Human herpesvirus 6 U69 kinase phosphorylates the methylenecyclopropane nucleosides cyclopropavir, MBX 2168, and MBX 1616 to their monophosphates

Antimicrobial Agents and Chemotherapy

Volumn 57, Issue 11, 2013, Pages 5760-5762

  Komazin Meredith, Gloria ^a   Cardinale, Steven C ^a   Williams, John D ^a   Peet, Norton P ^a   Prichard, Mark N ^b   Bowlin, Terry L ^a  

^a MICROBIOTIX INC   (United States)

^b UNIVERSITY OF ALABAMA AT BIRMINGHAM   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

CYCLOPROPANE DERIVATIVE; CYCLOPROPAVIR; MBX 1616; MBX 2168; PROTEIN KINASE U69 PROTEIN; UNCLASSIFIED DRUG; VIRUS ENZYME;

ANIMAL CELL; ARTICLE; BACULOVIRUS; CONTROLLED STUDY; DRUG EFFICACY; DRUG INHIBITION; DRUG MECHANISM; DRUG STRUCTURE; ENZYME PHOSPHORYLATION; ENZYME PURIFICATION; HUMAN HERPESVIRUS 6; IN VITRO STUDY; INSECT CELL; MICHAELIS MENTEN KINETICS; NONHUMAN; PRIORITY JOURNAL;

ANTIVIRAL AGENTS; BACULOVIRIDAE; CYCLOPROPANES; ENZYME ASSAYS; GUANINE; HERPESVIRUS 6, HUMAN; HUMANS; KINETICS; NUCLEOSIDES; PHOSPHORYLATION; PROTEIN KINASES; RECOMBINANT FUSION PROTEINS; SUBSTRATE SPECIFICITY; VIRAL PROTEINS;

EID: 84885908905     PISSN: 00664804     EISSN: 10986596     Source Type: Journal    
DOI: 10.1128/AAC.00978-13     Document Type: Article

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