Synthesis of [11C]-meta-Hydroxyephedrine ([11C]MHED)

Radiochemical Syntheses: Radiopharmaceuticals for Positron Emission Tomography

Volumn 1, Issue , 2012, Pages 191-198

  Lodi, Filippo ^a   Carpinelli, Assunta ^b   Malizia, Claudio ^a   Boschi, Stefano ^a  

^a UNIVERSITY OF BOLOGNA   (Italy)

^b UNIVERSITY OF MILANO BICOCCA   (Italy)

Author keywords

QC data for three repeat runs of 11C MHED; Synthesis of 11C meta hydroxyephedrine ( 11C MHED); Synthesis of 11C MHED

Indexed keywords

EID: 84886197506     PISSN: None     EISSN: None     Source Type: Book    
DOI: 10.1002/9781118140345.ch19     Document Type: Chapter

References (34)

1. Bengel FM, Schwaiger M. Assessment of cardiac sympathetic neuronal function using PET imaging. J Nucl Cardiol 2004;11:603-616.
2. DeGrado TR, Hutchins GD, Toorongian SA, Wieland DM, Schwaiger M. J Nucl Med 1993;34:1287-1293.
3. Schwaiger M, Kalff V, Rosenspire K, Haka MS, Molina E, Hutchins GD, Deeb M, Wolfe E Jr, Wieland DM. Circulation 1990;82:457-464.
4. 2 target has the same interface/dimension as the standard G.E. target made of different aluminum alloy, with superior surface properties in target chamber. The target uses thicker foil. Improved helium and water cooling as well as higher fill and operating pressure are used. No preconditioning of the target. The gas target was freshly loaded before irradiation.
5. Shimalite-nickel was obtained from Shimadzu (product no. 221-27719).
6. Molecular sieves 80/100 were purchased by Alltech (product no. 5624).
7. Carbosphere 60/80 was purchased from Alltech (product no. 5680).
8. Sicapent was purchased from Merck (product no. 1.00543).
9. Ascarite II 20-30 mesh was purchased from Sigma Aldrich (product no. 223921).
10. Iodine resublimed was obtained from Merck (product no. 1.04761).
11. Link JM, Clark JC, Larsen P, Krohn KA. J Labelled Comp Radiopharm 1995;37:76-78.
12. Larsen P, Ulin J, Dahlstrom K, Jensen M. Appl Radiat Isot 1997;48:153-157.
13. Porapak Q 50-80 mesh was purchased from Alltech.
14. Rosenspire KC, Haka MS, Van Dort ME, Jewett DM, Gildersleeve DL, Schwaiger M, Wieland DM. J Nucl Med 1990;31:1328-1334.
15. Metaraminol free base (1 mg) was purchased from ABX, (Germany) (product no. 3380).
16. N,N -dimethylformamide (≥99.5%) was purchased from Sigma-Aldrich (product no. 40228) and ABX (Germany).
17. 4 solution, and the mobile phase was stirred to mix and then passed through a sterile 0.22-μm filter before use.
18. Semipreparative HPLC column: Phenomenex Synergi Polar-RP, 10 μm, 250 × 10 mm, purchased from Phenomenex (part no. 00G-4351-N0). To obtain reproducible RT, it is mandatory to equilibrate the semipreparative column with at least 200-300 mL of mobile phase before synthesis.
19. Millex-GP sterile 0.22-μm filters (PES membrane) were purchased from Millipore (part no. SLGP033RS).
20. DRN4370 sterile and evacuated vials were purchased from Mallinckrodt.
21. Absolute ethanol (Ph. Eur. grade) was purchased from Carlo Erba Reagenti and diluted with water to 70% (product no. 4146052).
22. 4 0.1 M in THF was obtained from ABX (Germany) (product no. 802.0001).
23. Hydroiodic acid redistilled was obtained from ABX (Germany) (product no. 830).
24. European Pharmacopoeia 6th edition.
25. Analytical HPLC column: Phenomenex Synergi Polar-RP, 4 μm, 250 × 4.6 mm, purchased from Phenomenex (part no. 00G-4336-E0); analytical column was equilibrated with mobile phase for 30-60 min before use.
26. MHED hydrochloride reference standard was purchased from ABX, Germany (product no. 3400).
27. Varian, CP3380.
28. GC capillary column RTX-200 was purchased from Restek (product no. 15054).
29. pH 0-14 non-bleeding pH-indicator strips were obtained from Merck (product no. 1.09535.0001).
30. Capintec, Inc., USA.
31. Camberra, distributed in Italy by Technology Nuclear Electronics, Milan, Italy.
32. Areva CERCA LEA, Pierrelatte cedex, France.
33. Lonza, Verviers, Belgium.
34. European Pharmacopoeia: Sterility chapter (2.6.1).