Evaluation of routine hematology profile results and fructosamine, thyroxine, insulin, and proinsulin concentrations in lean, overweight, obese, and diabetic cats

Journal of the American Veterinary Medical Association

Volumn 243, Issue 9, 2013, Pages 1302-1309

  Hoenig, Margarethe ^a   Traas, Anne M ^b   Schaeffer, David J ^a  

^a UNIVERSITY OF ILLINOIS AT URBANA CHAMPAIGN   (United States)

^b BOEHRINGER INGELHEIM VETMEDICA INC   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

FRUCTOSAMINE; INSULIN; PROINSULIN; THYROXINE;

ANIMAL; ANIMAL DISEASE; ANIMAL FOOD; ANIMAL HUSBANDRY; ARTICLE; BLOOD; CAT; CAT DISEASE; DIABETES MELLITUS; FEMALE; MALE; METABOLISM; OBESITY;

ANIMAL FEED; ANIMAL HUSBANDRY; ANIMALS; CAT DISEASES; CATS; DIABETES MELLITUS; FEMALE; FRUCTOSAMINE; INSULIN; MALE; OBESITY; PROINSULIN; THYROXINE;

EID: 84885908966     PISSN: 00031488     EISSN: None     Source Type: Journal    
DOI: 10.2460/javma.243.9.1302     Document Type: Article

References (34)

1. Expert Committee on the Diagnosis and Classification of Diabetes Mellitus. Report of the Expert Committee on the Diagnosis and Classification of Diabetes Mellitus. Diabetes Care 2003; 26 (suppl 1): S5-S20.
2. Hoenig M, Alexander S, Holson J, et al. Influence of glucose dosage on interpretation of intravenous glucose tolerance tests in lean and obese cats. J Vet Intern Med 2002; 16: 529-532.
3. Hoenig M, Thomaseth K, Waldron M, et al. Insulin sensitivity, fat distribution, and adipocytokine response to different diets in lean and obese cats before and after weight loss. Am J Physiol Regul Integr Comp Physiol 2007; 292: R227-R234.
4. Appleton DJ, Rand JS, Sunvold GD. Insulin sensitivity decreases with obesity, and lean cats with low insulin sensitivity are at greatest risk of glucose intolerance with weight gain. J Feline Med Surg 2001; 3: 211-228.
5. Nelson RW, Himsel CA, Feldman EC, et al. Glucose tolerance and insulin response in normal-weight and obese cats. Am J Vet Res 1990; 51: 1357-1362.
6. Henson MS, Hegstad-Davies RL, Wang Q, et al. Evaluation of plasma islet amyloid polypeptide and serum glucose and insulin concentrations in nondiabetic cats classified by body condition score and in cats with naturally occurring diabetes mellitus. Am J Vet Res 2011; 72: 1052-1058.
7. American Diabetes Association. Diagnosis and classification of diabetes mellitus. Diabetes Care 2009; 32: S62-S67.
8. Hoenig M, Jordan ET, Ferguson DC, et al. Oral glucose leads to a differential response in glucose, insulin, and GLP-1 in lean versus obese cats. Domest Anim Endocrinol 2010; 38: 95-102.
9. Kley S, Caffall Z, Tittle E, et al. Development of a feline proinsulin immunoradiometric assay and a feline proinsulin enzymelinked immunosorbent assay (ELISA): a novel application to examine beta cell function in cats. Domest Anim Endocrinol 2008; 34: 311-318.
10. Laflamme DP. Development and validation of a body condition score system for cats. Feline Pract 1997; 25 (5-6): 13-17.
11. Scarlett JM, Donoghue S. Associations between body condition and disease in cats. J Am Vet Med Assoc 1998; 212: 1725-1731.
12. Marmor M, Willeberg P, Glickman LT, et al. Epizootiologic patterns of diabetes mellitus in dogs. Am J Vet Res 1982; 43: 465-470.
13. Fonseca VA. Defining and characterizing the progression of type 2 diabetes. Diabetes Care 2009; 32 (suppl 2): S151-S156.
14. Perseghin G. Viewpoints on the way to a consensus session: where does insulin resistance start? The liver. Diabetes Care 2009; 32 (suppl 2): S164-S167.
15. Abdul-Ghani MA, DeFronzo RA. Plasma glucose concentration and prediction of future risk of type 2 diabetes. Diabetes Care 2009; 32 (suppl 2): S194-S198.
16. Dankner R, Abdul-Ghani MA, Gerber Y, et al. Predicting the 20-year diabetes incidence rate. Diabetes Metab Res Rev 2007; 23: 551-558.
17. Hoenig M, Thomaseth K, Brandao J, et al. Assessment and mathematical modeling of glucose turnover and insulin sensitivity in lean and obese cats. Domest Anim Endocrinol 2006; 31: 373-389.
18. Opitz M. Stress hyperglycemia in cats. Berl Munch Tierarztl Wochenschr 1990; 103: 151-158.
19. Hoenig M, Hall G, Ferguson D, et al. A feline model of experimentally induced islet amyloidosis. Am J Pathol 2000; 157: 2143-2150.
20. Kley S, Hoenig M, Glushka J, et al. The impact of obesity, sex, and diet on hepatic glucose production in cats. Am J Physiol Regul Integr Comp Physiol 2009; 296: R936-R943.
21. Hoenig M, Jordan ET, Kley S, et al. Effect of macronutrients, age, and obesity on 6-and 24-h postprandial glucose. Am J Physiol Regul Integr Comp Physiol 2011; 301: R1798-R1807.
22. Hoenig M, Pach N, Thomaseth K, et al. Evaluation of long-term glucose homeostasis in lean and obese cats using continuous glucose monitoring. Am J Vet Res 2012; 73: 1100-1106.
23. Lutz TA, Rand JS, Ryan E. Fructosamine concentrations in hyperglycemic cats. Can Vet J 1995; 36: 155-159.
24. Reusch CE, Liehs MR, Hoyer M, et al. Fructosamine. A new parameter for diagnosis and metabolic control in diabetic dogs and cats. J Vet Intern Med 1993; 7: 177-182.
25. Nijpels G, Popp-Snijders C, Kostense PJ, et al. Fasting proinsulin and 2-h post-load glucose levels predict the conversion to NIDDM in subjects with impaired glucose tolerance: the Hoorn study. Diabetologia 1996; 39: 113-118.
26. Harita N, Hayashi T, Kogawa K, et al. Lower serum creatinine is a new risk factor of type 2 diabetes. Diabetes Care 2009; 32: 424-426.
27. Bain PJ. Liver. In: Latimer KS, Mahaffey EA, Prasse KW, eds. Duncan and Prasse's veterinary laboratory medicine: clinical pathology. 4th ed. Ames, Iowa: Iowa State Press, 2003; 193-214.
28. Jordan E, Kley S, Le NA, et al. Dyslipidemia in obese cats. Domest Anim Endocrinol 2008; 35: 290-299.
29. Niesen M, Bedi M, Lopez D. Diabetes alters LDL receptor and PCSK9 expression in rat liver. Arch Biochem Biophys 2008; 470: 111-115.
30. Duvillard L, Florentin E, Lizard G, et al. Cell surface expression of LDL receptor is decreased in type 2 diabetic patients and is normalized by insulin therapy. Diabetes Care 2003; 26: 1540-1544.
31. Hoenig M, Wilkins C, Holson JC, et al. Effects of obesity on lipid profiles in neutered male and female cats. Am J Vet Res 2003; 64: 299-303.
32. Ibrahim WH, Szabo J, Sunvold GD, et al. Effect of dietary protein quality and fatty acid composition on plasma lipoprotein concentrations and hepatic triglyceride fatty acid synthesis in obese cats undergoing rapid weight loss. Am J Vet Res 2000; 61: 566-572.
33. Hoenig M, McGoldrick JB, deBeer M, et al. Activity and tissuespecific expression of lipases and tumor-necrosis factor alpha in lean and obese cats. Domest Anim Endocrinol 2006; 30: 333-344.
34. Backus RC, Cave NJ, Ganjam VK, et al. Age and body weight effects on glucose and insulin tolerance in colony cats maintained since weaning on high dietary carbohydrate. J Anim Physiol Anim Nutr (Berl) 2010; 94: e318-e328.