Inhibition of hyaluronan synthesis in rats reduces renal ability to excrete fluid and electrolytes during acute hydration

Upsala Journal of Medical Sciences

Volumn 118, Issue 4, 2013, Pages 217-221

  Stridh, Sara ^a   Palm, Fredrik ^a,b   Hansell, Peter ^a  

^a UPPSALA UNIVERSITY   (Sweden)

^b LINKÖPING UNIVERSITY   (Sweden)

Author keywords

Diuresis; Fluid balance; Hyaluronan; Hydration; Interstitium; Kidney; Matrix; Medulla

Indexed keywords

DRINKING WATER; DYES, REAGENTS, INDICATORS, MARKERS AND BUFFERS; ELECTROLYTE; GLYCOSAMINOGLYCAN; HYALURONIC ACID; HYMECROMONE; SODIUM; WATER;

ANIMAL; ARTICLE; BLOOD PRESSURE; CATHETERIZATION; CHEMISTRY; DRUG ANTAGONISM; DRUG EFFECT; GLOMERULUS FILTRATION RATE; KIDNEY; MALE; METABOLISM; RAT; SPRAGUE DAWLEY RAT;

ANIMALS; BLOOD PRESSURE; CATHETERIZATION; DRINKING WATER; ELECTROLYTES; GLOMERULAR FILTRATION RATE; GLYCOSAMINOGLYCANS; HYALURONIC ACID; HYMECROMONE; INDICATORS AND REAGENTS; KIDNEY; MALE; RATS; RATS, SPRAGUE-DAWLEY; SODIUM; WATER;

EID: 84885455562     PISSN: 03009734     EISSN: None     Source Type: Journal    
DOI: 10.3109/03009734.2013.834013     Document Type: Article

References (20)

1. Fraser JR, Laurent TC, Laurent UB. Hyaluronan: its nature, distribution, functions and turnover. J Intern Med. 1997;242: 27-33.
2. Hansell P, Göransson V, Odlind C, Gerdin B, Hällgren R. Hyaluronan content in the kidney in different states of body hydration. Kidney Int. 2000;58:2061-8.
3. Göransson V, Johnsson C, Nylander O, Hansell P. Renome-dullary and intestinal hyaluronan content during body water excess: a study in rats and gerbils. J Physiol. 2002; 542:315-22.
4. Rugheimer L, Olerud J, Johnsson C, Takahashi T, Shimizu K, Hansell P. Hyaluronan synthases and hyaluronidases in the kidney during changes in hydration status. Matrix Biol. 2009; 28:390-5.
5. Stridh S, Palm F, Hansell P. Renal interstitial hyaluronan- functional aspects during normal and pathological conditions. Am J Physiol Regul Integr Comp Physiol. 2012;302:R1235-49.
6. Hansell P, Maric C, Alcorn D, Göransson V, Johnsson C, Hällgren R. Renomedullary interstitial cells regulate hyalur-onan turnover depending on growth media osmolality suggesting a role in renal water handling. Acta Physiol Scand. 1999;165:115-16.
7. Göransson V, Hansell P, Moss S, Alcorn D, Johnsson C, Hällgren R, et al. Renomedullary interstitial cells in culture; the osmolality and oxygen tension influence the extracellular amounts of hyaluronan and cellular expression of CD44. Matrix Biol. 2001;20:129-36.
8. Rugheimer L, Johnsson C, Maric C, Hansell P. Hormonal regulation of renomedullary hyaluronan. Acta Physiol (Oxf). 2008;193:191-8.
9. Hällgren R, Gerdin B, Tufveson G. Hyaluronic acid accumulation and redistribution in rejecting rat kidney graft. Relationship to the transplantation edema. J Exp Med. 1990;171:2063-76.
10. Johnsson C, Tufveson G, Wahlberg J, Hällgren R. Experimentally- induced warm renal ischemia induces cortical accumulation of hyaluronan in the kidney. Kidney Int. 1996; 50:1224-9.
11. Nilsson AB, Johnsson C, Friberg P, Hansell P. Renal cortical accumulation of hyaluronan in adult rats exposed neonatally to angiotensin-converting enzyme inhibition. Acta Physiol Scand. 2001;173:343-50.
12. Göransson V, Johnsson C, Jacobson A, Heldin P, Hällgren R, Hansell P. Renal hyaluronan accumulation and hyaluronan synthase expression after ischaemia-reperfusion injury in the rat. Nephrol Dial Transplant. 2004;19:823-30.
13. Rugheimer L, Carlsson C, Johnsson C, Hansell P. Renal hyaluronan content during experimental uncontrolled diabetes in rats. J Physiol Pharmacol. 2008;59:115-28.
14. Stridh S, Kerjaschki D, Chen Y, Rügheimer L, Astrand AB, Johnsson C, et al. Angiotensin converting enzyme inhibition blocks interstitial hyaluronan dissipation in the neonatal rat kidney via hyaluronan synthase 2 and hyaluronidase 1. Matrix Biol. 2011;30:62-9.
15. Ginetzinsky AG. Role of hyaluronidase in the reabsorption of water in renal tubules: the mechanism of action of the anti-diuretic hormone. Nature. 1958;182:1218-19.
16. Carbrey JM, Agre P. Discovery of the aquaporins and development of the field. Handb Exp Pharmacol. 2009;190:3-28.
17. Lai-Fook SJ, Brown LV. Effects of electric charge on hydraulic conductivity of pulmonary interstitium. J Appl Physiol. 1991; 70:1928-32.
18. Zawieja DC, Garcia C, Granger HJ. Oxygen radicals, enzymes, and fluid transport through pericardial interstitium. Am J Physiol. 1992;262:H136-43.
19. Kakizaki I, Takagaki K, Endo Y, Kudo D, Ikeya H, Miyoshi T, et al. Inhibition of hyaluronan synthesis in Streptococcus equi FM100 by 4-methylumbelliferone. Eur J Bio-chem. 2002;269:5066-75.
20. Kakizaki I, Kojima K, Takagaki K, Endo M, Kannagi R, Ito M, et al. A novel mechanism for the inhibition of hyalur-onan biosynthesis by 4-methylumbelliferone. J Biol Chem. 2004;279:33281-9.