Effects of an estrogen receptor α variant

New England Journal of Medicine

Volumn 369, Issue 17, 2013, Pages 1663-1664

  Clegg, Deborah J ^a   Palmer, Biff F ^a  

^a UNIVERSITY OF TEXAS SOUTHWESTERN MEDICAL CENTER   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ESTROGEN RECEPTOR ALPHA; GLUCOSE;

ANOVULATION; BREAST HYPOPLASIA; DELAYED PUBERTY; ENDOCRINE DISEASE; ENERGY METABOLISM; ESTROGEN RESPONSIVE ELEMENT; GENETIC TRANSCRIPTION; GENETIC VARIABILITY; GLUCOSE HOMEOSTASIS; HORMONE RESISTANCE; HUMAN; INFERTILITY; LETTER; METABOLIC SYNDROME X; NONHUMAN; OBESITY; PHENOTYPE; PRIORITY JOURNAL; PROTEIN DNA BINDING; RECEPTOR BINDING; STEROIDOGENESIS; TRANSGENIC MOUSE;

EID: 84886232635     PISSN: 00284793     EISSN: 15334406     Source Type: Journal    
DOI: 10.1056/NEJMc1310364     Document Type: Letter

References (3)

1. Quaynor SD, Stradtman EW Jr, Kim H-G, et al. Delayed puberty and estrogen resistance in a woman with estrogen receptor α variant. N Engl J Med 2013;369:164-71.
2. Glidewell-Kenney C, Hurley LA, Pfaff L, Weiss J, Levine JE, Jameson JL. Nonclassical estrogen receptor alpha signaling mediates negative feedback in the female mouse reproductive axis. Proc Natl Acad Sci U S A 2007;104:8173-7.
3. Park CJ, Zhao Z, Glidewell-Kenney C, et al. Genetic rescue of nonclassical ERα signaling normalizes energy balance in obese Erα-null mutant mice. J Clin Invest 2011;121:604-12.