-
1
-
-
0033052966
-
Structural differences between valine-12 and aspartate-12 Ras proteins may modify carcinoma aggression
-
Al-Mulla F, Milner-White EJ, Going JJ, Birnie GD. Structural differences between valine-12 and aspartate-12 Ras proteins may modify carcinoma aggression. J Pathol 187(4):433-438, 1999.
-
(1999)
J Pathol
, vol.187
, Issue.4
, pp. 433-438
-
-
Al-Mulla, F.1
Milner-White, E.J.2
Going, J.J.3
Birnie, G.D.4
-
2
-
-
81855199501
-
Cancer invasion and resistance: Interconnected processes of disease progression and therapy failure
-
Alexander S, Friedl P. Cancer invasion and resistance: Interconnected processes of disease progression and therapy failure. Trends Mol Med 18(1):13-26, 2012.
-
(2012)
Trends Mol Med
, vol.18
, Issue.1
, pp. 13-26
-
-
Alexander, S.1
Friedl, P.2
-
3
-
-
42649145667
-
Wild-type KRAS is required for panitumumab efficacy in patients with metastatic colorectal cancer
-
Amado RG, Wolf M, Peeters M, Van Cutsem E, Siena S, Freeman DJ, Juan T, Sikorski R, Suggs S, Radinsky R, Patterson SD, Chang DD. Wild-type KRAS is required for panitumumab efficacy in patients with metastatic colorectal cancer. J Clin Oncol 26(10):1626-1634, 2008.
-
(2008)
J Clin Oncol
, vol.26
, Issue.10
, pp. 1626-1634
-
-
Amado, R.G.1
Wolf, M.2
Peeters, M.3
Van Cutsem, E.4
Siena, S.5
Freeman, D.J.6
Juan, T.7
Sikorski, R.8
Suggs, S.9
Radinsky, R.10
Patterson, S.D.11
Chang, D.D.12
-
4
-
-
84869123358
-
Is Codon 13 KRAS Mutation Biologically Different from Codon 12 Mutation?
-
Amatu A, Sartore-Bianchi A, Bencardino K, Cassingena A, Venturini F, Giacobbe F, Pietrogiovanna L, Marrapese G, Gambaro A, Belotti A, Siena S. Is Codon 13 KRAS Mutation Biologically Different from Codon 12 Mutation?. Curr Colorectal Cancer Rep 8(4):272-276, 2012.
-
(2012)
Curr Colorectal Cancer Rep
, vol.8
, Issue.4
, pp. 272-276
-
-
Amatu, A.1
Sartore-Bianchi, A.2
Bencardino, K.3
Cassingena, A.4
Venturini, F.5
Giacobbe, F.6
Pietrogiovanna, L.7
Marrapese, G.8
Gambaro, A.9
Belotti, A.10
Siena, S.11
-
5
-
-
0032490124
-
Kirsten ras mutations in patients with colorectal cancer: the multicenter "RASCAL" study
-
Andreyev HJ, Norman AR, Cunningham D, Oates JR, Clarke PA. Kirsten ras mutations in patients with colorectal cancer: the multicenter "RASCAL" study. J Natl Cancer Inst 90(9):675-684, 1998.
-
(1998)
J Natl Cancer Inst
, vol.90
, Issue.9
, pp. 675-684
-
-
Andreyev, H.J.1
Norman, A.R.2
Cunningham, D.3
Oates, J.R.4
Clarke, P.A.5
-
6
-
-
76049098292
-
Prevalence and heterogeneity of KRAS, BRAF, and PIK3CA mutations in primary colorectal adenocarcinomas and their corresponding metastases
-
Baldus SE, Schaefer KL, Engers R, Hartleb D, Stoecklein NH, Gabbert HE. Prevalence and heterogeneity of KRAS, BRAF, and PIK3CA mutations in primary colorectal adenocarcinomas and their corresponding metastases. Clin Cancer Res 16(3):790-799, 2010.
-
(2010)
Clin Cancer Res
, vol.16
, Issue.3
, pp. 790-799
-
-
Baldus, S.E.1
Schaefer, K.L.2
Engers, R.3
Hartleb, D.4
Stoecklein, N.H.5
Gabbert, H.E.6
-
7
-
-
79960839494
-
KRAS mutations detected by the amplification refractory mutation system-Scorpion assays strongly correlate with therapeutic effect of cetuximab
-
Bando H, Yoshino T, Tsuchihara K, Ogasawara N, Fuse N, Kojima T, Tahara M, Kojima M, Kaneko K, Doi T, Ochiai A, Esumi H, Ohtsu A. KRAS mutations detected by the amplification refractory mutation system-Scorpion assays strongly correlate with therapeutic effect of cetuximab. Br J Cancer 105(3):403-406, 2011.
-
(2011)
Br J Cancer
, vol.105
, Issue.3
, pp. 403-406
-
-
Bando, H.1
Yoshino, T.2
Tsuchihara, K.3
Ogasawara, N.4
Fuse, N.5
Kojima, T.6
Tahara, M.7
Kojima, M.8
Kaneko, K.9
Doi, T.10
Ochiai, A.11
Esumi, H.12
Ohtsu, A.13
-
8
-
-
84886286323
-
Pyrosequencing analysis for detection of KRAS mutations in colorectal cancer
-
Baskin Y, Calibasi G, Canda E, Sarionulllu S, Yilmaz U. Pyrosequencing analysis for detection of KRAS mutations in colorectal cancer. In Vivo 25(3):519, 2011.
-
(2011)
In Vivo
, vol.25
, Issue.3
, pp. 519
-
-
Baskin, Y.1
Calibasi, G.2
Canda, E.3
Sarionulllu, S.4
Yilmaz, U.5
-
9
-
-
79952392467
-
Why don't we get more cancer? A proposed role of the microenvironment in restraining cancer progression
-
Bissell MJ, Hines WC. Why don't we get more cancer? A proposed role of the microenvironment in restraining cancer progression. Nat Med 17(3):320-329, 2011.
-
(2011)
Nat Med
, vol.17
, Issue.3
, pp. 320-329
-
-
Bissell, M.J.1
Hines, W.C.2
-
10
-
-
80053475784
-
KRAS and BRAF mutation analysis in metastatic colorectal cancer: A cost-effectiveness analysis from a Swiss perspective
-
Blank PR, Moch H, Szucs TD, Schwenkglenks M. KRAS and BRAF mutation analysis in metastatic colorectal cancer: A cost-effectiveness analysis from a Swiss perspective. Clin Cancer Res 17(19):6338-6346, 2011.
-
(2011)
Clin Cancer Res
, vol.17
, Issue.19
, pp. 6338-6346
-
-
Blank, P.R.1
Moch, H.2
Szucs, T.D.3
Schwenkglenks, M.4
-
11
-
-
84862276530
-
Activation of Ras signaling pathway by 8-oxoguanine DNA glycosylase bound to its excision product, 8-oxoguanine
-
Boldogh I, Hajas G, Aguilera-Aguirre L, Hegde ML, Radak Z, Bacsi A, Sur S, Hazra TK, Mitra S. Activation of Ras signaling pathway by 8-oxoguanine DNA glycosylase bound to its excision product, 8-oxoguanine. J Biol Chem 287(25):20769-20773, 2012.
-
(2012)
J Biol Chem
, vol.287
, Issue.25
, pp. 20769-20773
-
-
Boldogh, I.1
Hajas, G.2
Aguilera-Aguirre, L.3
Hegde, M.L.4
Radak, Z.5
Bacsi, A.6
Sur, S.7
Hazra, T.K.8
Mitra, S.9
-
12
-
-
79952811451
-
Allosteric modulation of Ras-GTP is linked to signal transduction through RAF kinase
-
Buhrman G, Kumar VS, Cirit M, Haugh JM, Mattos C. Allosteric modulation of Ras-GTP is linked to signal transduction through RAF kinase. J Biol Chem 286(5):3323-3331, 2011.
-
(2011)
J Biol Chem
, vol.286
, Issue.5
, pp. 3323-3331
-
-
Buhrman, G.1
Kumar, V.S.2
Cirit, M.3
Haugh, J.M.4
Mattos, C.5
-
13
-
-
77955597394
-
Detection of KRAS mutations in colorectal carcinoma patients with an integrated PCR/sequencing and real-time PCR approach
-
Carotenuto P, Roma C, Rachiglio AM, Tatangelo F, Pinto C, Ciardiello F, Nappi O, Iaffaioli V, Botti G, Normanno N. Detection of KRAS mutations in colorectal carcinoma patients with an integrated PCR/sequencing and real-time PCR approach. Pharmacogenomics 11(8):1169-1179, 2010.
-
(2010)
Pharmacogenomics
, vol.11
, Issue.8
, pp. 1169-1179
-
-
Carotenuto, P.1
Roma, C.2
Rachiglio, A.M.3
Tatangelo, F.4
Pinto, C.5
Ciardiello, F.6
Nappi, O.7
Iaffaioli, V.8
Botti, G.9
Normanno, N.10
-
14
-
-
33750474485
-
K-ras Asp12 mutant neither interacts with Raf, nor signals through Erk and is less tumorigenic than K-ras Val12
-
Cespedes MV, Sancho FJ, Guerrero S, Parreno M, Casanova I, Pavon MA, Marcuello E, Trias M, Cascante M, Capella G, Mangues R. K-ras Asp12 mutant neither interacts with Raf, nor signals through Erk and is less tumorigenic than K-ras Val12. Carcinogenesis 27(11):2190-2200, 2006.
-
(2006)
Carcinogenesis
, vol.27
, Issue.11
, pp. 2190-2200
-
-
Cespedes, M.V.1
Sancho, F.J.2
Guerrero, S.3
Parreno, M.4
Casanova, I.5
Pavon, M.A.6
Marcuello, E.7
Trias, M.8
Cascante, M.9
Capella, G.10
Mangues, R.11
-
15
-
-
84891713034
-
Senescence-associated secretory phenotypes reveal cell-nonautonomous functions of oncogenic RAS and the p53 tumor suppressor
-
Coppe JP, Patil CK, Rodier F, Sun Y, Munoz DP, Goldstein J, Nelson PS, Desprez PY, Campisi J. Senescence-associated secretory phenotypes reveal cell-nonautonomous functions of oncogenic RAS and the p53 tumor suppressor. PLoS Biol 6(12):2853-2868, 2008.
-
(2008)
PLoS Biol
, vol.6
, Issue.12
, pp. 2853-2868
-
-
Coppe, J.P.1
Patil, C.K.2
Rodier, F.3
Sun, Y.4
Munoz, D.P.5
Goldstein, J.6
Nelson, P.S.7
Desprez, P.Y.8
Campisi, J.9
-
16
-
-
84886261488
-
A simple method for improving the limit of detection for capillary electrophoresis DNA sequencing - A comparison of methodologies for KRAS variant detection
-
Davidson C, Zeringer E, Champion K, Gauthier M, Wang F, Boonyaratanakornkit J, Jones JR, Schreiber E. A simple method for improving the limit of detection for capillary electrophoresis DNA sequencing - A comparison of methodologies for KRAS variant detection. J Mol Diagn 14(6):740-741, 2012.
-
(2012)
J Mol Diagn
, vol.14
, Issue.6
, pp. 740-741
-
-
Davidson, C.1
Zeringer, E.2
Champion, K.3
Gauthier, M.4
Wang, F.5
Boonyaratanakornkit, J.6
Jones, J.R.7
Schreiber, E.8
-
17
-
-
77955277111
-
Effects of KRAS, BRAF, NRAS, and PIK3CA mutations on the efficacy of cetuximab plus chemotherapy in chemotherapy-refractory metastatic colorectal cancer: A retrospective consortium analysis
-
De Roock W, Claes B, Bernasconi D, De Schutter J, Biesmans B, Fountzilas G, Kalogeras KT, Kotoula V, Papamichael D, Laurent-Puig P, Penault-Llorca F, Rougier P, Vincenzi B, Santini D, Tonini G, Cappuzzo F, Frattini M, Molinari F, Saletti P, De Dosso S, et al. Effects of KRAS, BRAF, NRAS, and PIK3CA mutations on the efficacy of cetuximab plus chemotherapy in chemotherapy-refractory metastatic colorectal cancer: A retrospective consortium analysis. Lancet Oncol 11(8):753-762, 2010a.
-
(2010)
Lancet Oncol
, vol.11
, Issue.8
, pp. 753-762
-
-
De Roock, W.1
Claes, B.2
Bernasconi, D.3
De Schutter, J.4
Biesmans, B.5
Fountzilas, G.6
Kalogeras, K.T.7
Kotoula, V.8
Papamichael, D.9
Laurent-Puig, P.10
Penault-Llorca, F.11
Rougier, P.12
Vincenzi, B.13
Santini, D.14
Tonini, G.15
Cappuzzo, F.16
Frattini, M.17
Molinari, F.18
Saletti, P.19
De Dosso, S.20
more..
-
18
-
-
78049341541
-
Association of KRAS p.G13D mutation with outcome in patients with chemotherapy-refractory metastatic colorectal cancer treated with cetuximab
-
De Roock W, Jonker DJ, Di Nicolantonio F, Sartore-Bianchi A, Tu D, Siena S, Lamba S, Arena S, Frattini M, Piessevaux H, Van Cutsem E, O'Callaghan CJ, Khambata-Ford S, Zalcberg JR, Simes J, Karapetis CS, Bardelli A, Tejpar S. Association of KRAS p.G13D mutation with outcome in patients with chemotherapy-refractory metastatic colorectal cancer treated with cetuximab. JAMA 304(16):1812-1820, 2010b.
-
(2010)
JAMA
, vol.304
, Issue.16
, pp. 1812-1820
-
-
De Roock, W.1
Jonker, D.J.2
Di Nicolantonio, F.3
Sartore-Bianchi, A.4
Tu, D.5
Siena, S.6
Lamba, S.7
Arena, S.8
Frattini, M.9
Piessevaux, H.10
Van Cutsem, E.11
O'Callaghan, C.J.12
Khambata-Ford, S.13
Zalcberg, J.R.14
Simes, J.15
Karapetis, C.S.16
Bardelli, A.17
Tejpar, S.18
-
19
-
-
70349142170
-
RAS in cellular transformation and senescence
-
Denicola GM, Tuveson DA. RAS in cellular transformation and senescence. Eur J Cancer 45(Suppl 1):211-216, 2009.
-
(2009)
Eur J Cancer
, vol.45
, Issue.SUPPL. 1
, pp. 211-216
-
-
Denicola, G.M.1
Tuveson, D.A.2
-
20
-
-
84863000299
-
The molecular evolution of acquired resistance to targeted EGFR blockade in colorectal cancers
-
doi:10.1038/nature11219
-
Diaz LA, Williams RT, Wu J, Kinde I, Hecht JR, Berlin J, Allen B, Bozic I, Reiter JG, Nowak MA, Kinzler KW, Oliner KS, Vogelstein B. The molecular evolution of acquired resistance to targeted EGFR blockade in colorectal cancers. Nature doi:10.1038/nature11219, 2012.
-
(2012)
Nature
-
-
Diaz, L.A.1
Williams, R.T.2
Wu, J.3
Kinde, I.4
Hecht, J.R.5
Berlin, J.6
Allen, B.7
Bozic, I.8
Reiter, J.G.9
Nowak, M.A.10
Kinzler, K.W.11
Oliner, K.S.12
Vogelstein, B.13
-
21
-
-
0842289998
-
Detection of Isolated Tumor Cells by Polymerase Chain Reaction-Restriction Fragment Length Polymorphism for K-ras Mutations in Tissue Samples of 199 Colorectal Cancer Patients
-
Dieterle CP, Conzelmann M, Linnemann U, Berger MR. Detection of Isolated Tumor Cells by Polymerase Chain Reaction-Restriction Fragment Length Polymorphism for K-ras Mutations in Tissue Samples of 199 Colorectal Cancer Patients. Clin Cancer Res 10(2):641-650, 2004.
-
(2004)
Clin Cancer Res
, vol.10
, Issue.2
, pp. 641-650
-
-
Dieterle, C.P.1
Conzelmann, M.2
Linnemann, U.3
Berger, M.R.4
-
22
-
-
33846995628
-
Economics of new oncology drug development
-
DiMasi JA, Grabowski HG. Economics of new oncology drug development. J Clin Oncol 25(2):209-216, 2007.
-
(2007)
J Clin Oncol
, vol.25
, Issue.2
, pp. 209-216
-
-
DiMasi, J.A.1
Grabowski, H.G.2
-
23
-
-
67649382495
-
Activity of panitumumab alone or with chemotherapy in non-small cell lung carcinoma cell lines expressing mutant epidermal growth factor receptor
-
Freeman DJ, Bush T, Ogbagabriel S, Belmontes B, Juan T, Plewa C, Van G, Johnson C, Radinsky R. Activity of panitumumab alone or with chemotherapy in non-small cell lung carcinoma cell lines expressing mutant epidermal growth factor receptor. Mol Cancer Ther 8(6):1536-1546, 2009.
-
(2009)
Mol Cancer Ther
, vol.8
, Issue.6
, pp. 1536-1546
-
-
Freeman, D.J.1
Bush, T.2
Ogbagabriel, S.3
Belmontes, B.4
Juan, T.5
Plewa, C.6
Van, G.7
Johnson, C.8
Radinsky, R.9
-
24
-
-
44449090596
-
Association of K-ras mutational status and clinical outcomes in patients with metastatic colorectal cancer receiving panitumumab alone
-
Freeman DJ, Juan T, Reiner M, Hecht JR, Meropol NJ, Berlin J, Mitchell E, Sarosi I, Radinsky R, Amado RG. Association of K-ras mutational status and clinical outcomes in patients with metastatic colorectal cancer receiving panitumumab alone. Clin Colorectal Cancer 7(3):184-190, 2008.
-
(2008)
Clin Colorectal Cancer
, vol.7
, Issue.3
, pp. 184-190
-
-
Freeman, D.J.1
Juan, T.2
Reiner, M.3
Hecht, J.R.4
Meropol, N.J.5
Berlin, J.6
Mitchell, E.7
Sarosi, I.8
Radinsky, R.9
Amado, R.G.10
-
25
-
-
84878928981
-
Targeted therapy in metastatic colorectal cancer - An example of personalised medicine in action
-
doi:10.1016/j.ctrv.2012.12.011
-
Heinemann V, Douillard JY, Ducreux M, Peeters M. Targeted therapy in metastatic colorectal cancer - An example of personalised medicine in action. Cancer Treat Rev doi:10.1016/j.ctrv.2012.12.011, 2013.
-
(2013)
Cancer Treat Rev
-
-
Heinemann, V.1
Douillard, J.Y.2
Ducreux, M.3
Peeters, M.4
-
26
-
-
64049090889
-
Clinical relevance of EGFR- and KRAS-status in colorectal cancer patients treated with monoclonal antibodies directed against the EGFR
-
Heinemann V, Stintzing S, Kirchner T, Boeck S, Jung A. Clinical relevance of EGFR- and KRAS-status in colorectal cancer patients treated with monoclonal antibodies directed against the EGFR. Cancer Treat Rev 35(3):262-271, 2009.
-
(2009)
Cancer Treat Rev
, vol.35
, Issue.3
, pp. 262-271
-
-
Heinemann, V.1
Stintzing, S.2
Kirchner, T.3
Boeck, S.4
Jung, A.5
-
27
-
-
84871698081
-
Why imatinib remains an exception of cancer research
-
Horne SD, Stevens JB, Abdallah BY, Liu G, Bremer SW, Ye CJ, Heng HH. Why imatinib remains an exception of cancer research. J Cell Physiol 228(4):665-670, 2013.
-
(2013)
J Cell Physiol
, vol.228
, Issue.4
, pp. 665-670
-
-
Horne, S.D.1
Stevens, J.B.2
Abdallah, B.Y.3
Liu, G.4
Bremer, S.W.5
Ye, C.J.6
Heng, H.H.7
-
28
-
-
80051954603
-
Opportunities and challenges in the development of experimental drug combinations for cancer
-
Humphrey RW, Brockway-Lunardi LM, Bonk DT, Dohoney KM, Doroshow JH, Meech SJ, Ratain MJ, Topalian SL, Pardoll DM. Opportunities and challenges in the development of experimental drug combinations for cancer. J Natl Cancer Inst 103(16):1222-1226, 2011.
-
(2011)
J Natl Cancer Inst
, vol.103
, Issue.16
, pp. 1222-1226
-
-
Humphrey, R.W.1
Brockway-Lunardi, L.M.2
Bonk, D.T.3
Dohoney, K.M.4
Doroshow, J.H.5
Meech, S.J.6
Ratain, M.J.7
Topalian, S.L.8
Pardoll, D.M.9
-
29
-
-
84863116014
-
Effect of KRAS oncogene substitutions on protein behavior: Implications for signaling and clinical outcome
-
Ihle NT, Byers LA, Kim ES, Saintigny P, Lee JJ, Blumenschein GR, Tsao A, Liu S, Larsen JE, Wang J, Diao L, Coombes KR, Chen L, Zhang S, Abdelmelek MF, Tang X, Papadimitrakopoulou V, Minna JD, Lippman SM, Hong WK, et al. Effect of KRAS oncogene substitutions on protein behavior: Implications for signaling and clinical outcome. J Natl Cancer Inst 104(3):228-239, 2012.
-
(2012)
J Natl Cancer Inst
, vol.104
, Issue.3
, pp. 228-239
-
-
Ihle, N.T.1
Byers, L.A.2
Kim, E.S.3
Saintigny, P.4
Lee, J.J.5
Blumenschein, G.R.6
Tsao, A.7
Liu, S.8
Larsen, J.E.9
Wang, J.10
Diao, L.11
Coombes, K.R.12
Chen, L.13
Zhang, S.14
Abdelmelek, M.F.15
Tang, X.16
Papadimitrakopoulou, V.17
Minna, J.D.18
Lippman, S.M.19
Hong, W.K.20
more..
-
30
-
-
45449100940
-
Analysis of the effects of exposure to acute hypoxia on oxidative lesions and tumour progression in a transgenic mouse breast cancer model
-
Kalliomaki TM, McCallum G, Lunt SJ, Wells PG, Hill RP. Analysis of the effects of exposure to acute hypoxia on oxidative lesions and tumour progression in a transgenic mouse breast cancer model. BMC Cancer 8(1):151, 2008.
-
(2008)
BMC Cancer
, vol.8
, Issue.1
, pp. 151
-
-
Kalliomaki, T.M.1
McCallum, G.2
Lunt, S.J.3
Wells, P.G.4
Hill, R.P.5
-
31
-
-
65749102069
-
The HIF-1-active microenvironment: An environmental target for cancer therapy
-
Kizaka-Kondoh S, Tanaka S, Harada H, Hiraoka M. The HIF-1-active microenvironment: An environmental target for cancer therapy. Adv Drug Deliv Rev 61(7-8):623-632, 2009.
-
(2009)
Adv Drug Deliv Rev
, vol.61
, Issue.7-8
, pp. 623-632
-
-
Kizaka-Kondoh, S.1
Tanaka, S.2
Harada, H.3
Hiraoka, M.4
-
32
-
-
79955009779
-
Retaining cell-cell contact enables preparation and culture of spheroids composed of pure primary cancer cells from colorectal cancer
-
Kondo J, Endo H, Okuyama H, Ishikawa O, Iishi H, Tsujii M, Ohue M, Inoue M. Retaining cell-cell contact enables preparation and culture of spheroids composed of pure primary cancer cells from colorectal cancer. Proc Natl Acad Sci U S A 108(15):6235-6240, 2011.
-
(2011)
Proc Natl Acad Sci U S A
, vol.108
, Issue.15
, pp. 6235-6240
-
-
Kondo, J.1
Endo, H.2
Okuyama, H.3
Ishikawa, O.4
Iishi, H.5
Tsujii, M.6
Ohue, M.7
Inoue, M.8
-
33
-
-
79952006628
-
All about KRAS for clinical oncology practice: Gene profile, clinical implications and laboratory recommendations for somatic mutational testing in colorectal cancer
-
Linardou H, Briasoulis E, Dahabreh IJ, Mountzios G, Papadimitriou C, Papadopoulos S, Bafaloukos D, Kosmidis P, Murray S. All about KRAS for clinical oncology practice: Gene profile, clinical implications and laboratory recommendations for somatic mutational testing in colorectal cancer. Cancer Treat Rev 37(3):221-233, 2011.
-
(2011)
Cancer Treat Rev
, vol.37
, Issue.3
, pp. 221-233
-
-
Linardou, H.1
Briasoulis, E.2
Dahabreh, I.J.3
Mountzios, G.4
Papadimitriou, C.5
Papadopoulos, S.6
Bafaloukos, D.7
Kosmidis, P.8
Murray, S.9
-
34
-
-
43049163718
-
Free radicals and senescence
-
Lu T, Finkel T. Free radicals and senescence. Exp Cell Res 314(9):1918-1922, 2008.
-
(2008)
Exp Cell Res
, vol.314
, Issue.9
, pp. 1918-1922
-
-
Lu, T.1
Finkel, T.2
-
35
-
-
79951864807
-
Patient with colorectal cancer with heterogeneous KRAS molecular status responding to cetuximab-based chemotherapy
-
Mancuso A, Sollami R, Recine F, Cerbone L, Macciomei MC, Leone A. Patient with colorectal cancer with heterogeneous KRAS molecular status responding to cetuximab-based chemotherapy. J Clin Oncol 28(36):e756-e758, 2010.
-
(2010)
J Clin Oncol
, vol.28
, Issue.36
-
-
Mancuso, A.1
Sollami, R.2
Recine, F.3
Cerbone, L.4
Macciomei, M.C.5
Leone, A.6
-
36
-
-
0037182166
-
Detection of rare K-ras codon 12 mutations using allele-specific competitive blocker PCR
-
McKinzie PB, Parsons BL. Detection of rare K-ras codon 12 mutations using allele-specific competitive blocker PCR. Mutat Res 517(1-2):209-220, 2002.
-
(2002)
Mutat Res
, vol.517
, Issue.1-2
, pp. 209-220
-
-
McKinzie, P.B.1
Parsons, B.L.2
-
37
-
-
84862999938
-
Emergence of KRAS mutations and acquired resistance to anti-EGFR therapy in colorectal cancer
-
Misale S, Yaeger R, Hobor S, Scala E, Janakiraman M, Liska D, Valtorta E, Schiavo R, Buscarino M, Siravegna G, Bencardino K, Cercek A, Chen CT, Veronese S, Zanon C, Sartore-Bianchi A, Gambacorta M, Gallicchio M, Vakiani E, Boscaro V, et al. Emergence of KRAS mutations and acquired resistance to anti-EGFR therapy in colorectal cancer. Nature 486(7404):532-536, 2012.
-
(2012)
Nature
, vol.486
, Issue.7404
, pp. 532-536
-
-
Misale, S.1
Yaeger, R.2
Hobor, S.3
Scala, E.4
Janakiraman, M.5
Liska, D.6
Valtorta, E.7
Schiavo, R.8
Buscarino, M.9
Siravegna, G.10
Bencardino, K.11
Cercek, A.12
Chen, C.T.13
Veronese, S.14
Zanon, C.15
Sartore-Bianchi, A.16
Gambacorta, M.17
Gallicchio, M.18
Vakiani, E.19
Boscaro, V.20
more..
-
38
-
-
84861796999
-
The influence of KRAS and BRAF mutations on the efficacy of cetuximab-based first-line therapy of metastatic colorectal cancer: An analysis of the AIO KRK-0104-trial
-
Modest DP, Jung A, Moosmann N, Laubender RP, Giessen C, Schulz C, Haas M, Neumann J, Boeck S, Kirchner T, Heinemann V, Stintzing S. The influence of KRAS and BRAF mutations on the efficacy of cetuximab-based first-line therapy of metastatic colorectal cancer: An analysis of the AIO KRK-0104-trial. Int J Cancer 131(4):980-986, 2012.
-
(2012)
Int J Cancer
, vol.131
, Issue.4
, pp. 980-986
-
-
Modest, D.P.1
Jung, A.2
Moosmann, N.3
Laubender, R.P.4
Giessen, C.5
Schulz, C.6
Haas, M.7
Neumann, J.8
Boeck, S.9
Kirchner, T.10
Heinemann, V.11
Stintzing, S.12
-
39
-
-
79960435101
-
Increased detection sensitivity for KRAS mutations enhances the prediction of anti-EGFR monoclonal antibody resistance in metastatic colorectal cancer
-
Molinari F, Felicioni L, Buscarino M, De Dosso S, Buttitta F, Malatesta S, Movilia A, Luoni M, Boldorini R, Alabiso O, Girlando S, Soini B, Spitale A, Di Nicolantonio F, Saletti P, Crippa S, Mazzucchelli L, Marchetti A, Bardelli A, Frattini M. Increased detection sensitivity for KRAS mutations enhances the prediction of anti-EGFR monoclonal antibody resistance in metastatic colorectal cancer. Clin Cancer Res 17(14):4901-4914, 2011.
-
(2011)
Clin Cancer Res
, vol.17
, Issue.14
, pp. 4901-4914
-
-
Molinari, F.1
Felicioni, L.2
Buscarino, M.3
De Dosso, S.4
Buttitta, F.5
Malatesta, S.6
Movilia, A.7
Luoni, M.8
Boldorini, R.9
Alabiso, O.10
Girlando, S.11
Soini, B.12
Spitale, A.13
Di Nicolantonio, F.14
Saletti, P.15
Crippa, S.16
Mazzucchelli, L.17
Marchetti, A.18
Bardelli, A.19
Frattini, M.20
more..
-
40
-
-
23844497341
-
Sensitive sequencing method for KRAS mutation detection by pyrosequencing
-
Ogino S, Kawasaki T, Brahmandam M, Yan L, Cantor M, Nangyal C, Mino-Kenudson M, Lauwers GY, Loda M, Fuchs CS. Sensitive sequencing method for KRAS mutation detection by pyrosequencing. J Mol Diagn 7(3):413-421, 2005.
-
(2005)
J Mol Diagn
, vol.7
, Issue.3
, pp. 413-421
-
-
Ogino, S.1
Kawasaki, T.2
Brahmandam, M.3
Yan, L.4
Cantor, M.5
Nangyal, C.6
Mino-Kenudson, M.7
Lauwers, G.Y.8
Loda, M.9
Fuchs, C.S.10
-
41
-
-
50049087526
-
Many different tumor types have polyclonal tumor origin: Evidence and implications
-
Parsons BL. Many different tumor types have polyclonal tumor origin: Evidence and implications. Mutat Res 659(3):232-247, 2008.
-
(2008)
Mutat Res
, vol.659
, Issue.3
, pp. 232-247
-
-
Parsons, B.L.1
-
42
-
-
0030777020
-
Genotypic selection methods for the direct analysis of point mutations
-
Parsons BL, Heflich RH. Genotypic selection methods for the direct analysis of point mutations. Mutat Res 387(2):97-121, 1997.
-
(1997)
Mutat Res
, vol.387
, Issue.2
, pp. 97-121
-
-
Parsons, B.L.1
Heflich, R.H.2
-
43
-
-
77950582358
-
ACB-PCR quantification of K-RAS codon 12 GAT and GTT mutant fraction in colon tumor and non-tumor tissue
-
Parsons BL, Marchant-Miros KE, Delongchamp RR, Verkler TL, Patterson TA, McKinzie PB, Kim LT. ACB-PCR quantification of K-RAS codon 12 GAT and GTT mutant fraction in colon tumor and non-tumor tissue. Cancer Invest 28(4):364-375, 2010a.
-
(2010)
Cancer Invest
, vol.28
, Issue.4
, pp. 364-375
-
-
Parsons, B.L.1
Marchant-Miros, K.E.2
Delongchamp, R.R.3
Verkler, T.L.4
Patterson, T.A.5
McKinzie, P.B.6
Kim, L.T.7
-
44
-
-
84874606018
-
KRAS mutant tumor subpopulations can subvert durable responses to personalized cancer treatments
-
Parsons BL, Myers MB. KRAS mutant tumor subpopulations can subvert durable responses to personalized cancer treatments. Pers Med 10(2):191-199, 2013.
-
(2013)
Pers Med
, vol.10
, Issue.2
, pp. 191-199
-
-
Parsons, B.L.1
Myers, M.B.2
-
45
-
-
78349259232
-
Oncomutations as biomarkers of cancer risk
-
Parsons BL, Myers MB, Meng F, Wang Y, McKinzie PB. Oncomutations as biomarkers of cancer risk. Environ Mol Mutagen 51(8-9):836-850, 2010b.
-
(2010)
Environ Mol Mutagen
, vol.51
, Issue.8-9
, pp. 836-850
-
-
Parsons, B.L.1
Myers, M.B.2
Meng, F.3
Wang, Y.4
McKinzie, P.B.5
-
46
-
-
84873027952
-
Biomarkers of benefit from cetuximab-based therapy in metastatic colorectal cancer: Interaction of EGFR ligand expression with RAS/RAF, PIK3CA genotypes
-
Pentheroudakis G, Kotoula V, De Roock W, Kouvatseas G, Papakostas P, Makatsoris T, Papamichael D, Xanthakis I, Sgouros J, Televantou D, Kafiri G, Tsamandas AC, Razis E, Galani E, Bafaloukos D, Efstratiou I, Bompolaki I, Pectasides D, Pavlidis N, Tejpar S, et al. Biomarkers of benefit from cetuximab-based therapy in metastatic colorectal cancer: Interaction of EGFR ligand expression with RAS/RAF, PIK3CA genotypes. BMC Cancer 13:49, 2013.
-
(2013)
BMC Cancer
, vol.13
, pp. 49
-
-
Pentheroudakis, G.1
Kotoula, V.2
De Roock, W.3
Kouvatseas, G.4
Papakostas, P.5
Makatsoris, T.6
Papamichael, D.7
Xanthakis, I.8
Sgouros, J.9
Televantou, D.10
Kafiri, G.11
Tsamandas, A.C.12
Razis, E.13
Galani, E.14
Bafaloukos, D.15
Efstratiou, I.16
Bompolaki, I.17
Pectasides, D.18
Pavlidis, N.19
Tejpar, S.20
more..
-
47
-
-
84861147473
-
A comprehensive survey of ras mutations in cancer
-
Prior IA, Lewis PD, Mattos C. A comprehensive survey of ras mutations in cancer. Cancer Res 72(10):2457-2467, 2012.
-
(2012)
Cancer Res
, vol.72
, Issue.10
, pp. 2457-2467
-
-
Prior, I.A.1
Lewis, P.D.2
Mattos, C.3
-
48
-
-
77951432631
-
The causes of cancer revisited: "Mitochondrial malignancy" and ROS-induced oncogenic transformation - Why mitochondria are targets for cancer therapy
-
Ralph SJ, Rodriguez-Enriquez S, Neuzil J, Saavedra E, Moreno-Sanchez R. The causes of cancer revisited: "Mitochondrial malignancy" and ROS-induced oncogenic transformation - Why mitochondria are targets for cancer therapy. Mol Aspects Med 31(2):145-170, 2010.
-
(2010)
Mol Aspects Med
, vol.31
, Issue.2
, pp. 145-170
-
-
Ralph, S.J.1
Rodriguez-Enriquez, S.2
Neuzil, J.3
Saavedra, E.4
Moreno-Sanchez, R.5
-
49
-
-
79960798099
-
Intra-tumoral heterogeneity of KRAS and BRAF mutation status in patients with advanced colorectal cancer (aCRC) and cost-effectiveness of multiple sample testing
-
Richman SD, Chambers P, Seymour MT, Daly C, Grant S, Hemmings G, Quirke P. Intra-tumoral heterogeneity of KRAS and BRAF mutation status in patients with advanced colorectal cancer (aCRC) and cost-effectiveness of multiple sample testing. Anal Cell Path 34(1-2):61-66, 2011.
-
(2011)
Anal Cell Path
, vol.34
, Issue.1-2
, pp. 61-66
-
-
Richman, S.D.1
Chambers, P.2
Seymour, M.T.3
Daly, C.4
Grant, S.5
Hemmings, G.6
Quirke, P.7
-
50
-
-
79957722003
-
Selective killing of K-ras mutant cancer cells by small molecule inducers of oxidative stress
-
Shaw AT, Winslow MM, Magendantz M, Ouyang C, Dowdle J, Subramanian A, Lewis TA, Maglathin RL, Tolliday N, Jacks T. Selective killing of K-ras mutant cancer cells by small molecule inducers of oxidative stress. Proc Natl Acad Sci U S A 108(21):8773-8778, 2011.
-
(2011)
Proc Natl Acad Sci U S A
, vol.108
, Issue.21
, pp. 8773-8778
-
-
Shaw, A.T.1
Winslow, M.M.2
Magendantz, M.3
Ouyang, C.4
Dowdle, J.5
Subramanian, A.6
Lewis, T.A.7
Maglathin, R.L.8
Tolliday, N.9
Jacks, T.10
-
51
-
-
77949845433
-
Clonality Assessment and Clonal Ordering of Individual Neoplastic Crypts Shows Polyclonality of Colorectal Adenomas
-
Thirlwell C, Will OC, Domingo E, Graham TA, McDonald SA, Oukrif D, Jeffrey R, Gorman M, Rodriguez-Justo M, Chin-Aleong J, Clark SK, Novelli MR, Jankowski JA, Wright NA, Tomlinson IP, Leedham SJ. Clonality Assessment and Clonal Ordering of Individual Neoplastic Crypts Shows Polyclonality of Colorectal Adenomas. Gastroenterology 138(4):1441-1454.e7, 2010.
-
(2010)
Gastroenterology
, vol.138
, Issue.4
-
-
Thirlwell, C.1
Will, O.C.2
Domingo, E.3
Graham, T.A.4
McDonald, S.A.5
Oukrif, D.6
Jeffrey, R.7
Gorman, M.8
Rodriguez-Justo, M.9
Chin-Aleong, J.10
Clark, S.K.11
Novelli, M.R.12
Jankowski, J.A.13
Wright, N.A.14
Tomlinson, I.P.15
Leedham, S.J.16
-
52
-
-
35148881028
-
Drug resistance and the solid tumor microenvironment
-
Tredan O, Galmarini CM, Patel K, Tannock IF. Drug resistance and the solid tumor microenvironment. J Natl Cancer Inst 99(19):1441-1454, 2007.
-
(2007)
J Natl Cancer Inst
, vol.99
, Issue.19
, pp. 1441-1454
-
-
Tredan, O.1
Galmarini, C.M.2
Patel, K.3
Tannock, I.F.4
-
53
-
-
80052570533
-
Ras, ROS and proteotoxic stress: A delicate balance
-
Xu W, Trepel J, Neckers L. Ras, ROS and proteotoxic stress: A delicate balance. Cancer Cell 20(3):281-282, 2011.
-
(2011)
Cancer Cell
, vol.20
, Issue.3
, pp. 281-282
-
-
Xu, W.1
Trepel, J.2
Neckers, L.3
-
54
-
-
84872853570
-
Oncogenic and wild-type ras play divergent roles in the regulation of mitogen-activated protein kinase signaling
-
Young A, Lou D, McCormick F. Oncogenic and wild-type ras play divergent roles in the regulation of mitogen-activated protein kinase signaling. Cancer Discov 3(1):112-123, 2013.
-
(2013)
Cancer Discov
, vol.3
, Issue.1
, pp. 112-123
-
-
Young, A.1
Lou, D.2
McCormick, F.3
|