Relationship of serum inflammatory biomarkers with plaque inflammation assessed by FDG PET/CT: The dal-PLAQUE study

JACC: Cardiovascular Imaging

Volumn 6, Issue 10, 2013, Pages 1087-1094

  Duivenvoorden, Raphaël ^a   Mani, Venkatesh ^a   Woodward, Mark ^b   Kallend, David ^c   Suchankova, Gabriela ^c   Fuster, Valentin ^a   Rudd, James H F ^d   Tawakol, Ahmed ^e   Farkouh, Michael E ^a,f   Fayad, Zahi A ^a  

^a MOUNT SINAI SCHOOL OF MEDICINE   (United States)

^b UNIVERSITY OF SYDNEY   (Australia)

^c F HOFFMANN LA ROCHE LTD   (Switzerland)

^d UNIVERSITY OF CAMBRIDGE   (United Kingdom)

^e MASSACHUSETTS GENERAL HOSPITAL   (United States)

^f ST MICHAEL'S HOSPITAL   (Canada)

Author keywords

atherosclerosis; fluorodeoxyglucose F 18 positron emission tomography; inflammatory biomarkers

Indexed keywords

BIOLOGICAL MARKER; C REACTIVE PROTEIN; CHOLESTEROL ESTER TRANSFER PROTEIN INHIBITOR; DALCETRAPIB; ENDOTHELIAL LEUKOCYTE ADHESION MOLECULE 1; FLUORODEOXYGLUCOSE F 18; INTERLEUKIN 6; MYELOPEROXIDASE; PADGEM PROTEIN; PHOSPHOLIPASE A2; VASCULAR CELL ADHESION MOLECULE 1;

ADULT; ARTICLE; ATHEROSCLEROTIC PLAQUE; CARDIOVASCULAR DISEASE; CARDIOVASCULAR RISK; COMPUTER ASSISTED EMISSION TOMOGRAPHY; CONTROLLED STUDY; FEMALE; FOLLOW UP; HUMAN; ISCHEMIC HEART DISEASE; MAJOR CLINICAL STUDY; MALE; POST HOC ANALYSIS; PRIORITY JOURNAL; RANDOMIZED CONTROLLED TRIAL;

(18)F-FDG PET/CT; ATHEROSCLEROSIS; FLUORODEOXYGLUCOSE F 18 POSITRON EMISSION TOMOGRAPHY; FLUORODEOXYGLUCOSE F 18 POSITRON EMISSION TOMOGRAPHY/COMPUTED TOMOGRAPHY; HIGH-SENSITIVITY C-REACTIVE PROTEIN; HSCRP; IL-6; INFLAMMATORY BIOMARKERS; INTERLEUKIN 6; LIPOPROTEIN-ASSOCIATED PHOSPHOLIPASE A(2); LP-PLA(2); MATRIX METALLOPROTEINASE; MMP; MPO; MYELOPEROXIDASE; SE-SELECTIN; SICAM; SOLUBLE E-SELECTIN; SOLUBLE INTRACELLULAR ADHESION MOLECULE; SOLUBLE P-SELECTIN; SOLUBLE VASCULAR CELL ADHESION MOLECULE; SP-SELECTIN; SVCAM; TARGET-TO-BACKGROUND RATIO OF THE MOST DISEASED SEGMENT; TBR(MDS);

AORTA; AORTIC DISEASES; BIOLOGICAL MARKERS; CAROTID ARTERIES; CAROTID ARTERY DISEASES; DOUBLE-BLIND METHOD; FLUORODEOXYGLUCOSE F18; HUMANS; HYPOLIPIDEMIC AGENTS; INFLAMMATION MEDIATORS; LONGITUDINAL STUDIES; MULTIMODAL IMAGING; PEROXIDASE; PLAQUE, ATHEROSCLEROTIC; POSITRON-EMISSION TOMOGRAPHY; PREDICTIVE VALUE OF TESTS; RADIOPHARMACEUTICALS; SULFHYDRYL COMPOUNDS; TIME FACTORS; TOMOGRAPHY, X-RAY COMPUTED; TREATMENT OUTCOME;

EID: 84885990843     PISSN: 1936878X     EISSN: 18767591     Source Type: Journal    
DOI: 10.1016/j.jcmg.2013.03.009     Document Type: Article

References (31)

1. P. Libby, P.M. Ridker, and G.K. Hansson Progress and challenges in translating the biology of atherosclerosis Nature 473 2011 317 325
2. A.C. van der Wal, A.E. Becker, C.M. van der Loos, and P.K. Das Site of intimal rupture or erosion of thrombosed coronary atherosclerotic plaques is characterized by an inflammatory process irrespective of the dominant plaque morphology Circulation 89 1994 36 44
3. A. Mauriello, G. Sangiorgi, and S. Fratoni Diffuse and active inflammation occurs in both vulnerable and stable plaques of the entire coronary tree: a histopathologic study of patients dying of acute myocardial infarction J Am Coll Cardiol 45 2005 1585 1593
4. J. Danesh, J.G. Wheeler, and G.M. Hirschfield C-reactive protein and other circulating markers of inflammation in the prediction of coronary heart disease N Engl J Med 350 2004 1387 1397
5. N. Sarwar, A.S. Butterworth, D.F. Freitag for the IL6R Genetics Consortium Emerging Risk Factors Collaboration Interleukin-6 receptor pathways in coronary heart disease: a collaborative meta-analysis of 82 studies Lancet 379 2012 1205 1213
6. R. Zhang, M.L. Brennan, and X. Fu Association between myeloperoxidase levels and risk of coronary artery disease JAMA 286 2001 2136 2142
7. M.C. Meuwese, E.S. Stroes, and S.L. Hazen Serum myeloperoxidase levels are associated with the future risk of coronary artery disease in apparently healthy individuals: the EPIC-Norfolk Prospective Population Study J Am Coll Cardiol 50 2007 159 165
8. E. Di Angelantonio, P. Gao, L. Pennells for the Emerging Risk Factors Collaboration Lipid-related markers and cardiovascular disease prediction JAMA 307 2012 2499 2506
9. C.J. Packard, D.S. O'Reilly, M.J. Caslake for the West of Scotland Coronary Prevention Study Group Lipoprotein-associated phospholipase A2 as an independent predictor of coronary heart disease N Engl J Med 343 2000 1148 1155
10. P.M. Ridker, C.H. Hennekens, B. Roitman-Johnson, M.J. Stampfer, and J. Allen Plasma concentration of soluble intercellular adhesion molecule 1 and risks of future myocardial infarction in apparently healthy men Lancet 351 1998 88 92
11. I. Malik, J. Danesh, and P. Whincup Soluble adhesion molecules and prediction of coronary heart disease: a prospective study and meta-analysis Lancet 358 2001 971 976
12. S. Blankenberg, H.J. Rupprecht, O. Poirier for the AtheroGene Investigators Plasma concentrations and genetic variation of matrix metalloproteinase 9 and prognosis of patients with cardiovascular disease Circulation 107 2003 1579 1585
13. S. Beyzade, S. Zhang, Y.K. Wong, I.N. Day, P. Eriksson, and S. Ye Influences of matrix metalloproteinase-3 gene variation on extent of coronary atherosclerosis and risk of myocardial infarction J Am Coll Cardiol 41 2003 2130 2137
14. J.H. Rudd, F. Hyafil, and Z.A. Fayad Inflammation imaging in atherosclerosis Arterioscler Thromb Vasc Biol 29 2009 1009 1016
15. Z. Zhang, J. Machac, and G. Helft Non-invasive imaging of atherosclerotic plaque macrophage in a rabbit model with F-18 FDG PET: a histopathological correlation BMC Nucl Med 6 2006 3
16. A. Tawakol, R.Q. Migrino, and G.G. Bashian In vivo 18F-fluorodeoxyglucose positron emission tomography imaging provides a noninvasive measure of carotid plaque inflammation in patients J Am Coll Cardiol 48 2006 1818 1824
17. J.H. Rudd, K.S. Myers, and S. Bansilal Relationships among regional arterial inflammation, calcification, risk factors, and biomarkers: a prospective fluorodeoxyglucose positron-emission tomography/computed tomography imaging study Circ Cardiovasc Imaging 2 2009 107 115
18. Y.W. Wu, H.L. Kao, and M.F. Chen Characterization of plaques using 18F-FDG PET/CT in patients with carotid atherosclerosis and correlation with matrix metalloproteinase-1 J Nucl Med 48 2007 227 233
19. H.J. Yoo, S. Kim, and M.S. Park Vascular inflammation stratified by C-reactive protein and low-density lipoprotein cholesterol levels: analysis with 18F-FDG PET J Nucl Med 52 2011 10 17
20. S.J. Yang, S. Kim, and H.Y. Choi High-sensitivity C-reactive protein in the low- and intermediate-Framingham risk score groups: Analysis with 18F-fluorodeoxyglucose positron emission tomography Int J Cardiol 163 2013 277 281
21. Y.W. Wu, H.L. Kao, and C.L. Huang The effects of 3-month atorvastatin therapy on arterial inflammation, calcification, abdominal adipose tissue and circulating biomarkers Eur J Nucl Med Mol Imaging 39 2012 399 407
22. Z.A. Fayad, V. Mani, M. Woodward for the dal-PLAQUE Investigators Safety and efficacy of dalcetrapib on atherosclerotic disease using novel non-invasive multimodality imaging (dal-PLAQUE): a randomised clinical trial Lancet 378 2011 1547 1559
23. N. Tahara, H. Kai, and S. Yamagishi Vascular inflammation evaluated by [18F]-fluorodeoxyglucose positron emission tomography is associated with the metabolic syndrome J Am Coll Cardiol 49 2007 1533 1539
24. J. Bucerius, R. Duivenvoorden, and V. Mani Prevalence and risk factors of carotid vessel wall inflammation in coronary artery disease patients: FDG-PET and CT imaging study J Am Coll Cardiol Img 4 2011 1195 1205
25. J. Bucerius, V. Mani, and C. Moncrieff Impact of noninsulin-dependent type 2 diabetes on carotid wall 18F-fluorodeoxyglucose positron emission tomography uptake J Am Coll Cardiol 59 2012 2080 2088
26. A. Daugherty, J.L. Dunn, D.L. Rateri, and J.W. Heinecke Myeloperoxidase, a catalyst for lipoprotein oxidation, is expressed in human atherosclerotic lesions J Clin Invest 94 1994 437 444
27. E.A. Podrez, D. Schmidt, H.F. Hoff, and S.L. Hazen Myeloperoxidase- generated reactive nitrogen species convert LDL into an atherogenic form in vitro J Clin Invest 103 1999 1547 1560
28. L. Zheng, B. Nukuna, and M.L. Brennan Apolipoprotein A-I is a selective target for myeloperoxidase-catalyzed oxidation and functional impairment in subjects with cardiovascular disease J Clin Invest 114 2004 529 541
29. J.A. Vita, M.L. Brennan, and N. Gokce Serum myeloperoxidase levels independently predict endothelial dysfunction in humans Circulation 110 2004 1134 1139
30. S. Sugiyama, K. Kugiyama, M. Aikawa, S. Nakamura, H. Ogawa, and P. Libby Hypochlorous acid, a macrophage product, induces endothelial apoptosis and tissue factor expression: involvement of myeloperoxidase-mediated oxidant in plaque erosion and thrombogenesis Arterioscler Thromb Vasc Biol 24 2004 1309 1314
31. The HRP Initiative. Available at: http://www.hrpinitiative.com. Accessed March 1, 2013.