Galectin-3 expression in pituitary adenomas as a marker of aggressive behavior

Human Pathology

Volumn 44, Issue 11, 2013, Pages 2400-2409

  Righi, Alberto ^a,b   Morandi, Luca ^a   Leonardi, Elisa ^a   Farnedi, Anna ^a   Marucci, Gianluca ^a   Sisto, Andrea ^c   Frank, Giorgio ^d   Faustini Fustini, Marco ^e   Zoli, Matteo ^d   Mazzatenta, Diego ^d   Agati, Raffaele ^d   Foschini, Maria P ^a  

^a UNIVERSITY OF BOLOGNA   (Italy)

^b UNIVERSITY OF TURIN   (Italy)

^c UNIVERSITY OF EASTERN PIEDMONT   (Italy)

^d IRCCS ISTITUTO DELLE SCIENZE NEUROLOGICHE DI BOLOGNA   (Italy)

^e BELLARIA HOSPITAL   (Italy)

Author keywords

Galectin 3; Pituitary adenoma; Prognosis; RUNX1; RUNX2

Indexed keywords

BIOLOGICAL MARKER; CORTICOTROPIN; GALECTIN 3; KI 67 ANTIGEN; PROLACTIN; PROTEIN P53; TRANSCRIPTION FACTOR RUNX1; TRANSCRIPTION FACTOR RUNX2;

ADENOMA; ADULT; AGED; AGGRESSIVENESS; ARTICLE; CANCER SURGERY; CANCER SURVIVAL; CONTROLLED STUDY; FEMALE; FOLLOW UP; GENE OVEREXPRESSION; HUMAN; HUMAN TISSUE; HYPOPHYSIS ADENOMA; IMMUNOHISTOCHEMISTRY; IMMUNOREACTIVITY; LABELING INDEX; MAJOR CLINICAL STUDY; MALE; MITOSIS INDEX; NEURORADIOLOGY; PROGRESSION FREE SURVIVAL; QUANTITATIVE ANALYSIS; REAL TIME POLYMERASE CHAIN REACTION; REGULATORY MECHANISM; RETROSPECTIVE STUDY; TUMOR GROWTH; TUMOR INVASION; TUMOR RECURRENCE;

ACTH; ADRENOCORTICOTROPIN; CT; CYCLE THRESHOLD; FOLLICLE-STIMULATING HORMONE; FSH; GALECTIN-3; GH; GROWTH HORMONE; HIGH-POWER FIELD; HPF; IHC; IMMUNNOHISTOCHEMISTRY; LABELING INDEX; LGALS3; LH; LI; LUTEINIZING HORMONE; MAGNETIC RESONANCE IMAGING; MRI; PA; PITUITARY ADENOMA; PRL; PROGNOSIS; PROLACTIN; QRT-PCR; QUANTITATIVE REAL TIME-POLYMERASE CHAIN REACTION; RECEIVE OPERATING CHARACTERISTIC; ROC; RUNX1; RUNX2; THYROTROPIN; TSH;

ADENOMA; ADOLESCENT; ADRENOCORTICOTROPIC HORMONE; ADULT; AGED; CHILD; CORE BINDING FACTOR ALPHA 1 SUBUNIT; CORE BINDING FACTOR ALPHA 2 SUBUNIT; DISEASE PROGRESSION; DISEASE-FREE SURVIVAL; FEMALE; GALECTIN 3; GENE EXPRESSION REGULATION, NEOPLASTIC; HUMANS; MALE; MIDDLE AGED; NEOPLASM RECURRENCE, LOCAL; PITUITARY NEOPLASMS; PROGNOSIS; PROLACTIN; PROLACTINOMA; RETROSPECTIVE STUDIES; TUMOR MARKERS, BIOLOGICAL; YOUNG ADULT;

EID: 84885609748     PISSN: 00468177     EISSN: 15328392     Source Type: Journal    
DOI: 10.1016/j.humpath.2013.05.020     Document Type: Article

References (21)

1. F. Van den Brule, S. Califice, and V. Castronovo Expression of galectins in cancer: a critical review Glycoconj J 19 2004 537 542
2. N. Bergero, R. De Pompa, and C. Sacerdote Galectin-3 expression in parathyroid carcinoma: immunohistochemical study of 26 cases Hum Pathol 36 2005 908 914
3. F.J. Rodriguez, B.W. Scheithauer, and F. Roncaroli Galectin-3 expression is ubiquitous in tumors of the sellar region, nervous system, and mimics: an immunohistochemical and RT-PCR study Am J Surg Pathol 32 2008 1344 1352
4. A. Righi, L. Jin, and S. Zhang Identification and consequences of galectin-3 expression in pituitary tumors Mol Cell Endocrinol 326 2010 8 14
5. K.H. Ruebel, A.A. Leontovich, and L. Jin Patterns of gene expression in pituitary carcinomas and adenomas analyzed by high-density oligonucleotide arrays, reverse transcriptase-quantitative PCR, and protein expression Endocrine 29 2006 435 444
6. A. Suhardja, K. Kovacs, O. Greenberg, B.W. Scheithauer, and R.V. Lloyd Prognostic indicators in pituitary tumors Endocr Pathol 16 2005 1 9
7. L. Jin, D. Riss, and K. Ruebel Galectin-3 expression in functioning and silent ACTH-producing adenomas Endocr Pathol 16 2005 107 114
8. H.Y. Zhang, L. Jin, and G. Stilling RUNX1 and RUNX2 upregulate galectin-3 expression in human pituitary tumors Endocrine 35 2009 101 111
9. G. Stilling, Z. Sun, and S. Zhang MicroRNA expression in ACTH-producing pituitary tumors: up-regulation of microRNA-122 and -493 in pituitary carcinomas Endocrine 38 2010 67 75
10. R.V. Lloyd, K. Kovacs, and W.F. Young Jr. Tumors of the pituitary R.A. DeLellis, R.V. Lloyd, P.U. Heitz, C. Eng, World Health Organization classification of tumors: pathology and genetics: tumors of endocrine organs 2004 IARC Lyon 10 47
11. A. Righi, P. Agati, and A. Sisto A classification-tree approach of pituitary adenomas Hum Pathol 43 2012 1627 1637
12. E. Kaplan, and P. Meier Nonparametric estimation from incomplete observations J Am Stat Assoc 53 1958 457 481
13. S. Ezzat, and S.L. Asa Mechanisms of disease: the pathogenesis of pituitary tumors Nat Clin Pract Endocrinol Metab 2 2005 220 230
14. A. Righi, S. Zhang, and L. Jin Analysis of IMP3 expression in normal and neoplastic human pituitary tissues Endocr Pathol 21 2010 25 31
15. R.V. Lloyd Molecular pathology of pituitary adenomas J Neurooncol 54 2001 111 119
16. W.E. Farrell, and R.N. Clayton Epigenetic change in pituitary tumorigenesis Endocr Relat Cancer 10 2003 323 330
17. K.H. Ruebel, L. Jin, and X. Qian Effects of DNA methylation on galectin-3 expression in pituitary tumors Cancer Res 65 2005 1136 1140
18. S. Moisan, M. Demers, J. Mercier, T. Magnaldo, E.F. Potworowski, and Y. St-Pierre Upregulation of galectin-7 in murine lymphoma cells is associated with progression toward an aggressive phenotype Leukemia 17 2003 751 759
19. B.W. Scheithauer, O. Kurtkaya-Yapicier, K.T. Kovacs, W.F. Young Jr., and R.V. Lloyd Pituitary carcinoma: a clinicopathological review Neurosurgery 56 2005 1066 1074
20. P.J. Pernicone, B.W. Scheithauer, and T.J. Sebo Pituitary carcinoma: a clinicopathologic study of 15 cases Cancer 79 1997 804 812
21. D. Riss, L. Jin, and X. Qian Differential expression of galectin-3 in pituitary tumors Cancer Res 63 2003 2251 2255