Identification of apolipoprotein D as a cardioprotective gene using a mouse model of lethal atherosclerotic coronary artery disease

Proceedings of the National Academy of Sciences of the United States of America

Volumn 110, Issue 42, 2013, Pages 17023-17028

  Tsukamoto, Kosuke ^a   Mani, D R ^b   Shi, Jianru ^c,h   Zhang, Songwen ^a   Haagensen, Darrow E ^d   Otsuka, Fumiyuki ^e   Guan, Jian ^c   Smith, Jonathan D ^f   Weng, Wei ^g,i   Liao, Ronglih ^c   Kolodgie, Frank D ^e   Virmani, Renu ^e   Krieger, Monty ^a  

^a MASSACHUSETTS INSTITUTE OF TECHNOLOGY   (United States)

^b BROAD INSTITUTE OF MIT AND HARVARD   (United States)

^c BRIGHAM AND WOMEN S HOSPITAL   (United States)

^d Haagensen Research Foundation Inc   (United States)

^e CVPATH INSTITUTE   (United States)

^f CLEVELAND CLINIC LERNER COLLEGE OF MEDICINE   (United States)

^g ROCKEFELLER UNIVERSITY   (United States)

^h GOOD SAMARITAN HOSPITAL   (United States)

ⁱ InGenious Targeting Laboratory Inc   (United States)

Author keywords

Antioxidant; Lipocalin

Indexed keywords

APOLIPOPROTEIN D; CHOLESTEROL; MESSENGER RNA; TRIACYLGLYCEROL;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ANTIOXIDANT ACTIVITY; ARTERY LESION; ARTICLE; ATHEROSCLEROSIS; CELL COUNT; CELL VIABILITY; CHOLESTEROL BLOOD LEVEL; CONTROLLED STUDY; CORONARY ARTERY DISEASE; CORONARY ARTERY LIGATION; DISEASE COURSE; DYSLIPIDEMIA; GENE EXPRESSION; GENE EXPRESSION PROFILING; GENE IDENTIFICATION; HEART FAILURE; HEART INFARCTION; HEART MUSCLE CELL; HEART PROTECTION; LIPOPROTEIN BLOOD LEVEL; MICROARRAY ANALYSIS; MOUSE; NONHUMAN; PRIORITY JOURNAL; REPERFUSION INJURY; REVERSE TRANSCRIPTION POLYMERASE CHAIN REACTION; TRIACYLGLYCEROL BLOOD LEVEL;

ANTIOXIDANT; LIPOCALIN;

ANIMALS; ANTIOXIDANTS; APOLIPOPROTEINS D; APOLIPOPROTEINS E; CELL HYPOXIA; CELLS, CULTURED; CORONARY ARTERY DISEASE; DISEASE MODELS, ANIMAL; FEMALE; HUMANS; MICE; MICE, KNOCKOUT; MYOCARDIAL INFARCTION; MYOCARDIAL REPERFUSION INJURY; MYOCARDIUM; MYOCYTES, CARDIAC; RATS, WISTAR; SCAVENGER RECEPTORS, CLASS B;

EID: 84885764268     PISSN: 00278424     EISSN: 10916490     Source Type: Journal    
DOI: 10.1073/pnas.1315986110     Document Type: Article

References (42)

1. Zaragoza C, et al. (2011) Animal models of cardiovascular diseases. J Biomed Biotechnol 2011: 497841.
2. PlumpAS, et al. (1992) Severe hypercholesterolemia and atherosclerosis in apolipoprotein E-deficient mice created by homologous recombination in ES cells. Cell 71(2): 343-353.
3. Zhang SH, Reddick RL, Piedrahita JA, Maeda N (1992) Spontaneous hypercholesterolemia and arterial lesions in mice lacking apolipoprotein E. Science 258(5081): 468-471.
4. Ishibashi S, et al. (1993) Hypercholesterolemia in low density lipoprotein receptor knockout mice and its reversal by adenovirus-mediated gene delivery. J Clin Invest 92(2): 883-893.
5. Trigatti B, et al. (1999) Influence of the high density lipoprotein receptor SR-BI on reproductive and cardiovascular pathophysiology. Proc Natl Acad Sci USA 96(16): 9322-9327.
6. Braun A, et al. (2002) Loss of SR-BI expression leads to the early onset of occlusive atherosclerotic coronary artery disease, spontaneous myocardial infarctions, severe cardiac dysfunction, and premature death in apolipoprotein E-deficient mice. Circ Res 90(3): 270-276.
7. Braun A, et al. (2003) Probucol prevents early coronary heart disease and death in the high-density lipoprotein receptor SR-BI/apolipoprotein E double knockout mouse. Proc Natl Acad Sci USA 100(12): 7283-7288.
8. Rigotti A, Miettinen HE, Krieger M (2003) The role of the high-density lipoprotein receptor SR-BI in the lipid metabolism of endocrine and other tissues. Endocr Rev 24(3): 357-387.
9. Karackattu SL, Picard MH, Krieger M (2005) Lymphocytes are not required for the rapid onset of coronary heart disease in SR-BI/apoE double knockout mice. Arterioscler Thromb Vasc Biol 25(4): 803-808.
10. Zhang S, et al. (2005) Diet-induced occlusive coronary atherosclerosis, myocardial infarction, cardiac dysfunction, and premature death in scavenger receptor class B type Ideficient, hypomorphic apolipoprotein ER61 mice. Circulation 111(25): 3457-3464.
11. Nakagawa-Toyama Y, Zhang S, Krieger M (2012) Dietary manipulation and social isolation alter disease progression in a murine model of coronary heart disease. PLoS ONE 7(10):e47965.
12. Caligiuri G, Levy B, Pernow J, Thorén P, Hansson GK (1999) Myocardial infarction mediated by endothelin receptor signaling in hypercholesterolemic mice. Proc Natl Acad Sci USA 96(12): 6920-6924.
13. Cozen AE, et al. (2004) Macrophage-targeted overexpression of urokinase causes accelerated atherosclerosis, coronary artery occlusions, and premature death. Circulation 109(17): 2129-2135.
14. Fernández-Hernando C, et al. (2007) Loss of Akt1 leads to severe atherosclerosis and occlusive coronary artery disease. Cell Metab 6(6): 446-457.
15. Nakata S, et al. (2008) Spontaneous myocardial infarction in mice lacking all nitric oxide synthase isoforms. Circulation 117(17): 2211-2223.
16. Tarnavski O, et al. (2004) Mouse cardiac surgery: Comprehensive techniques for the generation of mouse models of human diseases and their application for genomic studies. Physiol Genomics 16(3): 349-360.
17. NHLBI Program for Genomic Applications, Harvard Medical School (2003) Genomics of Cardiovascular Development, Adaptation, and Remodeling. Available at www.cardiogenomics.org. Accessed October 21, 2009.
18. Jain M, et al. (2001) Cell therapy attenuates deleterious ventricular remodeling and improves cardiac performance after myocardial infarction. Circulation 103(14): 1920-1927.
19. Karamanlidis G, et al. (2010) Defective DNA replication impairs mitochondrial biogenesis in human failing hearts. Circ Res 106(9): 1541-1548.
20. Perdomo G, Henry Dong H (2009) Apolipoprotein D in lipid metabolism and its functional implication in atherosclerosis and aging. Aging (Albany, NY Online) 1(1): 17-27.
21. Muffat J, Walker DW (2010) Apolipoprotein D: An overview of its role in aging and age-related diseases. Cell Cycle 9(2): 269-273.
22. Do Carmo S, Jacomy H, Talbot PJ, Rassart E (2008) Neuroprotective effect of apolipoprotein D against human coronavirus OC43-induced encephalitis in mice. J Neurosci 28(41): 10330-10338.
23. Ganfornina MD, et al. (2010) ApoD, a glia-derived apolipoprotein, is required for peripheral nerve functional integrity and a timely response to injury. Glia 58(11): 1320-1334.
24. Bhatia S, et al. (2012) Selective reduction of hydroperoxyeicosatetraenoic acids to their hydroxy derivatives by apolipoprotein D: Implications for lipid antioxidant activity and Alzheimer's disease. Biochem J 442(3): 713-721.
25. Wang Y, Chen B, Shen D, Xue S (2009) Osteopontin protects against cardiac ischemiareperfusion injury through late preconditioning. Heart Vessels 24(2): 116-123.
26. Zhang Y, Cong Y, Wang S, Zhang S (2011) Antioxidant activities of recombinant amphioxus (Branchiostoma belcheri) apolipoprotein D. Mol Biol Rep 38(3): 1847-1851.
27. Eichinger A, Nasreen A, Kim HJ, Skerra A (2007) Structural insight into the dual ligand specificity and mode of high density lipoprotein association of apolipoprotein D. J Biol Chem 282(42): 31068-31075.
28. Oakley AJ, Bhatia S, Ecroyd H, Garner B (2012) Molecular dynamics analysis of apolipoprotein- D-lipid hydroperoxide interactions: Mechanism for selective oxidation of Met-93. PLoS ONE 7(3):e34057.
29. Pearlman WH, Guériguian JL, Sawyer ME (1973) A specific progesterone-binding component of human breast cyst fluid. J Biol Chem 248(16): 5736-5741.
30. Dilley WG, Haagensen DE, Cox CE, Wells SA, Jr. (1990) Immunologic and steroid binding properties of the GCDFP-24 protein isolated from human breast gross cystic disease fluid. Breast Cancer Res Treat 16(3): 253-260.
31. Morais Cabral JH, et al. (1995) Arachidonic acid binds to apolipoprotein D: Implications for the protein's function. FEBS Lett 366(1): 53-56.
32. Bajo-Grañeras R, Ganfornina MD, Martín-Tejedor E, Sanchez D (2011) Apolipoprotein D mediates autocrine protection of astrocytes and controls their reactivity level, contributing to the functional maintenance of paraquat-challenged dopaminergic systems. Glia 59(10): 1551-1566.
33. Walker DW, Muffat J, Rundel C, Benzer S (2006) Overexpression of a Drosophila homolog of apolipoprotein D leads to increased stress resistance and extended lifespan. Curr Biol 16(7): 674-679.
34. Miller NJ, Rice-Evans CA (1997) Factors influencing the antioxidant activity determined by the ABTS.+ radical cation assay. Free Radic Res 26(3): 195-199.
35. Aspinall JO, et al. (1995) Differential expression of apolipoprotein-D and prostate specific antigen in benign and malignant prostate tissues. J Urol 154(2 Pt 1): 622-628.
36. Blais Y, et al. (1995) Interleukin-6 inhibits the potent stimulatory action of androgens, glucocorticoids and interleukin-1 alpha on apolipoprotein D and GCDFP-15 expression in human breast cancer cells. Int J Cancer 62(6): 732-737.
37. Perdomo G, et al. (2010) A role of apolipoprotein D in triglyceride metabolism. J Lipid Res 51(6): 1298-1311.
38. Jiménez-Palomares M, Cózar-Castellano I, Ganfornina MD, Sánchez D, Perdomo G (2011) Genetic deficiency of apolipoprotein D in the mouse is associated with nonfasting hypertriglyceridemia and hyperinsulinemia. Metabolism 60(12): 1767-1774.
39. Wei YJ, et al. (2008) Apolipoprotein D as a novel marker in human end-stage heart failure: A preliminary study. Biomarkers 13(5): 535-548.
40. Roudkenar MH, et al. (2011) Neutrophil gelatinase-associated lipocalin: A new antioxidant that exerts its cytoprotective effect independent on Heme Oxygenase-1. Free Radic Res 45(7): 810-819.
41. Olsson MG, et al. (2011) Up-regulation of A1M/α1-microglobulin in skin by heme and reactive oxygen species gives protection from oxidative damage. PLoS ONE 6(11): e27505.
42. Leung WC, et al. (2004) Apolipoprotein D and platelet-derived growth factor-BB synergism mediates vascular smooth muscle cell migration. Circ Res 95(2): 179-186.