Effects of high dose intravenous fish oil on human atrial electrophysiology: Implications for possible anti- and pro-arrhythmic mechanisms in atrial fibrillation

International Journal of Cardiology

Volumn 168, Issue 3, 2013, Pages 2754-2760

  Kumar, Saurabh ^a,b   Sutherland, Fiona ^a   Lee, Justin M S ^a   Robinson, Timothy ^a   Heck, Patrick M ^a   Wong, Michael C G ^a,b   Kelland, Nicholas F ^a   Garg, Manohar L ^c   Sparks, Paul B ^a,b  

^a ROYAL MELBOURNE HOSPITAL   (Australia)

^b UNIVERSITY OF MELBOURNE   (Australia)

^c UNIVERSITY OF NEWCASTLE   (Australia)

Author keywords

Atrial fibrillation; Atrial flutter; Electrophysiology; Fish oil; Omega 3 polyunsaturated fatty acids

Indexed keywords

DOCOSAHEXAENOIC ACID; FISH OIL; ICOSAPENTAENOIC ACID; LIPID EMULSION; OMEGAVEN; OMEGA 3 FATTY ACID;

ADULT; AGED; ARTICLE; CONTROLLED STUDY; CORONARY SINUS; DRUG MEGADOSE; ELECTROCARDIOGRAPHY; EVENT RELATED POTENTIAL; FATTY ACID ANALYSIS; FEMALE; HEART ATRIUM CONDUCTION; HEART ATRIUM FIBRILLATION; HEART ATRIUM FLUTTER; HEART ELECTROPHYSIOLOGY; HEART MUSCLE REFRACTORY PERIOD; HUMAN; MAJOR CLINICAL STUDY; MALE; MORPHOLOGY; PERCEPTIVE THRESHOLD; PRIORITY JOURNAL; RANDOMIZED CONTROLLED TRIAL; SINUS RHYTHM; ADOLESCENT; ATRIAL FIBRILLATION; DRUG EFFECTS; ELECTROPHYSIOLOGY; HEART ATRIUM FUNCTION; INTRAVENOUS DRUG ADMINISTRATION; MIDDLE AGED; PROSPECTIVE STUDY; SINGLE BLIND PROCEDURE; YOUNG ADULT;

ADOLESCENT; ADULT; AGED; ATRIAL FIBRILLATION; ATRIAL FUNCTION; ELECTROPHYSIOLOGICAL PROCESSES; FATTY ACIDS, OMEGA-3; HUMANS; INFUSIONS, INTRAVENOUS; MIDDLE AGED; PROSPECTIVE STUDIES; SINGLE-BLIND METHOD; YOUNG ADULT;

EID: 84885595052     PISSN: 01675273     EISSN: 18741754     Source Type: Journal    
DOI: 10.1016/j.ijcard.2013.03.053     Document Type: Article

References (26)

1. D. Dobrev, and S. Nattel New antiarrhythmic drugs for treatment of atrial fibrillation Lancet 375 2010 1212 1223
2. D.M. Ninio, K.J. Murphy, P.R. Howe, and D.A. Saint Dietary fish oil protects against stretch-induced vulnerability to atrial fibrillation in a rabbit model J Cardiovasc Electrophysiol 16 2005 1189 1194
3. J.F. Sarrazin, G. Comeau, and P. Daleau Reduced incidence of vagally induced atrial fibrillation and expression levels of connexins by n-3 polyunsaturated fatty acids in dogs J Am Coll Cardiol 50 2007 1505 1512
4. M. Sakabe, A. Shiroshita-Takeshita, and A. Maguy Omega-3 polyunsaturated fatty acids prevent atrial fibrillation associated with heart failure but not atrial tachycardia remodeling Circulation 116 2007 2101 2109
5. G. Laurent, G. Moe, and X. Hu Long chain n-3 polyunsaturated fatty acids reduce atrial vulnerability in a novel canine pacing model Cardiovasc Res 77 2008 89 97
6. A. Ramadeen, G. Laurent, and C.C. dos Santos n-3 Polyunsaturated fatty acids alter expression of fibrotic and hypertrophic genes in a dog model of atrial cardiomyopathy Heart Rhythm 7 2010 520 528
7. Z. Zhang, C. Zhang, and H. Wang n-3 polyunsaturated fatty acids prevents atrial fibrillation by inhibiting inflammation in a canine sterile pericarditis model Int J Cardiol 153 2011 14 20
8. S. Kumar, F. Sutherland, and R. Rosso Effects of chronic omega-3 polyunsaturated fatty acid supplementation on human atrial electrophysiology Heart Rhythm 8 2011 562 568
9. S. Kumar, F. Sutherland, and A.W. Teh Effects of chronic omega-3 polyunsaturated fatty acid supplementation on human pulmonary vein and left atrial electrophysiology in paroxysmal atrial fibrillation Am J Cardiol 108 2011 531 535
10. E.S. Richardson, P.A. Iaizzo, and Y.F. Xiao Electrophysiological mechanisms of the anti-arrhythmic effects of omega-3 fatty acids J Cardiovasc Transl Res 4 2011 42 52
11. J.X. Kang, Y.F. Xiao, and A. Leaf Free, long-chain, polyunsaturated fatty acids reduce membrane electrical excitability in neonatal rat cardiac myocytes Proc Natl Acad Sci U S A 92 1995 3997 4001
12. D.N. da Cunha, R.L. Hamlin, G.E. Billman, and C.A. Carnes n-3 (omega-3) polyunsaturated fatty acids prevent acute atrial electrophysiological remodeling Br J Pharmacol 150 2007 281 285
13. F. Kabi Omegaven scientific brochure F.K.D. GmbH, 2006
14. S. Kumar, F. Sutherland, and J.B. Morton Long-term omega-3 polyunsaturated fatty acid supplementation reduces the recurrence of persistent atrial fibrillation after electrical cardioversion Heart Rhythm 9 2012 483 491
15. S. Kumar, F. Sutherland, and M. Wheeler Effects of chronic omega-3 polyunsaturated fatty acid supplementation on human atrial mechanical function after reversion of atrial arrhythmias to sinus rhythm: reversal of tachycardia-mediated atrial cardiomyopathy with fish oils Heart Rhythm 8 2011 643 649
16. P.R. Kowey, J.A. Reiffel, K.A. Ellenbogen, G.V. Naccarelli, and C.M. Pratt Efficacy and safety of prescription omega-3 fatty acids for the prevention of recurrent symptomatic atrial fibrillation: a randomised controlled trial JAMA 304 2010 2363 2372
17. E. Mantzioris, L.G. Cleland, R.A. Gibson, M.A. Neumann, M. Demasi, and M.J. James Biochemical effects of a diet containing foods enriched with n-3 fatty acids Am J Clin Nutr 72 2000 42 48
18. W.S. Harris, S.A. Sands, and S.L. Windsor Omega-3 fatty acids in cardiac biopsies from heart transplantation patients: correlation with erythrocytes and response to supplementation Circulation 110 2004 1645 1649
19. S. Kumar, J.M. Kalman, F. Sutherland, S.J. Spence, S. Finch, and P.B. Sparks Atrial fibrillation inducibility in the absence of structural heart disease or clinical atrial fibrillation: critical dependence on induction protocol, inducibility definition, and number of inductions Circ Arrhythm Electrophysiol 5 2012 531 536
20. E.G. Daoud, F. Bogun, and R. Goyal Effect of atrial fibrillation on atrial refractoriness in humans Circulation 94 1996 1600 1606
21. M. Haissaguerre, P. Sanders, and M. Hocini Changes in atrial fibrillation cycle length and inducibility during catheter ablation and their relation to outcome Circulation 109 2004 3007 3013
22. R. Schrepf, T. Limmert, P. Claus Weber, K. Theisen, and A. Sellmayer Immediate effects of n-3 fatty acid infusion on the induction of sustained ventricular tachycardia Lancet 363 2004 1441 1442
23. H.M. Den Ruijter, G. Berecki, T. Opthof, A.O. Verkerk, P.L. Zock, and R. Coronel Pro- and antiarrhythmic properties of a diet rich in fish oil Cardiovasc Res 73 2007 316 325
24. G.R. Li, H.Y. Sun, and X.H. Zhang Omega-3 polyunsaturated fatty acids inhibit transient outward and ultra-rapid delayed rectifier K + currents and Na + current in human atrial myocytes Cardiovasc Res 81 2009 286 293
25. X. Xu, M. Jiang, and Y. Wang Long-term fish oil supplementation induces cardiac electrical remodeling by changing channel protein expression in the rabbit model PLoS One 5 2010 e10140
26. A. Jahangiri, W.R. Leifert, G.S. Patten, and E.J. McMurchie Termination of asynchronous contractile activity in rat atrial myocytes by n-3 polyunsaturated fatty acids Mol Cell Biochem 206 2000 33 41