Polymer MALDI Sample Preparation

Mass Spectrometry in Polymer Chemistry

Volumn , Issue , 2012, Pages 119-148

  Hanton, Scott D ^a   Owens, Kevin G ^b  

^a Intertek ASA   (United States)

^b DREXEL UNIVERSITY   (United States)

Author keywords

Laser desorption (LD); Matrix assisted laser desorption ionization (MALDI); Matrix to analyte ratio; Polymer analytes; Salt to analyte ratio; Sample preparation; Solvent free; Time of flight mass spectrometers (TOFMS); Vortex method

Indexed keywords

EID: 84885515431     PISSN: None     EISSN: None     Source Type: Book    
DOI: 10.1002/9783527641826.ch5     Document Type: Chapter

References (53)

1. Tanaka, K., Waki, H., Ido, Y., Akita, S., Yoshido, Y., and Yoshido, T. (1988) Protein and polymer analyses up to M/Z 100,000 by laser ionization time-of-flight mass spectrometry. Rapid Commun. Mass Spectrom., 2, 151.
2. Karas, M. andHillenkamp, F. (1988) Laser desorption ionization of proteins with molecular masses exceeding 10,000 daltons. Anal. Chem., 60, 2299.
3. Bahr, U., Deppe, A., Karas, M., Hillenkamp, F., and Giessman, U. (1992) Mass spectrometry of synthetic polymers by UV-matrix-assisted laser desorption/ionization. Anal. Chem., 64, 2866.
4. Danis, P., Karr, D., Mayer, F., Holle, A., and Watson, C. (1992) The analysis of water-soluble polymers by matrix-assisted laser desorption time-of-flight mass spectrometry. Org. Mass Spectrom., 27, 843.
5. Hanton, S.D. (2001) Mass spectrometry of polymers and polymer surfaces. Chem. Rev., 101 (2), 527.
6. Nielen, M.W.F. (1999) MALDI time-of-flight mass spectrometry of synthetic polymers. Mass Spectrom. Rev., 18, 309.
7. Montaudo, G. and Lattimer, R.P. (eds) (2002)Mass Spectrometry of Polymers, CRC Press, Boca Raton, FL.
8. Burger, M., Muller, H., Seebach, D., Bornsen, O., Schar, M., and Widmer, M. (1993) Matrix-assisted laser desorption and ionization as a mass spectrometric tool for the analysis of poly[(R)-3- hydroxybutanoates]. Comparison with gel permeation chromatography. Macromolecules, 26, 4783.
9. Peng, L. and Kinsel, G.R. (2010) Improving the sensitivity of matrixassisted laser desorption/ionization (MALDI) mass spectrometry by using polyethylene glycol modified polyurethane MALDI target. Anal. Biochem., 400, 56-60.
10. Falkenhagen, J. and Weidner, S.M. (2005) Detection limits of matrix-associated laser desorption/ionisation mass spectrometry coupled to chromatography - a new application of solvent-free sample preparation. Rapid Commun. Mass Spectrom., 19, 3724.
11. Lehrle, R.S. and Sarson, D.S. (1995) Polymer molecular weight distribution: results from matrix-assisted laser desorption ionization compared with those from gel-permeation chromatography. Rapid Commun. Mass Spectrom., 9, 91-92.
12. Gentry, W.R. (1988) Low energy pulsed beam sources, in Atomic and Molecular Beam Methods (ed. G. Scoles), Oxford University Press, New York.
13. Meier, M.A.R., Adams, N., and Schubert, U.S. (2007) Statistical approach to understand MALDI-TOFMS matrices: discovery and evaluation of new MALDI matrices. Anal. Chem., 79, 863.
14. Hanton, S.D., Cornelio Clark, P.A., and Owens, K.G. (1999) Investigations of matrix-assisted laser desorption/ionization sample preparation by time-of-flight secondary ion mass spectrometry. J. Am. Soc. Mass Spectrom., 10, 104-111.
15. Hanton, S.D. and Owens, K.G. (2005) Using MESIMS to analyze polymer MALDI matrix solubility. J. Am. Soc. Mass Spectrom., 16, 1172-1180.
16. Hanton, S.D. (2004) New mass spectrometry techniques for the analysis of polymers for coatings applications: MALDIand ESI. JCT Coat. Tech., 1, 62-68.
17. http://polymers.msel.nist.gov/maldirecipes/index.cfm, accessed 1/17/2011.
18. King, R.C. (1994) Laser desorption/laser ionization time-of-flight mass spectrometry instrument design & investigation of the desorption and ionization mechanisms of matrix-assisted laser desorption/ionization. Ph.D. Thesis, Drexel University, Philadelphia, PA.
19. Weidner, S.M. and Falkenhagen, J. (2009) Imaging mass spectrometry for examining localization of polymeric composition in matrix-assisted laser desorption/ionization samples. Rapid Commun. Mass Spectrom., 23, 653-660.
20. Vorm, O., Roepstorff, P., and Mann, M. (1994) Improved resolution and very high sensitivity in MALDI TOF of matrix surfaces made by fast evaporation. Anal. Chem., 66, 3281.
21. Smirnov, I.P., Zhu, X., Taylor, T., Huang, Y., Ross, P., Papayanopoulos, I.A., Martin, S.A., and Pappin, D.J. (2004) Suppression of a-cyano-4- hydroxycinnamic acid matrix clusters and reduction of chemical noise in MALDI-TOF mass spectrometry. Anal. Chem., 76 (10), 2958.
22. Hensel, R.R. (1996) The quantitative aspects of matrix-assisted laser desorption/ionization time-of-flight mass spectrometry. Ph.D. Thesis, Drexel University, Philadelphia, PA.
23. Hensel, R.R., King, R.C., and Owens, K.G. (1997) Electrospray sample preparation for improved quantitation in matrixassisted laser desorption/ionization timeof- flight mass spectrometry. Rapid Commun. Mass Spectrom., 11 (16), 1785-1793.
24. Chavez-Eng, C.M. (2002) Quantitative aspects of matrix-assisted laser desorption/ionization using electrospray deposition. Ph.D. Thesis, Drexel University, Philadelphia, PA.
25. Hanton, S.D., Owens, K.G., Blair, W., Hyder, I.Z., Stets, J.R., Guttman, C.M., and Giuseppetti, A. (2004) Investigations of electrospray sample deposition for polymer MALDI. J. Am. Soc. Mass Spectrom., 15 (2), 168.
26. Yao, J., Dey, M., Pastor, S.J., and Wilkins, C.L. (1995) Analysis of high mass biomolecules using electrostatic fields and matrix-assisted laser desorption/ionization in a Fouriertransform mass spectrometer. Anal. Chem., 67, 3638.
27. Yao, J., Scott, J.R., Young, M.K., and Wilkins, C.L. (1998) Importance of matrix: analyte ratio for buffer tolerance using 2, 5-dihydroxybenzoic acid as a matrix in matrix-assisted laser desorption/ionization-Fourier transform mass spectrometry and matrix-assisted laser desorption/ionization-time of flight. J. Am. Soc. Mass Spectrom., 9, 805.
28. Wang, L., May, S.W., Browner, R.F., and Pollack, S.H. (1996) Low flow interface for liquid chromatographyinductively coupled plasma mass spectrometry speciation using an oscillating capillary nebulizer. J. Anal. At. Spectrom., 11, 1137.
29. Wang, L. and Browner, R.F.(March 10 1998) Oscillating Capillary Nebulizer, US Patent #5725153.
30. Hoang, T.T.,May, S.W., and Browner, R.F. (2002) Developments with the oscillating capillary nebulizer - effects of spray chamber design, droplet size and turbulence on analytical signals and analytical transport efficiency of selected biochemically important organoselenium compounds. J. Anal. At. Spectrom, 17, 1575.
31. Perez, J., Petzold, C.J., Watkins, M.A., Vaughn,W.E., and Kenttamaa, H.I. (1999) Laser desorption in transmission geometry inside a Fourier-transform ion cyclotron resonance mass spectrometer. J. Am. Soc. Mass Spectrom., 10, 1105.
32. Lake, D.A., Johnston, M.V., McEwen, C.N., and Larsen, B.S. (2000) Sample preparation for high throughput accurate mass analysis by matrix-assisted laser desorption/ionization time-of-flight mass spectrometry. Rapid Commun. Mass Spectrom., 14, 1008.
33. Dally, J.E. (2006) Investigation of biopharmaceutical cell culture and fermentation using matrix-assisted laser desorption ionization time-of-flight mass spectrometry. Ph.D. Thesis, University of the Sciences in Philadelphia.
34. Holcomb, A. and Owens, K.G. (2010) Optimization of a modified aerospray deposition device for the preparation of samples for quantitative analysis by MALDI TOFMS. Anal. Chim. Acta, 658, 49.
35. Skelton, R., Dubois, F., and Zenobi, R. (2000) A MALDI sample preparation method suitable for insoluble polymers. Anal. Chem., 72, 1707-1710.
36. Przybilla, L., Brand, J.-D., Yoshimura, K., Rader, H.J., and Mullen, K. (2000) MALDI-TOF mass spectrometry of insoluble giant polycyclic aromatic hydrocarbons by a new method of sample preparation. Anal. Chem., 72 4591-4597.
37. Marie, A., Fournier, F., and Tabet, J.C. (2000) Characterization of synthetic polymers by MALDI-TOF/MS: investigation into new methods of sample target preparation and consequence on mass spectrum finger print. Anal. Chem., 72, 5106-5114.
38. Trimpin, S., Rouhanipour, A., Rader, H.J., and Mullen, K. (2001) New aspects in matrix-assisted laser desorption/ionization time-of-flight mass spectrometry: a universal solvent-free sample preparation. Rapid Commun.Mass Spectrom., 15, 1364-1373.
39. Trimpin, S. (2010) Solvent free MALDI sample preparation, in MALDI Mass Spectrometry for Synthetic Polymer Analysis (ed. L. Li), John Wiley & Sons, Inc., Hoboken, NJ.
40. Hanton, S.D and Parees, D.M. (2005) Extending the solvent-free MALDI sample preparation method. J. Am. Soc. Mass Spectrom., 16, 90-93.
41. Hanton, S.D., McEvoy, T.M., and Stets, J.R. (2008) Imaging the morphology of solvent-free prepared MALDI samples. JASMS, 19, 874-881.
42. Hanton, S.D. and Stets, J.R. (2009) Determining the time needed for the vortex method for preparing solvent-free MALDI samples of low molecular mass polymers. JASMS, 20, 1115-1118.
43. Hoteling, A.J. (2004) MALDI TOF PSD and CID: Understanding precision, resolution, and mass accuracy andMALDI TOFMS: investigation of discrimination issues related to solubility. Ph.D. Thesis, Drexel University, Philadelphia, PA.
44. Erb, W.J. (2007) Exploration of the fundamentals of matrix assisted laser desorption/ionization time-of-flight mass spectrometry. Ph.D. Thesis, Drexel University, Philadelphia, PA.
45. Montaudo, G., Montaudo, M.S., Puglisi, C., and Samperi, F. (1995) Characterization of polymers by matrix-assisted laser desorption/ionization time-of-flight mass spectrometry: molecular weight estimates in samples of varying polydispersity. Rapid Commun. Mass Spectrom., 9, 453-460.
46. Hanton, S.D. and Liu, X.M. (2000) GPC separation of polymer samples for MALDI analysis. Anal. Chem., 72, 4550-4554.
47. Dwyer, J. and Botten, D. (1996) A novel sample preparation device for MALDIMS. Am. Lab., 28 (17), 51-54.
48. Hoteling, A.J., Mourey, T.H., and Owens, K.G. (2005) The importance of solubility in the sample preparation of poly (ethylene terephthalate) for MALD/I TOFMS. Anal. Chem., 77 (3), 750.
49. Szyszka, R., Hanton, S.D., Henning, D., and Owens, K.G. (2011) Development of a combined standard additions/internal standards method to quantify residual PEG in ethoxylated surfactants by MALDI TOFMS. J. Am. Soc. Mass Spectrom., 22 (4), 633-640.
50. Szyszka, R., Henning, D., Hanton, S.D., and Owens, K.G. (2009) Quantitation of PEG contaminants in ethoxylated surfactant samples by MALDI TOFMS using standard additions and internal standards methods, ASMS poster.
51. Brandt, H., Ehmann, T., and Otto, M. (2010) Toward prediction: using chemometrics for the optimization of sample preparation in MALDI-TOF MS of synthetic polymers. Anal. Chem., 82 (19), 8169-8175.
52. Brandt, H., Ehmann, T., and Otto, M. (2010) Solvent selection for matrixassisted laser desorption/ionization time-of-flight mass spectrometric analysis of synthetic polymers employing solubility parameters. Rapid Commun. Mass Spectrom., 24, 2439-2444.
53. Brandt, H., Ehmann, T., and Otto, M. (2010) Investigating the effect of mixing ratio on molar mass distributions of synthetic polymers determined by MALDI-TOF mass spectrometry using design of experiments. J. Am. Soc. Mass Spectrom., 21, 1870-1875.