Microvascular obstruction in the right ventricle in reperfused anterior myocardial infarction. Macroscopic and pathologic evidence in a swine model

Thrombosis Research

Volumn 132, Issue 5, 2013, Pages 592-598

  Bonanad, Clara ^a   Ruiz Sauri, Amparo ^b   Forteza, Maria J ^a   Chaustre, Fabian ^c   Minana, Gema ^a   Gomez, Cristina ^a   Diaz, Ana ^b   Noguera, Inmaculada ^b   De Dios, Elena ^a   Nunez, Julio ^a   Mainar, Luis ^a   Sanchis, Juan ^a   Morales, Jose M ^b   Monleon, Daniel ^b   Chorro, Francisco J ^a   Bodi, Vicente ^a  

^a HOSPITAL CLÍNICO UNIVERSITARIO   (Spain)

^b UNIVERSITY OF VALENCIA   (Spain)

^c UNIVERSITAT POLITÈCNICA DE VALÈNCIA   (Spain)

Author keywords

Microvascular obstruction; myocardial infarction; right ventricle

Indexed keywords

ANGIOPLASTY; ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ANTERIOR MYOCARDIAL INFARCTION; ARTICLE; BALLOON OCCLUSION; BLOOD VESSEL OCCLUSION; CONTROLLED STUDY; ELECTRON MICROSCOPY; ERYTHROCYTE; HEART INFARCTION SIZE; HEART MUSCLE CELL; HEART MUSCLE INJURY; HEART MUSCLE ISCHEMIA; HEART MUSCLE REPERFUSION; HEART RIGHT VENTRICLE INFARCTION; HISTOLOGY; LEFT ANTERIOR DESCENDING CORONARY ARTERY; MICROVASCULAR OBSTRUCTION; NONHUMAN; NUCLEAR MAGNETIC RESONANCE; OXIDATIVE STRESS; PORCINE MODEL; PRIORITY JOURNAL; REPERFUSION INJURY; SCANNING ELECTRON MICROSCOPY; ST SEGMENT ELEVATION; ST SEGMENT ELEVATION MYOCARDIAL INFARCTION; TRANSMISSION ELECTRON MICROSCOPY;

2,3,5-TRIPHENYLTETRAZOLIUM CHLORIDE; LAD; LEFT ANTERIOR DESCENDING; LEFT VENTRICLE; LV; MICROVASCULAR OBSTRUCTION; MVO; MYOCARDIAL INFARCTION; RIGHT VENTRICLE; RV; SCANNING ELECTRON MICROSCOPY; SEM; ST-SEGMENT ELEVATION MYOCARDIAL INFARCTION; STEMI; T-S; TEM; THIOFLAVIN-S; TRANSMISSION ELECTRON MICROSCOPY; TTZ;

ANIMALS; CORONARY VESSELS; FEMALE; HEART VENTRICLES; MAGNETIC RESONANCE IMAGING; MICROVESSELS; MYOCARDIAL INFARCTION; SWINE;

EID: 84886092782     PISSN: 00493848     EISSN: 18792472     Source Type: Journal    
DOI: 10.1016/j.thromres.2013.08.009     Document Type: Article

References (24)

1. P.G. Steg, S.K. James, and D. Atar ESC Guidelines for the management of acute myocardial infarction in patients presenting with ST-segment elevation: The Task Force on the management of ST-segment elevation acute myocardial infarction of the European Society Eur Heart J 33 2012 2569 2619
2. S.C. Bekkers, S.K. Yazdani, R. Virmani, and J. Waltenberger Microvascular obstruction: underlying pathophysiology and clinical diagnosis J Am Coll Cardiol 55 2010 1649 1660
3. K.C. Wu, R.J. Kim, D.A. Bluemke, C.E. Rochitte, E.A. Zerhouni, and L.C. Becker Quantification and time course of microvascular obstruction by contrast-enhanced echocardiography and magnetic resonance imaging following acute myocardial infarction and reperfusion J Am Coll Cardiol 32 1998 1756 1764
4. M. Nagao, H. Higashino, H. Matsuoka, H. Kawakami, T. Mochizuki, and K. Murase Clinical importance of microvascular obstruction on contrast-enhanced MRI in reperfused acute myocardial infarction Circ J 72 2008 200 204
5. K.C. Wu, E.A. Zerhouni, R.M. Judd, C.H. Lugo-Olivieri, L.A. Barouch, and S.P. Schulman Prognostic significance of microvascular obstruction by magnetic resonance imaging in patients with acute myocardial infarction Circulation 97 1998 765 772
6. O. Husser, V. Bodi, and J. Sanchis Predictors of cardiovascular magnetic resonance-derived microvascular obstruction on patient admission in STEMI Int J Cardiol 166 1 2013 Jun 5 77 84
7. O. Husser, J.V. Monmeneu, and J. Sanchis Cardiovascular magnetic resonance-derived intramyocardial hemorrhage after STEMI: Influence on long-term prognosis, adverse left ventricular remodeling and relationship with microvascular obstruction Int J Cardiol 2012 [Epub ahead of print]
8. G. Klug, A. Mayr, and S. Schenk Prognostic value at 5 years of microvascular obstruction after acute myocardial infarction assessed by cardiovascular magnetic resonance J Cardiovasc Magn Reson 14 2012 46
9. M.D. Cerqueira, N.J. Weissman, and V. Dilsizian Standardized myocardial segmentation and nomenclature for tomographic imaging of the heart Circulation 105 2002 539 542
10. T. Miszalski-Jamka, P. Klimeczek, and M. Tomala Extent of RV dysfunction and myocardial infarction assessed by CMR are independent outcome predictors early after STEMI treated with primary angioplasty JACC Cardiovasc Imaging 3 2010 1237 1246
11. H.R. Andersen, E. Falk, and D. Nielsen Right ventricular infarction: frequency, size and topography in coronary heart disease: a prospective study comprising 107 consecutive autopsies from a coronary care unit J Am Coll Cardiol 10 1987 1223 1232
12. H.S. Cabin, K.S. Clubb, F.J. Wackers, and B.L. Zaret Right ventricular myocardial infarction with anterior wall left ventricular infarction: an autopsy study Am Heart J 113 1987 16
13. N.K. Tahirkheli, W.D. Edwards, R.A. Nishimura, and D.R. Holmes Right ventricular infarction associated with anteroseptal myocardial infarction: a clinicopathologic study of nine cases Cardiovasc Pathol 9 2000 175 179
14. E. Tobinick, H.R. Schelbert, and H. Henning Right ventricular ejection fraction in patients with acute anterior and inferior myocardial infarction assessed by radionuclide angiography Circulation 57 1978 1078 1084
15. A. Marmor, E.M. Geltman, D.R. Biello, B.E. Sobel, B.A. Siegel, and R. Roberts Functional response of the right ventricle to myocardial infarction: dependence on the site of left ventricular infarction Circulation 64 1981 1005 1011
16. C.J. Jensen, M. Jochims, P. Hunold, G.V. Sabin, T. Schlosser, and O. Bruder Right ventricular involvement in acute left ventricular myocardial infarction: prognostic implications of MRI findings AJR 194 2010 592 598
17. V. Bodi, J. Sanchis, and L. Mainar Right ventricular involvement in anterior myocardial infarction. A translational approach Cardiovasc Res 87 2010 601 608
18. R.H. Peter, B.W. Ramo, N. Ratliff, and J.J. Morris Collateral vessel development after right ventricular infarction in the pig Am J Cardiol 29 1972 56 60
19. N. Dib, E.B. Diethrich, A. Campbell, A. Gahremanpour, M. McGarry, and S.R. Opie A percutaneous swine model of myocardial infarction Pharmacol Toxicol Methods 53 2006 256 263
20. J.A. Fallavollita, and J.M. Canty Ischemic cardiomyopathy in pigs with two-vessel occlusion and viable, chronically dysfunctional myocardium Am J Physiol Heart Circ Physiol 282 2002 H1370 H1379
21. P. Merlos, M.P. López-Lereu, and J.V. Monmeneu Long-term prognostic value of a comprehensive assessment of cardiac magnetic resonance indexes after an ST-segment Elevation Myocardial Infaction Rev Esp Cardiol 66 8 2013 613 622
22. U. Näslund, S. Häggmark, G. Johansson, S.L. Marklund, and S. Reiz A closed-chest myocardial occlusion-reperfusion model in the pig: techniques, morbidity and mortality Eur Heart J 13 1992 1282 1289
23. A.M. Abarbanell, J.L. Herrmann, and B.R. Weil Animal models of myocardial and vascular injury J Surg Res 162 2 2010 Aug 239 249
24. M. Saeed, S.W. Hetts, L. Do, and M.W. Wilson Coronary Microemboli Effects in Preexisting Acute Infarcts in a Swine Model: Cardiac MR Imaging Indices, Injury Biomarkers, and Histopathologic Assessment Radiology 268 1 2013 Jul 98 108