Vagus Nerve Stimulation Increases Energy Expenditure: Relation to Brown Adipose Tissue Activity

PLoS ONE

Volumn 8, Issue 10, 2013, Pages

  Vijgen, Guy H E J ^a,b   Bouvy, Nicole D ^b   Leenen, Loes ^c   Rijkers, Kim ^b   Cornips, Erwin ^b   Majoie, Marian ^c   Brans, Boudewijn ^b   van Marken Lichtenbelt, Wouter D ^a  

^a MAASTRICHT UNIVERSITY   (Netherlands)

^b MAASTRICHT UNIVERSITY MEDICAL CENTER   (Netherlands)

^c EPILEPSY CENTER KEMPENHAEGHE   (Netherlands)

Author keywords

[No Author keywords available]

Indexed keywords

CARBAMAZEPINE; CLOBAZAM; CLONAZEPAM; ETIRACETAM; FLUORODEOXYGLUCOSE F 18; GABAPENTIN; HARKOSERIDE; LAMOTRIGINE; OXCARBAZEPINE; PHENYTOIN; RETIGABINE; TOPIRAMATE; VALPROIC ACID;

ADULT; AGED; ARTICLE; BASAL METABOLIC RATE; BODY MASS; BROWN ADIPOSE TISSUE; CALORIMETRY; CLINICAL ARTICLE; COLD EXPOSURE; COMPUTER ASSISTED EMISSION TOMOGRAPHY; CONTROLLED STUDY; CORE TEMPERATURE; CORRELATION ANALYSIS; ENERGY BALANCE; ENERGY EXPENDITURE; EPILEPSY; FEMALE; HUMAN; LIVER METABOLISM; MALE; MUSCLE METABOLISM; ROOM TEMPERATURE; SKIN BLOOD FLOW; SKIN TEMPERATURE; VAGUS NERVE STIMULATION; WEIGHT CONTROL; ANALYSIS OF VARIANCE; CLINICAL TRIAL; COLD; ENERGY METABOLISM; METABOLISM; MIDDLE AGED; PHYSIOLOGY; POSITRON EMISSION TOMOGRAPHY;

ADIPOSE TISSUE, BROWN; ADULT; ANALYSIS OF VARIANCE; CALORIMETRY, INDIRECT; COLD TEMPERATURE; ENERGY METABOLISM; EPILEPSY; FEMALE; HUMANS; MALE; MIDDLE AGED; POSITRON-EMISSION TOMOGRAPHY; VAGUS NERVE STIMULATION;

EID: 84886025322     PISSN: None     EISSN: 19326203     Source Type: Journal    
DOI: 10.1371/journal.pone.0077221     Document Type: Article

References (40)

1. Simpson SA, Shaw C, McNamara R, (2011) What is the most effective way to maintain weight loss in adults? BMJ 343: d8042.
2. Cannon B, Nedergaard J, (2004) Brown adipose tissue: function and physiological significance. Physiol Rev 84: 277-359.
3. van Marken Lichtenbelt WD, Vanhommerig JW, Smulders NM, Drossaerts JM, Kemerink GJ, et al. (2009) Cold-activated brown adipose tissue in healthy men. N Engl J Med 360: 1500-1508.
4. Virtanen KA, Lidell ME, Orava J, Heglind M, Westergren R, et al. (2009) Functional brown adipose tissue in healthy adults. N Engl J Med 360: 1518-1525.
5. Vijgen GH, Bouvy ND, Teule GJ, Brans B, Schrauwen P, et al. (2011) Brown adipose tissue in morbidly obese subjects. Plos One 6: e17247.
6. Yoneshiro T, Aita S, Matsushita M, Kameya T, Nakada K, et al. (2011) Brown Adipose Tissue, Whole-Body Energy Expenditure, and Thermogenesis in Healthy Adult Men. Obesity (Silver Spring) 19: 13-16.
7. Fruhbeck G, Becerril S, Sainz N, Garrastachu P, Garcia-Velloso MJ, (2009) BAT: a new target for human obesity? Trends Pharmacol Sci 30: 387-396.
8. Zingaretti MC, Crosta F, Vitali A, Guerrieri M, Frontini A, et al. (2009) The presence of UCP1 demonstrates that metabolically active adipose tissue in the neck of adult humans truly represents brown adipose tissue. FASEB J 23: 3113-3120.
9. Arch JR, Ainsworth AT, Cawthorne MA, Piercy V, Sennitt MV, et al. (1984) Atypical beta-adrenoceptor on brown adipocytes as target for anti-obesity drugs. Nature 309: 163-165.
10. Mano-Otagiri A, Iwasaki-Sekino A, Nemoto T, Ohata H, Shuto Y,et al. Genetic suppression of ghrelin receptors activates brown adipocyte function and decreases fat storage in rats. Regul Pept 160: 81-90.
11. Mano-Otagiri A, Ohata H, Iwasaki-Sekino A, Nemoto T, Shibasaki T, (2009) Ghrelin suppresses noradrenaline release in the brown adipose tissue of rats. J Endocrinol 201: 341-349.
12. Dedeurwaerdere S, Gilby K, Vonck K, Delbeke J, Boon P, et al. (2006) Vagus nerve stimulation does not affect spatial memory in fast rats, but has both anti-convulsive and pro-convulsive effects on amygdala-kindled seizures. Neuroscience 140: 1443-1451.
13. Laskiewicz J, Krolczyk G, Zurowski G, Sobocki J, Matyja A, et al. (2003) Effects of vagal neuromodulation and vagotomy on control of food intake and body weight in rats. J Physiol Pharmacol 54: 603-610.
14. Kosel M, Schlaepfer TE, (2003) Beyond the treatment of epilepsy: new applications of vagus nerve stimulation in psychiatry. CNS Spectr 8: 515-521.
15. Privitera MD, Welty TE, Ficker DM, Welge J (2002) Vagus nerve stimulation for partial seizures. Cochrane Database Syst Rev: CD002896.
16. Pardo JV, Sheikh SA, Kuskowski MA, Surerus-Johnson C, Hagen MC, et al. (2007) Weight loss during chronic, cervical vagus nerve stimulation in depressed patients with obesity: an observation. Int J Obes (Lond) 31: 1756-1759.
17. Burneo JG, Faught E, Knowlton R, Morawetz R, Kuzniecky R, (2002) Weight loss associated with vagus nerve stimulation. Neurology 59: 463-464.
18. Bodenlos JS, Kose S, Borckardt JJ, Nahas Z, Shaw, et al, (2007) Vagus nerve stimulation and emotional responses to food among depressed patients. J Diabetes Sci Technol 1: 771-779.
19. Bodenlos JS, Kose S, Borckardt JJ, Nahas Z, Shaw D, et al. (2007) Vagus nerve stimulation acutely alters food craving in adults with depression. Appetite 48: 145-153.
20. Bligh J, Johnson KG, (1973) Glossary of terms for thermal physiology. J Appl Physiol 35: 941-961.
21. van Marken Lichtenbelt WD, Daanen HA, Wouters L, Fronczek R, Raymann RJ, et al. (2006) Evaluation of wireless determination of skin temperature using iButtons. Physiol Behav 88: 489-497.
22. Kingma B, Frijns A, van Marken Lichtenbelt W, (2012) The thermoneutral zone: implications for metabolic studies. Front Biosci (Elite Ed) 4: 1975-1985.
23. Vijgen GH, Bouvy ND, Teule GJ, Brans B, Hoeks J, et al. (2012) Increase in Brown Adipose Tissue Activity after Weight Loss in Morbidly Obese Subjects. J Clin Endocrinol Metab.
24. Vosselman MJ, Brans B, van der Lans AA, Wierts R, van Baak MA, et al. (2013) Brown adipose tissue activity after a high-calorie meal in humans. Am J Clin Nutr.
25. Prechtl JC, Powley TL, (1990) The fiber composition of the abdominal vagus of the rat. Anat Embryol (Berl) 181: 101-115.
26. Murphy KG, Bloom SR, (2006) Gut hormones and the regulation of energy homeostasis. Nature 444: 854-859.
27. Ruffin M, Nicolaidis S, (1999) Electrical stimulation of the ventromedial hypothalamus enhances both fat utilization and metabolic rate that precede and parallel the inhibition of feeding behavior. Brain Res 846: 23-29.
28. Saito M, Minokoshi Y, Shimazu T, (1989) Accelerated norepinephrine turnover in peripheral tissues after ventromedial hypothalamic stimulation in rats. Brain Res 481: 298-303.
29. Perkins MN, Rothwell NJ, Stock MJ, Stone TW, (1981) Activation of brown adipose tissue thermogenesis by the ventromedial hypothalamus. Nature 289: 401-402.
30. Saindon CS, Blecha F, Musch TI, Morgan DA, Fels RJ, et al. (2001) Effect of cervical vagotomy on sympathetic nerve responses to peripheral interleukin-1beta. Auton Neurosci 87: 243-248.
31. Balbo SL, Grassiolli S, Ribeiro RA, Bonfleur ML, Gravena C, et al. (2007) Fat storage is partially dependent on vagal activity and insulin secretion of hypothalamic obese rat. Endocrine 31: 142-148.
32. Nagase H, Bray GA, York DA, (1996) Effect of galanin and enterostatin on sympathetic nerve activity to interscapular brown adipose tissue. Brain Res 709: 44-50.
33. Nagase H, Nakajima A, Sekihara H, York DA, Bray GA, (2002) Regulation of feeding behavior, gastric emptying, and sympathetic nerve activity to interscapular brown adipose tissue by galanin and enterostatin: the involvement of vagal-central nervous system interactions. J Gastroenterol 37Suppl 14: 118-127.
34. Val-Laillet D, Biraben A, Randuineau G, Malbert CH, (2010) Chronic vagus nerve stimulation decreased weight gain, food consumption and sweet craving in adult obese minipigs. Appetite 55: 245-252.
35. Sobocki J, Fourtanier G, Estany J, Otal P, (2006) Does vagal nerve stimulation affect body composition and metabolism? Experimental study of a new potential technique in bariatric surgery. Surgery 139: 209-216.
36. Saito M, Okamatsu-Ogura Y, Matsushita M, Watanabe K, Yoneshiro T, et al. (2009) High Incidence of Metabolically Active Brown Adipose Tissue in Healthy Adult Humans: Effects of Cold Exposure and Adiposity. Diabetes 58: 1526-1531.
37. Vijgen GH, van Marken Lichtenbelt W (2012) Brown adipose tissue: clinical impact of a re-discovered thermogenic organ. Front Biosci Accepted for publication.
38. Wu C, Cheng W, Xing H, Dang Y, Li F, et al. (2011) Brown adipose tissue can be activated or inhibited within an hour before 18F-FDG injection: a preliminary study with microPET. J Biomed Biotechnol 2011: 159834.
39. Agrawal A, Nair N, Baghel NS, (2009) A novel approach for reduction of brown fat uptake on FDG PET. Br J Radiol 82: 626-631.
40. Randle PJ, Garland PB, Hales CN, Newsholme EA, (1963) The glucose fatty-acid cycle. Its role in insulin sensitivity and the metabolic disturbances of diabetes mellitus. Lancet 1: 785-789.