Proteinuria: It is time to look beyond the proximal tubule

American Journal of Physiology - Renal Physiology

Volumn 305, Issue 8, 2013, Pages

  Erkan, Elif ^a  

^a CHILDREN S HOSPITAL OF PITTSBURGH   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

EID: 84885600674     PISSN: 1931857X     EISSN: 15221466     Source Type: Journal    
DOI: 10.1152/ajprenal.00425.2013     Document Type: Editorial

References (10)

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3. Donadelli R, Zanchi C, Morigi M, Buelli S, Batani C, Tomasoni S, Corna D, Rottoli D, Benigni A, Abbate M, Remuzzi G, Zoja C. Protein overload induces fractalkine upregulation in proximal tubular cells through nuclear factor kappaB-and p38 mitogen-activated protein kinasedependent pathways. J Am Soc Nephrol 14: 2436-2446, 2003.
4. Eddy AA, Giachelli CM. Renal expression of genes that promote interstitial inflammation and fibrosis in rats with protein-overload proteinuria. Kidney Int 47: 1546-1557, 1995.
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6. Motoyoshi Y, Matsusaka T, Saito A, Pastan I, Willnow TE, Mizutani S, Ichikawa I. Megalin contributes to the early injury of proximal tubule cells during nonselective proteinuria. Kidney Int 74: 1262-1269, 2008.
7. Svenningsen P, Friis UG, Versland JB, Buhl KB, Moller Frederiksen B, Andersen H, Zachar RM, Bistrup C, Skott O, Jorgensen JS, Andersen RF, Jensen BL. Mechanisms of renal NaCl retention in proteinuric disease. Acta Physiol (Oxf) 207: 536-545.
8. Theilig F, Kriz W, Jerichow T, Schrade P, Hahnel B, Willnow T, Le Hir M, Bachmann S. Abrogation of protein uptake through megalindeficient proximal tubules does not safeguard against tubulointerstitial injury. J Am Soc Nephrol 18: 1824-1834, 2007.
9. Tojo A, Kinugasa S. Mechanisms of glomerular albumin filtration and tubular reabsorption. Int J Nephrol 2012: 481520, 2012.
10. Zoja C, Donadelli R, Colleoni S, Figliuzzi M, Bonazzola S, Morigi M, Remuzzi G. Protein overload stimulates RANTES production by proximal tubular cells depending on NF-kappa B activation. Kidney Int 53: 1608-1615, 1998.