 84886244116     PISSN: 03057453     EISSN: 14602091     Source Type: Journal    
DOI: 10.1093/jac/dkt255     Document Type: Article

References (20)

1. Piscitelli SC, Shwed J, Schreckenberger Pet al. Streptococcus milleri group: renewed interest in an elusive pathogen. Eur J Clin Microbiol Infect Dis 1992; 11: 491-8
2. Jacobs JA, van Baar GJ, London NH et al. Prevalence of macrolide resistance genes in clinical isolates of the Streptococcus anginosus ('S. milleri') group. Antimicrob Agents Chemother 2001; 45: 2375-7
3. Asmah N, Eberspächer B, Regnath Tet al. Prevalence of erythromycin and clindamycin resistance among clinical isolates of the Streptococcus anginosus group in Germany. J Med Microbiol 2009; 58: 222-7
4. Leclercq R. Mechanisms of resistance to macrolides and lincosamides: nature of the resistance elements and their clinical implications. Clin Infect Dis 2002; 34: 482-92
5. Brisson-Noë l A, Courvalin P. Nucleotide sequence of gene linA encoding resistance to lincosamides in Staphylococcus haemolyticus. Gene 1986; 43: 247-53
6. Lü thje P, Schwarz S. Antimicrobial resistance of coagulase-negative staphylococci from bovine subclinical mastitis with particular reference to macrolide-lincosamide resistance phenotypes and genotypes. J Antimicrob Chemother 2006; 57: 966-9
7. Le Bouter A, Leclercq R, Cattoir V. Molecular basis of resistance to macrolides, lincosamides and streptogramins in Staphylococcus saprophyticus clinical isolates. Int J Antimicrob Agents 2011; 37: 118-23
8. Wang J, Shoemaker NB,Wang GR et al. Characterization of a Bacteroides mobilizable transposon, NBU2, which carries a functional lincomycin resistance gene. J Bacteriol 2000; 182: 3559-71
9. Heir E, Lindstedt BA, Leegaard TM et al. Prevalence and characterization of integrons in blood culture Enterobacteriaceae and gastrointestinal Escherichia coli in Norway and reporting of a novel class 1 integronlocated lincosamide resistance gene. Ann Clin Microbiol Antimicrob 2004; 3: 12
10. Bozdogan B, Berrezouga L, Kuo MS et al. A new resistance gene, linB, conferring resistance to lincosamides by nucleotidylation in Enterococcus faecium HM1025. Antimicrob Agents Chemother 1999; 43: 925-9
11. de Azavedo JC, McGavin M, Duncan Cet al. Prevalence and mechanisms of macrolide resistance in invasive and noninvasive group B streptococcus isolates from Ontario, Canada. Antimicrob Agents Chemother 2001; 45: 3504-8
12. Lü thje P, Schwarz S. Molecular basis of resistance to macrolides and lincosamides among staphylococci and streptococci from various animal sources collected in the resistance monitoring program BfT-GermVet. Int J Antimicrob Agents 2007; 29: 528-35
13. Achard A, Villers C, Pichereau V et al. New lnu(C) gene conferring resistance to lincomycin by nucleotidylation in Streptococcus agalactiae UCN36. Antimicrob Agents Chemother 2005; 49: 2716-9
14. Petinaki E, Guérin-Fauble ́e V, Pichereau V et al. Lincomycin resistance gene lnu(D) in Streptococcus uberis. Antimicrob Agents Chemother 2008; 52: 626-30
15. Haenni M, Saras E, Bertin S et al. Diversityand mobility of integrative and conjugative elements in bovine isolates of Streptococcus agalactiae, S. dysgalactiae subsp. dysgalactiae, and S. uberis. Appl Environ Microbiol 2010; 76: 7957-65
16. Haenni M, Saras E, Chaussie're S et al. ermB-mediated erythromycin resistance in Streptococcus uberis from bovine mastitis. Vet J 2011; 189: 356-8
17. Poyart C, Quesne G, Coulon S et al. Identification of streptococci to species level by sequencing the gene encoding the manganesedependent superoxide dismutase. J Clin Microbiol 1998; 36: 41-7
18. Liu YG, Whittier RF. Thermal asymmetric interlaced PCR: automatable amplification and sequencing of insert end fragments from P1 and YAC clones for chromosome walking. Genomics 1995; 25: 674-81
19. Achard A, Leclercq R. Characterization of a small mobilizable transposon, MTnSag1, in Streptococcus agalactiae. J Bacteriol 2007; 189: 4328-31
20. Grinwis ME, Sibley CD, Parkins MD et al. Macrolide and clindamycin resistance in Streptococcus milleri group isolates from the airways of cystic fibrosis patients. Antimicrob Agents Chemother 2010; 54: 2823-9.