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Volumn 41, Issue 10, 2013, Pages 903-911

Immunomodulation with donor regulatory T cells armed with Fas-ligand alleviates graft-versus-host disease

Author keywords

[No Author keywords available]

Indexed keywords

FAS LIGAND; TRANSCRIPTION FACTOR FOXP3;

EID: 84885852637     PISSN: 0301472X     EISSN: 18732399     Source Type: Journal    
DOI: 10.1016/j.exphem.2013.04.016     Document Type: Article
Times cited : (14)

References (45)
  • 1
    • 0030472390 scopus 로고    scopus 로고
    • Transplantation of polarized type 2 donor T cells reduces mortality caused by experimental graft-versus-host disease
    • Krenger W., Cooke K.R., Crawford J.M., et al. Transplantation of polarized type 2 donor T cells reduces mortality caused by experimental graft-versus-host disease. Transplantation 1996, 62:1278-1285.
    • (1996) Transplantation , vol.62 , pp. 1278-1285
    • Krenger, W.1    Cooke, K.R.2    Crawford, J.M.3
  • 3
    • 0037025943 scopus 로고    scopus 로고
    • + regulatory T cells suppress lethal acute graft-versus-host disease after allogeneic bone marrow transplantation
    • + regulatory T cells suppress lethal acute graft-versus-host disease after allogeneic bone marrow transplantation. J Exp Med 2002, 196:389-399.
    • (2002) J Exp Med , vol.196 , pp. 389-399
    • Hoffmann, P.1    Ermann, J.2    Edinger, M.3    Fathman, C.G.4    Strober, S.5
  • 4
    • 0037093217 scopus 로고    scopus 로고
    • The infusion of exvivo activated and expanded CD4(+)CD25(+) immune regulatory cells inhibits graft-versus-host disease lethality
    • Taylor P.A., Lees C.J., Blazar B.R. The infusion of exvivo activated and expanded CD4(+)CD25(+) immune regulatory cells inhibits graft-versus-host disease lethality. Blood 2002, 99:3493-3499.
    • (2002) Blood , vol.99 , pp. 3493-3499
    • Taylor, P.A.1    Lees, C.J.2    Blazar, B.R.3
  • 5
    • 0141461418 scopus 로고    scopus 로고
    • CD4+CD25+ regulatory T cells preserve graft-versus-tumor activity while inhibiting graft-versus-host disease after bone marrow transplantation
    • Edinger M., Hoffmann P., Ermann J., et al. CD4+CD25+ regulatory T cells preserve graft-versus-tumor activity while inhibiting graft-versus-host disease after bone marrow transplantation. Nat Med 2003, 9:1144-1150.
    • (2003) Nat Med , vol.9 , pp. 1144-1150
    • Edinger, M.1    Hoffmann, P.2    Ermann, J.3
  • 6
    • 14944346738 scopus 로고    scopus 로고
    • Only the CD62L+ subpopulation of CD4+CD25+ regulatory T cells protects from lethal acute GVHD
    • Ermann J., Hoffmann P., Edinger M., et al. Only the CD62L+ subpopulation of CD4+CD25+ regulatory T cells protects from lethal acute GVHD. Blood 2005, 105:2220-2226.
    • (2005) Blood , vol.105 , pp. 2220-2226
    • Ermann, J.1    Hoffmann, P.2    Edinger, M.3
  • 7
    • 0346690399 scopus 로고    scopus 로고
    • Recipient-type specific CD4+CD25+ regulatory T cells favor immune reconstitution and control graft-versus-host disease while maintaining graft-versus leukemia
    • Trenado A., Charlotte F., Fisson S., et al. Recipient-type specific CD4+CD25+ regulatory T cells favor immune reconstitution and control graft-versus-host disease while maintaining graft-versus leukemia. J Clin Invest 2003, 112:1688-1696.
    • (2003) J Clin Invest , vol.112 , pp. 1688-1696
    • Trenado, A.1    Charlotte, F.2    Fisson, S.3
  • 8
    • 32644482551 scopus 로고    scopus 로고
    • Clinical application of expanded CD4+25+ cells
    • June C.H., Blazar B.R. Clinical application of expanded CD4+25+ cells. Semin Immunol 2006, 18:78-88.
    • (2006) Semin Immunol , vol.18 , pp. 78-88
    • June, C.H.1    Blazar, B.R.2
  • 9
    • 67349115219 scopus 로고    scopus 로고
    • In situ activation and expansion of host tregs: A new approach to enhance donor chimerism and stable engraftment in major histocompatibility complex-matched allogeneic hematopoietic cell transplantation
    • Shatry A., Levy R.B. In situ activation and expansion of host tregs: A new approach to enhance donor chimerism and stable engraftment in major histocompatibility complex-matched allogeneic hematopoietic cell transplantation. Biol Blood Marrow Transplant 2009, 15:785-794.
    • (2009) Biol Blood Marrow Transplant , vol.15 , pp. 785-794
    • Shatry, A.1    Levy, R.B.2
  • 10
    • 60249100179 scopus 로고    scopus 로고
    • Host CD4+CD25+ T cells can expand and comprise a major component of the Treg compartment after experimental HCT
    • Bayer A.L., Jones M., Chirinos J., et al. Host CD4+CD25+ T cells can expand and comprise a major component of the Treg compartment after experimental HCT. Blood 2009, 113:733-743.
    • (2009) Blood , vol.113 , pp. 733-743
    • Bayer, A.L.1    Jones, M.2    Chirinos, J.3
  • 11
    • 84858072808 scopus 로고    scopus 로고
    • IL-2-targeted therapy ameliorates the severity of graft-versus-host disease: exvivo selective depletion of host-reactive T cells and invivo therapy
    • Yarkoni S., Prigozhina T.B., Slavin S., Askenasy N. IL-2-targeted therapy ameliorates the severity of graft-versus-host disease: exvivo selective depletion of host-reactive T cells and invivo therapy. Biol Blood Marrow Transplant 2012, 18:523-535.
    • (2012) Biol Blood Marrow Transplant , vol.18 , pp. 523-535
    • Yarkoni, S.1    Prigozhina, T.B.2    Slavin, S.3    Askenasy, N.4
  • 12
    • 13544277369 scopus 로고    scopus 로고
    • Induction of tolerance using Fas ligand: A double-edged immunomodulator
    • Askenasy N., Yolcu E.S., Yaniv I., Shirwan H. Induction of tolerance using Fas ligand: A double-edged immunomodulator. Blood 2005, 105:1396-1404.
    • (2005) Blood , vol.105 , pp. 1396-1404
    • Askenasy, N.1    Yolcu, E.S.2    Yaniv, I.3    Shirwan, H.4
  • 13
    • 18744416830 scopus 로고    scopus 로고
    • Cell membrane modification for rapid display of proteins as a novel means of immunomodulation: FasL-decorated cells prevent islet graft rejection
    • Yolcu E.S., Askenasy N., Singh N.P., Cherradi S.E., Shirwan H. Cell membrane modification for rapid display of proteins as a novel means of immunomodulation: FasL-decorated cells prevent islet graft rejection. Immunity 2002, 17:795-808.
    • (2002) Immunity , vol.17 , pp. 795-808
    • Yolcu, E.S.1    Askenasy, N.2    Singh, N.P.3    Cherradi, S.E.4    Shirwan, H.5
  • 14
    • 49049110769 scopus 로고    scopus 로고
    • Induction of tolerance to cardiac allografts using donor splenocytes engineered to display on their surface an exogenous Fas ligand protein
    • Yolcu E.S., Gu X., Lacelle C., et al. Induction of tolerance to cardiac allografts using donor splenocytes engineered to display on their surface an exogenous Fas ligand protein. J Immunol 2008, 181:931-939.
    • (2008) J Immunol , vol.181 , pp. 931-939
    • Yolcu, E.S.1    Gu, X.2    Lacelle, C.3
  • 15
    • 82755190052 scopus 로고    scopus 로고
    • Pancreatic islets engineered with SA-FasL protein establish robust localized tolerance by inducing regulatory T cells in mice
    • Yolcu E.S., Zhao H., Bandura-Morgan L., et al. Pancreatic islets engineered with SA-FasL protein establish robust localized tolerance by inducing regulatory T cells in mice. J Immunol 2011, 187:5901-5909.
    • (2011) J Immunol , vol.187 , pp. 5901-5909
    • Yolcu, E.S.1    Zhao, H.2    Bandura-Morgan, L.3
  • 16
    • 81455132550 scopus 로고    scopus 로고
    • Engineering of bone marrow cells with fas-ligand protein-enhances donor-specific tolerance to solid organs
    • Askenasy E.M., Shushlav Y., Sun Z., Shirwan H., Yolcu E.S., Askenasy N. Engineering of bone marrow cells with fas-ligand protein-enhances donor-specific tolerance to solid organs. Transplant Proc 2011, 43:3545-3548.
    • (2011) Transplant Proc , vol.43 , pp. 3545-3548
    • Askenasy, E.M.1    Shushlav, Y.2    Sun, Z.3    Shirwan, H.4    Yolcu, E.S.5    Askenasy, N.6
  • 17
    • 79958022977 scopus 로고    scopus 로고
    • Killer Treg restore immune homeostasis and suppress autoimmune diabetes in prediabetic NOD mice
    • Kaminitz A., Yolcu E.S., Stein J., Yaniv I., Shirwan H., Askenasy N. Killer Treg restore immune homeostasis and suppress autoimmune diabetes in prediabetic NOD mice. J Autoimmun 2011, 37:39-47.
    • (2011) J Autoimmun , vol.37 , pp. 39-47
    • Kaminitz, A.1    Yolcu, E.S.2    Stein, J.3    Yaniv, I.4    Shirwan, H.5    Askenasy, N.6
  • 18
    • 84880300759 scopus 로고    scopus 로고
    • Immunomodulation with regulatory T cells and Fas-ligand ameliorate established inflammatory colitis
    • Kaminitz A., Askenasy N., Yolcu E.S. Immunomodulation with regulatory T cells and Fas-ligand ameliorate established inflammatory colitis. Gut 2013, 62:1228-1230.
    • (2013) Gut , vol.62 , pp. 1228-1230
    • Kaminitz, A.1    Askenasy, N.2    Yolcu, E.S.3
  • 19
  • 20
    • 43449091559 scopus 로고    scopus 로고
    • HLA-haploidentical bone marrow transplantation for hematologic malignancies using nonmyeloablative conditioning and high-dose, posttransplantation cyclophosphamide
    • Luznik L., O'Donnell P.V., Symons H.J., et al. HLA-haploidentical bone marrow transplantation for hematologic malignancies using nonmyeloablative conditioning and high-dose, posttransplantation cyclophosphamide. Biol Blood Marrow Transplant 2008, 14:641-650.
    • (2008) Biol Blood Marrow Transplant , vol.14 , pp. 641-650
    • Luznik, L.1    O'Donnell, P.V.2    Symons, H.J.3
  • 21
    • 55549091691 scopus 로고    scopus 로고
    • Prevention of acute graft-vs-host disease by a single low-dose cyclophosphamide injection following allogeneic bone marrow transplantation
    • Prigozhina T.B., Elkin G., Khitrin S., Slavin S. Prevention of acute graft-vs-host disease by a single low-dose cyclophosphamide injection following allogeneic bone marrow transplantation. Exp Hematol 2008, 36:1750-1759.
    • (2008) Exp Hematol , vol.36 , pp. 1750-1759
    • Prigozhina, T.B.1    Elkin, G.2    Khitrin, S.3    Slavin, S.4
  • 22
    • 84872621203 scopus 로고    scopus 로고
    • Depletion of naive lymphocytes with Fas-ligand exvivo prevents GvHD without impairing T cell support of engraftment or GVT activity
    • Askenasy N., Ash S., Askenasy E.M., Yaniv I., Stein J. Depletion of naive lymphocytes with Fas-ligand exvivo prevents GvHD without impairing T cell support of engraftment or GVT activity. Biol Blood Marrow Transplant 2013, 19:185-195.
    • (2013) Biol Blood Marrow Transplant , vol.19 , pp. 185-195
    • Askenasy, N.1    Ash, S.2    Askenasy, E.M.3    Yaniv, I.4    Stein, J.5
  • 23
    • 68249109933 scopus 로고    scopus 로고
    • Low levels of allogeneic but not syngeneic hematopoietic chimerism reverse autoimmune insulitis in prediabetic NOD mice
    • Kaminitz A., Mizrahi K., Yaniv I., Farkas D.L., Stein J., Askenasy N. Low levels of allogeneic but not syngeneic hematopoietic chimerism reverse autoimmune insulitis in prediabetic NOD mice. J Autoimmun 2009, 33:83-91.
    • (2009) J Autoimmun , vol.33 , pp. 83-91
    • Kaminitz, A.1    Mizrahi, K.2    Yaniv, I.3    Farkas, D.L.4    Stein, J.5    Askenasy, N.6
  • 24
    • 78149469328 scopus 로고    scopus 로고
    • Graft versus neuroblastoma reaction is efficiently elicited by allogeneic bone marrow transplantation through cytolytic activity in the absence of GVHD
    • Ash S., Gigi V., Askenasy N., Fabian I., Stein J., Yaniv I. Graft versus neuroblastoma reaction is efficiently elicited by allogeneic bone marrow transplantation through cytolytic activity in the absence of GVHD. Cancer Immunol Immunother 2009, 58:2073-2084.
    • (2009) Cancer Immunol Immunother , vol.58 , pp. 2073-2084
    • Ash, S.1    Gigi, V.2    Askenasy, N.3    Fabian, I.4    Stein, J.5    Yaniv, I.6
  • 26
    • 0037124359 scopus 로고    scopus 로고
    • Identification of regulatory T cells in tolerated allografts
    • Graca L., Cobbold S.P., Waldmann H. Identification of regulatory T cells in tolerated allografts. J Exp Med 2002, 195:1641-1646.
    • (2002) J Exp Med , vol.195 , pp. 1641-1646
    • Graca, L.1    Cobbold, S.P.2    Waldmann, H.3
  • 27
    • 0036498560 scopus 로고    scopus 로고
    • Tracking the immunoregulatory mechanisms active during allograft tolerance
    • Sanchez-Fueyo A., Weber M., Domenig C., et al. Tracking the immunoregulatory mechanisms active during allograft tolerance. J Immunol 2002, 168:2274-2281.
    • (2002) J Immunol , vol.168 , pp. 2274-2281
    • Sanchez-Fueyo, A.1    Weber, M.2    Domenig, C.3
  • 28
    • 34250821627 scopus 로고    scopus 로고
    • Specific recruitment of CD4+CD25++ regulatory T cells into the allograft in heart transplant recipients
    • Schmidt-Lucke C., Aicher A., Romagnani P., et al. Specific recruitment of CD4+CD25++ regulatory T cells into the allograft in heart transplant recipients. Am J Physiol Heart Circ Physiol 2007, 292:H2425-H2431.
    • (2007) Am J Physiol Heart Circ Physiol , vol.292
    • Schmidt-Lucke, C.1    Aicher, A.2    Romagnani, P.3
  • 29
    • 0037450727 scopus 로고    scopus 로고
    • T cell regulation as a side effect of homeostasis and competition
    • Barthlott T., Kassiotis G., Stockinger B. T cell regulation as a side effect of homeostasis and competition. J Exp Med 2003, 197:451-460.
    • (2003) J Exp Med , vol.197 , pp. 451-460
    • Barthlott, T.1    Kassiotis, G.2    Stockinger, B.3
  • 30
    • 30744458573 scopus 로고    scopus 로고
    • Lymphopenia and interleukin-2 therapy alter homeostasis of CD4+CD25+ regulatory T cells
    • Zhang H., Chua K.S., Guimond M., et al. Lymphopenia and interleukin-2 therapy alter homeostasis of CD4+CD25+ regulatory T cells. Nat Med 2005, 11:1238-1243.
    • (2005) Nat Med , vol.11 , pp. 1238-1243
    • Zhang, H.1    Chua, K.S.2    Guimond, M.3
  • 31
    • 71649085278 scopus 로고    scopus 로고
    • Consideration of strategies for hematopoietic cell transplantation
    • Yaniv I., Ash S., Farkas D.L., Askenasy N., Stein J. Consideration of strategies for hematopoietic cell transplantation. J Autoimmun 2009, 33:255-259.
    • (2009) J Autoimmun , vol.33 , pp. 255-259
    • Yaniv, I.1    Ash, S.2    Farkas, D.L.3    Askenasy, N.4    Stein, J.5
  • 32
    • 79251472114 scopus 로고    scopus 로고
    • Apoptosis of purified CD4+ T cell subsets is dominated by cytokine deprivation and absence of other cells in new onset diabetic NOD mice
    • Kaminitz A., Askenasy E.M., Yaniv I., Stein J., Askenasy N. Apoptosis of purified CD4+ T cell subsets is dominated by cytokine deprivation and absence of other cells in new onset diabetic NOD mice. PLoS One 2010, 5:e15684.
    • (2010) PLoS One , vol.5
    • Kaminitz, A.1    Askenasy, E.M.2    Yaniv, I.3    Stein, J.4    Askenasy, N.5
  • 33
    • 79959609103 scopus 로고    scopus 로고
    • Effector and naturally occurring regulatory T cells display no abnormalities in activation induced cell death in NOD mice
    • Kaminitz A., Yolcu E.S., Askenasy E.M., et al. Effector and naturally occurring regulatory T cells display no abnormalities in activation induced cell death in NOD mice. PLoS One 2011, 6:e21630.
    • (2011) PLoS One , vol.6
    • Kaminitz, A.1    Yolcu, E.S.2    Askenasy, E.M.3
  • 34
    • 78149465322 scopus 로고    scopus 로고
    • Immunomodulation with dendritic cells and donor lymphocyte infusion converge to induce graft vs neuroblastoma reactions without GVHD after allogeneic bone marrow transplantation
    • Ash S., Stein J., Askenasy N., Yaniv I. Immunomodulation with dendritic cells and donor lymphocyte infusion converge to induce graft vs neuroblastoma reactions without GVHD after allogeneic bone marrow transplantation. Br J Cancer 2010, 103:1597-1605.
    • (2010) Br J Cancer , vol.103 , pp. 1597-1605
    • Ash, S.1    Stein, J.2    Askenasy, N.3    Yaniv, I.4
  • 35
    • 15244340167 scopus 로고    scopus 로고
    • Foxp3+ CD25- CD4 T cells constitute a reservoir of committed regulatory cells that regain CD25 expression upon homeostatic expansion
    • Zelenay S., Lopes-Carvalho T., Caramalho I., Moraes-Fontes M.F., Rebelo M., Demengeot J. Foxp3+ CD25- CD4 T cells constitute a reservoir of committed regulatory cells that regain CD25 expression upon homeostatic expansion. Proc Natl Acad Sci U S A 2005, 102:4091-4096.
    • (2005) Proc Natl Acad Sci U S A , vol.102 , pp. 4091-4096
    • Zelenay, S.1    Lopes-Carvalho, T.2    Caramalho, I.3    Moraes-Fontes, M.F.4    Rebelo, M.5    Demengeot, J.6
  • 36
    • 60549115770 scopus 로고    scopus 로고
    • Heterogeneity of natural Foxp3+ T cells: a committed regulatory T-cell lineage and an uncommitted minor population retaining plasticity
    • Komatsu N., Mariotti-Ferrandiz M.E., Wang Y., Malissen B., Waldmann H., Hori S. Heterogeneity of natural Foxp3+ T cells: a committed regulatory T-cell lineage and an uncommitted minor population retaining plasticity. Proc Natl Acad Sci U S A 2009, 106:1903-1908.
    • (2009) Proc Natl Acad Sci U S A , vol.106 , pp. 1903-1908
    • Komatsu, N.1    Mariotti-Ferrandiz, M.E.2    Wang, Y.3    Malissen, B.4    Waldmann, H.5    Hori, S.6
  • 37
    • 0033543962 scopus 로고    scopus 로고
    • Effect of graft-versus-host disease (GVHD) on host hematopoietic progenitor cells is mediated by Fas-Fas ligand interactions but this does not explain the effect of GVHD on donor cells
    • Iwasaki T., Hamano T., Saheki K., et al. Effect of graft-versus-host disease (GVHD) on host hematopoietic progenitor cells is mediated by Fas-Fas ligand interactions but this does not explain the effect of GVHD on donor cells. Cell Immunol 1999, 197:30-38.
    • (1999) Cell Immunol , vol.197 , pp. 30-38
    • Iwasaki, T.1    Hamano, T.2    Saheki, K.3
  • 38
    • 1642529828 scopus 로고    scopus 로고
    • Donor T cells lacking Fas ligand and perforin retain the capacity to induce severe GvHD in minor histocompatibility antigen mismatched bone-marrow transplantation recipients
    • Marks L., Altman N.H., Podack E.R., Levy R.B. Donor T cells lacking Fas ligand and perforin retain the capacity to induce severe GvHD in minor histocompatibility antigen mismatched bone-marrow transplantation recipients. Transplantation 2004, 77:804-812.
    • (2004) Transplantation , vol.77 , pp. 804-812
    • Marks, L.1    Altman, N.H.2    Podack, E.R.3    Levy, R.B.4
  • 39
    • 0034653419 scopus 로고    scopus 로고
    • Inhibition of autoimmune diabetes by Fas ligand: the paradox is solved
    • Kim S., Kim K.A., Hwang D.Y., et al. Inhibition of autoimmune diabetes by Fas ligand: the paradox is solved. J Immunol 2000, 164:2931-2936.
    • (2000) J Immunol , vol.164 , pp. 2931-2936
    • Kim, S.1    Kim, K.A.2    Hwang, D.Y.3
  • 40
    • 0033980662 scopus 로고    scopus 로고
    • Fas-deficient lpr mice are more susceptible to graft-versus-host disease
    • van Den Brink M.R., Moore E., Horndasch K.J., et al. Fas-deficient lpr mice are more susceptible to graft-versus-host disease. J Immunol 2000, 164:469-480.
    • (2000) J Immunol , vol.164 , pp. 469-480
    • van Den Brink, M.R.1    Moore, E.2    Horndasch, K.J.3
  • 43
    • 77955924797 scopus 로고    scopus 로고
    • Immunosuppressive therapy exacerbates autoimmunity in NOD mice and diminishes the protective activity of regulatory T cells
    • Kaminitz A., Mizrahi K., Yaniv I., Stein J., Askenasy N. Immunosuppressive therapy exacerbates autoimmunity in NOD mice and diminishes the protective activity of regulatory T cells. J Autoimmun 2010, 35:145-152.
    • (2010) J Autoimmun , vol.35 , pp. 145-152
    • Kaminitz, A.1    Mizrahi, K.2    Yaniv, I.3    Stein, J.4    Askenasy, N.5
  • 44
    • 78751696183 scopus 로고    scopus 로고
    • Infusion of exvivo expanded T regulatory cells in adults transplanted with umbilical cord blood: safety profile and detection kinetics
    • Brunstein C.G., Miller J.S., Cao Q., et al. Infusion of exvivo expanded T regulatory cells in adults transplanted with umbilical cord blood: safety profile and detection kinetics. Blood 2011, 117:1061-1070.
    • (2011) Blood , vol.117 , pp. 1061-1070
    • Brunstein, C.G.1    Miller, J.S.2    Cao, Q.3
  • 45
    • 79953809817 scopus 로고    scopus 로고
    • Tregs prevent GVHD and promote immune reconstitution in HLA-haploidentical transplantation
    • Di Ianni M., Falzetti F., Carotti A., et al. Tregs prevent GVHD and promote immune reconstitution in HLA-haploidentical transplantation. Blood 2011, 117:3921-3928.
    • (2011) Blood , vol.117 , pp. 3921-3928
    • Di Ianni, M.1    Falzetti, F.2    Carotti, A.3


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