Should we monitor vitamin B12 and folate levels in Crohn's disease patients?

Scandinavian Journal of Gastroenterology

Volumn 48, Issue 11, 2013, Pages 1272-1277

  Bermejo, Fernando ^a   Algaba, Alicia ^a   Guerra, Iván ^a   Chaparro, María ^b   De La Poza, Gema ^a   Valer, Paz ^a   Piqueras, Belén ^a   Bermejo, Andrea ^a   García Alonso, Javier ^a   Pérez, María José ^a   Gisbert, Javier P ^b  

^a HOSPITAL UNIVERSITARIO DE FUENLABRADA   (Spain)

^b HOSPITAL UNIVERSITARIO DE LA PRINCESA   (Spain)

Author keywords

Anemia; Crohn's disease; Folate; Ileal resection; Vitamin B12

Indexed keywords

CYANOCOBALAMIN; FOLIC ACID; HEMOGLOBIN; MERCAPTOPURINE;

ADULT; ANATOMIC LANDMARK; ARTICLE; CONTROLLED STUDY; CROHN DISEASE; CYANOCOBALAMIN DEFICIENCY; DISEASE ACTIVITY; DISEASE ASSOCIATION; DISEASE DURATION; FEMALE; FOLIC ACID DEFICIENCY; HEMOGLOBIN BLOOD LEVEL; HUMAN; ILEUM RESECTION; IMMUNOSUPPRESSIVE TREATMENT; MACROCYTIC ANEMIA; MAJOR CLINICAL STUDY; MALE; PATIENT MONITORING; PREDICTOR VARIABLE; PREVALENCE; PRIORITY JOURNAL; PROSPECTIVE STUDY; RISK FACTOR; SMALL INTESTINE RESECTION; ULCERATIVE COLITIS; VITAMIN BLOOD LEVEL;

ADULT; CASE-CONTROL STUDIES; COLITIS, ULCERATIVE; CROHN DISEASE; FEMALE; FOLIC ACID; FOLIC ACID DEFICIENCY; HUMANS; INTESTINE, SMALL; MALE; MIDDLE AGED; PREVALENCE; PROSPECTIVE STUDIES; RISK FACTORS; VITAMIN B 12; VITAMIN B 12 DEFICIENCY;

EID: 84885901373     PISSN: 00365521     EISSN: 15027708     Source Type: Journal    
DOI: 10.3109/00365521.2013.836752     Document Type: Article

References (27)

1. Nielsen MJ, Rasmussen MR, Andersen CB, Nexø E, Moestrup SK. Vitamin B12 transport from food to the body's cells-A sophisticated, multistep pathway. Nat Rev Gastroenterol Hepatol 2012;9:345-54.
2. Berlin H, Berlin R, Brante G. Oral treatment of pernicious anemia with high doses of vitamin B12 without intrinsic factor. Acta Med Scand 1968;184:247-58.
3. Hoffbrand V, Provan D. ABC of clinical haematology. Macrocytic anaemias. BMJ 1997;314:430-3.
4. Lachner C, Steinle NI, Regenold WT. The neuropsychiatry of vitamin B12 deficiency in elderly patients. J Neuropsychiatry Clin Neurosci 2012;24:5-15.
5. Vasilopoulos S, Saiean K, Emmons J, Berger WL, Abu-Hajir M, Seetharam B, et al. Terminal ileum resection is associated with higher plasma homocysteine levels in Crohn's disease. J Clin Gastroenterol 2001;33:132-6.
6. Chowers Y, Sela BA, Holland R, Fidder H, Simoni FB, Bar-Meir S. Increased levels of homocysteine in patients with Crohn's disease are related to folate levels. Am J Gastroenterol 2000;95:3498-502.
7. Fernandez-Banares F, Abad-Lacruz A, Xiol X, Gine JJ, Dolz C, Cabre E, et al. Vitamin status in patients with inflammatory bowel disease. Am J Gastroenterol 1989;84: 744-8.
8. Wright JD, Bialostosky K, Gunter EW, Carroll MD, Najjar MF, Bowman BA, et al. Blood folate and vitamin B12: United States, 1988-94. Vital Health Stat 1998;11:1-78.
9. Hoffbrand AV, Stewart JS, Booth CC, Mollin DL. Folate deficiency in Crohn's disease: Incidence, pathogenesis, and treatment. Br Med J 1968;2:71-5.
10. Lakatos L, Pandur T, David G, Balogh Z, Kuronya P, Tollas A, et al. Association of extraintestinal manifestations of inflammatory bowel disease in a province of western Hungary with disease phenotype: Results of a 25-year followup study. World J Gastroenterol 2003;9:2300-7.
11. Headstrom PD, Rulyak SJ, Lee SD. Prevalence of and risk factors for vitamin B12 deficiency in patients with Crohn's disease. Inflamm Bowel Dis 2008;14:217-23.
12. Yakut M, Ustun Y, Kabacam G, Soykan I. Serum vitamin B12 and folate status in patients with inflammatory bowel diseases. Eur J Intern Med 2010;21:320-3.
13. Lennard-Jones JE. Classification of inflammatory bowel disease. Scand J Gastroenterol 1989;170(suppl):2-6.
14. Harvey RF, Bradshaw JM. A simple index of Crohn's disease activity. Lancet 1980;1:514.
15. Truelove SC, Witts LJ. Cortisone in ulcerative colitis. Final report on a therapeutic trial. BMJ 1955;2:1041-8.
16. Hwang C, Ross V, Mahadevan U. Micronutrient deficiencies in inflammatory bowel disease: From A to zinc. Inflamm Bowel Dis 2012;18:1961-81.
17. Gasche C, Berstad A, Befrits R, Beglinger C, Dignass A, Erichsen K, et al. Guidelines on the diagnosis and management of iron deficiency and anemia in inflammatory bowel diseases. Inflamm Bowel Dis 2007;13:1545-53.
18. Dyer N, Dawson AM. Malnutrition and malabsorption in Crohn's disease with reference to the effect of surgery. Br J Surg 1973;60:134-40.
19. Kuroki F, Iida M, Tominaga M, Matsumoto T, Hirakawa K, Sugiyama S, et al. Multiple vitamin status in Crohn's disease. Digest Dis Sci 1993;38:1614-18.
20. Duerksen DR, Fallows G, Bernstein CN. Vitamin B12 malabsorption in patients with limited ileal resection. Nutrition 2006;22:1210-13.
21. Thuesen BH, Husemoen LL, Ovesen L, Jorgensen T, Fenger M, Linneberg A. Lifestyle and genetic determinants of folate and vitamin B12 levels in a general adult population. Br J Nutr 2010;103:1195-204.
22. Colapinto CK, O'Connor DL, Tremblay MS. Folate status of the population in the Canadian Health Measures Survey. CMAJ 2011;183:E100-6.
23. Vagianos K, Bernstein CN. Homocysteinemia and B vitamin status among adult patients with inflammatory bowel disease: A one-year prospective follow-up study. Inflamm Bowel Dis 2012;18:718-24.
24. Kulnigg S, Gasche C. Systematic review: Managing anaemia in Crohn's disease. Aliment Pharmacol Ther 2006;24: 1507-23.
25. Yang DT, Cook RJ. Spurious elevations of vitamin B12 with pernicious anemia. N Engl J Med 2012;366:1742-3.
26. Carmel R, Agrawal YP. Failures of cobalamin assays in pernicious anemia. N Engl J Med 2012;367:385-6.
27. Stabler SP. Vitamin B12 deficiency. N Engl JMed 2013;368: 149-60.