Selective peptide inhibitors of bifunctional thymidylate synthase-dihydrofolate reductase from Toxoplasma gondii provide insights into domain-domain communication and allosteric regulation

Protein Science

Volumn 22, Issue 9, 2013, Pages 1161-1173

  Landau, Mark J ^a   Sharma, Hitesh ^a   Anderson, Karen S ^a  

^a YALE UNIVERSITY SCHOOL OF MEDICINE   (United States)

Author keywords

Allosteric sites; Conformational changes; Enzyme kinetics; Peptide inhibition; Species selectivity

Indexed keywords

ANTIPROTOZOAL AGENT; APOENZYME; DIHYDROFOLATE REDUCTASE INHIBITOR; DIMER; PEPTIDE; THYMIDYLATE SYNTHASE DIHYDROFOLATE REDUCTASE INHIBITOR; THYMIDYLATE SYNTHASE INHIBITOR; UNCLASSIFIED DRUG; DIHYDROFOLATE REDUCTASE; ENZYME INHIBITOR; MULTIENZYME COMPLEX; THYMIDYLATE SYNTHASE; THYMIDYLATE SYNTHASE-DIHYDROFOLATE REDUCTASE;

ALLOSTERISM; ANTIPROTOZOAL ACTIVITY; ARTICLE; CONFORMATIONAL TRANSITION; ENZYME BINDING; ENZYME INHIBITION; FLUORESCENCE SPECTROSCOPY; MUTAGENESIS; NONHUMAN; PRIORITY JOURNAL; PROTEIN DOMAIN; PROTEIN PROTEIN INTERACTION; SPECIES DIFFERENCE; TOXOPLASMA GONDII; AMINO ACID SEQUENCE; ANTAGONISTS AND INHIBITORS; CHEMICAL STRUCTURE; CHEMISTRY; DOSE RESPONSE; DRUG EFFECTS; ENZYMOLOGY; GENETICS; METABOLISM; MOLECULAR GENETICS; PROTEIN TERTIARY STRUCTURE; SPECTROFLUOROMETRY; STRUCTURE ACTIVITY RELATION; SYNTHESIS; TOXOPLASMA;

ALLOSTERIC REGULATION; AMINO ACID SEQUENCE; DOSE-RESPONSE RELATIONSHIP, DRUG; ENZYME INHIBITORS; MODELS, MOLECULAR; MOLECULAR SEQUENCE DATA; MOLECULAR STRUCTURE; MULTIENZYME COMPLEXES; PEPTIDES; PROTEIN STRUCTURE, TERTIARY; SPECTROMETRY, FLUORESCENCE; STRUCTURE-ACTIVITY RELATIONSHIP; TETRAHYDROFOLATE DEHYDROGENASE; THYMIDYLATE SYNTHASE; TOXOPLASMA;

EID: 84886026811     PISSN: 09618368     EISSN: 1469896X     Source Type: Journal    
DOI: 10.1002/pro.2300     Document Type: Article

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