Hepatitis B vaccination with or without hepatitis B immunoglobulin at birth to babies born of HBsAg-positive mothers prevents overt HBV transmission but may not prevent occult HBV infection in babies: A randomized controlled trial

Journal of Viral Hepatitis

Volumn 20, Issue 11, 2013, Pages 801-810

  Pande, C ^a,b   Sarin, S K ^a,b,c   Patra, S ^d   Kumar, A ^b,c   Mishra, S ^a   Srivastava, S ^a   Bhutia, K ^d   Gupta, E ^c   Mukhopadhyay, C K ^b   Dutta, A K ^e   Trivedi, S S ^d  

^a G B PANT HOSPITAL   (India)

^b JAWAHARLAL NEHRU UNIVERSITY   (India)

^c INSTITUTE OF LIVER AND BILIARY SCIENCES   (India)

^d LADY HARDINGE MEDICAL COLLEGE   (India)

^e KALAWATI SARAN CHILDREN'S HOSPITAL   (India)

Author keywords

antenatal; HBsAg; HBV DNA; hepatitis B; placenta; pregnancy; vertical transmission

Indexed keywords

ANTIVIRUS AGENT; HEPATITIS B ANTIBODY; HEPATITIS B SURFACE ANTIGEN; HEPATITIS B(E) ANTIBODY; HEPATITIS B(E) ANTIGEN; HEPATITIS VACCINE; PLACEBO; RECOMBINANT VACCINE;

ADULT; ANTIVIRAL THERAPY; ARTICLE; CESAREAN SECTION; CONTROLLED STUDY; DRUG EFFICACY; FEMALE; FOLLOW UP; HEPATITIS B; HEPATITIS B VIRUS; HUMAN; IMMUNE RESPONSE; INFANT; INFECTION RISK; LOW RISK POPULATION; MAJOR CLINICAL STUDY; NEWBORN CARE; OUTCOME ASSESSMENT; PLACENTA DISORDER; PREGNANCY; PREGNANT WOMAN; PRIORITY JOURNAL; PROSPECTIVE STUDY; RANDOMIZED CONTROLLED TRIAL; VACCINATION; VAGINAL DELIVERY; VIRUS TRANSMISSION;

ANTENATAL; HBSAG; HBV DNA; HEPATITIS B; PLACENTA; PREGNANCY; VERTICAL TRANSMISSION;

ADULT; FEMALE; FOLLOW-UP STUDIES; HEPATITIS B; HEPATITIS B ANTIBODIES; HEPATITIS B VACCINES; HUMANS; IMMUNOGLOBULINS, INTRAVENOUS; INFECTIOUS DISEASE TRANSMISSION, VERTICAL; MALE; PLACEBOS; PREGNANCY; PROSPECTIVE STUDIES; TREATMENT OUTCOME; YOUNG ADULT;

EID: 84885448090     PISSN: 13520504     EISSN: 13652893     Source Type: Journal    
DOI: 10.1111/jvh.12102     Document Type: Article

References (24)

1. McMahon BJ,. Natural history of chronic hepatitis B. Clin Liver Dis 2010; 14 (3): 381-396.
2. Beasley RP, Hwang LY, Lee GC, et al,. Prevention of perinatally transmitted hepatitis B virus infections with hepatitis B virus infections with hepatitis B immune globulin and hepatitis B vaccine. Lancet 1983; 2 (8359): 1099-1102. (Pubitemid 14242389)
3. Lavanchy D, Hepatitis B,. Virus epidemiology, disease burden, treatment, and current and emerging prevention and control measures. J Viral Hepat 2004; 11 (2): 97-107. (Pubitemid 38365759)
4. McMahon BJ, Holck P, Bulkow L, Snowball M,. Serologic and clinical outcomes of 1536 Alaska Natives chronically infected with hepatitis B virus. Ann Intern Med 2001; 135 (9): 759-768. (Pubitemid 33051260)
5. André FE, Zuckerman AJ,. Review: protective efficacy of hepatitis B vaccines in neonates. J Med Virol 1994; 44 (2): 144-151. (Pubitemid 24324005)
6. Lok ASF, McMahon BJ,. Chronic hepatitis B: update 2009. Hepatology 2009; 50 (3): 661-662.
7. Lee C, Gong Y, Brok J, Boxall EH, Gluud C,. Effect of hepatitis B immunisation in newborn infants of mothers positive for hepatitis B surface antigen: systematic review and meta-analysis. BMJ 2006; 332 (7537): 328-336.
8. Lo KJ, Tsai YT, Lee SD, et al,. Immunoprophylaxis of infection with hepatitis B virus in infants born to hepatitis B surface antigen-positive carrier mothers. J Infect Dis 1985; 152 (4): 817-822. (Pubitemid 16215962)
9. Poovorawan Y, Sanpavat S, Pongpunlert W, et al,. Comparison of a recombinant DNA hepatitis B vaccine alone or in combination with hepatitis B immune globulin for the prevention of perinatal acquisition of hepatitis B carriage. Vaccine. 1990; 8 Suppl: S56-59. discussion S60-62. (Pubitemid 20154762)
10. Assateerawatt A, Tanphaichitr VS, Suvatte V, In-ngarm L,. Immunogenicity and protective efficacy of low dose recombinant DNA hepatitis B vaccine in normal and high-risk neonates. Asian Pac J Allergy Immunol 1991; 9 (2): 89-93.
11. Milne A, West DJ, Chinh DV, Moyes CD, Poerschke G,. Field evaluation of the efficacy and immunogenicity of recombinant hepatitis B vaccine without HBIG in newborn Vietnamese infants. J Med Virol 2002; 67 (3): 327-333. (Pubitemid 34569069)
12. Mast EE, Margolis HS, Fiore AE, et al,. A comprehensive immunization strategy to eliminate transmission of hepatitis B virus infection in the United States: recommendations of the Advisory Committee on Immunization Practices (ACIP) part 1: immunization of infants, children, and adolescents. MMWR Recomm Rep. 2005; 54 (RR-16): 1-31.
13. Mulrooney-Cousins PM, Michalak TI,. Persistent occult hepatitis B virus infection: experimental findings and clinical implications. World J Gastroenterol 2007; 13 (43): 5682-5686. (Pubitemid 350120219)
14. Raimondo G, Allain J-P, Brunetto MR, et al,. Statements from the Taormina expert meeting on occult hepatitis B virus infection. J Hepatol 2008; 49 (4): 652-657.
15. Carman WF, Zanetti AR, Karayiannis P, et al,. Vaccine-induced escape mutant of hepatitis B virus. Lancet 1990; 336 (8711): 325-329. (Pubitemid 20264145)
16. Velu V, Saravanan S, Nandakumar S, et al,. Transmission of "a" determinant variants of hepatitis B virus in immunized babies born to HBsAg carrier mothers. Jpn J Infect Dis 2008; 61 (1): 73-76. (Pubitemid 351338536)
17. Hsu H-Y, Chang M-H, Ni Y-H, Chen H-L,. Survey of hepatitis B surface variant infection in children 15 years after a nationwide vaccination programme in Taiwan. Gut 2004; 53 (10): 1499-1503. (Pubitemid 39265274)
18. Mu S-C, Lin Y-M, Jow G-M, Chen B-F,. Occult hepatitis B virus infection in hepatitis B vaccinated children in Taiwan. J Hepatol 2009; 50 (2): 264-272.
19. Xu L, Wei Y, Chen T, et al,. Occult HBV infection in anti-HBs-positive young adults after neonatal HB vaccination. Vaccine 2010; 28 (37): 5986-5992.
20. Song Y-M, Sung J, Yang S, Choe YH, Chang YS, Park WS,. Factors associated with immunoprophylaxis failure against vertical transmission of hepatitis B virus. Eur J Pediatr 2007; 166 (8): 813-818. (Pubitemid 46988175)
21. Hu Y, Wu Q, Xu B, Zhou Z, Wang Z, Zhou Y-H,. Influence of maternal antibody against hepatitis B surface antigen on active immune response to hepatitis B vaccine in infants. Vaccine 2008; 26 (48): 6064-6067.
22. Elefsiniotis IS, Papadakis M, Vlahos G, Daskalakis G, Saroglou G, Antsaklis A,. Clinical significance of hepatitis B surface antigen in cord blood of hepatitis B e-antigen-negative chronic hepatitis B virus-infected mothers. Intervirology 2009; 52 (3): 132-134.
23. Bai H, Zhang L, Ma L, Dou X-G, Feng G-H, Zhao G-Z,. Relationship of hepatitis B virus infection of placental barrier and hepatitis B virus intra-uterine transmission mechanism. World J Gastroenterol 2007; 13 (26): 3625-3630. (Pubitemid 47162272)
24. Bhat P, Anderson DA,. Hepatitis B virus translocates across a trophoblastic barrier. J Virol 2007; 81 (13): 7200-7207. (Pubitemid 46986656)