A large hospital outbreak of Klebsiella pneumoniae (DHA-1 and SHV-11 positive): Importance of detection and treatment of ampC β-lactamases

Open Infectious Diseases Journal

Volumn 3, Issue 1, 2009, Pages 55-60

  Vanwynsberghe, Timothy ^a   Verhamme, Katia ^a   Raymaekers, Marijke ^b   Cartuyvels, Reinoud ^b   Van Vaerenbergh, Kristien ^a   Boel, An ^a   de Beenhouwer, Hans ^a  

^a OLV HOSPITAL   (Belgium)

^b VIRGA JESSE HOSPITAL   (Belgium)

Author keywords

Ampc; Cefepime treatment; DHA 1; K. pneumonia; SHV 11; lactamases

Indexed keywords

EID: 84885849601     PISSN: None     EISSN: 18742793     Source Type: Journal    
DOI: 10.2174/1874279300903010055     Document Type: Article

References (39)

1. Babic M, Hujer AM, Bonomo RA. What's new in antibiotic resistance? Focus on β-lactamases. Drug Resist Updat 2006; 9: 142-156.
2. Hefland MS, Bonomo RA. β-lactamases: a survey of protein diversity. Curr Drug Targets Infect Disord 2003; 3: 9-23.
3. th ed. Washington DC: ASM press 2007, pp. 1114-1145.
4. Ambler RP. The structure of β-lactamases. Philos Trans R Soc Lond B Biol Sci 1980; 289: 321-331.
5. Vanwynsberghe T, Verhamme K, Raymaekers M, Cartuyvels R, Boel A, De Beenhouwer H. Outbreak of Klebsiella pneumoniae strain harbouring an AmpC (DHA-1) and a blaSHV-11 in a Belgian hospital, August-December 2006. Euro Surveill 2007; 12: e0702013.
6. Jarlier V, Nicolas M, Fournier G, Philippon A. Extended spectrum P-lactamases conferring transferable resistance to newer P-lactam agents in Enterobacteriaceae: hospital prevalence and susceptibility patterns. Rev Infect Dis 1988; 10: 867-878.
7. Jacoby GA, Walsh KE, Walker VJ. Identification of extended-spectrum, AmpC, and carbapenem-hydrolyzing P-lactamases in Escherichia coli and Klebsiella pneumoniae by disk tests. J Clin Microbiol 2006; 44: 1971-1976.
8. Black JA, Moland ES, Thomson KS. AmpC disk test for detection of plasmid-mediated AmpC β-lactamases in Enterobacteriaceae lacking chromosomal AmpC β-lactamases. J Clin Microbiol 2005; 43: 3110-3113.
9. Tenover FC, Arbeit RD, Mickelsen PA, Murray BE, Persing DH, Swaminathan B. Interpreting chromosomal DNA restriction patterns produced by pulsed-field gel electrophoresis: criteria for bacterial strain typing. J Clin Microbiol 1995; 33: 2233-2239.
10. Jacoby GA, Bush K. Amino acid sequences for TEM, SHV and OXA extended spectrum and inhibitor resistant β-lactamases. 2005 [cited 2007 Dec] Available from: http://www.lahey.org/studies/webt.htm
11. Lee K, Hong SG, Park YJ, et al. Evaluation of phenotypic screening methods for detecting plasmid-mediated AmpC β-lactamases-producing isolates of Escherichia coli and Klebsiella pneumoniae. Diagn Microbiol Infect Dis 2005; 53: 319-323.
12. Mirelis B, Rivera A, Miró E, Mesa RJ, Navarro F, Coll P. A simple phenotypic method for differentiation between acquired and chromosomal AmpC β-lactamases in Escherichia coli. Enferm Infect Microbiol Clin 2006; 24: 370-372.
13. Philippon A, Arlet G, Jacoby GA. Plasmid-determined AmpC-type β-lactamases. Antimicrob Agents Chemother 2002; 46: 1-11.
14. Walther-Rasmussen J, Høiby N. Plasmid-borne AmpC β-lactamases. Can J Microbiol 2002; 48: 479-493.
15. Jacobs C, Frère JM, Normark S. Cytosolic intermediates for cell wall biosynthesis and degradation control inducible p-lactam resistance in gram-negative bacteria. Cell 1997; 88: 823-832.
16. Gaillot O, Clement C, Simonet M, Philippon A. Novel transferable p-lactam resistance with cephalosporinase characteristics in Salmonella enteritidis. J Antimicrob Chemother 1997; 39: 85-87.
17. th Réunion Interdisciplinaire Chimiothérapie Anti-Infectieuse, abstr. 24/C4, 2000.
18. Fortineau N, Poirel L, Nordmann P. Plasmid-mediated and inducible cephalosporinase DHA-2 from Klebsiella pneumoniae. J Antimicrob Chemother 2001; 47: 207-210.
19. Wu LT, Hung SW, Chuang YC, Chen HE, Jones RN, Yu WL. Identification of a novel cephalosporinase (DHA-3) in Klebsiella pneumoniae isolated in Taiwan. Clin Microbiol Infect 2005; 11: 893-897.
20. Moland ES, Hanson ND, Black JA, Hossain A, Song W, Thomson KS. Prevalence of newer p-Lactamases in gram-negative clinical isolates collected in the United States from 2001 to 2002. J Clin Microbiol 2006; 44: 3318-3324.
21. Yan JJ, Ko WC, Yung JC, Chuang CL, Wu JJ. Emergence of Klebsiella pneumoniae isolates producing inducible DHA-1 p-lactamase in a university hospital in Taiwan. J Clin Microbiol 2002; 40: 3121-3126.
22. Lee K, Lee M, Shin JH, et al. Prevalence of plasmid-mediated AmpC β-lactamases in Escherichia coli and Klebsiella pneumoniae in Korea. Microb Drug Resist 2006; 12: 44-49.
23. Muratani T, Kobayashi T, Matsumoto T. Emergence and prevalence of p-lactamase-producing Klebsiella pneumoniae resistant to cephems in Japan. Int J Antimicrob Agents 2006; 27: 491-499.
24. Song W, Kim JS, Kim HS, et al. Increasing trend in the prevalence of plasmid-mediated AmpC β-lactamases in Enterobacteriaceae lacking chromosomal AmpC gene at a Korean university hospital from 2002 to 2004. Diagn Microbiol Infect Dis 2006; 55: 219-224.
25. Yan JJ, Hsueh PR, Lu JJ, et al. Extended-spectrum β-lactamases and plasmid-mediated AmpC enzymes among clinical isolates of Escherichia coli and Klebsiella pneumoniae from seven medical centers in Taiwan. Antimicrob Agents Chemother 2006; 50: 861-864.
26. Zaidi MB, Leon V, Canche C, et al. Rapid and widespread dissemination of multidrug-resistant blaCMY-2 Salmonella Typhimurium in Mexico. J Antimicrob Chemother 2007; 60: 398-401.
27. Nadjar D, Rouveau M, Verdet C, et al. Outbreak of Klebsiella pneumoniae producing transferable AmpC-type p-lactamase (ACC-1) originating from Hafnia alvei. FEMS Microbiol Lett 2000; 187: 35-40.
28. Pai H, Seo MR, Choi TY. Association of QnrB determinants and production of extended-spectrum β-lactamases or plasmid-mediated AmpC β-lactamases in clinical isolates of Klebsiella pneumoniae. Antimicrob Agents Chemother 2007; 51: 366-368.
29. Song W, Jeong SH, Kim JS, et al. Use of boronic acid disk methods to detect the combined expression of plasmid-mediated AmpC β-lactamases and extended-spectrum β-lactamases in clinical isolates of Klebsiella spp., Salmonella spp., and Proteus mirabilis. Diagn Microbiol Infect Dis 2006; 57: 315-318.
30. Thomson KS, Sanders CC. Detection of extended-spectrum β-lactamases in members of the family Enterobacteriaceae: comparison of the double disk and three-dimensional tests. Antimicrob Agents Chemother 1992; 36: 1877-1882.
31. Doi Y, Paterson DL. Detection of plasmid-mediated class C β-lactamases. Int J Infect Dis 2007; 11: 191-197.
32. Perez-Perez FJ, Hanson ND. Detection of plasmid-mediated AmpC p-lactamase genes in clinical isolates by using multiplex PCR. J Clin Microbiol 2002; 40: 2153-2162.
33. Pai H, Kang CI, Byeon JH, et al. Epidemiology and clinical features of bloodstream infections caused by AmpC-type-p-lactamase-producing Klebsiella pneumoniae. Antimicrob Agents Chemother 2004; 48: 3720-3728.
34. Kang CI, Pai H, Kim SH, et al. Cefepime and the inoculum effect in tests with Klebsiella pneumoniae producing plasmid-mediated AmpC-type p-lactamase. J Antimicrob Chemother 2004; 54: 1130-1133.
35. Owens RC, Jr, Rice L. Hospital-based strategies for combating resistance. Clin Infect Dis 2006; 42: S173-S181.
36. Barnaud G, Benzerara Y, Gravisse J, et al. Selection during cefepime treatment of a new cephalosporinase variant with extended-spectrum resistance to cefepime in an Enterobacter aerogenes clinical isolate. Antimicrob Agents Chemother 2004; 48: 1040-1042.
37. Mammeri H, Poirel L, Bemer P, Drugeon H, Nordmann P. Resistance to cefepime and cefpirome due to a 4-amino-acid deletion in the chromosome-encoded AmpC p-lactamase of a Serratia marcescens clinical isolate. Antimicrob Agents Chemother 2004; 48: 716-720.
38. Alvarez M, Tran JH, Chow N, Jacoby GA. Epidemiology of conjugative plasmid-mediated AmpC β-lactamases in the United States. Antimicrob Agents Chemother 2004; 48: 533-537.
39. Lee K, Yong D, Choi YS, et al. Reduced imipenem susceptibility in Klebsiella pneumoniae clinical isolates with plasmid-mediated CMY-2 and DHA-1 β-lactamases co-mediated by porin loss. Int J Antimicrob Agents 2007; 29: 201-206.