Prolonged autophagy by MTOR inhibitor leads radioresistant cancer cells into senescence

Autophagy

Volumn 9, Issue 10, 2013, Pages 1631-1632

  Nam, Hae Yun ^a   Han, Myung Woul ^b   Chang, Hyo Won ^a   Kim, Sang Yoon ^a,c   Kim, Seong Who ^a  

^a University of Ulsan College of Medicine   (South Korea)

^b University of Ulsan College of Medicine   (South Korea)

^c Korea Institute of Science and Technology   (South Korea)

Author keywords

Autophagy; Cellular senescence; Irradiation; MTOR inhibitor; RB

Indexed keywords

2 (4 AMINO 1 ISOPROPYL 1H PYRAZOLO[3,4 D]PYRIMIDIN 3 YL) 1H INDOL 5 OL; BETA GALACTOSIDASE; MAMMALIAN TARGET OF RAPAMYCIN INHIBITOR; PROTEIN P53; RAPAMYCIN; RETINOBLASTOMA PROTEIN; RETINOBLASTOMA PROTEIN 1; TRANSCRIPTION FACTOR E2F1; UNCLASSIFIED DRUG; MTOR PROTEIN, HUMAN; TARGET OF RAPAMYCIN KINASE;

AUTOPHAGY; CANCER CELL; CANCER RADIOTHERAPY; DNA DAMAGE; ENZYME ACTIVITY; HUMAN; HUMAN CELL; IRRADIATION; PROTEIN PHOSPHORYLATION; RADIATION DOSE; RADIOSENSITIVITY; SENESCENCE; SHORT SURVEY; ANIMAL; ANTAGONISTS AND INHIBITORS; CELL AGING; CELL PROLIFERATION; DRUG EFFECTS; METABOLISM; NEOPLASM; PATHOLOGY; PHYSIOLOGY; RADIATION RESPONSE;

ANIMALS; AUTOPHAGY; CELL AGING; CELL PROLIFERATION; HUMANS; NEOPLASMS; RADIATION TOLERANCE; RETINOBLASTOMA PROTEIN; TOR SERINE-THREONINE KINASES;

EID: 84885574879     PISSN: 15548627     EISSN: 15548635     Source Type: Journal    
DOI: 10.4161/auto.25879     Document Type: Short Survey

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