Effect of supplementation of probiotic bacillus coagulans unique IS-2 (ATCC PAT-11748) on hypercholesterolemic subjects: A clinical study

International Journal of Probiotics and Prebiotics

Volumn 6, Issue 2, 2011, Pages 89-94

  Sudha, M Ratna ^a   Radkar, Neelam ^b   Maurya, Asin ^b  

^a Unique Biotech Limited   (India)

^b LOKMANYA TILAK MUNICIPAL GENERAL HOSPITAL   (India)

Author keywords

Acute toxicity; Bacillus coagulans Unique IS2; Cholesterol; Clinical studies

Indexed keywords

HIGH DENSITY LIPOPROTEIN CHOLESTEROL; PROBIOTIC AGENT; TRIACYLGLYCEROL;

ADULT; ARTICLE; BACILLUS COAGULANS; CHOLESTEROL BLOOD LEVEL; CLINICAL ARTICLE; CLINICAL STUDY; DRUG CAPSULE; DRUG DOSE INCREASE; DRUG MECHANISM; FEMALE; HUMAN; HYPERCHOLESTEROLEMIA; MALE; PHASE 2 CLINICAL TRIAL;

EID: 84885631133     PISSN: 15551431     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Article

References (21)

1. Agerbaek, M., Gerdes, L.U., Richelsen, B. (1995). Hypocholesterolemic effect of a new fermented milk product in healthy middleaged men. European Journal of Clinical Nutrition 49: 346-352.
2. Colditz, G.A., Willett, W.C., Stampfer, M.J., Manson, J.E., Hennekens, C.H., Arky, R.A., Speizer, F.E. (1990). Weight as a risk factor for clinical diabetes in women. American Journal of Epidemiology 132: 501-513.
3. Danielson, A.D., Peo, E.R., Shahani, K.M. Lewis, A.J., Whalen, RJ., Amer, M. A. (1989). Anticholesterolemic property of Lactobacillus acidophilus yoghurt fed to mature boars. Journal of Animal Science 67: 966-974.
4. De Vuyst, L, Avonts, L., Makras, E. (2004). Probotics, prebiotics and gut health (Chap. 17). Remade, C, Reusens, B. (Eds.), Functional Foods, Ageing and Degenerative Disease. Woodhead Publishing Ltd., Cambridge, United Kingdom, 416-482.
5. Pereira, D.I.A., Gibson, G.R. (2002). Effects of Consumption of Probiotics and Prebiotics on Serum Lipid Levels in Humans. Critical Reviews in Biochemistry and Molecular Biology 37: 259-281.
6. Demacker, P. N. M., Hifmans, A. G. M. (1980). Estimation of HDL cholesterol by enzymatic method. Clinical Chemistry 26: 1775-80.
7. Fossati, P., Lorenzo, P. (1982). Serum triglycerides determined calorimetrically with an enzyme that produces hydrogen peroxide. Clinical Chemistry 28: 2007-16.
8. Friedewald, W.T., Levy, R.I., Fredericson, D.S. (1979). Estimation of the concentration of low-density lipoprotein cholesterol in plasma without diffuse use of preparative ultracentrifugation. Clinical Chemistry 18: 499-502.
9. Gandhi, A.B. (1988). Lactobacillus sporogenes: An advancement in lactobacillus therapy. The Eastern Pharmacist, 41-44.
10. Grunewald, K. K., Mitchell. K. (1983). Serum cholesterol levels in mice fed fermented and unfermented acidophilus milk. Journal of Pood Protection 46: 315-318.
11. Harrison, V.C., Peat, G. (1975). Serum cholesterol and bowel flora in the newborn. American Journal of Clinical Nutrition 28: 1351-1355.
12. Levine, G.N., Keaney, J.F., Vita, J.A. (1995). Cholesterol reduction in cardiovascular dis280 ease. Clinical benefits and possible mechanisms. New England Journal of Medicine 332: 512-521.
13. Lieberman, L. L. (1958). A method for the estimation of serum cholesterol. Clinical Chemistry 2: 26-30.
14. Lipid Research Clinics Program. (1984). The lipid research clinics coronary prevention trial results. 1. Reduction in incidence of coronary heart disease. Journal of the American Medical Association 251: 351-363.
15. Manson, J. E., Tosteson, H., Ridker, P.M., Satterfield, S., Herbert, P., Conner, G.T.O. (1992). The primary prevention of myocardial infarction. New England Journal of Medicine 326: 1406-1416.
16. Mohan C, Arora, R., Khalilullah, M. (1990). Preliminary observation on effect of Lactobacillus sporogenes on serum lipid levels in hypercholesterolemic patients. Indian Journal of Medical Research 92: 431-432.
17. Richelsen, B., Kristensen, K., Pedersen, S.B. (1996). Long-term (6 months) effect of a new fermented milk product on the level of plasma lipoproteins a placebo-controlled and double blind study. European Journal of Clinical Nutrition 50: 811-815.
18. Sudha, R. M., Sunita, M. and Sekhar, B. M. (2011). Safety studies of Bacillus coagulans Unique IS-2 in rats: Morphological, Biochemical and clinical evaluations. International Journal of Probiotics and Prebiotics 6:43-48.
19. Sudha, R. M., Chauhan, P., Dixit, K., Babu, S. and Jamil, K. (2011). Molecular typing and probiotic attributes of a new strain of Bacillus coagulans Unique IS-2: a potent biotherapeutic agent. Genetic engineering and Biotechnology Journal GEBJ-7.
20. Taylor, G.R.J., Williams, CM. (1998). Effects of probiotics and prebiotics on blood lipids. British Journal of Nutrition 80: S225-S230.
21. Thompson, L. U., Jenkins, D.J.A., Amer, M. A., Reichert, R., Jenkins, A., Kamulsky, J. (1982). Effect of fermented and unfermented milks on serum cholesterol. American Journal of Clinical Nutrition 36: 1106-1111.