The advantage of circulating tumor cells over serum carcinoembryonic antigen for predicting treatment responses in rectal cancer

Future Oncology

Volumn 9, Issue 10, 2013, Pages 1489-1500

  Sun, Wenjie ^a,b   Huang, Ting ^c,d   Li, Guichao ^a,b   Shen, Weiqi ^a,b   Zhu, Ji ^a,b   Jin, Qinghui ^c   Zhao, Jianlong ^c   Jia, Chunping ^c   Zhang, Zhen ^a,b  

^a FUDAN UNIVERSITY SHANGHAI CANCER CENTER   (China)

^b FUDAN UNIVERSITY   (China)

^c SHANGHAI INSTITUTE OF MICROSYSTEM AND INFORMATION TECHNOLOGY   (China)

^d NANTONG UNIVERSITY   (China)

Author keywords

chemoradiotherapy; circulating tumor cells; rectal cancer; serum carcinoembryonic antigen

Indexed keywords

CARCINOEMBRYONIC ANTIGEN; EPITHELIAL CELL ADHESION MOLECULE; TUMOR MARKER;

ADULT; ARTICLE; CANCER RECURRENCE; CANCER STAGING; CHEMORADIOTHERAPY; CIRCULATING TUMOR CELL; FEMALE; FLOW CYTOMETRY; HUMAN; HUMAN CELL; MAJOR CLINICAL STUDY; MALE; METASTASIS; PRIORITY JOURNAL; RECTUM CANCER; TREATMENT OUTCOME; TREATMENT RESPONSE;

ADULT; AGED; CARCINOEMBRYONIC ANTIGEN; CELL LINE, TUMOR; DISEASE PROGRESSION; FEMALE; HUMANS; MALE; MIDDLE AGED; NEOPLASM METASTASIS; NEOPLASM STAGING; NEOPLASTIC CELLS, CIRCULATING; RECTAL NEOPLASMS; REPRODUCIBILITY OF RESULTS; SENSITIVITY AND SPECIFICITY; TREATMENT OUTCOME;

EID: 84885619193     PISSN: 14796694     EISSN: 17448301     Source Type: Journal    
DOI: 10.2217/fon.13.91     Document Type: Article

References (43)

1. Byers T, Levin B, Rothenberger D, Dodd GD, Smith RA. American Cancer Society guidelines for screening and surveillance for early detection of colorectal polyps and cancer: update 1997. American Cancer Society Detection and Treatment Advisory Group on Colorectal Cancer. CA Cancer J. Clin. 47(3), 154-160 (1997
2. Mandel JS, Church TR, Bond JH et al. The effect of fecal occult-blood screening on the incidence of colorectal cancer. N. Engl. J. Med. 343(22), 1603-1607 (2000 (Pubitemid 32162983)
3. Smith RA, Cokkinides V, Eyre HJ. Cancer screening in the United States, 2007: a review of current guidelines, practices, and prospects. CA Cancer J. Clin. 57(2), 90-104 (2007 (Pubitemid 46535709)
4. Locker GY, Hamilton S, Harris J et al. ASCO 2006 update of recommendations for the use of tumor markers in gastrointestinal cancer. J. Clin. Oncol. 24(33), 5313-5327 (2006 (Pubitemid 46631379)
5. Boey J, Cheung HC, Lai CK, Wong J. A prospective evaluation of serum carcinoembryonic antigen (CEA) levels in the management of colorectal carcinoma. World J. Surg. 8(3), 279-286 (1984 (Pubitemid 15024857)
6. Lin JK, Lin CC, Yang SH et al. Early postoperative CEA level is a better prognostic indicator than is preoperative CEA level in predicting prognosis of patients with curable colorectal cancer. Int. J. Colorectal Dis. 26(9), 1135-1141 (2011
7. Park JW, Lim SB, Kim DY et al. Carcinoembryonic antigen as a predictor of pathologic response and a prognostic factor in locally advanced rectal cancer patients treated with preoperative chemoradiotherapy and surgery. Int. J. Radiat. Oncol. Biol. Phys. 74(3), 810-817 (2009
8. Hiraiwa K, Takeuchi H, Hasegawa H et al. Clinical significance of circulating tumor cells in blood from patients with gastrointestinal cancers. Ann. Surg. Oncol. 15(11), 3092-3100 (2008). Demonstrates that serum carcinoembryonic antigen might cause a delay in judging responses of therapy and its lack of sensitivity remains an unsolved problem in clinical practice.
9. Allard WJ, Matera J, Miller MC et al. Tumor cells circulate in the peripheral blood of all major carcinomas but not in healthy subjects or patients with nonmalignant diseases. Clin. Cancer Res. 10(20), 6897-6904 (2004 (Pubitemid 39383039)
10. Koyanagi K, Bilchik AJ, Saha S et al. Prognostic relevance of occult nodal micrometastases and circulating tumor cells in colorectal cancer in a prospective multicenter trial. Clin. Cancer Res. 14(22), 7391-7396 (2008
11. Matsusaka S, Suenaga M, Mishima Y et al. Circulating tumor cells as a surrogate marker for determining response to chemotherapy in Japanese patients with metastatic colorectal cancer. Cancer Sci. 102(6), 1188-1192 (2011
12. Garcia JA, Rosenberg JE, Weinberg V et al. Evaluation and significance of circulating epithelial cells in patients with hormone-refractory prostate cancer. BJU Int. 99(3), 519-524 (2007 (Pubitemid 46238821)
13. Hofman V, Bonnetaud C, Ilie MI et al. Preoperative circulating tumor cell detection using the isolation by size of epithelial tumor cell method for patients with lung cancer is a new prognostic biomarker. Clin. Cancer Res. 17(4), 827-835 (2011
14. Xu W, Cao L, Chen L et al. Isolation of circulating tumor cells in patients with hepatocellular carcinoma using a novel cell separation strategy. Clin. Cancer Res. 17(11), 3783-3793 (2011
15. Zheng S, Lin HK, Lu B et al. 3D microfilter device for viable circulating tumor cell (CTC) enrichment from blood. Biomed. Microdevices 13(1), 203-213 (2011
16. Miller MC, Doyle GV, Terstappen LW. Significance of circulating tumor cells detected by the cell search system in patients with metastatic breast colorectal and prostate cancer. J. Oncol. 2010, 617421(2010
17. Sastre J, Maestro ML, Puente J et al. Circulating tumor cells in colorectal cancer: correlation with clinical and pathological variables. Ann. Oncol. 19(5), 935-938 (2008 (Pubitemid 351627310)
18. Dworak O, Keilholz L, Hoffmann A. Pathological features of rectal cancer after preoperative radiochemotherapy. Int. J. Colorectal Dis. 12(1), 19-23 (1997). n Criteria of tumor regression grade by Dworak is shown in detail in this study, which has been widely used for pathological evaluation after neoadjuvant chemoradiotherapy for rectal cancer. (Pubitemid 27138353)
19. Elshimali YI, Grody WW. The clinical significance of circulating tumor cells in the peripheral blood. Diagn. Mol. Pathol. 15(4), 187-194 (2006 (Pubitemid 44813657)
20. Dworak O, Keilholz L, Hoffmann A. Pathological features of rectal cancer after preoperative radiochemotherapy. Int. J. Colorectal Dis. 12(1), 19-23 (1997 (Pubitemid 27138353)
21. Yie SM, Lou B, Ye SR et al. Detection of survivin-expressing circulating cancer cells (CCCs) in peripheral blood of patients with gastric and colorectal cancer reveals high risks of relapse. Ann. Surg. Oncol. 15(11), 3073-3082 (2008
22. Elshimali YI, Grody WW. The clinical significance of circulating tumor cells in the peripheral blood. Diagn. Mol. Pathol. 15(4), 187-194 (2006 (Pubitemid 44813657)
23. Wong SC, Ng SS, Cheung MT et al. Clinical significance of CDX2-positive circulating tumour cells in colorectal cancer patients. Br. J. Cancer 104(6), 1000-1006 (2011
24. Yie SM, Lou B, Ye SR et al. Detection of survivin-expressing circulating cancer cells (CCCs) in peripheral blood of patients with gastric and colorectal cancer reveals high risks of relapse. Ann. Surg. Oncol. 15(11), 3073-3082 (2008
25. Tol J, Koopman M, Miller MC et al. Circulating tumour cells early predict progression-free and overall survival in advanced colorectal cancer patients treated with chemotherapy and targeted agents. Ann. Oncol. 21(5), 1006-1012 (2010
26. Cohen SJ, Punt CJ, Iannotti N et al. Relationship of circulating tumor cells to tumor response, progression-free survival, and overall survival in patients with metastatic colorectal cancer. J. Clin. Oncol. 26(19), 3213-3221 (2008
27. Kim CJ, Yeatman TJ, Coppola D et al. Local excision of T2 and T3 rectal cancers after downstaging chemoradiation. Ann. Surg. 234(3), 352-358 (2001
28. Huh JW, Jung EJ, Park YA, Lee KY, Sohn SK. Preoperative chemoradiation followed by transanal excision for rectal cancer. J. Surg. Res. 148(2), 244-250 (2008 (Pubitemid 351915759)
29. Habr-Gama A, Perez RO, Nadalin W et al. Operative versus nonoperative treatment for stage 0 distal rectal cancer following chemoradiation therapy: long-term results. Ann. Surg. 240(4), 711-717 (2004
30. Hoffmann KT, Rau B, Wust P et al. Restaging of locally advanced carcinoma of the rectum with MR imaging after preoperative radio-chemotherapy plus regional hyperthermia. Strahlenther. Onkol. 178(7), 386-392 (2002 (Pubitemid 34665786)
31. Denecke T, Rau B, Hoffmann KT et al. Comparison of CT, MRI and FDG-PET in response prediction of patients with locally advanced rectal cancer after multimodal preoperative therapy: is there a benefit in using functional imaging. Eur. Radiol. 15(8), 1658-1666 (2005 (Pubitemid 41102362)
32. Tarantino I, Warschkow R, Worni M et al. Elevated preoperative CEA is associated with worse survival in stage I-III rectal cancer patients. Br. J. Cancer 107(2), 266-274 (2012
33. Song S, Hong JC, McDonnell SE et al. Combined modality therapy for rectal cancer: the relative value of posttreatment versus pretreatment CEA as a prognostic marker for disease recurrence. Ann. Surg. Oncol. 19(8), 2471-2476 (2012
34. Kim CW, Yu CS, Yang SS et al. Clinical significance of pre- to post-chemoradiotherapy s-CEA reduction ratio in rectal cancer patients treated with preoperative chemoradiotherapy and curative resection. Ann. Surg. Oncol. 18(12), 3271-3277 (2011
35. Lankiewicz S, Zimmermann S, Hollmann C et al. Circulating tumour cells as a predictive factor for response to systemic chemotherapy in patients with advanced colorectal cancer. Mol. Oncol. 2(4), 349-355 (2008
36. Ballesta AM, Molina R, Filella X, Jo J, Giménez N. Carcinoembryonic antigen in staging and follow-up of patients with solid tumors. Tumour Biol. 16(1), 32-41 (1995
37. Went PT, Lugli A, Meier S et al. Frequent EpCam protein expression in human carcinomas. Hum. Pathol. 35(1), 122-128 (2004 (Pubitemid 38133932)
38. Rao CG, Chianese D, Doyle GV et al. Expression of epithelial cell adhesion molecule in carcinoma cells present in blood and primary and metastatic tumors. Int. J. Oncol. 27(1), 49-57 (2005). Indicates that heterogeneity of expression of EpCAM exists in carcinomas and its downregulation can also be observed in circulating tumor cells.
39. Kevans D, Wang LM, Sheahan K et al. Epithelial-mesenchymal transition (EMT) protein expression in a cohort of stage II colorectal cancer patients with characterized tumor budding and mismatch repair protein status. Int. J. Surg. Pathol. 19(6), 751-760 (2011
40. Bhangu A, Wood G, Mirnezami A, Darzi A, Tekkis P, Goldin R. Epithelial mesenchymal transition in colorectal cancer: Seminal role in promoting disease progression and resistance to neoadjuvant therapy. Surg. Oncol. 21(4), 316-323 (2012
41. Kouso H, Yano T, Maruyama R et al. Differences in the expression of epithelial-mesenchymal transition related molecules between primary tumors and pulmonary metastatic tumors in colorectal cancer. Surg. Today 43(1), 73-80 (2013
42. Mocellin S, Keilholz U, Rossi CR et al. Circulating tumor cells: the 'leukemic phase' of solid cancers. Trends Mol. Med. 12(3), 130-139 (2006
43. Balic M, Williams A, Lin H et al. Circulating tumor cells: from bench to bedside. Annu. Rev. Med. 64, 31-44 (2013).