Periatrial Epicardial Fat Is Associated with Markers of Endothelial Dysfunction in Patients with Atrial Fibrillation

PLoS ONE

Volumn 8, Issue 10, 2013, Pages

  Girerd, Nicolas ^a   Scridon, Alina ^b   Bessière, Francis ^a   Chauveau, Samuel ^a   Geloen, Alain ^c   Boussel, Loic ^d   Morel, Elodie ^e   Chevalier, Philippe ^a,e  

^a HOSPICES CIVILS DE LYON   (France)

^b UNIVERSITY OF MEDICINE AND PHARMACY   (Romania)

^c INSERM   (France)

^d CROIX ROUSSE HOSPITAL   (France)

^e LOUIS PRADEL HOSPITAL   (France)

Author keywords

[No Author keywords available]

Indexed keywords

BIOLOGICAL MARKER; INTERCELLULAR ADHESION MOLECULE 1; INTERLEUKIN 8; TRANSFORMING GROWTH FACTOR BETA1; VASCULOTROPIN; VON WILLEBRAND FACTOR;

ADIPOSE TISSUE; ADOLESCENT; ADULT; ARTICLE; BLOOD SAMPLING; BODY MASS; CATHETER ABLATION; CHILD; CLINICAL ARTICLE; ENDOTHELIAL DYSFUNCTION; ESOPHAGUS; FEMALE; HEART ATRIUM FIBRILLATION; HEART CATHETERIZATION; HEART VOLUME; HUMAN; HUMAN TISSUE; MALE; MULTIDETECTOR COMPUTED TOMOGRAPHY; PERIATRIAL EPICARDIAL FAT; PROTEIN BLOOD LEVEL; SCHOOL CHILD; THORACIC AORTA;

ADIPOSE TISSUE; ATRIAL FIBRILLATION; BIOLOGICAL MARKERS; ENDOTHELIUM; FEMALE; HUMANS; MALE; MIDDLE AGED; PERICARDIUM;

EID: 84885463893     PISSN: None     EISSN: 19326203     Source Type: Journal    
DOI: 10.1371/journal.pone.0077167     Document Type: Article

References (34)

1. Wanahita N, Messerli FH, Bangalore S, Gami AS, Somers VK, et al. (2008) Atrial fibrillation and obesity--results of a meta-analysis. Am Heart J 155: 310-315. doi:10.1016/j.ahj.2007.10.004. PubMed: 18215602. doi:10.1016/j.ahj.2007.10.004 PubMed: 18215602.
2. Tsang TS, Barnes ME, Miyasaka Y, Cha SS, Bailey KR, et al. (2008) Obesity as a risk factor for the progression of paroxysmal to permanent atrial fibrillation: a longitudinal cohort study of 21 years. Eur Heart J 29: 2227-2233. doi:10.1093/eurheartj/ehn324. PubMed: 18611964.
3. Al Chekakie MO, Welles CC, Metoyer R, Ibrahim A, Shapira AR, et al. (2010) Pericardial fat is independently associated with human atrial fibrillation. J Am Coll Cardiol 56: 784-788. doi:10.1016/j.jacc.2010.03.071. PubMed: 20797492.
4. Batal O, Schoenhagen P, Shao M, Ayyad AE, Van Wagoner DR, et al. (2010) Left atrial epicardial adiposity and atrial fibrillation. Circ Arrhythm. J Electrophysiol 3: 230-236.
5. Shin SY, Yong HS, Lim HE, Na JO, Choi CU, et al. (2011) Total and interatrial epicardial adipose tissues are independently associated with left atrial remodeling in patients with atrial fibrillation. J Cardiovasc Electrophysiol 22: 647-655. doi:10.1111/j.1540-8167.2010.01993.x. PubMed: 21235672.
6. Thanassoulis G, Massaro JM, O'Donnell CJ, Hoffmann U, Levy D, et al. (2010) Pericardial fat is associated with prevalent atrial fibrillation: the Framingham Heart Study. Circ Arrhythm. J Electrophysiol 3: 345-350.
7. Nagashima K, Okumura Y, Watanabe I, Nakai T, Ohkubo K, et al. (2011) Association between epicardial adipose tissue volumes on 3-dimensional reconstructed CT images and recurrence of atrial fibrillation after catheter ablation. Circ J 75: 2559-2565. doi:10.1253/circj.CJ-11-0554. PubMed: 21869533.
8. Wong CX, Abed HS, Molaee P, Nelson AJ, Brooks AG, et al. (2011) Pericardial fat is associated with atrial fibrillation severity and ablation outcome. J Am Coll Cardiol 57: 1745-1751. doi:10.1016/S0735-1097(11)61745-2. PubMed: 21511110.
9. Lin YK, Chen YC, Chang SL, Lin YJ, Chen JH, et al.; (2012) Heart failure epicardial fat increases atrial arrhythmogenesis. Int J Cardiol, 167: 1979-83 Epub ahead of print, 10.1016/j.ijcard.2012.05.009. PubMed: 22633668.
10. Lin YK, Chen YC, Chen JH, Chen SA, Chen YJ, (2012) Adipocytes modulate the electrophysiology of atrial myocytes: implications in obesity-induced atrial fibrillation. Basic Res Cardiol 107: 293. doi:10.1007/s00395-012-0293-1. PubMed: 22886089.
11. Nagashima K, Okumura Y, Watanabe I, Nakai T, Ohkubo K, et al. (2012) Does location of epicardial adipose tissue correspond to endocardial high dominant frequency or complex fractionated atrial electrogram sites during atrial fibrillation? Circ Arrhythm. J Electrophysiol 5: 676-683.
12. Chen PS, Turker I, (2012) Epicardial adipose tissue and neural mechanisms of atrial fibrillation. Circ Arrhythm. J Electrophysiol 5: 618-620.
13. Lin YK, Chen YJ, Chen SA, (2010) Potential atrial arrhythmogenicity of adipocytes: implications for the genesis of atrial fibrillation. Med Hypotheses 74: 1026-1029. doi:10.1016/j.mehy.2010.01.004. PubMed: 20149554.
14. Ziccardi P, Nappo F, Giugliano G, Esposito K, Marfella R, et al. (2002) Reduction of inflammatory cytokine concentrations and improvement of endothelial functions in obese women after weight loss over one year. Circulation 105: 804-809. doi:10.1161/hc0702.104279. PubMed: 11854119.
15. Hanzu FA, Palomo M, Kalko SG, Parrizas M, Garaulet M, et al. (2011) Translational evidence of endothelial damage in obese individuals: inflammatory and prothrombotic responses. J Thromb Haemost 9: 1236-1245. doi:10.1111/j.1538-7836.2011.04285.x. PubMed: 21481180.
16. Bosanská L, Michalský D, Lacinová Z, Dostálová I, Bártlová M, et al. (2010) The influence of obesity and different fat depots on adipose tissue gene expression and protein levels of cell adhesion molecules. Physiol Res 59: 79-88. PubMed: 19249917.
17. Parikh NI, Keyes MJ, Larson MG, Pou KM, Hamburg NM, et al. (2009) Visceral and subcutaneous adiposity and brachial artery vasodilator function. Obesity (Silver Spring) 17: 2054-2059. doi:10.1038/oby.2009.60. PubMed: 19282819.
18. Aydin H, Toprak A, Deyneli O, Yazici D, Tarçin O, et al. (2010) Epicardial fat tissue thickness correlates with endothelial dysfunction and other cardiovascular risk factors in patients with metabolic syndrome. Metab Syndr Relat Disord 8: 229-234. doi:10.1089/met.2009.0080. PubMed: 20156077.
19. Shin SY, Na JO, Lim HE, Choi CU, Choi JI, et al. (2011) Improved endothelial function in patients with atrial fibrillation through maintenance of sinus rhythm by successful catheter ablation. J Cardiovasc Electrophysiol 22: 376-382. doi:10.1111/j.1540-8167.2010.01919.x. PubMed: 20958832.
20. Kamiyama N, (1998) Expression of cell adhesion molecules and the appearance of adherent leukocytes on the left atrial endothelium with atrial fibrillation: rabbit experimental model. Jpn Circ J 62: 837-843. doi:10.1253/jcj.62.837. PubMed: 9856600.
21. Akar JG, Jeske W, Wilber DJ, (2008) Acute onset human atrial fibrillation is associated with local cardiac platelet activation and endothelial dysfunction. J Am Coll Cardiol 51: 1790-1793. doi:10.1016/j.jacc.2007.11.083. PubMed: 18452786.
22. Pinto A, Tuttolomondo A, Casuccio A, Di Raimondo D, Di Sciacca R, et al. (2009) Immuno-inflammatory predictors of stroke at follow-up in patients with chronic non-valvular atrial fibrillation (NVAF). Clin Sci (Lond) 116: 781-789. doi:10.1042/CS20080372. PubMed: 18980576.
23. Acevedo M, Corbalan R, Braun S, Pereira J, Gonzalez I, et al.; (2012) Biochemical predictors of cardiac rhythm at 1 year follow-up in patients with non-valvular atrial fibrillation. J Thromb Thrombolysis. 33(4):: 383-3882010.1007/s11239-11012-10690-11231.
24. Scridon A, Morel E, Nonin-Babary E, Girerd N, Fernandez C, et al. (2012) Increased intracardiac vascular endothelial growth factor levels in patients with paroxysmal, but not persistent atrial fibrillation. Europace 14: 948-953. doi:10.1093/europace/eur418. PubMed: 22308085.
25. Pearson TA, Mensah GA, Alexander RW, Anderson JL, Cannon RO 3rd, et al. (2003) Markers of inflammation and cardiovascular disease: application to clinical and public health practice: A statement for healthcare professionals from the Centers for Disease Control and Prevention and the American Heart Association. Circulation 107: 499-511. doi:10.1161/01.CIR.0000052939.59093.45. PubMed: 12551878.
26. Liu T, Li G, (2011) Periatrial epicardial fat, local pro- and anti-inflammatory balance, and atrial fibrillation. J Am Coll Cardiol 57: 1249; author reply: 21371644.
27. Mazurek T, Zhang L, Zalewski A, Mannion JD, Diehl JT, et al. (2003) Human epicardial adipose tissue is a source of inflammatory mediators. Circulation 108: 2460-2466. doi:10.1161/01.CIR.0000099542.57313.C5. PubMed: 14581396.
28. Mizia-Stec K, (2006) Cytokines and adhesive molecules in detection of endothelial dysfunction. Pharmacol Rep 58 (Suppl):: 21-32. PubMed: 17332668.
29. Lawson C, Wolf S, (2009) ICAM-1 signaling in endothelial cells. Pharmacol Rep 61: 22-32. PubMed: 19307690.
30. Zhang C, (2008) The role of inflammatory cytokines in endothelial dysfunction. Basic Res Cardiol 103: 398-406. doi:10.1007/s00395-008-0733-0. PubMed: 18600364.
31. Roldán V, Marín F, Muiña B, Torregrosa JM, Hernández-Romero D, et al. (2011) Plasma von Willebrand factor levels are an independent risk factor for adverse events including mortality and major bleeding in anticoagulated atrial fibrillation patients. J Am Coll Cardiol 57: 2496-2504. doi:10.1016/j.jacc.2010.12.033. PubMed: 21497043.
32. Lip GY, Lane D, Van Walraven C, Hart RG, (2006) Additive role of plasma von Willebrand factor levels to clinical factors for risk stratification of patients with atrial fibrillation. Stroke 37: 2294-2300. doi:10.1161/01.STR.0000236840.00467.84. PubMed: 16888271.
33. Chevalier P, Tabib A, Meyronnet D, Chalabreysse L, Restier L, et al. (2005) Quantitative study of nerves of the human left atrium. Heart Rhythm 2: 518-522. doi:10.1016/j.hrthm.2005.01.022. PubMed: 15840477.
34. Thijssen DH, de Groot P, Kooijman M, Smits P, Hopman MT, (2006) Sympathetic nervous system contributes to the age-related impairment of flow-mediated dilation of the superficial femoral artery. Am J Physiol Heart Circ Physiol 291: H3122-H3129. doi:10.1152/ajpheart.00240.2006. PubMed: 16844924.