Metabolic pathways of T-2 toxin in in vivo and in vitro systems of Wistar rats

Journal of Agricultural and Food Chemistry

Volumn 61, Issue 40, 2013, Pages 9734-9743

  Yang, Shupeng ^a,b   Li, Yanshen ^a,b   Cao, Xingyuan ^a,b   Hu, Dingfei ^c   Wang, Zhanhui ^a,b   Wang, Ying ^a,b   Shen, Jianzhong ^a,b   Zhang, Suxia ^a,b  

^a CHINA AGRICULTURAL UNIVERSITY   (China)

^b AGRO ENVIRONMENTAL PROTECTION INSTITUTE   (China)

^c University of Iowa   (United States)

Author keywords

metabolites; rat; T 2 toxin; trichothecenes; UPLC Q TOF MS

Indexed keywords

BIOMOLECULES; HYDROXYLATION; ISOMERS; LIQUID CHROMATOGRAPHY; MASS SPECTROMETRY; METABOLISM; PLANTS (BOTANY); RATING; RATS; TOXIC MATERIALS;

DE-EPOXIDATION; METABOLIC PATHWAYS; QUADRUPOLE/TIME OF FLIGHTS; T-2 TOXIN; TANDEM MASS SPECTROMETRY; TRICHOTHECENES; ULTRAPERFORMANCE LIQUID CHROMATOGRAPHY; UPLC-Q/TOF-MS;

METABOLITES;

RATTUS; RATTUS NORVEGICUS;

T 2 TOXIN;

ANIMAL; ARTICLE; COMPUTER PROGRAM; FEMALE; HYDROXYLATION; LIQUID CHROMATOGRAPHY; LIVER MICROSOME; MALE; MASS SPECTROMETRY; METABOLISM; PHYSIOLOGY; RAT; URINE; WISTAR RAT;

ANIMALS; CHROMATOGRAPHY, LIQUID; FEMALE; HYDROXYLATION; MALE; MASS SPECTROMETRY; METABOLIC NETWORKS AND PATHWAYS; MICROSOMES, LIVER; RATS; RATS, WISTAR; SOFTWARE; T-2 TOXIN;

EID: 84885436459     PISSN: 00218561     EISSN: 15205118     Source Type: Journal    
DOI: 10.1021/jf4012054     Document Type: Article

References (35)

1. Li, Y.; Wang, Z.; Beier, R. C.; Shen, J.; De Smet, D.; De Saeger, S.; Zhang, S. T-2 toxin, a trichothecene mycotoxin: review of toxicity, metabolism, and analytical methods J. Agric. Food Chem. 2011, 59, 3441-3453
2. Gutleb, A. C.; Morrison, E.; Murk, A. J. Cytotoxicity assays for mycotoxins produced by Fusarium strains: a review Environ. Toxicol. Pharmacol. 2002, 11, 309-320 (Pubitemid 34694011)
3. Weidner, M.; Welsch, T.; Hubner, F.; Schwerdt, G.; Gekle, M.; Humpf, H. U. Identification and apoptotic potential of T-2 toxin metabolites in human cells J. Agric. Food Chem. 2012, 60, 5676-5684
4. Islam, Z.; Nagase, M.; Yoshizawa, T.; Yamauchi, K.; Sakato, N. T-2 toxin induces thymic apoptosis in vivo in mice Toxicol. Appl. Pharmacol. 1998, 148, 205-214 (Pubitemid 28105602)
5. Hymery, N.; Sibiril, Y.; Parent-Massin, D. Improvement of human dendritic cell culture for immunotoxicological investigations Cell Biol. Toxicol. 2006, 22, 243-255 (Pubitemid 44050814)
6. Minervini, F.; Fornelli, F.; Lucivero, G.; Romano, C.; Visconti, A. T-2 toxin immunotoxicity on human B and T lymphoid cell lines Toxicology 2005, 210, 81-91 (Pubitemid 40459644)
7. Wu, J.; Jing, L.; Yuan, H.; Peng, S. Q. T-2 toxin induces apoptosis in ovarian granulosa cells of rats through reactive oxygen species-mediated mitochondrial pathway Toxicol. Lett. 2011, 202, 168-177
8. Yang, J. Y.; Zhang, Y. F.; Liang, A. M.; Kong, X. F.; Li, Y. X.; Ma, K. W.; Jing, A. H.; Feng, S. Y.; Qiao, X. L. Toxic effects of T-2 toxin on reproductive system in male mice Toxicol. Ind. Health 2010, 26, 25-31
9. Caloni, F.; Cortinovis, C. Effects of fusariotoxins in the equine species Vet. J. 2010, 186, 157-161
10. Thompson, W. L.; Wannemacher, R. W., Jr. In vivo effects of T-2 mycotoxin on synthesis of proteins and DNA in rat tissues Toxicol. Appl. Pharmacol. 1990, 105, 483-491 (Pubitemid 20373278)
11. Wu, Q.; Dohnal, V.; Huang, L.; Kuca, K.; Yuan, Z. Metabolic pathways of trichothecenes Drug Metab. Rev. 2010, 42, 250-267
12. Bennett, J. W.; Klich, M. Mycotoxins Clin. Microbiol. Rev. 2003, 16, 497-516 (Pubitemid 36871318)
13. Velazco, V.; Faifer, G. C.; Godoy, H. M. Differential effects of T-2 toxin on bone marrow and spleen erythropoiesis in mice Food Chem. Toxicol.: Int. J. 1996, 34, 371-375 (Pubitemid 26150386)
14. EFSA Panel on Contaminants in the Food Chain (CONTAM). Scientific Opinion on the risks for animal and public health related to the presence of T-2 and HT-2 toxin in food and feed. EFSA J. 2011, 9, 2481.
15. Adejumo, T. O.; Hettwer, U.; Karlovsky, P. Occurrence of Fusarium species and trichothecenes in Nigerian maize Int. J. Food Microbiol. 2007, 116, 350-357 (Pubitemid 46604839)
16. Schollenberger, M.; Muller, H. M.; Rufle, M.; Suchy, S.; Plank, S.; Drochner, W. Natural occurrence of 16 fusarium toxins in grains and feedstuffs of plant origin from Germany Mycopathologia 2006, 161, 43-52 (Pubitemid 43042221)
17. Omurtag, G. Z.; Yazicioglu, D. Occurrence of T-2 toxin in processed cereals and pulses in Turkey determined by HPLC and TLC Food Addit. Contam. 2001, 18, 844-849 (Pubitemid 32821559)
18. Ohta, M.; Ishii, K.; Ueno, Y. Metabolism of trichothecene mycotoxins. I. Microsomal deacetylation of T-2 toxin in animal tissues J. Biochem. 1977, 82, 1591-1598 (Pubitemid 8240318)
19. Ellison, R. A.; Kotsonis, F. N. In vitro metabolism of T-2 toxin Appl. Microbiol. 1974, 27, 423-424
20. 3H-labeled T-2 toxin Appl. Environ. Microbiol. 1980, 39, 1172-1177 (Pubitemid 10001985)
21. Visconti, A.; Mirocha, C. J. Identification of various T-2 toxin metabolites in chicken excreta and tissues Appl. Environ. Microbiol. 1985, 49, 1246-1250 (Pubitemid 15056842)
22. Yoshizawa, T.; Swanson, S. P.; Mirocha, C. J. In vitro metabolism of T-2 toxin in rats Appl. Environ. Microbiol. 1980, 40, 901-906 (Pubitemid 11215933)
23. Yoshizawa, T.; Mirocha, C. J.; Behrens, J. C.; Swanson, S. P. Metabolic fate of T-2 toxin in a lactating cow Food Cosmet. Toxicol. 1981, 19, 31-39 (Pubitemid 11129863)
24. Yoshizawa, T.; Sakamoto, T.; Okamoto, K. In vitro formation of 3′-hydroxy T-2 and 3′-hydroxy HT-2 toxins from T-2 toxin by liver homogenates from mice and monkeys Appl. Environ. Microbiol. 1984, 47, 130-134 (Pubitemid 14186972)
25. Visconti, A.; Treeful, L. M.; Mirocha, C. J. Identification of iso-TC-1 as a new T-2 toxin metabolite in cow urine Biomed. Mass Spectrom. 1985, 12, 689-694 (Pubitemid 16172768)
26. Yoshizawa, T.; Sakamoto, T.; Kuwamura, K. Structures of deepoxytrichothecene metabolites from 3′-hydroxy HT-2 toxin and T-2 tetraol in rats Appl. Environ. Microbiol. 1985, 50, 676-679 (Pubitemid 16244146)
27. Kajal Chatterjee, A. V.; Mirocha, C. J. Deepoxy T-2 tetraol: a metabolite of T-2 toxin found in cow urine J. Agric. Food Chem. 1986, 34, 695-697
28. Swanson, S. P.; Nicoletti, J.; Rood, H. D., Jr.; Buck, W. B.; Cote, L. M.; Yoshizawa, T. Metabolism of three trichothecene mycotoxins, T-2 toxin, diacetoxyscirpenol and deoxynivalenol, by bovine rumen microorganisms J. Chromatogr. 1987, 414, 335-342 (Pubitemid 17041684)
29. Richard, A.; Corley, S. P. S.; William, B. Glucuronide conjugates of T-2 toxin and metabolites in swine bile and urine J. Agric. Food Chem. 1985, 33, 1085-1089
30. Welsch, T.; Humpf, H. U. HT-2 toxin 4-glucuronide as new T-2 toxin metabolite: enzymatic synthesis, analysis, and species specific formation of T-2 and HT-2 toxin glucuronides by rat, mouse, pig, and human liver microsomes J. Agric. Food Chem. 2012, 60, 10170-10178
31. Wu, Q.; Engemann, A.; Cramer, B.; Welsch, T.; Yuan, Z. Intestinal metabolism of T-2 toxin in the pig cecum model Mycotoxin Res. 2012, 28, 191-198
32. Wu, Q.; Huang, L.; Liu, Z.; Yao, M.; Wang, Y.; Dai, M.; Yuan, Z. A comparison of hepatic in vitro metabolism of T-2 toxin in rats, pigs, chickens, and carp Xenobiotica; Fate Foreign Compds. Biol. Syst. 2011, 41, 863-873
33. Tolonen, A.; Turpeinen, M.; Pelkonen, O. Liquid chromatography-mass spectrometry in in vitro drug metabolite screening Drug Discov. Today 2009, 14, 120-133
34. Wu, H.; Li, L.; Shen, J.; Wang, Y.; Liu, K.; Zhang, S. In vitro metabolism of cyadox in rat, chicken and swine using ultra-performance liquid chromatography quadrupole time-of-flight mass spectrometry J. Pharm. Biomed. Anal. 2012, 67-68, 175-185
35. Lowry, O. H.; Rosebrough, N. J.; Farr, A. L.; Randall, R. J. Protein measurement with the Folin phenol reagent J. Biol. Chem. 1951, 193, 265-275