Enhanced biofuel production through coupled acetic acid and xylose consumption by engineered yeast

Nature Communications

Volumn 4, Issue , 2013, Pages

  Wei, Na ^a   Quarterman, Josh ^a   Kim, Soo Rin ^a   Cate, Jamie H D ^b,c   Jin, Yong Su ^a  

^a UNIVERSITY OF ILLINOIS AT URBANA CHAMPAIGN   (United States)

^b UNIVERSITY OF CALIFORNIA   (United States)

^c LAWRENCE BERKELEY NATIONAL LABORATORY   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ACETIC ACID; ALCOHOL; NICOTINAMIDE ADENINE DINUCLEOTIDE; XYLOSE;

ACETATE; ACETIC ACID; ANOXIC CONDITIONS; BIOENGINEERING; BIOFUEL; BIOMASS POWER; CELLULOSE; DETOXIFICATION; ETHANOL; FERMENTATION; GREENHOUSE GAS; PRODUCTIVITY; REDOX CONDITIONS; SUGAR; YEAST;

ALCOHOL PRODUCTION; ARTICLE; BIOFUEL PRODUCTION; BIOMASS; CARBON SOURCE; CATABOLISM; CONTROLLED STUDY; DETOXIFICATION; ENZYME ACTIVITY; FERMENTATION; MASS FRAGMENTOGRAPHY; METABOLIC ENGINEERING; NONHUMAN; OXIDATION; OXIDATION REDUCTION STATE; YEAST;

ACETIC ACID; ANAEROBIOSIS; BIOFUELS; BIOMASS; CELLULOSE; ETHANOL; FERMENTATION; GENE EXPRESSION REGULATION, FUNGAL; GENETIC VECTORS; METABOLIC ENGINEERING; NAD; OXIDATION-REDUCTION; SACCHAROMYCES CEREVISIAE; SACCHAROMYCES CEREVISIAE PROTEINS; TRANSFORMATION, GENETIC; XYLOSE;

EID: 84885439374     PISSN: None     EISSN: 20411723     Source Type: Journal    
DOI: 10.1038/ncomms3580     Document Type: Article

References (39)

1. Farrell, A. E. et al. Ethanol can contribute to energy and environmental goals. Science 311, 506-508 (2006). (Pubitemid 43157725)
2. Hahn-Hagerdal, B., Galbe, M., Gorwa-Grauslund, M. F., Liden, G. & Zacchi, G. Bio-ethanol-the fuel of tomorrow from the residues of today. Trends Biotechnol. 24, 549-556 (2006). (Pubitemid 44781248)
3. Ragauskas, A. J. et al. The path forward for biofuels and biomaterials. Science 311, 484-489 (2006). (Pubitemid 43158454)
4. Tilman, D. et al. Beneficial biofuels-the food, energy, and environment trilemma. Science 325, 270-271 (2009).
5. Somerville, C. The billion-ton biofuels vision. Science 312, 1277-1277 (2006).
6. Hahn-Hagerdal, B., Karhumaa, K., Fonseca, C., Spencer-Martins, I. & Gorwa-Grauslund, M. F. Towards industrial pentose-fermenting yeast strains. Appl. Microbiol. Biotechnol. 74, 937-953 (2007). (Pubitemid 46434767)
7. Jeffries, T. W. & Jin, Y. S. Metabolic engineering for improved fermentation of pentoses by yeasts. Appl. Microbiol. Biotechnol. 63, 495-509 (2004). (Pubitemid 38232698)
8. Klinke, H. B., Thomsen, A. B. & Ahring, B. K. Inhibition of ethanol-producing yeast and bacteria by degradation products produced during pre-treatment of biomass. Appl. Microbiol. Biotechnol. 66, 10-26 (2004).
9. Palmqvist, E. & Hahn-Hagerdal, B. Fermentation of lignocellulosic hydrolysates. I: inhibition and detoxification. Bioresour. Technol. 74, 17-24 (2000). (Pubitemid 30190274)
10. Almeida, J. R. M. et al. Increased tolerance and conversion of inhibitors in lignocellulosic hydrolysates by Saccharomyces cerevisiae. J. Chem. Technol. Biotechnol. 82, 340-349 (2007). (Pubitemid 46672130)
11. Pampulha, M. E. & Loureirodias, M. C. Combined effect of acetic-acid, Ph and ethanol on intracellular Ph of fermenting yeast. Appl. Microbiol. Biotechnol. 31, 547-550 (1989).
12. Bellissimi, E., van Dijken, J. P., Pronk, J. T. & van Maris, A. J. A. Effects of acetic acid on the kinetics of xylose fermentation by an engineered, xylose-isomerasebased Saccharomyces cerevisiae strain. FEMS Yeast Res. 9, 358-364 (2009).
13. Jeffries, T. W. Emerging technology for fermenting D-xylose. Trends Biotechnol. 3, 208-212 (1985). (Pubitemid 15003572)
14. Matsushika, A., Inoue, H., Kodaki, T. & Sawayama, S. Ethanol production from xylose in engineered Saccharomyces cerevisiae strains: current state and perspectives. Appl. Microbiol. Biotechnol. 84, 37-53 (2009).
15. Hahn-Hagerdal, B., Karhumaa, K., Jeppsson, M. & Gorwa-Grauslund, M. F. in Advances in Biochemical Engineering/Biotechnology, Vol. 108, (eds S. Belkin et al.) 147-177 (Springer, 2007).
16. Jeffries, T. W. Engineering yeasts for xylose metabolism. Curr. Opin. Biotechnol. 17, 320-326 (2006). (Pubitemid 43850265)
17. Ho, N. W. Y., Chen, Z. & Brainard, A. P. Genetically engineered Saccharomyces yeast capable of effective cofermentation of glucose and xylose. Appl. Environ. Microbiol. 64, 1852-1859 (1998). (Pubitemid 28234795)
18. Kotter, P. & Ciriacy, M. Xylose fermentation by Saccharomyces cerevisiae. Appl. Microbiol. Biotechnol. 38, 776-783 (1993). (Pubitemid 23079905)
19. Tantirungkij, M., Nakashima, N., Seki, T. & Yoshida, T. Construction of xyloseassimilating Saccharomyces cerevisiae. J. Ferment. Bioeng. 75, 83-88 (1993).
20. Walfridsson, M., Anderlund, M., Bao, X. & Hahn-Hagerdal, B. Expression of different levels of enzymes from the Pichia stipitis XYL1 and XYL2 genes in Saccharomyces cerevisiae and its effects on product formation during xylose utilisation. Appl. Microbiol. Biotechnol. 48, 218-224 (1997). (Pubitemid 27394753)
21. Jin, Y.-S. & Jeffries, T. W. Stoichiometric network constraints on xylose metabolism by recombinant Saccharomyces cerevisiae. Metab. Eng. 6, 229-238 (2004). (Pubitemid 38958528)
22. Bruinenberg, P. M., De Bot, P. H. M., Van Dijken, J. P. & Scheffers, W. A. The role of redox balances in the anaerobic fermentation of xylose by yeasts. Eur. J. Appl. Microbiol. Biotechnol. 18, 287-292 (1983). (Pubitemid 14178387)
23. Thauer, R. K., Mollerzinkhan, D. & Spormann, A. M. Biochemistry of acetate catabolism in anaerobic chemotropic bacteria. Annu. Rev. Microbiol. 43, 43-67 (1989). (Pubitemid 19250040)
24. Jones, D. T. & Woods, D. R. Acetone-butanol fermentation revisited. Microbiol. Rev. 50, 484-524 (1986). (Pubitemid 17202900)
25. Kuyper, M. et al. High-level functional expression of a fungal xylose isomerase: the key to efficient ethanolic fermentation of xylose by Saccharomyces cerevisiae. FEMS Yeast Res. 4, 69-78 (2003). (Pubitemid 38367533)
26. Karhumaa, K., Sanchez, R. G., Hahn-Hagerdal, B. & Gorwa-Grauslund, M. F. Comparison of the xylose reductase-xylitol dehydrogenase and the xylose isomerase pathways for xylose fermentation by recombinant Saccharomyces cerevisiae. Microb. Cell. Fact 6, 5 (2007).
27. Eliasson, A., Christensson, C., Wahlbom, C. F. & Hahn-Hagerdal, B. Anaerobic xylose fermentation by recombinant Saccharomyces cerevisiae carrying XYL1, XYL2, and XKS1 in mineral medium chemostat cultures. Appl. Environ. Microbiol. 66, 3381-3386 (2000). (Pubitemid 30624580)
28. Sonderegger, M. & Sauer, U. Evolutionary engineering of Saccharomyces cerevisiae for anaerobic growth on xylose. Appl. Environ. Microbiol. 69, 1990-1998 (2003). (Pubitemid 36443611)
29. Kim, S. R. et al. Rational and evolutionary engineering approaches uncover a small set of genetic changes efficient for rapid xylose fermentation in Saccharomyces cerevisiae. PLoS One 8, e57048 (2013).
30. Wahlbom, C. F. & Hahn-Hagerdal, B. Furfural, 5-hydroxymethyl furfural, and acetoin act as external electron acceptors during anaerobic fermentation of xylose in recombinant Saccharomyces cerevisiae. Biotechnol. Bioeng. 78, 172-178 (2002). (Pubitemid 34712341)
31. Bruinenberg, P. M., De Bot, P. H. M., Van Dijken, J. P. & Scheffers, W. A. NADH-linked aldose reductase: the key to anaerobic alcoholic fermentation of xylose by yeasts. Appl. Microbiol. Biotechnol. 19, 256-260 (1984). (Pubitemid 14118231)
32. Almeida, J. R. M., Bertilsson, M., Hahn-Hagerdal, B., Liden, G. & Gorwa-Grauslund, M.-F. Carbon fluxes of xylose-consuming Saccharomyces cerevisiae strains are affected differently by NADH and NADPH usage in HMF reduction. Appl. Microbiol. Biotechnol. 84, 751-761 (2009).
33. Almeida, J. R. M. et al. NADH-versus NADPH-coupled reduction of 5-hydroxymethyl furfural (HMF) and its implications on product distribution in Saccharomyces cerevisiae. Appl. Microbiol. Biotechnol. 78, 939-945 (2008).
34. Zhou, H., Cheng, J. S., Wang, B. L., Fink, G. R. & Stephanopoulos, G. Xylose isomerase overexpression along with engineering of the pentose phosphate pathway and evolutionary engineering enable rapid xylose utilization and ethanol production by Saccharomyces cerevisiae. Metab. Eng. 14, 611-622 (2012).
35. Medina, V. G., Almering, M. J. H., van Maris, A. J. A. & Pronk, J. T. Elimination of glycerol production in anaerobic cultures of a Saccharomyces cerevisiae strain engineered to use acetic acid as an electron acceptor. Appl. Environ. Microbiol. 76, 190-195 (2010).
36. Ansell, R., Granath, K., Hohmann, S., Thevelein, J. M. & Adler, L. The two isoenzymes for yeast NAD(\+)-dependent glycerol 3-phosphate dehydrogenase encoded by GPD1 and GPD2 have distinct roles in osmoadaptation and redox regulation. EMBO J. 16, 2179-2187 (1997). (Pubitemid 27258621)
37. Palmqvist, E. & Hahn-Hagerdal, B. Fermentation of lignocellulosic hydrolysates. II: inhibitors and mechanisms of inhibition. Bioresour. Technol. 74, 25-33 (2000). (Pubitemid 30190275)
38. Badotti, F. et al. Switching the mode of sucrose utilization by Saccharomyces cerevisiae. Microb. Cell Fact. 7, 4 (2008).
39. Mumberg, D., Muller, R. & Funk, M. Yeast vectors for the controlled expression of heterologous proteins in different genetic backgrounds. Gene 156, 119-122 (1995).