Enhanced autophagy blocks angiogenesis via degradation of gastrin-releasing peptide in neuroblastoma cells

Autophagy

Volumn 9, Issue 10, 2013, Pages 1579-1590

  Kim, Kwang Woon ^a   Paul, Pritha ^a   Qiao, Jingbo ^a   Lee, Sora ^a   Chung, Dai H ^a  

^a VANDERBILT UNIVERSITY MEDICAL CENTER   (United States)

Author keywords

Angiogenesis; Autophagy; Endothelial cells; GRP; Neuroblastoma; Rapamycin

Indexed keywords

AUTOPHAGY PROTEIN 5; BECLIN 1; GASTRIN RELEASING PEPTIDE; GASTRIN RELEASING PEPTIDE RECEPTOR; MAMMALIAN TARGET OF RAPAMYCIN; RAPAMYCIN; RC 3095; SHORT HAIRPIN RNA; PROTEIN KINASE B; SMALL INTERFERING RNA;

ANGIOGENESIS; ARTICLE; AUTOPHAGOSOME; AUTOPHAGY; CONTROLLED STUDY; DRUG MECHANISM; ENDOTHELIUM CELL; HORMONE RELEASE; HUMAN; HUMAN CELL; NEUROBLASTOMA CELL; PROTEIN DEGRADATION; PROTEIN EXPRESSION; CELL PROLIFERATION; GENE EXPRESSION REGULATION; GENETICS; METABOLISM; NEOVASCULARIZATION (PATHOLOGY); NEUROBLASTOMA; PATHOLOGY; PHYSIOLOGY; TUMOR CELL LINE; VASCULARIZATION;

AUTOPHAGY; CELL LINE, TUMOR; CELL PROLIFERATION; ENDOTHELIAL CELLS; GASTRIN-RELEASING PEPTIDE; GENE EXPRESSION REGULATION, NEOPLASTIC; HUMANS; NEOVASCULARIZATION, PATHOLOGIC; NEUROBLASTOMA; PROTEOLYSIS; PROTO-ONCOGENE PROTEINS C-AKT; RNA, SMALL INTERFERING;

EID: 84885641447     PISSN: 15548627     EISSN: 15548635     Source Type: Journal    
DOI: 10.4161/auto.25987     Document Type: Article

References (23)

1. Brodeur GM. Neuroblastoma: biological insights into a clinical enigma. Nat Rev Cancer 2003; 3:203-16; PMID:12612655; http://dx.doi.org/10.1038/nrc1014
2. Meitar D, Crawford SE, Rademaker AW, Cohn SL. Tumor angiogenesis correlates with metastatic disease, N-myc amplification, and poor outcome in human neuroblastoma. J Clin Oncol 1996; 14:405-14; PMID:8636750
3. Ferrara N, Alitalo K. Clinical applications of angiogenic growth factors and their inhibitors. Nat Med 1999; 5:1359-64; PMID:10581076; http://dx.doi.org/10.1038/70928
4. Kim S, Hu W, Kelly DR, Hellmich MR, Evers BM, Chung DH. Gastrin-releasing peptide is a growth factor for human neuroblastomas. Ann Surg 2002; 235:621-9, discussion 629-30; PMID:11981207; http://dx.doi.org/10.1097/00000658-200205000- 00003
5. Kang J, Ishola TA, Baregamian N, Mourot JM, Rychahou PG, Evers BM, Chung DH. Bombesin induces angiogenesis and neuroblastoma growth. Cancer Lett 2007; 253:273-81; PMID:17383815; http://dx.doi.org/10.1016/j.canlet.2007.02.007
6. Qiao J, Kang J, Ishola TA, Rychahou PG, Evers BM, Chung DH. Gastrin-releasing peptide receptor silencing suppresses the tumorigenesis and metastatic potential of neuroblastoma. Proc Natl Acad Sci U S A 2008; 105:12891-6; PMID:18753628; http://dx.doi.org/10.1073/pnas.0711861105
7. Hahn-Windgassen A, Nogueira V, Chen CC, Skeen JE, Sonenberg N, Hay N. Akt activates the mammalian target of rapamycin by regulating cellular ATP level and AMPK activity. J Biol Chem 2005; 280:32081-9; PMID:16027121; http://dx.doi.org/10.1074/jbc.M502876200
8. Kim KW, Mutter RW, Cao C, Albert JM, Freeman M, Hallahan DE, Lu B. Autophagy for cancer therapy through inhibition of pro-apoptotic proteins and mammalian target of rapamycin signaling. J Biol Chem 2006; 281:36883-90; PMID:17005556; http://dx.doi.org/10.1074/jbc.M607094200
9. Kroemer G, Jäättelä M. Lysosomes and autophagy in cell death control. Nat Rev Cancer 2005; 5:886-97; PMID:16239905; http://dx.doi.org/10.1038/nrc1738
10. Glick D, Barth S, Macleod KF. Autophagy: cellular and molecular mechanisms. J Pathol 2010; 221:3-12; PMID:20225336; http://dx.doi.org/10.1002/ path.2697
11. Kim JH, Kim JH, Yu YS, Mun JY, Kim KW. Autophagy-induced regression of hyaloid vessels in early ocular development. Autophagy 2010; 6:922-8; PMID:20818164; http://dx.doi.org/10.4161/auto.6.7.13306
12. Lee SJ, Kim HP, Jin Y, Choi AM, Ryter SW. Beclin 1 deficiency is associated with increased hypoxiainduced angiogenesis. Autophagy 2011; 7:829-39; PMID:21685724; http://dx.doi.org/10.4161/auto.7.8.15598
13. Arjamaa O, Nikinmaa M, Salminen A, Kaarniranta K. Regulatory role of HIF-1a in the pathogenesis of age-related macular degeneration (AMD). Ageing Res Rev 2009; 8:349-58; PMID:19589398; http://dx.doi.org/10.1016/j.arr.2009.06.002
14. Cardona C, Bleehen NM, Reeve JG. Characterization of ligand binding and processing by gastrin-releasing peptide receptors in a small-cell lung cancer cell line. Biochem J 1992; 281:115-20; PMID:1310003
15. Yamamoto A, Tagawa Y, Yoshimori T, Moriyama Y, Masaki R, Tashiro Y. Bafilomycin A1 prevents maturation of autophagic vacuoles by inhibiting fusion between autophagosomes and lysosomes in rat hepatoma cell line, H-4-II-E cells. Cell Struct Funct 1998; 23:33-42; PMID:9639028; http://dx.doi.org/10.1247/csf. 23.33
16. Eng KE, Panas MD, Karlsson Hedestam GB, McInerney GM. A novel quantitative flow cytometrybased assay for autophagy. Autophagy 2010; 6:634-41; PMID:20458170; http://dx.doi.org/10.4161/auto.6.5.12112
17. Noda T, Ohsumi Y. Tor, a phosphatidylinositol kinase homologue, controls autophagy in yeast. J Biol Chem 1998; 273:3963-6; PMID:9461583; http://dx.doi.org/10.1074/jbc.273.7.3963
18. Blommaart EF, Luiken JJ, Blommaart PJ, van Woerkom GM, Meijer AJ. Phosphorylation of ribosomal protein S6 is inhibitory for autophagy in isolated rat hepatocytes. J Biol Chem 1995; 270:2320-6; PMID:7836465; http://dx.doi.org/10.1074/jbc.270.5.2320
19. Martínez A, Zudaire E, Julián M, Moody TW, Cuttitta F. Gastrin-releasing peptide (GRP) induces angiogenesis and the specific GRP blocker 77427 inhibits tumor growth in vitro and in vivo. Oncogene 2005; 24:4106-13; PMID:15750618; http://dx.doi.org/10.1038/sj.onc.1208581
20. Bae D, Lu S, Taglienti CA, Mercurio AM. Metabolic stress induces the lysosomal degradation of neuropilin-1 but not neuropilin-2. J Biol Chem 2008; 283:28074-80; PMID:18708346; http://dx.doi.org/10.1074/jbc.M804203200
21. Shinohara ET, Cao C, Niermann K, Mu Y, Zeng F, Hallahan DE, Lu B. Enhanced radiation damage of tumor vasculature by mTOR inhibitors. Oncogene 2005; 24:5414-22; PMID:15940265; http://dx.doi.org/10.1038/sj.onc.1208715
22. Kim KW, Hwang M, Moretti L, Jaboin JJ, Cha YI, Lu B. Autophagy upregulation by inhibitors of caspase-3 and mTOR enhances radiotherapy in a mouse model of lung cancer. Autophagy 2008; 4:659-68; PMID:18424912
23. Mizushima N, Yamamoto A, Hatano M, Kobayashi Y, Kabeya Y, Suzuki K, Tokuhisa T, Ohsumi Y, Yoshimori T. Dissection of autophagosome formation using Apg5-deficient mouse embryonic stem cells. J Cell Biol 2001; 152:657-68; PMID:11266458; http://dx.doi.org/10.1083/jcb.152.4.657