Dietary salt intake modulates differential splicing of the Na-K-2Cl cotransporter NKCC2

American Journal of Physiology - Renal Physiology

Volumn 305, Issue 8, 2013, Pages

  Schießl, Ina Maria ^a   Rosenauer, Agnes ^a   Kattler, Veronika ^a   Minuth, Will W ^a   Oppermann, Mona ^b   Castrop, Hayo ^a  

^a UNIVERSITY OF REGENSBURG   (Germany)

^b UNIVERSITY HOSPITAL REGENSBURG   (Germany)

Author keywords

Differential spacing; NKCC2; Salt transport

Indexed keywords

ISOPROTEIN; SALT INTAKE; SLC12A1 PROTEIN, MOUSE; SODIUM POTASSIUM CHLORIDE COTRANSPORTER 2; WATER;

ADMINISTRATION AND DOSAGE; ALTERNATIVE RNA SPLICING; ANIMAL; C57BL MOUSE; FEMALE; GENETICS; MALE; METABOLISM; MOUSE; PHARMACOLOGY; SALT INTAKE;

ALTERNATIVE SPLICING; ANIMALS; FEMALE; MALE; MICE; MICE, INBRED C57BL; PROTEIN ISOFORMS; SODIUM CHLORIDE, DIETARY; SOLUTE CARRIER FAMILY 12, MEMBER 1; WATER;

EID: 84885621560     PISSN: 1931857X     EISSN: 15221466     Source Type: Journal    
DOI: 10.1152/ajprenal.00259.2013     Document Type: Article

References (43)

1. +-Cl2 cotransporter (NKCC2s) splice variants. J Gen Physiol 126: 325-337, 2005.
2. Caceres PS, Ares GR, Ortiz PA. cAMP stimulates apical exocytosis of the renal Na(+)-K(+)-2Cl(-) cotransporter NKCC2 in the thick ascending limb: role of protein kinase A. J Biol Chem 284: 24965-24971, 2009.
3. Carota I, Theilig F, Oppermann M, Kongsuphol P, Rosenauer A, Schreiber R, Jensen BL, Walter S, Kunzelmann K, Castrop H. Localization and functional characterization of the human NKCC2 isoforms. Acta Physiol (Oxf) 199: 327-338, 2010.
4. Castrop H, Hocherl K, Kurtz A, Schweda F, Todorov V, Wagner C. Physiology of kidney renin. Physiol Rev 90: 607-673, 2010.
5. Castrop H, Schnermann J. Isoforms of renal Na-K-2Cl cotransporter NKCC2: expression and functional significance. Am J Physiol Renal Physiol 295: F859-F866, 2008.
6. Ecelbarger CA, Kim GH, Wade JB, Knepper MA. Regulation of the abundance of renal sodium transporters and channels by vasopressin. Exp Neurol 171: 227-234, 2001.
7. Flemmer AW, Gimenez I, Dowd BF, Darman RB, Forbush B. Activation of the Na-K-Cl cotransporter NKCC1 detected with a phosphospecific antibody. J Biol Chem 277: 37551-37558, 2002.
8. Gamba G, Miyanoshita A, Lombardi M, Lytton J, Lee WS, Hediger MA, Hebert SC. Molecular cloning, primary structure, and characterization of two members of the mammalian electroneutral sodium-(potassium)-chloride cotransporter family expressed in kidney. J Biol Chem 269: 17713-17722, 1994.
9. Gimenez I, Forbush B. Short-term stimulation of the renal Na-K-Cl cotransporter (NKCC2) by vasopressin involves phosphorylation and membrane translocation of the protein. J Biol Chem 278: 26946-26951, 2003.
10. Gimenez I, Isenring P, Forbush B. Spatially distributed alternative splice variants of the renal Na-K-Cl cotransporter exhibit dramatically different affinities for the transported ions. J Biol Chem 277: 8767-8770, 2002.
11. Haas M, Forbush B 3rd. The Na-K-Cl cotransporters. J Bioenerg Biomembr 30: 161-172, 1998.
12. +-2Cl) cotransport at a chloride site. Am J Physiol Cell Physiol 245: C235-C240, 1983.
13. Hao S, Bellner L, Ferreri NR. NKCC2A and NFAT5 regulate renal TNF production induced by hypertonic NaCl intake. Am J Physiol Renal Physiol 304: F533-F542, 2013.
14. Herrera M, Garvin JL. Angiotensin II stimulates thick ascending limb NO production via AT(2) receptors and Akt1-dependent nitric-oxide synthase 3 (NOS3) activation. J Biol Chem 285: 14932-14940.
15. Herrera M, Silva GB, Garvin JL. Angiotensin II stimulates thick ascending limb superoxide production via protein kinase C(alpha)-dependent NADPH oxidase activation. J Biol Chem 285: 21323-21328.
16. Igarashi P, Vanden Heuvel GB, Payne JA, Forbush B, 3rd. Cloning, embryonic expression, and alternative splicing of a murine kidney-specific Na-K-Cl cotransporter. Am J Physiol Renal Fluid Electrolyte Physiol 269: F405-F418, 1995.
17. Kan Z, Rouchka EC, Gish WR, States DJ. Gene structure prediction and alternative splicing analysis using genomically aligned ESTs. Genome Res 11: 889-900, 2001.
18. Knepper MA, Kim GH, Fernandez-Llama P, Ecelbarger CA. Regulation of thick ascending limb transport by vasopressin. J Am Soc Nephrol 10: 628-634, 1999.
19. Kwon TH, Nielsen J, Kim YH, Knepper MA, Frokiaer J, Nielsen S. Regulation of sodium transporters in the thick ascending limb of rat kidney: response to angiotensin II. Am J Physiol Renal Physiol 285: F152-F165, 2003.
20. + cotransport in macula densa cells. Am J Physiol Renal Fluid Electrolyte Physiol 258: F1466-F1469, 1990.
21. Masilamani S, Wang X, Kim GH, Brooks H, Nielsen J, Nielsen S, Nakamura K, Stokes JB, Knepper MA. Time course of renal Na-KATPase, NHE3, NKCC2, NCC, and ENaC abundance changes with dietary NaCl restriction. Am J Physiol Renal Physiol 283: F648-F657, 2002.
22. Mederle K, Mutig K, Paliege A, Carota I, Bachmann S, Castrop H, Oppermann M. Loss of WNK3 is compensated for by the WNK1/SPAK axis in the kidney of the mouse. Am J Physiol Renal Physiol 304: F1198-F1209, 2013.
23. Minuth WW, Strehl R, Schumacher K, de Vries U. Long term culture of epithelia in a continuous fluid gradient for biomaterial testing and tissue engineering. J Biomater Sci Polym Ed 12: 353-365, 2001.
24. Miyata N, Park F, Li XF, Cowley AW Jr. Distribution of angiotensin AT1 and AT2 receptor subtypes in the rat kidney. Am J Physiol Renal Physiol 277: F437-F446, 1999.
25. Morton JJ, Padfield PL, Forsling ML. A radioimmunoassay for plasma arginine-vasopressin in man and dog: application to physiological and pathological states. J Endocrinol 65: 411-424, 1975.
26. Oppermann M, Mizel D, Huang G, Li C, Deng C, Theilig F, Bachmann S, Briggs J, Schnermann J, Castrop H. Macula densa control of renin secretion and preglomerular resistance in mice with selective deletion of the B isoform of the Na, K,2Cl co-transporter. J Am Soc Nephrol 17: 2143-2152, 2006.
27. Oppermann M, Mizel D, Kim SM, Chen L, Faulhaber-Walter R, Huang Y, Li C, Deng C, Briggs J, Schnermann J, Castrop H. Renal function in mice with targeted disruption of the A isoform of the Na-K-2Cl co-transporter. J Am Soc Nephrol 18: 440-448, 2007.
28. Payne JA, Forbush B, 3rd. Alternatively spliced isoforms of the putative renal Na-K-Cl cotransporter are differentially distributed within the rabbit kidney. Proc Natl Acad Sci USA 91: 4544-4548, 1994.
29. +-2Cl-cotransporter isoforms. J Biol Chem 277: 11004-11012, 2002.
30. Poumarat JS, Houillier P, Rismondo C, Roques B, Lazar G, Paillard M, Blanchard A. The luminal membrane of rat thick limb expresses AT1 receptor and aminopeptidase activities. Kidney Int 62: 434-445, 2002.
31. Rieg T, Tang T, Uchida S, Hammond HK, Fenton RA, Vallon V. Adenylyl cyclase 6 enhances NKCC2 expression and mediates vasopressin-induced phosphorylation of NKCC2 and NCC. Am J Pathol 182: 96-106, 2013.
32. Russell JM. Sodium-potassium-chloride cotransport. Physiol Rev 80: 211-276, 2000.
33. + cotransport. Pflügers Arch 414: 286-290, 1989.
34. Schnermann J, Briggs J, Schubert G. In situ studies of the distal convoluted tubule in the rat. I. Evidence for NaCl secretion. Am J Physiol Renal Fluid Electrolyte Physiol 243: F160-F166, 1982.
35. Schumacher K, Strehl R, Kloth S, Tauc M, Minuth WW. The influence of culture medi on embryonic renal collecting duct cell differentiation. In Vitro Cell Dev Biol Anim 35: 465-471, 1999.
36. Thomson SC, Bachmann S, Bostanjoglo M, Ecelbarger CA, Peterson OW, Schwartz D, Bao D, Blantz RC. Temporal adjustment of the juxtaglomerular apparatus during sustained inhibition of proximal reabsorption. J Clin Invest 104: 1149-1158, 1999.
37. Thomson SC, Blantz RC, Vallon V. Increased tubular flow induces resetting of tubuloglomerular feedback in euvolemic rats. Am J Physiol Renal Fluid Electrolyte Physiol 270: F461-F468, 1996.
38. Thurau K, Schnermann J. [The sodium concentration in the macula densa cells as a regulating factor for glomerular filtration (micropuncture experiments)]. Klin Wochenschr 43: 410-413, 1965.
39. Tian Y, Riazi S, Khan O, Klein JD, Sugimura Y, Verbalis JG, Ecelbarger CA. Renal ENaC subunit, Na-K-2Cl and Na-Cl cotransporter abundances in aged, water-restricted F344 x Brown Norway rats. Kidney Int 69: 304-312, 2006.
40. Vargas-Poussou R, Feldmann D, Vollmer M, Konrad M, Kelly L, van den Heuvel LP, Tebourbi L, Brandis M, Karolyi L, Hebert SC, Lemmink HH, Deschenes G, Hildebrandt F, Seyberth HW, Guay-Woodford LM, Knoers NV, Antignac C. Novel molecular variants of the Na-K-2Cl cotransporter gene are responsible for antenatal Bartter syndrome. Am J Hum Genet 62: 1332-1340, 1998.
41. + transporter subcellular distribution, abundance, and phosphorylation status. Am J Physiol Renal Physiol 295: F1003-F1016, 2008.
42. Yang T, Huang YG, Singh I, Schnermann J, Briggs JP. Localization of bumetanide-and thiazide-sensitive Na-K-Cl cotransporters along the rat nephron. Am J Physiol Renal Fluid Electrolyte Physiol 271: F931-F939, 1996.
43. Ye T, Liu ZQ, Sun CF, Zheng Y, Ma AQ, Fang Y. Altered expression of renal bumetanide-sensitive sodium-potassium-2 chloride cotransporter and Cl-channel-K2 gene in angiotensin II-infused hypertensive rats. Chin Med J (Engl) 118: 1945-1951, 2005.