Pigmented villonodular synovitis: Current concepts about diagnosis and management

Future Oncology

Volumn 9, Issue 10, 2013, Pages 1515-1531

  Verspoor, Floortje G M ^a   Van Der Geest, Ingrid C M ^a   Vegt, Erik ^b   Veth, Rene P H ^a   Van Der Graaf, Winette T ^a   Schreuder, Hw Bart ^a  

^a RADBOUD UNIVERSITY MEDICAL CENTER   (Netherlands)

^b ANTONI VAN LEEUWENHOEK HOSPITAL   (Netherlands)

Author keywords

arthroscopy; drug therapy; follow up study; giant cell tumors; isotope synoviorthesis; operative; pigmented villonodular; radiotherapy; surgical procedure; synovitis; treatment outcome

Indexed keywords

DYSPROSIUM IRON HYDROXIDE DY 165; HEMOSIDERIN; IMATINIB; NILOTINIB; RHENIUM 186; TRIAMCINOLONE HEXACETONIDE; TUMOR NECROSIS FACTOR ALPHA; YTTRIUM 90;

ARTHROSCOPY; BONE NECROSIS; CANCER IMMUNOTHERAPY; CANCER PALLIATIVE THERAPY; CANCER RECURRENCE; CANCER REGRESSION; CANCER SURVIVAL; CRYOSURGERY; EDEMA; EXTERNAL BEAM RADIOTHERAPY; FEBRILE NEUTROPENIA; FEMUR FRACTURE; FOLLOW UP; GASTROINTESTINAL STROMAL TUMOR; GASTROINTESTINAL TOXICITY; HUMAN; IMPOTENCE; JOINT FUNCTION; JOINT STIFFNESS; LONG TERM CARE; OSTEOARTHRITIS; OUTCOME ASSESSMENT; PIGMENTED VILLONODULAR SYNOVITIS; PLASTIC SURGERY; POSTOPERATIVE COMPLICATION; PRACTICE GUIDELINE; PRIORITY JOURNAL; RADIATION NECROSIS; RECURRENCE FREE SURVIVAL; REGISTER; REVIEW; SKIN MANIFESTATION; SURVIVAL RATE; SYNOVECTOMY; TOTAL HIP PROSTHESIS; TREATMENT DURATION; TREATMENT OUTCOME; WOUND HEALING;

HUMANS; SYNOVITIS, PIGMENTED VILLONODULAR;

EID: 84885667746     PISSN: 14796694     EISSN: 17448301     Source Type: Journal    
DOI: 10.2217/fon.13.124     Document Type: Review

References (79)

1. Chassaignac CM. Cancer de la gaine des tendons. Gazette des Hopitaux Civils et Militaires 47, 185-186 (1852
2. Jaffe H, Lichtenstein L, Sutro C. Pigmented villonodular synovitis, bursitis and tenosynovitis. Arch. Pathol. 31, 731-765 (1941
3. Granowitz SP, D'Antonio J, Mankin HL. The pathogenesis and long-term end results of pigmented villonodular synovitis. Clin. Orthop. Relat. Res. 114, 335-351 (1976
4. The International Agency for Research on Cancer. Pathology and Genetics of Tumours of Soft Tissue and Bone. Fletcher CD, Unni KK, Mertens F (Eds.). International Agency for Research on Cancer Press, Lyon, France (2002). n Clarifies the inconsistent nomenclature of the past. Pigmented villonodular synovitis (PVNS) is a benign intra-articular giant cell tumor.
5. West RB, Rubin BP, Miller MA et al. A landscape effect in tenosynovial giant-cell tumor from activation of CSF1 expression by a translocation in a minority of tumor cells. Proc. Natl Acad. Sci. USA 103(3), 690-695 (2006 PVNS was found to be a neoplastic process with specific genetic changes and a reactive component known as the 'paracrine landscape effect'. This new insight may lead to the development of new treatment strategies, such as targeted therapy (Pubitemid 43153087)
6. Cupp JS, Miller MA, Montgomery KD et al. Translocation and expression of CSF1 in pigmented villonodular synovitis, tenosynovial giant cell tumor, rheumatoid arthritis and other reactive synovitides. Am. J. Surg. Pathol. 31(6), 970-976 (2007 (Pubitemid 47165154)
7. Fiocco U, Sfriso P, Lunardi F et al. Molecular pathways involved in synovial cell inflammation and tumoral proliferation in diffuse pigmented villonodular synovitis. Autoimmun. Rev. 9(11), 780-784 (2010
8. Cassier PA, Gelderblom H, Stacchiotti S et al. Efficacy of imatinib mesylate for the treatment of locally advanced and/or metastatic tenosynovial giant cell tumor/pigmented villonodular synovitis. Cancer 118(6), 1649-1655 (2012
9. Ravi V, Wang WL, Lewis VO. Treatment of tenosynovial giant cell tumor and pigmented villonodular synovitis. Curr. Opin. Oncol. 23(4), 361-366 (2011
10. Rao AS, Vigorita VJ. Pigmented villonodular synovitis (giant-cell tumor of the tendon sheath and synovial membrane). A review of eighty-one cases. J. Bone Joint Surg. 66(1), 76-94 (1984 (Pubitemid 14186734)
11. Myers BW, Masi AT. Pigmented villonodular synovitis and tenosynovitis: a clinical epidemiologic study of 166 cases and literature review. Medicine 59(3), 223-238 (1980 (Pubitemid 10117857)
12. Byers PD, Cotton RE, Deacon OW et al. The diagnosis and treatment of pigmented villonodular synovitis. J. Bone Joint Surg. 50(2), 290-305 (1968
13. Schwartz HS, Unni KK, Pritchard DJ. Pigmented villonodular synovitis. A retrospective review of affected large joints. Clin. Orthop. Relat. Res. 247, 243-255 (1989 (Pubitemid 19253014)
14. Miller WE. Villonodular synovitis: pigmented and nonpigmented variations. South Med. J. 75(9), 1084-1085 (1982 (Pubitemid 13241284)
15. Hughes TH, Sartoris DJ, Schweitzer ME, Resnick DL. Pigmented villonodular synovitis: MRI characteristics. Skeletal Radiol. 24(1), 7-12 (1995
16. Sharma V, Cheng EY. Outcomes after excision of pigmented villonodular synovitis of the knee. Clin. Orthop. Rel. Res. 467(11), 2852-2858 (2009
17. Chiari C, Pirich C, Brannath W, Kotz R, Trieb K. What affects the recurrence and clinical outcome of pigmented villonodular synovitis? Clin. Orthop. Rel. Res. 450, 172-178 (2006). nn Describes 1- and 5-year recurrence-free survival scores and functions scores for PVNS. However, different disease locations, subtypes, primary and recurrent PVNS are all taken together to increase patient numbers, which makes it difficult to interpret and compare results. (Pubitemid 44342132)
18. Flandry FC, Hughston JC, Jacobson KE, Barrack RL, McCann SB, Kurtz DM. Surgical treatment of diffuse pigmented villonodular synovitis of the knee. Clin. Orthop. Rel. Res. 300, 183-192 (1994 (Pubitemid 24085495)
19. Ogilvie-Harris DJ, McLean J, Zarnett ME. Pigmented villonodular synovitis of the knee. The results of total arthroscopic synovectomy, partial arthroscopic synovectomy, and arthroscopic local excision. J. Bone Joint Surg. 74(1), 119-123 (1992
20. Zvijac JE, Lau AC, Hechtman KS, Uribe JW, Tjin EW. Arthroscopic treatment of pigmented villonodular synovitis of the knee. Arthroscopy 15(6), 613-617 (1999 (Pubitemid 29427179)
21. Johansson JE, Ajjoub S, Coughlin LP. Pigmented villonodular synovitis of joints. Clin. Orthop. Rel. Res. 163, 159-166 (1982 (Pubitemid 12188103)
22. Chin KR, Barr SJ, Winalski C, Zurakowski D, Brick GW. Treatment of advanced primary and recurrent diffuse pigmented villonodular synovitis of the knee. J. Bone Joint Surg. 84(12), 2192-2202 (2002 (Pubitemid 35417699)
23. De Ponti A, Sansone V, Malcher MD. Result of arthroscopic treatment of pigmented villonodular synovitis of the knee. Arthroscopy 19(6), 602-607 (2003 (Pubitemid 36807693)
24. de Visser E, Veth RP, Pruszczynski M, Wobbes T, Van de Putte LB. Diffuse and localized pigmented villonodular synovitis: evaluation of treatment of 38 patients. Arch. Orthop. Trauma Surg. 119(7-8), 401-404 (1999
25. Klompmaker J, Veth RP, Robinson PH, Molenaar WM, Nielsen HK. Pigmented villonodular synovitis. Arch. Orthop. Trauma Surg. 109(4), 205-210 (1990 (Pubitemid 20221949)
26. Muscolo DL, Makino A, Costa-Paz M, Ayerza MA. Localized pigmented villonodular synovitis of the posterior compartment of the knee: diagnosis with magnetic resonance imaging. Arthroscopy 11(4), 482-485 (1995
27. Mohler DG, Kessler BD. Open synovectomy with cryosurgical adjuvant for treatment of diffuse pigmented villonodular synovitis of the knee. Bull. Hosp. Jt. Dis. 59(2), 99-105 (2000 (Pubitemid 30660993)
28. Chung SM, Janes JM. Diffuse pigmented villonodular synovitis of the hip joint. Review of the literature and report of four cases. J. Bone Joint Surg. 47, 293-303 (1965
29. Della Valle AG, Piccaluga F, Potter HG, Salvati EA, Pusso R. Pigmented villonodular synovitis of the hip: 2- to 23-year followup study. Clin. Orthop. Rel. Res. 388, 187-199 (2001 (Pubitemid 32595021)
30. Kroot EJ, Kraan MC, Smeets TJ, Maas M, Tak PP, Wouters JM. Tumour necrosis factor alpha blockade in treatment resistant pigmented villonodular synovitis. Ann. Rheum. Dis. 64(3), 497-499 (2005 (Pubitemid 40283070)
31. Chin KR, Brick GW. Extraarticular pigmented villonodular synovitis: a cause for failed knee arthroscopy. Clin. Orthop. Rel. Res. 404, 330-338 (2002 (Pubitemid 35351088)
32. Mankin H, Trahan C, Hornicek F. Pigmented villonodular synovitis of joints. J. Surg. Oncol. 103(5), 386-389 (2011
33. Ottaviani S, Ayral X, Dougados M, Gossec L. Pigmented villonodular synovitis: a retrospective single-center study of 122 cases and review of the literature. Semin. Arthritis Rheum. 40(6), 539-546 (2011
34. Poletti SC, Gates IHS, Martinez SM, Richardson WJ. The use of magnetic resonance imaging in the diagnosis of pigmented villonodular synovitis. Orthopedics 13(2), 185-190 (1990 (Pubitemid 20059650)
35. Moskovich R, Parisien JS. Localized pigmented villonodular synovitis of the knee. Arthroscopic treatment. Clin. Orthop. Relat. Res. (271), 218-224 (1991
36. Murphey MD, Rhee JH, Lewis RB, Fanburg-Smith JC, Flemming DJ, Walker EA. Pigmented villonodular synovitis: radiologic-pathologic correlation. Radiographics 28(5), 1493-1518 (2008
37. Cheng XG, You YH, Liu W, Zhao T, Qu H. MRI features of pigmented vilonodular synovitis (PVNS). Clin. Rheumatol. 23(1), 31-34 (2004 (Pubitemid 38247968)
38. Liu C, Zhao J, Chen L. Clinical results of arthroscopic treatment for localized pigmented villonodular synovitis of knee. Zhongguo Xiu Fu Chong Jian Wai Ke Za Zhi 23(9), 1042-1044 (2009
39. Ogilvie-Harris DJ, Weisleder L. Arthroscopic synovectomy of the knee: is it helpful? Arthroscopy 11(1), 91-95 (1995
40. Barile A, Sabatini M, Iannessi F et al. Pigmented villonodular synovitis (PVNS) of the knee joint: magnetic resonance imaging (MRI) using standard and dynamic paramagnetic contrast media. Report of 52 cases surgically and histologically controlled. Radiol. Med. 107(4), 356-366 (2004 (Pubitemid 38655913)
41. Dines JS, Deberardino TM, Wells JL et al. Long-term follow-up of surgically treated localized pigmented villonodular synovitis of the knee. Arthroscopy 23(9), 930-937 (2007 (Pubitemid 47375036)
42. Blanco CE, Leon HO, Guthrie TB. Combined partial arthroscopic synovectomy and radiation therapy for diffuse pigmented villonodular synovitis of the knee. Arthroscopy 17(5), 527-531 (2001
43. Neyret P, Pinaroli A, Selmi TAS, Servien E. Surgical management of pigmented villonodular synovitis of the knee: retrospective analysis of 28 cases. Rev. Chir. Orthop. 92(5), 437-447 (2006 (Pubitemid 44338594)
44. Ustinova VF, Podliashuk EL, Rodionova SS. Combined treatment of the diffuse form of pigmented villonodular synovitis. Med. Radiol. (Mosk) 31(3), 27-31 (1986
45. Lu KH. Subcutaneous pigmented villonodular synovitis caused by portal contamination during knee arthroscopy and open synovectomy. Arthroscopy 20(4), 9-13 (2004
46. Tyler WK, Vidal AF, Williams RJ, Healey JH. Pigmented villonodular synovitis. J. Am. Acad. Orthop. Surg. 14(6), 376-385 (2006 (Pubitemid 44916652)
47. Flipo RM, Desvigne-Noulet MC, Cotten A et al. Pigmented villonodular synovitis of the hip. Results of a national survey apropos of 58 cases. Rev. Rhum. Ed. Fr. 61(2), 85-95 (1994
48. Hamlin BR, Duffy GP, Trousdale RT, Morrey BF. Total knee arthroplasty in patients who have pigmented villonodular synovitis. J. Bone Joint Surg. 80(1), 76-82 (1998 (Pubitemid 28087304)
49. Veth R, van Hoesel R, Pruszczynski M, Hoogenhout J, Schreuder B, Wobbes T. Limb salvage in musculoskeletal oncology. Lancet Oncol. 4(6), 343-350 (2003 (Pubitemid 36748421)
50. Veth R, Schreuder B, van Beem H, Pruszczynski M, de Rooy J. Cryosurgery in aggressive, benign, and low-grade malignant bone tumours. Lancet Oncol. 6(1), 25-34 (2005 (Pubitemid 40089717)
51. Berger B, Ganswindt U, Bamberg M, Hehr T. External beam radiotherapy as postoperative treatment of diffuse pigmented villonodular synovitis. Int. J. Radiat. Oncol. Biol. Phys. 67(4), 1130-1134 (2007
52. Heyd R, Micke O, Berger B, Eich HT, Ackermann H, Seegenschmiedt MH. Radiation therapy for treatment of pigmented villonodular synovitis: results of a national patterns of care study. Int. J. Radiat. Oncol. Biol. Phys. 78(1), 199-204 (2010
53. Nassar WA, Bassiony AA, Elghazaly HA. Treatment of diffuse pigmented villonodular synovitis of the knee with combined surgical and radiosynovectomy. HSS J. 5(1), 19-23 (2009
54. Heyd R, Seegenschmiedt MH, Micke O. The role of external beam radiation therapy in the adjuvant treatment of pigmented villonodular synovitis. Z. Orthop. Unfall. 149(6), 677-82 (2011
55. Ozturk H, Bulut O, Oztemur Z, Bulut S. Pigmented villonodular synovitis managed by Yttrium 90 after debulking surgery. Saudi Med. J. 29(8), 1197-1200 (2008
56. Shabat S, Kollender Y, Merimsky O et al. The use of surgery and yttrium 90 in the management of extensive and diffuse pigmented villonodular synovitis of large joints. Rheumatology 41(10), 1113-1118 (2002 (Pubitemid 35203537)
57. Gumpel JM, Shawe DJ. Diffuse pigmented villonodular synovitis: non-surgical management. Ann. Rheum. Dis. 50(8), 531-533 (1991
58. Bickels J, Isaakov J, Kollender Y, Meller I. Unacceptable complications following intra-articular injection of yttrium 90 in the ankle joint for diffuse pigmented villonodular synovitis. J. Bone Joint Surg. 90(2), 326-328 (2008 (Pubitemid 351341044)
59. Kisielinski K, Bremer D, Knutsen A, Rottger P, Fitzek JG. Complications following radiosynoviorthesis in osteoarthritis and arthroplasty: osteonecrosis and intra-articular infection. Joint Bone Spine 77(3), 252-257 (2010
60. Jahangier ZN, Jacobs JW, Lafeber FP et al. Is radiation synovectomy for arthritis of the knee more effective than intraarticular treatment with glucocorticoids? Results of an eighteen-month, randomized, double-blind, placebo-controlled, crossover trial. Arthritis Rheum. 52(11), 3391-3402 (2005 (Pubitemid 41612205)
61. Jahangier ZN, Jacobs JW, Kraan MC et al. Pretreatment macrophage infiltration of the synovium predicts the clinical effect of both radiation synovectomy and intra-articular glucocorticoids. Ann. Rheum. Dis. 65(10), 1286-1292 (2006 (Pubitemid 44620438)
62. Kampen WU, Voth M, Pinkert J, Krause A. Therapeutic status of radiosynoviorthesis of the knee with yttrium (90Y) colloid in rheumatoid arthritis and related indications. Rheumatology 46(1), 16-24 (2007 (Pubitemid 44932778)
63. Fiocco U, Sfriso P, Oliviero F et al. Intra-articular treatment with the TNF-a antagonist, etanercept, in severe diffuse pigmented villonodular synovitis of the knee. Reumatismo 58(4), 268-274 (2006 (Pubitemid 46785644)
64. Kobak S. Intraarticular adalimumab in a patient with pigmented villonodular synovitis. Rheumatol. Int. 31(2), 251-254 (2011
65. O'Keefe RJ, Rosier RN, Teot LA, Stewart JM, Hicks DG. Cytokine and matrix metalloproteinase expression in pigmented villonodular synovitis may mediate bone and cartilage destruction. Iowa Orthop. J. 18, 26-34 (1998
66. Blay JY, El Sayadi H, Thiesse P, Garret J, Ray-Coquard I. Complete response to imatinib in relapsing pigmented villonodular synovitis/tenosynovial giant cell tumor (PVNS/TGCT). Ann. Oncol. 19(4), 821-822 (2008 (Pubitemid 351461057)
67. Moller E, Mandahl N, Mertens F, Panagopoulos I. Molecular identification of COL6A3-CSFI fusion transcripts in tenosynovial giant cell tumors. Gene Chromosomes Cancer 47(1), 21-25 (2008
68. Dewar AL, Cambareri AC, Zannettino AC et al. Macrophage colony-stimulating factor receptor c-fms is a novel target of imatinib. Blood 105(8), 3127-3132 (2005
69. Blay JY, Le Cesne A, Ray-Coquard I et al. Prospective multicentric randomized phase III study of imatinib in patients with advanced gastrointestinal stromal tumors comparing interruption versus continuation of treatment beyond 1 year: the French Sarcoma Group. J. Clin. Oncol. 25(9), 1107-1113 (2007 (Pubitemid 46596763)
70. Snoots WM, Watkins D, Dockery D, Mennel R, Cheek BS. Pigmented villonodular synovitis responsive to imatinib therapy. Proc. (Bayl. Univ. Med. Cent.) 24(2), 134-138 (2011
71. Thanopoulou E, Judson I. The safety profile of imatinib in CML and GIST: long-term considerations. Arch. Toxicol. 86(1), 1-12 (2012
72. Sciot R, Debiec-Rychter M. GIST under imatinib therapy. Semin. Diagn. Pathol. 23(2), 84-90 (2006
73. Rosa MA, Galli M, Fadda G, Maggiano N, Gambino GF. Proliferating cell nuclear antigen labelling index in localised pigmented villo-nodular synovitis and its relationship to the size of nodules. Int. Orthop. 24(4), 197-201 (2000
74. Weckauf H, Helmchen B, Hinz U et al. Expression of cell cycle-related gene products in different forms of primary versus recurrent PVNS. Cancer Lett. 210(1), 111-118 (2004 (Pubitemid 38692595)
75. Enneking WF, Dunham W, Gebhardt MC, Malawar M, Pritchard DJ. A system for the functional evaluation of reconstructive procedures after surgical treatment of tumors of the musculoskeletal system. Clin. Orthop. Relat. Res. (286), 241-246 (1993 (Pubitemid 23059493)
76. Pavlica L, Nikolic D, Tadic J, Tatic V, Bralovic S, Panajotovic L. Pigmented villonodular synovitis-analysis of 50 patients. Vojnosanit. Pregl. 54(3), 209-216 (1997
77. Rochwerger A, Groulier P, Curvale G, Franceschi JP, Dufour M. Pigmented villonodular synovitis of the knee. Treatment results in 22 cases. Rev. Chir. Orthop. Reparatrice Appar. Mot. 84(7), 600-606 (1998
78. Ushijima M, Hashimoto H, Tsuneyoshi M, Enjoji M. Pigmented villonodular synovitis. A clinicopathologic study of 52 cases. Acta Pathol. Jpn 36(3), 317-326 (1986 (Pubitemid 16141582)
79. Wang A, Zhao Y. Acupuncture treatment of synovitis with effusion - a report of 50 cases. J. Tradit. Chin. Med. 25(3), 204-205 (2005).