Folic acid stimulates proliferation of transplanted neural stem cells after focal cerebral ischemia in rats

Journal of Nutritional Biochemistry

Volumn 24, Issue 11, 2013, Pages 1817-1822

  Liu, Huan ^a   Cao, Jiasong ^a   Zhang, Haihong ^a   Qin, Shanchun ^a   Yu, Min ^a   Zhang, Xumei ^a   Wang, Xuan ^a   Gao, Yuxia ^a   Wilson, John X ^b   Huang, Guowei ^a  

^a TIANJIN MEDICAL UNIVERSITY   (China)

^b UNIVERSITY AT BUFFALO   (United States)

Author keywords

Folic acid; MCAO; Neural stem cells; Proliferation; Transplantation

Indexed keywords

BROXURIDINE; FOLIC ACID; SUPERPARAMAGNETIC IRON OXIDE;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; BRAIN ISCHEMIA; CELL PROLIFERATION; CONTROLLED STUDY; CORPUS STRIATUM; DRUG BLOOD LEVEL; DRUG MECHANISM; IMMUNOHISTOCHEMISTRY; IN VITRO STUDY; IN VIVO STUDY; MALE; MIDDLE CEREBRAL ARTERY OCCLUSION; NERVOUS SYSTEM DEVELOPMENT; NEURAL STEM CELL TRANSPLANTATION; NEWBORN; NONHUMAN; NUCLEAR MAGNETIC RESONANCE IMAGING; RAT; SUPPLEMENTATION;

RATTUS;

FOLIC ACID; MCAO; NEURAL STEM CELLS; PROLIFERATION; TRANSPLANTATION;

ANIMALS; BRAIN ISCHEMIA; CELL MOVEMENT; CELL PROLIFERATION; DEXTRANS; FOLIC ACID; INFARCTION, MIDDLE CEREBRAL ARTERY; MAGNETIC RESONANCE IMAGING; MAGNETITE NANOPARTICLES; MALE; NEURAL STEM CELLS; RATS; RATS, SPRAGUE-DAWLEY; STEM CELL TRANSPLANTATION;

EID: 84885839429     PISSN: 09552863     EISSN: 18734847     Source Type: Journal    
DOI: 10.1016/j.jnutbio.2013.04.002     Document Type: Article

References (17)

1. Huo Y., Qin X., Wang J., Sun N., Zeng Q., Xu X., et al. Efficacy of folic acid supplementation in stroke prevention: new insight from a meta-analysis. Int J Clin Pract 2012, 66:544-551.
2. Hankey G.J., Eikelboom J.W., Yi Q., Lees K.R., Chen C., Xavier D., et al. Antiplatelet therapy and the effects of B vitamins in patients with previous stroke or transient ischaemic attack: a post-hoc subanalysis of VITATOPS, a randomised, placebo-controlled trial. Lancet Neurol 2012, 11:512-520.
3. Zhang X., Huang G., Liu H., Chang H., Wilson J.X. Folic acid enhances notch signaling, hippocampal neurogenesis, and cognitive function in a rat model of cerebral ischemia. Nutr Neurosci 2012, 15:55-61.
4. Bliss T.M., Andres R.H., Steinberg G.K. Optimizing the success of cell transplantation therapy for stroke. Neurobiol Dis 2010, 37:275-283.
5. Lindvall O., Kokaia Z. Stem cell research in stroke: how far from the clinic?. Stroke 2011, 42:2369-2375.
6. Liu H., Huang G.W., Zhang X.M., Ren D.L., Wilson J.X. Folic acid supplementation stimulates notch signaling and cell proliferation in embryonic neural stem cells. J Clin Biochem Nutr 2010, 47:174-180.
7. Kim H., Zahir T., Tator C.H., Shoichet M.S. Effects of dibutyryl cyclic-AMP on survival and neuronal differentiation of neural stem/progenitor cells transplanted into spinal cord injured rats. PLoS One 2011, 6:e21744.
8. Jin K., Mao X., Xie L., Galvan V., Lai B., Wang Y., et al. Transplantation of human neural precursor cells in matrigel scaffolding improves outcome from focal cerebral ischemia after delayed postischemic treatment in rats. J Cereb Blood Flow Metab 2010, 30:534-544.
9. Ryu J.K., Cho T., Wang Y.T., McLarnon J.G. Neural progenitor cells attenuate inflammatory reactivity and neuronal loss in an animal model of inflamed AD brain. J Neuroinflammation 2009, 6:39.
10. Thu M.S., Najbauer J., Kendall S.E., Harutyunyan I., Sangalang N., Gutova M., et al. Iron labeling and pre-clinical MRI visualization of therapeutic human neural stem cells in a murine glioma model. PLoS One 2009, 4:e7218.
11. Song M., Kim Y., Kim Y., Ryu S., Song I., Kim S.U., et al. MRI tracking of intravenously transplanted human neural stem cells in rat focal ischemia model. Neurosci Res 2009, 64:235-239.
12. Berman S.C., Galpoththawela C., Gilad A.A., Bulte J.W., Walczak P. Long-term MR cell tracking of neural stem cells grafted in immunocompetent versus immunodeficient mice reveals distinct differences in contrast between live and dead cells. Magn Reson Med 2011, 65:564-574.
13. Iskandar B.J., Rizk E., Meier B., Hariharan N., Bottiglieri T., Finnell R.H., et al. Folate regulation of axonal regeneration in the rodent central nervous system through DNA methylation. J Clin Invest 2010, 120:1603-1616.
14. Iskandar B.J., Nelson A., Resnick D., Skene J.H., Gao P., Johnson C., et al. Folic acid supplementation enhances repair of the adult central nervous system. Ann Neurol 2004, 56:221-227.
15. Neri M., Maderna C., Cavazzin C., Deidda-Vigoriti V., Politi L.S., Scotti G., et al. Efficient in vitro labeling of human neural precursor cells with superparamagnetic iron oxide particles: relevance for in vivo cell tracking. Stem Cells 2008, 26:505-516.
16. Ding G., Jiang Q., Li L., Zhang L., Zhang Z., Lu M., et al. Longitudinal magnetic resonance imaging of sildenafil treatment of embolic stroke in aged rats. Stroke 2011, 42:3537-3541.
17. Toth Z.E., Leker R.R., Shahar T., Bratincsak A., Szalayova I., Key S., et al. Bone marrow-derived nonreactive astrocytes in the mouse brain after permanent middle cerebral artery occlusion. Stem Cells Dev 2011, 20:539-546.