A Mouse Model of Adoptive Immunotherapeutic Targeting of Autoimmune Arthritis Using Allo-Tolerogenic Dendritic Cells

PLoS ONE

Volumn 8, Issue 10, 2013, Pages

  Yang, Jie ^a,b   Yang, Yiming ^a   Ren, Yana ^a   Xie, Rufeng ^a   Zou, Hejian ^b   Fan, Huahua ^a  

^a Shanghai Blood Center   (China)

^b FUDAN UNIVERSITY   (China)

Author keywords

[No Author keywords available]

Indexed keywords

ARGINASE; COLLAGEN TYPE 2; COLLAGEN TYPE 2 ANTIBODY; FAS LIGAND; GRANULOCYTE MACROPHAGE COLONY STIMULATING FACTOR; INDOLEAMINE 2,3 DIOXYGENASE; INTERLEUKIN 10; INTERLEUKIN 12P40; PROTEIN ANTIBODY; TRANSFORMING GROWTH FACTOR BETA1; UNCLASSIFIED DRUG;

ADOPTIVE IMMUNOTHERAPY; ADOPTIVE TRANSFER; ALLO TOLEROGENIC DENDRITIC CELL; ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ANTIARTHRITIC ACTIVITY; ANTIBODY PRODUCTION; ANTIGEN SPECIFICITY; ARTHRITIS; ARTICLE; AUTOIMMUNE ARTHRITIS; AUTOIMMUNE DISEASE; BONE MARROW CELL; CD4 CD8 RATIO; CD4+ T LYMPHOCYTE; CONTROLLED STUDY; CYTOKINE PRODUCTION; CYTOKINE RELEASE; DENDRITIC CELL; HISTOPATHOLOGY; IMMUNIZATION; IMMUNOSUPPRESSIVE TREATMENT; IN VITRO STUDY; IN VIVO STUDY; INCIDENCE; LYMPHOCYTE PROLIFERATION; MALE; MOUSE; NONHUMAN; OUTCOME ASSESSMENT; PHENOTYPE; POLARIZATION; REGULATORY T LYMPHOCYTE; SCORING SYSTEM; T LYMPHOCYTE SUBPOPULATION; TH17 CELL;

ANIMALS; ARTHRITIS, EXPERIMENTAL; ARTHRITIS, RHEUMATOID; AUTOIMMUNE DISEASES; CD4-POSITIVE T-LYMPHOCYTES; CELL PROLIFERATION; COLLAGEN TYPE II; DENDRITIC CELLS; DISEASE MODELS, ANIMAL; IMMUNE TOLERANCE; IMMUNOTHERAPY; INTERLEUKIN-10; MICE; MICE, INBRED C57BL; T-LYMPHOCYTES, REGULATORY; TH17 CELLS; TRANSFORMING GROWTH FACTOR BETA1;

EID: 84886239367     PISSN: None     EISSN: 19326203     Source Type: Journal    
DOI: 10.1371/journal.pone.0077729     Document Type: Article

References (32)

1. Lutzky V, Hannawi S, Thomas R, (2007) Cells of the synovium in rheumatoid arthritis. Dendritic cells. Arthritis Res Ther 9: 219. doi:10.1186/ar2200. PubMed: 17850683.
2. Zhao Y, Zhang A, Du H, Guo S, Ning B, et al. (2012) Tolerogenic dendritic cells and rheumatoid arthritis: current status and perspectives. Rheumatol Int 32: 837-844. doi:10.1007/s00296-011-2133-2. PubMed: 21904923.
3. Bevaart L, Vervoordeldonk MJ, Tak PP, (2010) Evaluation of therapeutic targets in animal models of arthritis: how does it relate to rheumatoid arthritis? Arthritis Rheum 62: 2192-2205. doi:10.1002/art.27503. PubMed: 20506322.
4. Torres-Aguilar H, Aguilar-Ruiz SR, González-Pérez G, Munguía R, Bajaña S, et al. (2010) Tolerogenic dendritic cells generated with different immunosuppressive cytokines induce antigen-specific anergy and regulatory properties in memory CD4+ T cells. J Immunol 184: 1765-1775. doi:10.4049/jimmunol.0902133. PubMed: 20083662.
5. Khan S, Greenberg JD, Bhardwaj N, (2009) Dendritic cells as targets for therapy in rheumatoid arthritis. Nat Rev Rheumatol 5: 566-571. doi:10.1038/nrrheum.2009.185. PubMed: 19798032.
6. Jaen O, Rullé S, Bessis N, Zago A, Boissier MC, et al. (2009) Dendritic cells modulated by innate immunity improve collagen-induced arthritis and induce regulatory T cells in vivo. Immunology 126: 35-44. doi:10.1111/j.1365-2567.2008.02875.x. PubMed: 18754812.
7. Healy LJ, Collins HL, Thompson SJ, (2008) Systemic administration of tolerogenic dendritic cells ameliorates murine inflammatory arthritis. Open Rheumatol J 2: 71-80. PubMed: 19156221.
8. Ko HJ, Cho ML, Lee SY, Oh HJ, Heo YJ, et al. (2010) CTLA4-Ig modifies dendritic cells from mice with collagen-induced arthritis to increase the CD4+CD25+Foxp3+ regulatory T cell population. J Autoimmun 34: 111-120. doi:10.1016/j.jaut.2009.07.006. PubMed: 19665867.
9. Criado G, Simelyte E, Inglis JJ, Essex D, Williams RO, (2009) Indoleamine 2,3 dioxygenase-mediated tryptophan catabolism regulates accumulation of Th1/Th17 cells in the joint in collagen-induced arthritis. Arthritis Rheum 60: 1342-1351. doi:10.1002/art.24446. PubMed: 19404944.
10. Brand DD, Latham KA, Rosloniec EF, (2007) Collagen-induced arthritis. Nat Protoc 2: 1269-1275. doi:10.1038/nprot.2007.173. PubMed: 17546023.
11. Lan YY, Wang Z, Raimondi G, Wu W, Colvin BL, et al. (2006) "Alternatively activated" dendritic cells preferentially secrete IL-10, expand Foxp3+CD4+ T cells, and induce long-term organ allograft survival in combination with CTLA4-Ig. J Immunol 177: 5868-5877. PubMed: 17056511.
12. Popov I, Li M, Zheng X, San H, Zhang X, et al. (2006) Preventing autoimmune arthritis using antigen-specific immature dendritic cells: a novel tolerogenic vaccine. Arthritis Res Ther 8: R141. doi:10.1186/ar2031. PubMed: 16911769.
13. Lim DS, Kang MS, Jeong JA, Bae YS, (2009) Semi-mature DC are immunogenic and not tolerogenic when inoculated at a high dose in collagen-induced arthritis mice. Eur J Immunol 39: 1334-1343. doi:10.1002/eji.200838987. PubMed: 19350558.
14. Salazar L, Aravena O, Contreras-Levicoy J, Pesce B, Catalan D, et al. (2007) Short-term lipopolysaccharide stimulation induces differentiation of murine bone marrow-derived dendritic cells into a tolerogenic phenotype. Eur Cytokine Netw 18: 78-85. PubMed: 17594940.
15. Amodio G, Gregori S, (2012) Dendritic cells a double-edge sword in autoimmune responses. Front Immunol 3: 233. PubMed: 22876246.
16. Gregori S, Casorati M, Amuchastegui S, Smiroldo S, Davalli AM, et al. (2001) Regulatory T cells induced by 1 alpha,25-dihydroxyvitamin D3 and mycophenolate mofetil treatment mediate transplantation tolerance. J Immunol 167: 1945-1953. PubMed: 11489974.
17. Manicassamy S, Pulendran B, (2011) Dendritic cell control of tolerogenic responses. Immunol Rev 241: 206-227. doi:10.1111/j.1600-065X.2011.01015.x. PubMed: 21488899.
18. Haile Lydia A, Greten, Tim F, Korangy Firouzeh (2012) Immune Suppression: The Hallmark of Myeloid Derived Suppressor Cells. Immunol Investig 41: 581-594. doi:10.3109/08820139.2012.680635. PubMed: 23017136.
19. Cripps JG, Gorham JD, (2011) MDSC in autoimmunity. Int Immunopharmacol 11: 789-793. doi:10.1016/j.intimp.2011.01.026. PubMed: 21310255.
20. Jiao Z, Hua S, Wang W, Wang H, Gao J, et al. (2013) Increased circulating myeloid-derived suppressor cells correlated negatively with Th17 cells in patients with rheumatoid arthritis. Scand J Rheumatol 42: 85-90. doi:10.3109/03009742.2012.716450. PubMed: 23126644.
21. Bäcklund J, Li C, Jansson E, Carlsen S, Merky P, et al. (2013) C57BL/6 mice need MHC class II Aq to develop collagen-induced arthritis dependent on autoreactive T cells. Ann Rheum Dis 72: 1225-1232. doi:10.1136/annrheumdis-2012-202055. PubMed: 23041839.
22. Inglis JJ, Simelyte E, McCann FE, Criado G, Williams RO, (2008) Protocol for the induction of arthritis in C57BL/6 mice. Nat Protoc 3: 612--618. doi:10.1038/nprot.2008.19. PubMed: 18388943.
23. Inglis JJ, Criado G, Medghalchi M, Andrews M, Sandison A, et al. (2007) Collagen-induced arthritis in C57BL/6 mice is associated with a robust and sustained T-cell response to type II collagen. Arthritis Res Ther 9: R113. doi:10.1186/ar2319. PubMed: 17967186.
24. Martin E, Capini C, Duggan E, Lutzky VP, Stumbles P, et al. (2007) Antigen-specific suppression of established arthritis in mice by dendritic cells deficient in NF-kappaB. Arthritis Rheum 56: 2255-2266. doi:10.1002/art.22655. PubMed: 17599748.
25. Stoop JN, Harry RA, von Delwig A, Isaacs JD, Robinson JH, et al. (2010) Therapeutic effect of tolerogenic dendritic cells in established collagen-induced arthritis is associated with a reduction in Th17 responses. Arthritis Rheum 62: 3656-3665. doi:10.1002/art.27756. PubMed: 20862679.
26. Kornete M, Piccirillo CA, (2012) Functional crosstalk between dendritic cells and Foxp3(+) regulatory T cells in the maintenance of immune tolerance. Front Immunol 3: 165. PubMed: 22737152.
27. Heo YJ, Joo YB, Oh HJ, Park MK, Heo YM, et al. (2010) IL-10 suppresses Th17 cells and promotes regulatory T cells in the CD4+ T cell population of rheumatoid arthritis patients. Immunol Lett 127: 150-156. doi:10.1016/j.imlet.2009.10.006. PubMed: 19895848.
28. Park KS, Park MJ, Cho ML, Kwok SK, Ju JH, et al. (2009) Type II collagen oral tolerance; mechanism and role in collagen-induced arthritis and rheumatoid arthritis. Mod Rheumatol 19: 581-589. doi:10.1007/s10165-009-0210-0. PubMed: 19697097.
29. Rutella S, De Cristofaro R, Ferraccioli G, (2009) Function and dysfunction of dendritic cells in autoimmune rheumatic diseases. Hum Immunol 70: 360-373. doi:10.1016/j.humimm.2009.01.023. PubMed: 19405176.
30. Fujita S, Seino K, Sato K, Sato Y, Eizumi K, et al. (2006) Regulatory dendritic cells act as regulators of acute lethal systemic inflammatory response. Blood 107: 3656-3664. doi:10.1182/blood-2005-10-4190. PubMed: 16410444.
31. Pfaffl MW, (2001) A new mathematical model for relative quantification in real-time RT-PCR. Nucleic Acids Res 29: e45. doi:10.1093/nar/29.9.e45. PubMed: 11328886.
32. Kong N, Lan Q, Chen M, Wang J, Shi W, et al. (2012) Antigen-specific transforming growth factor beta-induced Treg cells, but not natural Treg cells, ameliorate autoimmune arthritis in mice by shifting the Th17/Treg cell balance from Th17 predominance to Treg cell predominance. Arthritis Rheum 64: 2548-2558. doi:10.1002/art.34513. PubMed: 22605463.