Anti-pituitary antibodies and hypogonadotropic hypogonadism in type 2 diabetes: In search of a role

Diabetes Care

Volumn 36, Issue 8, 2013, Pages

  Bellastella, Giuseppe ^a   Ida Maiorino, Maria ^a   Olita, Laura ^a   De Bellis, Annamaria ^a   Giugliano, Dario ^a   Esposito, Katherine ^a  

^a SECOND UNIVERSITY OF NAPLES   (Italy)

Author keywords

[No Author keywords available]

Indexed keywords

GONADOTROPIN; INSULIN; MONOCLONAL ANTIBODY; ORAL ANTIDIABETIC AGENT; PITUITARY ANTIBODY; TESTOSTERONE; UNCLASSIFIED DRUG; AUTOANTIBODY;

ADULT; ANDROGEN DEFICIENCY; ANTIBODY DETECTION; ANTIBODY TITER; CONTROLLED STUDY; ERECTILE DYSFUNCTION; GONADOTROPIN BLOOD LEVEL; GONADOTROPIN SECRETING CELL; HUMAN; HYPOGONADOTROPIC HYPOGONADISM; IMMUNOFLUORESCENCE TEST; IMMUNOHISTOCHEMISTRY; LETTER; MAJOR CLINICAL STUDY; MALE; NON INSULIN DEPENDENT DIABETES MELLITUS; PATHOGENESIS; PREVALENCE; PROLACTIN SECRETING CELL; TESTOSTERONE BLOOD LEVEL; COMPLICATION; HYPOGONADISM; HYPOPHYSIS; IMMUNOLOGY; MIDDLE AGED;

ADULT; AUTOANTIBODIES; DIABETES MELLITUS, TYPE 2; HUMANS; HYPOGONADISM; MALE; MIDDLE AGED; PITUITARY GLAND;

EID: 84886037475     PISSN: 01495992     EISSN: 19355548     Source Type: Journal    
DOI: 10.2337/dc13-0637     Document Type: Letter

References (5)

1. Dhindsa S, Prabhakar S, Sethi M, Bandyopadhyay A, Chaudhuri A, Dandona P. Frequent occurrence of hypogonadotropic hypogonadism in type 2 diabetes. J Clin Endocrinol Metab 2004;89:5462-5468
2. Kobayashi T, Yabe S, Kikuchi T, Kanda T, Kobayashi I. Presence of anti-pituitary antibodies and GAD antibodies in NIDDM and IDDM. Diabetes Care 1997;20:864-866
3. De Bellis A, Sinisi AA, Conte M, et al. Antipituitary antibodies against gonadotropinsecreting cells in adult male patients with apparently idiopathic hypogonadotropic hypogonadism. J Clin Endocrinol Metab 2007;92:604-607
4. BellastellaG, Rotondi M, Pane E, et al.; Italian Autoimmune Hypophysitis Network Study. Predictive role of the immunostaining pattern of immunofluorescence and the titers of antipituitary antibodies at presentation for the occurrence of autoimmune hypopituitarism in patients with autoimmune polyendocrine syndromes over a five-year follow-up. J Clin Endocrinol Metab 2010; 95:3750-3757
5. Takeda H, Kawasaki E, Shimizu I, et al.; Ehime Study. Clinical, autoimmune, and genetic characteristics of adult-onset diabetic patients with GAD autoantibodies in Japan (Ehime Study). Diabetes Care 2002; 25:995-1001