Uric acid levels, even in the normal range, are associated with increased cardiovascular risk: The Guangzhou Biobank Cohort Study

International Journal of Cardiology

Volumn 168, Issue 3, 2013, Pages 2238-2241

  Jin, Ya Li ^a   Zhu, Tong ^a   Xu, Lin ^b   Zhang, Wei Sen ^a   Liu, Bin ^a   Jiang, Chao Qiang ^a   Yu, Hong ^a   Huang, Li Ming ^a   Cheng, Kar Keung ^c   Thomas, G Neil ^c,d   Lam, Tai Hing ^b  

^a Guangzhou No 12 Hospital   (China)

^b UNIVERSITY OF HONG KONG   (Hong Kong)

^c UNIVERSITY OF BIRMINGHAM   (United Kingdom)

^d UNIVERSITY OF HEIDELBERG   (Germany)

Author keywords

Cardiovascular risk; Diabetes; Hyperuricemia; Uric acid

Indexed keywords

ANTIHYPERTENSIVE AGENT; APOLIPOPROTEIN A1; CHOLESTEROL; GLUCOSE; HIGH DENSITY LIPOPROTEIN CHOLESTEROL; URIC ACID;

ADULT; AGED; ARTICLE; BODY MASS; CARDIOVASCULAR RISK; CHINA; COHORT ANALYSIS; DIASTOLIC BLOOD PRESSURE; DYSLIPIDEMIA; FEMALE; GLUCOSE BLOOD LEVEL; HUMAN; HYPERTENSION; LEUKOCYTE COUNT; MAJOR CLINICAL STUDY; MALE; METABOLIC DISORDER; OBESITY; PRIORITY JOURNAL; PULSE PRESSURE; RISK ASSESSMENT; RISK FACTOR; SYSTOLIC BLOOD PRESSURE; URIC ACID BLOOD LEVEL; WAIST CIRCUMFERENCE; WAIST HIP RATIO; BLOOD; CARDIOVASCULAR DISEASES; CLINICAL TRIAL; EPIDEMIOLOGY; MIDDLE AGED; MULTICENTER STUDY; PREVALENCE; PROCEDURES; PROGNOSIS; QUESTIONNAIRE; REFERENCE VALUE; RETROSPECTIVE STUDY; SURVIVAL RATE; TRENDS; UNITED KINGDOM; VERY ELDERLY;

AGED; AGED, 80 AND OVER; CARDIOVASCULAR DISEASES; CHINA; FEMALE; GREAT BRITAIN; HUMANS; MALE; MIDDLE AGED; PREVALENCE; PROGNOSIS; QUESTIONNAIRES; REFERENCE VALUES; RETROSPECTIVE STUDIES; RISK ASSESSMENT; RISK FACTORS; SURVIVAL RATE; URIC ACID;

EID: 84885642947     PISSN: 01675273     EISSN: 18741754     Source Type: Journal    
DOI: 10.1016/j.ijcard.2013.01.214     Document Type: Article

References (34)

1. M. Tomita, S. Mizuno, and H. Yamanaka Does hyperuricemia affect mortality? A prospective cohort study of Japanese male workers J Epidemiol 10 2000 403 409
2. A. Reunanen, H. Takkunen, P. Knekt, and A. Aromaa Hyperuricemia as a risk factor for cardiovascular mortality Acta Med Scand Suppl 668 1982 49 59
3. S.H. Park, W.Y. Shin, and E.Y. Lee The impact of hyperuricemia on in-hospital mortality and incidence of acute kidney injury in patients undergoing percutaneous coronary intervention Circ J 75 2011 692 697
4. W.C. Liu, C.C. Hung, and S.C. Chen Association of hyperuricemia with renal outcomes, cardiovascular disease, and mortality Clin J Am Soc Nephrol 7 2012 541 548
5. J. Fang, and M.H. Alderman Serum uric acid and cardiovascular mortality the NHANES I epidemiologic follow-up study, 1971-1992. National Health and Nutrition Examination Survey JAMA 283 2000 2404 2410
6. L.K. Niskanen, D.E. Laaksonen, and K. Nyyssonen Uric acid level as a risk factor for cardiovascular and all-cause mortality in middle-aged men: a prospective cohort study Arch Intern Med 164 2004 1546 1551
7. C. Meisinger, W. Koenig, J. Baumert, and A. Doring Uric acid levels are associated with all-cause and cardiovascular disease mortality independent of systemic inflammation in men from the general population: the MONICA/KORA cohort study Arterioscler Thromb Vasc Biol 28 2008 1186 1192
8. A. Mazza, S. Zamboni, and E. Rizzato Serum uric acid shows a J-shaped trend with coronary mortality in non-insulin-dependent diabetic elderly people. The CArdiovascular STudy in the ELderly (CASTEL) Acta Diabetol 44 2007 99 105
9. A.G. Ioachimescu, D.M. Brennan, B.M. Hoar, S.L. Hazen, and B.J. Hoogwerf Serum uric acid is an independent predictor of all-cause mortality in patients at high risk of cardiovascular disease: a preventive cardiology information system (PreCIS) database cohort study Arthritis Rheum 58 2008 623 630
10. E.S. Ford Uric acid and mortality from all-causes and cardiovascular disease among adults with and without diagnosed diabetes: findings from the National Health and Nutrition Examination Survey III Linked Mortality Study Diabetes Res Clin Pract 93 2011 e84 e86
11. G. Ong, W.A. Davis, and T.M. Davis Serum uric acid does not predict cardiovascular or all-cause mortality in type 2 diabetes: the Fremantle Diabetes Study Diabetologia 53 2010 1288 1294
12. F. Panero, G. Gruden, and M. Perotto Uric acid is not an independent predictor of cardiovascular mortality in type 2 diabetes: a population-based study Atherosclerosis 221 2012 183 188
13. C. Jiang, G.N. Thomas, and T.H. Lam Cohort profile: the Guangzhou Biobank Cohort Study, a Guangzhou-Hong Kong-Birmingham collaboration Int J Epidemiol 35 2006 844 852
14. Z. Lu, B. Dong, and H. Wu Serum uric acid level in primary hypertension among Chinese nonagenarians/centenarians J Hum Hypertens 23 2009 113 121
15. G.N. Thomas, C.Q. Jiang, and S.M. McGhee Association of vascular risk factors with increasing glycemia even in normoglycemic subjects in an older Chinese population: the Guangzhou Biobank Cohort Study Metabolism 55 2006 1035 1041
16. K.G. Alberti, R.H. Eckel, and S.M. Grundy Harmonizing the metabolic syndrome: a joint interim statement of the International Diabetes Federation Task Force on Epidemiology and Prevention; National Heart, Lung, and Blood Institute; American Heart Association; World Heart Federation; International Atherosclerosis Society; and International Association for the Study of Obesity Circulation 120 2009 1640 1645
17. T. Okura, J. Higaki, and M. Kurata Elevated serum uric acid is an independent predictor for cardiovascular events in patients with severe coronary artery stenosis: subanalysis of the Japanese Coronary Artery Disease (JCAD) Study Circ J 73 2009 885 891
18. A.M. Strasak, C.C. Kelleher, and L.J. Brant Serum uric acid is an independent predictor for all major forms of cardiovascular death in 28,613 elderly women: a prospective 21-year follow-up study Int J Cardiol 125 2008 232 239
19. D.G. Beevers, and G.Y. Lip Is uric acid really an independent cardiovascular risk factor? Lancet 352 1998 1556
20. T. Kawai, M. Ohishi, and Y. Takeya Serum uric acid is an independent risk factor for cardiovascular disease and mortality in hypertensive patients Hypertens Res 2012
21. S.Y. Kim, J.P. Guevara, K.M. Kim, H.K. Choi, D.F. Heitjan, and D.A. Albert Hyperuricemia and risk of stroke: a systematic review and meta-analysis Arthritis Rheum 61 2009 885 892
22. D.I. Feig, D.H. Kang, and R.J. Johnson Uric acid and cardiovascular risk N Engl J Med 359 2008 1811 1821
23. F. Facchini, Y.D. Chen, C.B. Hollenbeck, and G.M. Reaven Relationship between resistance to insulin-mediated glucose uptake, urinary uric acid clearance, and plasma uric acid concentration JAMA 266 1991 3008 3011
24. F. Matsuura, S. Yamashita, and T. Nakamura Effect of visceral fat accumulation on uric acid metabolism in male obese subjects: visceral fat obesity is linked more closely to overproduction of uric acid than subcutaneous fat obesity Metabolism 47 1998 929 933
25. J.O. Clausen, K. Borch-Johnsen, H. Ibsen, and O. Pedersen Analysis of the relationship between fasting serum uric acid and the insulin sensitivity index in a population-based sample of 380 young healthy Caucasians Eur J Endocrinol 138 1998 63 69
26. L.Y. Chen, W.H. Zhu, and Z.W. Chen Relationship between hyperuricemia and metabolic syndrome J Zhejiang Univ Sci B 8 2007 593 598
27. E. Krishnan, B.J. Pandya, L. Chung, A. Hariri, and O. Dabbous Hyperuricemia in young adults and risk of insulin resistance, prediabetes, and diabetes: a 15-year follow-up study Am J Epidemiol 176 2012 108 116
28. A. Bedir, M. Topbas, F. Tanyeri, M. Alvur, and N. Arik Leptin might be a regulator of serum uric acid concentrations in humans Jpn Heart J 44 2003 527 536
29. T. Lyngdoh, P. Marques-Vidal, and F. Paccaud Elevated serum uric acid is associated with high circulating inflammatory cytokines in the population-based Colaus study PLoS One 6 2011 e19901
30. C. Ruggiero, A. Cherubini, and A. Ble Uric acid and inflammatory markers Eur Heart J 27 2006 1174 1181
31. R.J. Johnson, D.H. Kang, and D. Feig Is there a pathogenetic role for uric acid in hypertension and cardiovascular and renal disease? Hypertension 41 2003 1183 1190
32. U.M. Khosla, S. Zharikov, and J.L. Finch Hyperuricemia induces endothelial dysfunction Kidney Int 67 2005 1739 1742
33. G. Mercuro, C. Vitale, and E. Cerquetani Effect of hyperuricemia upon endothelial function in patients at increased cardiovascular risk Am J Cardiol 94 2004 932 935
34. R.J.A. Little, and D.B. Rubin Statistical analysis with missing data 1987 Wiley New York