Drug Discrimination and In Vivo Structure-Activity Relationships

Drug Discrimination: Applications to Medicinal Chemistry and Drug Studies

Volumn , Issue , 2011, Pages 163-181

  Glennon, Richard A ^a   Young, Richard ^a  

^a VIRGINIA COMMONWEALTH UNIVERSITY   (United States)

Author keywords

DD structure activity relationships; NACh receptor agents; QSAR studies

Indexed keywords

EID: 84886058754     PISSN: None     EISSN: None     Source Type: Book    
DOI: 10.1002/9781118023150.ch5     Document Type: Chapter

References (23)

1. Nichols , D.E. , Glennon , R.A. ( 1984 ) Medicinal chemistry and structure - activity relationships of hallucinogenic agents . In: Jacobs , B. Ed. Hallucinogens: Neurochemical, Behavioral, and Clinical Perspectives , Raven Press , New York , pp 95-142 .
2. Nichols , D.E. ( 1994 ) Medicinal chemistry and structure - activity relationships . In: A.K. , Cho , and D.S. , Segal , Eds. Amphetamine and Its Analogs: Psychopharmacology, Toxicology, and Abuse . Academic Press , New York , pp 3-41 .
3. Glennon , R. A. ( 2008 ) Hallucinogens, stimulants, and related drugs of abuse , In: D.A. , Williams , T. , Lemke , Eds. Foye's Textbook of Medicinal Chemistry , Williams and Wilkins , Baltimore , pp 631-651 .
4. Glennon , R.A. ( 1989 ) Stimulus properties of hallucinogenic phenalkylamines and related designer drugs: formulation of structure - activity relationships . NIDA Research Monograph , 94 , 43-67 .
5. Glennon , R.A. ( 1989 ) Synthesis and evaluation of amphetamine analogs . In: M. , Klein , F. , Sapienza , H. , McClain , Jr. , Eds. Clandestinely Produced Dugs, Analogues, and Precursors . United States Department of Justice , Washington, D.C. , pp 39-65 .
6. Glennon , R.A. ( 1994 ). Classical hallucinogens: an introductory overview . NIDA Research Monograph , 146 , 4-32 .
7. Glennon , R.A. , Young , R. , Benington , F. , Morin , R.D. ( 1982 ). Behavioral and serotonin receptor properties of 4 - substituted derivatives of the hallucinogen 1 - (2,5 - dimethoxyphen - yl) - 2 - aminopropane . Journal of Medicinal Chemistry , 25 , 1163-1168 .
8. Glennon , R.A. , Young , R. ( 1982 ). A comparison of the behavioral properties of di - and trimethoxyphenylisopropylamines . Pharmacology, Biochemistry, and Behavior , 17 , 603-607 .
9. Snyder , S.H , Faillace , L.A. , Weingartner , H. ( 1968 ). DOM (STP), a new hallucinogenic drug, and DOET: effects in normal subjects . American Journal of Psychiatry , 125 , 113-120 .
10. Glennon , R.A. , Young , R. , Rosecrans , J.A. ( 1982 ). A comparison of the behavioral effects of DOM homologs . Pharmacology , Biochemistry , and Behavior , 16 , 557-559 .
11. Glennon , R.A. , Young , R. , Jacyno , J.M. ( 1983 ). Indolealkylamine and phenalkylamine hallucinogens: effect of a - methyl and N - methyl substituents on behavioral activity . Behavioral Pharmacology , 32 , 1267-1273 .
12. Glennon , R.A. , Young , R. , Hauck , A.E. , McKenney , J.D. ( 1984 ). Structure - activity studies on amphetamine analogs using drug discrimination methodology . Pharmacology , Biochemistry , and Behavior , 21 , 895-901 .
13. Abraham , D.J. , Ed . ( 2003 ) Burger's Medicinal Chemistry and Drug Discovery. Volume 1: Drug Discovery . 6th Ed. , Wiley - Interscience , Hoboken , NJ .
14. Glennon , R.A. , Seggel , M.R. ( 1989 ) Interaction of phenylisopropylamines with 5 - HT 2 receptors: a QSAR analysis . In: Magee , P.S. Ed. Bioactive Mechanisms , ACS Press , Washington DC .
15. Seggel , M.R. , Yousif , M.Y. , Lyon , R.A. , Titeler , M. , Roth , B.L. , Suba , E.A. , Glennon , R.A. ( 1990 ). An SAR study of the binding of 4 - substituted analogues of 1 - (2 ,5 - dimethoxyphenyl) - 2 - aminopropane at 5 - HT 2 serotonin receptors . Journal of Medicinal Chemistry , 33 , 1032-1036 .
16. Young , R. , Glennon , R.A. ( 1987 ). Stimulus properties of benzodiazepines: correlations with binding affi nities , therapeutic potency , and structure activity relationships (SAR) . Psychopharmacology (Berlin) , 93 , 529-533 .
17. Glennon , R.A. , Fiedler , W. , Dukat , M. , Damaj , I. , Martin , B. ( 1996 ). Pyrrolidine - modifi ed analogues of nicotine: a structure - affi nity investigation . European Journal of Medicinal Chemistry , 31 , 875-888 .
18. Dukat , M. , Damaj , M.I. , Glassco , W. , Dumas , D. , May , E.L. , Martin , B.R. , Glennon , R.A. ( 1994 ). Epibatidine: a very high affi nity nicotine - receptor ligand . Medicinal Chemistry Research , 4 , 131-139 .
19. Dukat , M. , Damaj , M.I. , Young , R. , Vann , R. , Collins , A.C. , Marks , M.J. , Martin , B.R. , Glennon , R.A. ( 2002 ). Functional diversity among 5 - substituted nicotine analogs; in vitro and in vivo investigations . European Journal of Pharmacology , 435 , 171-180 .
20. Glennon , R.A. , Dukat , M. ( 1998 ) Nicotinic cholinergic receptor pharmacophores . In: S.P. , Arneric , J.D. , Brioni , Eds. , Neuronal Nicotinic Receptors: Pharmacologic and Therapeutic Opportunities . Wiley - Liss Inc. , New York , pp 271-284 .
21. Glennon , R.A. ( 2004 ) Medicinal chemistry of a 4ß2 nicotinic cholinergic receptor ligands . In: F.D. , King , G. , Lawton , A.W. , Oxford , Eds. Progress in Medicinal Chemistry , Volume 42 , Elsevier Science B. V. , Amsterdam , pp 55-123 .
22. Arvidsson , L.E. , Hacksell , U. , Johansson , A.M. , Nilsson , J.L. , Lindberg , P. , Sanchez , D. , Wikström , H. , Svensson , K. , Hjorth , S. , Carlsson , A. ( 1984 ). 8 - Hydroxy - 2 - (alkylamino) tetralins and related compounds as central 5 - hydroxytryptamine receptor agonists . Journal of Medicinal Chemistry , 27 , 45-51 .
23. Glennon , R.A. ( 1986 ). Discriminative stimulus poperties of the 5HT 1A agonist 8 - hydroxy - 2 - (di - n - propylamino)tetralin (8 - OH DPAT) . Pharmacology , Biochemistry , and Behavior , 25 , 135-139 .