MiR-424 regulates monocytic differentiation of human leukemia U937 cells by directly targeting CDX2

Biotechnology Letters

Volumn 35, Issue 11, 2013, Pages 1799-1806

  Shen, Xiao ^a   Tang, Jinhai ^b   Hu, Jinhang ^a   Guo, Le ^a   Xing, Yingying ^a   Xi, Tao ^a  

^a CHINA PHARMACEUTICAL UNIVERSITY   (China)

^b JIANGSU CANCER HOSPITAL   (China)

Author keywords

CDX2; Fes; Human leukemia cells (U937); miR 125b; miR 424; Monocytic differentiation

Indexed keywords

CDX2; FES; HUMAN LEUKEMIA CELLS; MIR-125B; MIR-424; MONOCYTIC DIFFERENTIATIONS;

CELL CULTURE;

DISEASES;

CDX2 PROTEIN, HUMAN; COLONY STIMULATING FACTOR RECEPTOR; FES PROTEIN, HUMAN; HOMEODOMAIN PROTEIN; MICRORNA; MIRN125 MICRORNA, HUMAN; MIRN424 MICRORNA, HUMAN; ONCOPROTEIN; PROTEIN KINASE FES; PROTO ONCOGENE PROTEIN SPI 1; PROTO-ONCOGENE PROTEIN SPI-1; TRANSACTIVATOR PROTEIN;

ARTICLE; BIOSYNTHESIS; CELL DIFFERENTIATION; CELL STRAIN U937; DOWN REGULATION; DRUG EFFECT; GENE EXPRESSION; HUMAN; METABOLISM; MONOCYTE; PHYSIOLOGY;

CELL DIFFERENTIATION; DOWN-REGULATION; GENE EXPRESSION; HOMEODOMAIN PROTEINS; HUMANS; MICRORNAS; MONOCYTES; PROTO-ONCOGENE PROTEINS; PROTO-ONCOGENE PROTEINS C-FES; RECEPTORS, COLONY-STIMULATING FACTOR; TRANS-ACTIVATORS; U937 CELLS;

EID: 84885593359     PISSN: 01415492     EISSN: 15736776     Source Type: Journal    
DOI: 10.1007/s10529-013-1264-9     Document Type: Article

References (19)

1. Bousquet M, Quelen C, Rosati R et al (2008) Myeloid cell differentiation arrest by miR-125b-1 in myelodysplastic syndrome and acute myeloid leukemia with the t(2;11)(p21;q23) translocation. J Exp Med 205: 2499-2506.
2. Bousquet M, Harris MH, Zhou B, Lodish HF (2010) MicroRNA miR-125b causes leukemia. Proc Natl Acad Sci USA 107: 21558-21563.
3. Faraoni I, Laterza S, Ardiri D, Ciardi C, Fazi F, Lo-Coco F (2012) MiR-424 and miR-155 deregulated expression in cytogenetically normal acute myeloid leukaemia: correlation with NPM1 and FLT3 mutation status. J Hematol Oncol 5: 26-30.
4. Forrest ARR, Kanamori-Katayama M, Tomaru Y et al (2010) Induction of microRNAs mir-155, mir-222, mir-424 and mir-503, promotes monocytic differentiation through combinatorial regulation. Leukemia 24: 460-466.
5. Gefen N, Binder V, Zaliova M, Linka Y, Morrow M, Novosel A, Edry L, Hertzberg L, Shomron N, Williams O, Trka J, Borkhardt A, Izraeli S (2010) Hsa-mir-125b-2 is highly expressed in childhood ETV6/RUNX1 (TEL/AML1) leukemias and confers survival advantage to growth inhibitory signals independent of p53. Leukemia 24: 89-96.
6. Kasashima K, Nakamura Y, Kozu T (2004) Altered expression profiles of microRNAs during TPA-induced differentiation of HL-60 cells. Biochem Biophys Res Commun 322: 403-410.
7. Kuckenberg P, Buhl S, Woynecki T, Furden BV, Tolkunova E, Seiffe F, Moser M, Tomilin A, Winterhager E, Schorle H (2010) The transcription factor TCFAP2C/AP-2γ cooperates with CDX2 to maintain trophectoderm formation. Mol Cell Biol 30: 3310-3320.
8. Lin KY, Zhang XJ, Feng DD, Zhang H, Zeng CW, Han BW, Zhou AD, Qu LH, Xu L, Chen YQ (2011) miR-125b, a target of CDX2, regulates cell differentiation through repression of the core binding factor in hematopoietic malignancies. J Biol Chem 286: 38253-38263.
9. Marcucci G, Maharry K, Wu YZ et al (2010) IDH1 and IDH2 gene mutations identify novel molecular subsets within de novo cytogenetically normal acute myeloid leukemia: a cancer and leukemia group B study. J Clin Oncol 28: 2348-2355.
10. Rahimian A, Soleimani M, Kaviani S, Aghaee-Bakhtiari SH, Atashi A, Arefian E, Nikougoftar M (2011) Bypassing the maturation arrest in myeloid cell line U937 by over-expression of microRNA-424. Hematology 16: 298-302.
11. Rawat VPS, Thoene S, Naidu VM et al (2008) Overexpression of CDX2 perturbs HOX gene expression in murine progenitors depending on its N-terminal domain and is closely correlated with deregulated HOX gene expression in human acute myeloid leukemia. Blood 111: 309-319.
12. Riedt T, Ebinger M, Salih HR, Tomiuk J, Handgretinger R, Kanz L, Grünebach F, Lengerke C (2009) Aberrant expression of the homeobox gene CDX2 in pediatric acute lymphoblastic leukemia. Blood 113: 4049-4051.
13. Rosa A, Ballarino M, Sorrentino A, Sthandier O, De Angelis FG, Marchioni M, Masella B, Guarini A, Fatica A, Peschle C, Bozzoni I (2007) The interplay between the master transcription factor PU. 1 and miR-424 regulates human monocyte/macrophage differentiation. Proc Natl Acad Sci USA 104: 19849-19854.
14. Scholl C, Bansal D, Döhner K, Eiwen K, Huntly BJP, Lee BH, Rücker FG, Schlenk RF, Bullinger L, Döhner H, Gilliland DG, Fröhling S (2007) The homeobox gene CDX2 is aberrantly expressed in most cases of acute myeloid leukemia and promotes leukemogenesis. J Clin Invest 117: 1037-1048.
15. Schotte D, Pieters R, Den Boer ML (2012) MicroRNAs in acute leukemia: from biological players to clinical contributors. Leukemia 26: 1-12.
16. Thoene S, Rawat VPS, Heilmeier B, Hoster E, Metzeler KH, Herold T, Hiddemann W, Gokbuget N, Hoelzer D, Bohlander SK, Feuring-Buske M, Buske C (2009) The homeobox gene CDX2 is aberrantly expressed and associated with an inferior prognosis in patients with acute lymphoblastic leukemia. Leukemia 23: 649-655.
17. Vardiman JW, Thiele J, Arber DA, Brunning RD, Borowitz MJ, Porwit A, Harris NL, Le Beau MM, Hellström-Lindberg E, Tefferi A, Bloomfield CD (2009) The 2008 revision of the World Health Organization (WHO) classification of myeloid neoplasms and acute leukemia: rationale and important changes. Blood 114: 937-951.
18. Zeng CW, Zhang XJ, Lin KY, Ye H, Feng SY, Zhang H, Chen YQ (2012) Camptothecin induces apoptosis in cancer cells via microRNA-125b-mediated mitochondrial pathways. Mol Pharmacol 81: 578-586.
19. Zhang YJ, Gao JS, Tang XL, Tucker LD, Quesenberry P, Rigoutsos I, Ramratnam B (2009) MicroRNA 125a and its regulation of the p53 tumor suppressor gene. FEBS Lett 583: 3725-3730.