Solvent-free, green and efficient synthesis of pyrano[4, 3-b]pyrans by grinding and their biological evaluation as antitumor and antioxidant agents

Medicinal Chemistry Research

Volumn 22, Issue 12, 2013, Pages 5934-5939

  Rajguru, Deepika ^a   Keshwal, Balwant S ^a   Jain, Shubha ^a  

^a VIKRAM UNIVERSITY   (India)

Author keywords

Antioxidant activity; Cytotoxicity; Green chemistry; Grinding; One pot synthesis; Pyrano 4, 3 b pyrans; Solvent free

Indexed keywords

1,1 DIPHENYL 2 PICRYLHYDRAZYL; 2 AMINO 4 (5 CHLOROTHIOPHEN 2 YL) 7 METHYL 5 OXO 4H,5H PYRANO[4,3-B]PYRAN 3 CARBONITRILE; 2 AMINO 4 (FURAN 2 YL) 7 METHYL 5 OXO 4H,5H PYRANO[4,3-B]PYRAN 3 CARBONITRILE; 2 AMINO 7 METHYL 4 (3 METHYLTHIOPHEN 2 YL) 5 OXO 4H,5H PYRANO[4,3-B]PYRAN 3 CARBONITRILE; 2 AMINO 7 METHYL 4 (5 METHYLTHIOPHEN 2 YL) 5 OXO 4H,5H PYRANO[4,3-B]PYRAN 3 CARBONITRILE; 2 AMINO 7 METHYL 5 OXO 4 (THIOPHEN 2 YL) 4H,5H PYRANO[4,3-B]PYRAN 3 CARBONITRILE; ANTINEOPLASTIC AGENT; ANTIOXIDANT; FREE RADICAL; ORGANIC SOLVENT; PYRAN DERIVATIVE; PYRANO[4, 3- B ]PYRAN DERIVATIVE; UNCLASSIFIED DRUG;

ANTINEOPLASTIC ACTIVITY; ANTIOXIDANT ACTIVITY; ARTICLE; CANCER CELL CULTURE; CARBON NUCLEAR MAGNETIC RESONANCE; CATALYST; CONTROLLED STUDY; DRUG ABSORPTION; DRUG CYTOTOXICITY; DRUG INHIBITION; DRUG SYNTHESIS; GREEN CHEMISTRY; GRINDING; HUMAN; HUMAN CELL; IC 50; IN VITRO STUDY; INFRARED SPECTROMETRY; PROTON NUCLEAR MAGNETIC RESONANCE; REACTION ANALYSIS; REACTION TIME; STRUCTURE ACTIVITY RELATION;

EID: 84886101069     PISSN: 10542523     EISSN: 15548120     Source Type: Journal    
DOI: 10.1007/s00044-013-0586-4     Document Type: Article

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