메뉴 건너뛰기




Volumn 48, Issue 9, 2013, Pages 999-1005

Combination therapy with a nucleos(t)ide analogue and interferon for chronic hepatitis B: Simultaneous or sequential

Author keywords

Adefovir; Chronic hepatitis B; Entecavir; Interferon; Lamivudine; Nucleos(t)ide analogue

Indexed keywords

ADEFOVIR DIPIVOXIL; ALPHA INTERFERON; ENTECAVIR; INTERFERON; LAMIVUDINE; NUCLEOSIDE DERIVATIVE; NUCLEOTIDE DERIVATIVE; PEGINTERFERON; TENOFOVIR;

EID: 84885432221     PISSN: 09441174     EISSN: 14355922     Source Type: Journal    
DOI: 10.1007/s00535-012-0742-5     Document Type: Review
Times cited : (20)

References (52)
  • 1
    • 54849146600 scopus 로고    scopus 로고
    • Hepatitis B virus infection
    • 18832247 10.1056/NEJMra0801644 1:CAS:528:DC%2BD1cXhtFOru7bL
    • Dienstag JL. Hepatitis B virus infection. N Engl J Med. 2008;359:1486-500.
    • (2008) N Engl J Med , vol.359 , pp. 1486-1500
    • Dienstag, J.L.1
  • 2
    • 59749096640 scopus 로고    scopus 로고
    • Hepatitis B virus infection
    • 19217993 10.1016/S0140-6736(09)60207-5 1:CAS:528:DC%2BD1MXhvFGltLk%3D
    • Liaw YF, Chu CM. Hepatitis B virus infection. Lancet. 2009;373:582-92.
    • (2009) Lancet , vol.373 , pp. 582-592
    • Liaw, Y.F.1    Chu, C.M.2
  • 3
    • 0032499913 scopus 로고    scopus 로고
    • A one-year trial of lamivudine for chronic hepatitis B. Asia Hepatitis Lamivudine Study Group
    • 9654535 10.1056/NEJM199807093390201 1:CAS:528:DyaK1cXkvVSqtbY%3D
    • Lai CL, Chien RN, Leung NW, Chang TT, Guan R, Tai DI, et al. A one-year trial of lamivudine for chronic hepatitis B. Asia Hepatitis Lamivudine Study Group. N Engl J Med. 1998;339:61-8.
    • (1998) N Engl J Med , vol.339 , pp. 61-68
    • Lai, C.L.1    Chien, R.N.2    Leung, N.W.3    Chang, T.T.4    Guan, R.5    Tai, D.I.6
  • 4
    • 0033592764 scopus 로고    scopus 로고
    • Lamivudine as initial treatment for chronic hepatitis B in the United States
    • 10528035 10.1056/NEJM199910213411702 1:CAS:528:DyaK1MXnt1Cqs78%3D
    • Dienstag JL, Schiff ER, Wright TL, Perrillo RP, Hann HW, Goodman Z, et al. Lamivudine as initial treatment for chronic hepatitis B in the United States. N Engl J Med. 1999;341:1256-63.
    • (1999) N Engl J Med , vol.341 , pp. 1256-1263
    • Dienstag, J.L.1    Schiff, E.R.2    Wright, T.L.3    Perrillo, R.P.4    Hann, H.W.5    Goodman, Z.6
  • 5
    • 37349120537 scopus 로고    scopus 로고
    • Telbivudine versus lamivudine in patients with chronic hepatitis B
    • 18094378 10.1056/NEJMoa066422 1:CAS:528:DC%2BD2sXhsVKht7nF
    • Lai CL, Gane E, Liaw YF, Hsu CW, Thongsawat S, Wang Y, et al. Telbivudine versus lamivudine in patients with chronic hepatitis B. N Engl J Med. 2007;357:2576-88.
    • (2007) N Engl J Med , vol.357 , pp. 2576-2588
    • Lai, C.L.1    Gane, E.2    Liaw, Y.F.3    Hsu, C.W.4    Thongsawat, S.5    Wang, Y.6
  • 6
    • 33644818518 scopus 로고    scopus 로고
    • A comparison of entecavir and lamivudine for HBeAg-positive chronic hepatitis B
    • 16525137 10.1056/NEJMoa051285 1:CAS:528:DC%2BD28XitFWms7Y%3D
    • Chang TT, Gish RG, de Man R, Gadano A, Sollano J, Chao YC, et al. A comparison of entecavir and lamivudine for HBeAg-positive chronic hepatitis B. N Engl J Med. 2006;354:1001-10.
    • (2006) N Engl J Med , vol.354 , pp. 1001-1010
    • Chang, T.T.1    Gish, R.G.2    De Man, R.3    Gadano, A.4    Sollano, J.5    Chao, Y.C.6
  • 7
    • 33644822860 scopus 로고    scopus 로고
    • Entecavir versus lamivudine for patients with HBeAg-negative chronic hepatitis B
    • 16525138 10.1056/NEJMoa051287 1:CAS:528:DC%2BD28XitFWlsrY%3D
    • Lai CL, Shouval D, Lok AS, Chang TT, Cheinquer H, Goodman Z, et al. Entecavir versus lamivudine for patients with HBeAg-negative chronic hepatitis B. N Engl J Med. 2006;354:1011-20.
    • (2006) N Engl J Med , vol.354 , pp. 1011-1020
    • Lai, C.L.1    Shouval, D.2    Lok, A.S.3    Chang, T.T.4    Cheinquer, H.5    Goodman, Z.6
  • 8
    • 0037468421 scopus 로고    scopus 로고
    • Adefovir dipivoxil for the treatment of hepatitis B e antigen-positive chronic hepatitis B
    • 12606735 10.1056/NEJMoa020681 1:CAS:528:DC%2BD3sXhsFKisrc%3D
    • Marcellin P, Chang TT, Lim SG, Tong MJ, Sievert W, Shiffman ML, et al. Adefovir dipivoxil for the treatment of hepatitis B e antigen-positive chronic hepatitis B. N Engl J Med. 2003;348:808-16.
    • (2003) N Engl J Med , vol.348 , pp. 808-816
    • Marcellin, P.1    Chang, T.T.2    Lim, S.G.3    Tong, M.J.4    Sievert, W.5    Shiffman, M.L.6
  • 9
    • 21244455293 scopus 로고    scopus 로고
    • Long-term therapy with adefovir dipivoxil for HBeAg-negative chronic hepatitis B
    • 15987916 10.1056/NEJMoa042957 1:CAS:528:DC%2BD2MXls1Sksbc%3D
    • Hadziyannis SJ, Tassopoulos NC, Heathcote EJ, Chang TT, Kitis G, Rizzetto M, et al. Long-term therapy with adefovir dipivoxil for HBeAg-negative chronic hepatitis B. N Engl J Med. 2005;352:2673-81.
    • (2005) N Engl J Med , vol.352 , pp. 2673-2681
    • Hadziyannis, S.J.1    Tassopoulos, N.C.2    Heathcote, E.J.3    Chang, T.T.4    Kitis, G.5    Rizzetto, M.6
  • 10
    • 57349095400 scopus 로고    scopus 로고
    • Tenofovir disoproxil fumarate versus adefovir dipivoxil for chronic hepatitis B
    • 19052126 10.1056/NEJMoa0802878 1:CAS:528:DC%2BD1cXhsVCrurjL
    • Marcellin P, Heathcote EJ, Buti M, Gane E, de Man RA, Krastev Z, et al. Tenofovir disoproxil fumarate versus adefovir dipivoxil for chronic hepatitis B. N Engl J Med. 2008;359:2442-55.
    • (2008) N Engl J Med , vol.359 , pp. 2442-2455
    • Marcellin, P.1    Heathcote, E.J.2    Buti, M.3    Gane, E.4    De Man, R.A.5    Krastev, Z.6
  • 11
    • 0027378724 scopus 로고
    • Effect of alpha-interferon treatment in patients with hepatitis B e antigen-positive chronic hepatitis B. A meta-analysis
    • 8328741 10.7326/0003-4819-119-4-199308150-00011 1:STN:280: DyaK3szhvFWqsQ%3D%3D
    • Wong DK, Cheung AM, O'Rourke K, Naylor CD, Detsky AS, Heathcote J. Effect of alpha-interferon treatment in patients with hepatitis B e antigen-positive chronic hepatitis B. A meta-analysis. Ann Intern Med. 1993;119:312-23.
    • (1993) Ann Intern Med , vol.119 , pp. 312-323
    • Wong, D.K.1    Cheung, A.M.2    O'Rourke, K.3    Naylor, C.D.4    Detsky, A.S.5    Heathcote, J.6
  • 12
    • 74849118783 scopus 로고    scopus 로고
    • Long-term efficacy of interferon alpha therapy on hepatitis B viral replication in patients with chronic hepatitis B: A meta-analysis
    • 19900483 10.1016/j.antiviral.2009.10.023 1:CAS:528:DC%2BC3cXhtVejsrc%3D
    • Yang YF, Zhao W, Xia HM, Zhong YD, Huang P, Wen J. Long-term efficacy of interferon alpha therapy on hepatitis B viral replication in patients with chronic hepatitis B: a meta-analysis. Antiviral Res. 2010;85:361-5.
    • (2010) Antiviral Res , vol.85 , pp. 361-365
    • Yang, Y.F.1    Zhao, W.2    Xia, H.M.3    Zhong, Y.D.4    Huang, P.5    Wen, J.6
  • 13
    • 51049107683 scopus 로고    scopus 로고
    • Asian-Pacific consensus statement on the management of chronic hepatitis B: A 2008 update
    • 19669255 10.1007/s12072-008-9080-3
    • Liaw YF, Leung N, Kao JH, Piratvisuth T, Gane E, Han KH, et al. Asian-Pacific consensus statement on the management of chronic hepatitis B: a 2008 update. Hepatol Int. 2008;2:263-83.
    • (2008) Hepatol Int , vol.2 , pp. 263-283
    • Liaw, Y.F.1    Leung, N.2    Kao, J.H.3    Piratvisuth, T.4    Gane, E.5    Han, K.H.6
  • 14
    • 70349240414 scopus 로고    scopus 로고
    • Chronic hepatitis B: Update 2009
    • 19714720 10.1002/hep.23190
    • Lok AS, McMahon BJ. Chronic hepatitis B: update 2009. Hepatology. 2009;50:661-2.
    • (2009) Hepatology , vol.50 , pp. 661-662
    • Lok, A.S.1    McMahon, B.J.2
  • 15
    • 84862664371 scopus 로고    scopus 로고
    • EASL clinical practice guidelines: Management of chronic hepatitis B virus infection
    • European Association for the Study of the Liver
    • European Association for the Study of the Liver. EASL clinical practice guidelines: management of chronic hepatitis B virus infection. J Hepatol. 2012;57:167-85.
    • (2012) J Hepatol , vol.57 , pp. 167-185
  • 16
    • 0030776176 scopus 로고    scopus 로고
    • Lack of effect of antiviral therapy in nondividing hepatocyte cultures on the closed circular DNA of woodchuck hepatitis virus
    • 9371599 1:CAS:528:DyaK2sXnsVCktLw%3D
    • Moraleda G, Saputelli J, Aldrich CE, Averett D, Condreay L, Mason WS. Lack of effect of antiviral therapy in nondividing hepatocyte cultures on the closed circular DNA of woodchuck hepatitis virus. J Virol. 1997;71:9392-9.
    • (1997) J Virol , vol.71 , pp. 9392-9399
    • Moraleda, G.1    Saputelli, J.2    Aldrich, C.E.3    Averett, D.4    Condreay, L.5    Mason, W.S.6
  • 17
    • 0034234540 scopus 로고    scopus 로고
    • Increased hepatocyte turnover and inhibition of woodchuck hepatitis B virus replication by adefovir in vitro do not lead to reduction of the closed circular DNA
    • 10869302 10.1053/jhep.2000.8701 1:CAS:528:DC%2BD3cXltFWgsL8%3D
    • Dandri M, Burda MR, Will H, Petersen J. Increased hepatocyte turnover and inhibition of woodchuck hepatitis B virus replication by adefovir in vitro do not lead to reduction of the closed circular DNA. Hepatology. 2000;32:139-46.
    • (2000) Hepatology , vol.32 , pp. 139-146
    • Dandri, M.1    Burda, M.R.2    Will, H.3    Petersen, J.4
  • 18
    • 0028916425 scopus 로고
    • Hepatitis B virus immunopathogenesis
    • 7612225 10.1146/annurev.iy.13.040195.000333 1:CAS:528:DyaK2MXltFamtLY%3D
    • Chisari FV, Ferrari C. Hepatitis B virus immunopathogenesis. Annu Rev Immunol. 1995;13:29-60.
    • (1995) Annu Rev Immunol , vol.13 , pp. 29-60
    • Chisari, F.V.1    Ferrari, C.2
  • 19
    • 0032169470 scopus 로고    scopus 로고
    • Lamivudine treatment can restore T cell responsiveness in chronic hepatitis B
    • 9727065 10.1172/JCI3731 1:CAS:528:DyaK1cXlvVCqtL0%3D
    • Boni C, Bertoletti A, Penna A, Cavalli A, Pilli M, Urbani S, et al. Lamivudine treatment can restore T cell responsiveness in chronic hepatitis B. J Clin Invest. 1998;102:968-75.
    • (1998) J Clin Invest , vol.102 , pp. 968-975
    • Boni, C.1    Bertoletti, A.2    Penna, A.3    Cavalli, A.4    Pilli, M.5    Urbani, S.6
  • 20
    • 17744383748 scopus 로고    scopus 로고
    • Lamivudine treatment can overcome cytotoxic T-cell hyporesponsiveness in chronic hepatitis B: New perspectives for immune therapy
    • 11283861 10.1053/jhep.2001.23045 1:CAS:528:DC%2BD3MXivVGqsLk%3D
    • Boni C, Penna A, Ogg GS, Bertoletti A, Pilli M, Cavallo C, et al. Lamivudine treatment can overcome cytotoxic T-cell hyporesponsiveness in chronic hepatitis B: new perspectives for immune therapy. Hepatology. 2001;33:963-71.
    • (2001) Hepatology , vol.33 , pp. 963-971
    • Boni, C.1    Penna, A.2    Ogg, G.S.3    Bertoletti, A.4    Pilli, M.5    Cavallo, C.6
  • 21
    • 0032101831 scopus 로고    scopus 로고
    • Combination alpha-interferon and lamivudine therapy for alpha-interferon-resistant chronic hepatitis B infection: Results of a pilot study
    • 9672165 10.1016/S0168-8278(98)80338-3 1:CAS:528:DyaK1cXmvVSltLw%3D
    • Mutimer D, Naoumov N, Honkoop P, Marinos G, Ahmed M, de Man R, et al. Combination alpha-interferon and lamivudine therapy for alpha-interferon- resistant chronic hepatitis B infection: results of a pilot study. J Hepatol. 1998;28:923-9.
    • (1998) J Hepatol , vol.28 , pp. 923-929
    • Mutimer, D.1    Naoumov, N.2    Honkoop, P.3    Marinos, G.4    Ahmed, M.5    De Man, R.6
  • 22
    • 0034843958 scopus 로고    scopus 로고
    • Long-term efficacy of interferon alpha-2b and lamivudine in combination compared to lamivudine monotherapy in patients with chronic hepatitis B. An Italian multicenter, randomized trial
    • 11592603 10.1016/S0168-8278(01)00145-3 1:CAS:528:DC%2BD3MXnslKrsbk%3D
    • Barbaro G, Zechini F, Pellicelli AM, Francavilla R, Scotto G, Bacca D, et al. Long-term efficacy of interferon alpha-2b and lamivudine in combination compared to lamivudine monotherapy in patients with chronic hepatitis B. An Italian multicenter, randomized trial. J Hepatol. 2001;35:406-11.
    • (2001) J Hepatol , vol.35 , pp. 406-411
    • Barbaro, G.1    Zechini, F.2    Pellicelli, A.M.3    Francavilla, R.4    Scotto, G.5    Bacca, D.6
  • 23
    • 0035742578 scopus 로고    scopus 로고
    • Lamivudine and alpha-interferon in combination long term for precore mutant chronic hepatitis B
    • 11738109 10.1016/S0168-8278(01)00201-X 1:CAS:528:DC%2BD38XmtVCmsA%3D%3D
    • Tatulli I, Francavilla R, Rizzo GL, Vinciguerra V, Ierardi E, Amoruso A, et al. Lamivudine and alpha-interferon in combination long term for precore mutant chronic hepatitis B. J Hepatol. 2001;35:805-10.
    • (2001) J Hepatol , vol.35 , pp. 805-810
    • Tatulli, I.1    Francavilla, R.2    Rizzo, G.L.3    Vinciguerra, V.4    Ierardi, E.5    Amoruso, A.6
  • 24
    • 19944428132 scopus 로고    scopus 로고
    • Pegylated interferon alfa-2b alone or in combination with lamivudine for HBeAg-positive chronic hepatitis B: A randomised trial
    • 15639293 10.1016/S0140-6736(05)17701-0 1:CAS:528:DC%2BD2MXhvF2gsQ%3D%3D
    • Janssen HL, van Zonneveld M, Senturk H, Zeuzem S, Akarca US, Cakaloglu Y, et al. Pegylated interferon alfa-2b alone or in combination with lamivudine for HBeAg-positive chronic hepatitis B: a randomised trial. Lancet. 2005;365:123-9.
    • (2005) Lancet , vol.365 , pp. 123-129
    • Janssen, H.L.1    Van Zonneveld, M.2    Senturk, H.3    Zeuzem, S.4    Akarca, U.S.5    Cakaloglu, Y.6
  • 25
    • 21244447705 scopus 로고    scopus 로고
    • Peginterferon Alfa-2a, lamivudine, and the combination for HBeAg-positive chronic hepatitis B
    • 15987917 10.1056/NEJMoa043470 1:CAS:528:DC%2BD2MXls1SktL8%3D
    • Lau GK, Piratvisuth T, Luo KX, Marcellin P, Thongsawat S, Cooksley G, et al. Peginterferon Alfa-2a, lamivudine, and the combination for HBeAg-positive chronic hepatitis B. N Engl J Med. 2005;352:2682-95.
    • (2005) N Engl J Med , vol.352 , pp. 2682-2695
    • Lau, G.K.1    Piratvisuth, T.2    Luo, K.X.3    Marcellin, P.4    Thongsawat, S.5    Cooksley, G.6
  • 26
    • 4544239807 scopus 로고    scopus 로고
    • Peginterferon alfa-2a alone, lamivudine alone, and the two in combination in patients with HBeAg-negative chronic hepatitis B
    • 15371578 10.1056/NEJMoa040431 1:CAS:528:DC%2BD2cXns12rsr0%3D
    • Marcellin P, Lau GK, Bonino F, Farci P, Hadziyannis S, Jin R, et al. Peginterferon alfa-2a alone, lamivudine alone, and the two in combination in patients with HBeAg-negative chronic hepatitis B. N Engl J Med. 2004;351:1206-17.
    • (2004) N Engl J Med , vol.351 , pp. 1206-1217
    • Marcellin, P.1    Lau, G.K.2    Bonino, F.3    Farci, P.4    Hadziyannis, S.5    Jin, R.6
  • 27
    • 33645730480 scopus 로고    scopus 로고
    • Peg-interferon improves liver histology in patients with HBeAg-positive chronic hepatitis B: No additional benefit of combination with lamivudine
    • 16629642 10.1111/j.1478-3231.2006.01257.x
    • van Zonneveld M, Zondervan PE, Cakaloglu Y, Simon C, Akarca US, So TM, et al. Peg-interferon improves liver histology in patients with HBeAg-positive chronic hepatitis B: no additional benefit of combination with lamivudine. Liver Int. 2006;26:399-405.
    • (2006) Liver Int , vol.26 , pp. 399-405
    • Van Zonneveld, M.1    Zondervan, P.E.2    Cakaloglu, Y.3    Simon, C.4    Akarca, U.S.5    So, T.M.6
  • 28
    • 77955976756 scopus 로고    scopus 로고
    • Telbivudine (LDT) plus peg-interferon (PEGIFN) in HBeAg-positive chronic hepatitis B - Very potent antiviral efficacy but risk of peripheral neuropathy (PN)
    • 10.1016/S0168-8278(10)60015-3
    • Marcellin P, Avila C, Wursthorn K, Chuang WL, Lau GK, Peng CY, et al. Telbivudine (LDT) plus peg-interferon (PEGIFN) in HBeAg-positive chronic hepatitis B - very potent antiviral efficacy but risk of peripheral neuropathy (PN). J Hepatol. 2010;52:S6-7.
    • (2010) J Hepatol , vol.52
    • Marcellin, P.1    Avila, C.2    Wursthorn, K.3    Chuang, W.L.4    Lau, G.K.5    Peng, C.Y.6
  • 29
    • 33748929265 scopus 로고    scopus 로고
    • Peginterferon alpha-2b plus adefovir induce strong cccDNA decline and HBsAg reduction in patients with chronic hepatitis B
    • 16941693 10.1002/hep.21282 1:CAS:528:DC%2BD28XhtVeqt7bM
    • Wursthorn K, Lutgehetmann M, Dandri M, Volz T, Buggisch P, Zollner B, et al. Peginterferon alpha-2b plus adefovir induce strong cccDNA decline and HBsAg reduction in patients with chronic hepatitis B. Hepatology. 2006;44:675-84.
    • (2006) Hepatology , vol.44 , pp. 675-684
    • Wursthorn, K.1    Lutgehetmann, M.2    Dandri, M.3    Volz, T.4    Buggisch, P.5    Zollner, B.6
  • 30
    • 80053118707 scopus 로고    scopus 로고
    • Intrahepatic response markers in chronic hepatitis B patients treated with peginterferon alpha-2a and adefovir
    • 21557773 10.1111/j.1440-1746.2011.06766.x 1:CAS:528:DC%2BC3MXhsVWjs7fK
    • Takkenberg B, Terpstra V, Zaaijer H, Weegink C, Dijkgraaf M, Jansen P, et al. Intrahepatic response markers in chronic hepatitis B patients treated with peginterferon alpha-2a and adefovir. J Gastroenterol Hepatol. 2011;26:1527-35.
    • (2011) J Gastroenterol Hepatol , vol.26 , pp. 1527-1535
    • Takkenberg, B.1    Terpstra, V.2    Zaaijer, H.3    Weegink, C.4    Dijkgraaf, M.5    Jansen, P.6
  • 31
    • 0344530467 scopus 로고    scopus 로고
    • Treatment of chronic hepatitis B with the sequential administration of interferon and lamivudine
    • 14696461 1:CAS:528:DC%2BD3sXhtVSlsbfE
    • Hasan F, al-Khaldi J, Asker H, Varghese R, Siddique I, al-Shammali M, et al. Treatment of chronic hepatitis B with the sequential administration of interferon and lamivudine. Hepatogastroenterology. 2003;50:2040-2.
    • (2003) Hepatogastroenterology , vol.50 , pp. 2040-2042
    • Hasan, F.1    Al-Khaldi, J.2    Asker, H.3    Varghese, R.4    Siddique, I.5    Al-Shammali, M.6
  • 32
    • 13444309139 scopus 로고    scopus 로고
    • A randomized, controlled trial of combination therapy for chronic hepatitis B: Comparing pegylated interferon-alpha2b and lamivudine with lamivudine alone
    • 15710957 10.7326/0003-4819-142-4-200502150-00006 1:CAS:528: DC%2BD2MXjvFWiu7o%3D
    • Chan HL, Leung NW, Hui AY, Wong VW, Liew CT, Chim AM, et al. A randomized, controlled trial of combination therapy for chronic hepatitis B: comparing pegylated interferon-alpha2b and lamivudine with lamivudine alone. Ann Intern Med. 2005;142:240-50.
    • (2005) Ann Intern Med , vol.142 , pp. 240-250
    • Chan, H.L.1    Leung, N.W.2    Hui, A.Y.3    Wong, V.W.4    Liew, C.T.5    Chim, A.M.6
  • 33
    • 20044380567 scopus 로고    scopus 로고
    • Long-term follow-up of peginterferon and lamivudine combination treatment in HBeAg-positive chronic hepatitis B
    • 15880608 10.1002/hep.20695 1:CAS:528:DC%2BD2MXlvVSnu7c%3D
    • Chan HL, Hui AY, Wong VW, Chim AM, Wong ML, Sung JJ. Long-term follow-up of peginterferon and lamivudine combination treatment in HBeAg-positive chronic hepatitis B. Hepatology. 2005;41:1357-64.
    • (2005) Hepatology , vol.41 , pp. 1357-1364
    • Chan, H.L.1    Hui, A.Y.2    Wong, V.W.3    Chim, A.M.4    Wong, M.L.5    Sung, J.J.6
  • 34
    • 0034861494 scopus 로고    scopus 로고
    • Sequential treatment with lamivudine and interferon monotherapies in patients with chronic hepatitis B not responding to interferon alone: Results of a pilot study
    • 11526544 10.1053/jhep.2001.26819 1:CAS:528:DC%2BD3MXmvV2kt7g%3D
    • Serfaty L, Thabut D, Zoulim F, Andreani T, Chazouillères O, Carbonell N, et al. Sequential treatment with lamivudine and interferon monotherapies in patients with chronic hepatitis B not responding to interferon alone: results of a pilot study. Hepatology. 2001;34:573-7.
    • (2001) Hepatology , vol.34 , pp. 573-577
    • Serfaty, L.1    Thabut, D.2    Zoulim, F.3    Andreani, T.4    Chazouillères, O.5    Carbonell, N.6
  • 35
    • 33846080133 scopus 로고    scopus 로고
    • Effect of lowering HBV DNA levels by initial antiviral therapy before adding immunomodulator on treatment of chronic hepatitis B
    • 17266689 10.1111/j.1572-0241.2006.01006.x 1:CAS:528:DC%2BD2sXhvVOms7Y%3D
    • Sarin SK, Sood A, Kumar M, Arora A, Amrapurkar D, Sharma BC, et al. Effect of lowering HBV DNA levels by initial antiviral therapy before adding immunomodulator on treatment of chronic hepatitis B. Am J Gastroenterol. 2007;102:96-104.
    • (2007) Am J Gastroenterol , vol.102 , pp. 96-104
    • Sarin, S.K.1    Sood, A.2    Kumar, M.3    Arora, A.4    Amrapurkar, D.5    Sharma, B.C.6
  • 36
    • 33644886354 scopus 로고    scopus 로고
    • A partially overlapping treatment course with lamivudine and interferon in hepatitis B e antigen-negative chronic hepatitis B
    • 16393286 10.1111/j.1365-2036.2006.02731.x 1:CAS:528:DC%2BD28XhsVehtbg%3D
    • Manesis EK, Papatheodoridis GV, Hadziyannis SJ. A partially overlapping treatment course with lamivudine and interferon in hepatitis B e antigen-negative chronic hepatitis B. Aliment Pharmacol Ther. 2006;23:99-106.
    • (2006) Aliment Pharmacol Ther , vol.23 , pp. 99-106
    • Manesis, E.K.1    Papatheodoridis, G.V.2    Hadziyannis, S.J.3
  • 37
    • 34548543638 scopus 로고    scopus 로고
    • Lamivudine/pegylated interferon alfa-2b sequential combination therapy compared with lamivudine monotherapy in HBeAg-negative chronic hepatitis B
    • 17683500 10.1111/j.1440-1746.2007.05103.x 1:CAS:528:DC%2BD2sXht1yltbjI
    • Vassiliadis T, Tziomalos K, Patsiaoura K, Zagris T, Giouleme O, Soufleris K, et al. Lamivudine/pegylated interferon alfa-2b sequential combination therapy compared with lamivudine monotherapy in HBeAg-negative chronic hepatitis B. J Gastroenterol Hepatol. 2007;22:1582-8.
    • (2007) J Gastroenterol Hepatol , vol.22 , pp. 1582-1588
    • Vassiliadis, T.1    Tziomalos, K.2    Patsiaoura, K.3    Zagris, T.4    Giouleme, O.5    Soufleris, K.6
  • 38
    • 39049185195 scopus 로고    scopus 로고
    • Sequential treatment with lamivudine and interferon-alpha monotherapies in hepatitis B e antigen-negative Chinese patients and its suppression of lamivudine-resistant mutations
    • 16987866 10.1093/jac/dkl385 1:CAS:528:DC%2BD28Xht1yqtrfO
    • Shi M, Wang RS, Zhang H, Zhu YF, Han B, Zhang Y, et al. Sequential treatment with lamivudine and interferon-alpha monotherapies in hepatitis B e antigen-negative Chinese patients and its suppression of lamivudine-resistant mutations. J Antimicrob Chemother. 2006;58:1031-5.
    • (2006) J Antimicrob Chemother , vol.58 , pp. 1031-1035
    • Shi, M.1    Wang, R.S.2    Zhang, H.3    Zhu, Y.F.4    Han, B.5    Zhang, Y.6
  • 39
    • 0034874826 scopus 로고    scopus 로고
    • Geographic distribution of hepatitis B virus (HBV) genotype in patients with chronic HBV infection in Japan
    • 11526547 10.1053/jhep.2001.27221 1:STN:280:DC%2BD3Mvot1ykug%3D%3D
    • Orito E, Ichida T, Sakugawa H, Sata M, Horiike N, Hino K, et al. Geographic distribution of hepatitis B virus (HBV) genotype in patients with chronic HBV infection in Japan. Hepatology. 2001;34:590-4.
    • (2001) Hepatology , vol.34 , pp. 590-594
    • Orito, E.1    Ichida, T.2    Sakugawa, H.3    Sata, M.4    Horiike, N.5    Hino, K.6
  • 40
    • 32644460117 scopus 로고    scopus 로고
    • Hepatitis B virus genotypes and response to antiviral therapy
    • 16506363 1:CAS:528:DC%2BD28XhvFKgs7o%3D
    • Enomoto M, Tamori A, Nishiguchi S. Hepatitis B virus genotypes and response to antiviral therapy. Clin Lab. 2006;52:43-7.
    • (2006) Clin Lab , vol.52 , pp. 43-47
    • Enomoto, M.1    Tamori, A.2    Nishiguchi, S.3
  • 41
    • 33947236756 scopus 로고    scopus 로고
    • Lamivudine and IFN-beta sequential therapy in HBe antigen-positive patients with chronic hepatitis B virus genotype C infection
    • 17348818 10.1089/jir.2006.0140 1:CAS:528:DC%2BD2sXis1CjsbY%3D
    • Enomoto M, Tamori A, Kohmoto MT, Hayashi T, Jomura H, Habu D, et al. Lamivudine and IFN-beta sequential therapy in HBe antigen-positive patients with chronic hepatitis B virus genotype C infection. J Interferon Cytokine Res. 2007;27:201-7.
    • (2007) J Interferon Cytokine Res , vol.27 , pp. 201-207
    • Enomoto, M.1    Tamori, A.2    Kohmoto, M.T.3    Hayashi, T.4    Jomura, H.5    Habu, D.6
  • 42
    • 34447644610 scopus 로고    scopus 로고
    • Management of HBV infection in Japan
    • Minami M, Okanoue T. Management of HBV infection in Japan. Hepatol Res. 2007;37[s1]:S79-82.
    • (2007) Hepatol Res , vol.37 , Issue.S1
    • Minami, M.1    Okanoue, T.2
  • 43
    • 77954364665 scopus 로고    scopus 로고
    • Effect of nucleoside analog-interferon sequential therapy on patients with acute exacerbation of chronic hepatitis B
    • 20412327 10.1111/j.1872-034X.2010.00639.x 1:CAS:528:DC%2BC3cXos1Snurg%3D
    • Okuse C, Yotsuyanagi H, Yamada N, Okamoto M, Ikeda H, Kobayashi M, et al. Effect of nucleoside analog-interferon sequential therapy on patients with acute exacerbation of chronic hepatitis B. Hepatol Res. 2010;40:461-9.
    • (2010) Hepatol Res , vol.40 , pp. 461-469
    • Okuse, C.1    Yotsuyanagi, H.2    Yamada, N.3    Okamoto, M.4    Ikeda, H.5    Kobayashi, M.6
  • 44
    • 79960678798 scopus 로고    scopus 로고
    • Sequential therapy with adefovir dipivoxil and pegylated interferon alfa-2a for HBeAg-negative patients
    • 20487260 10.1111/j.1365-2893.2010.01332.x 1:STN:280: DC%2BC3MnotVymtg%3D%3D
    • Moucari R, Boyer N, Ripault MP, Castelnau C, Mackiewicz V, Dauvergne A, et al. Sequential therapy with adefovir dipivoxil and pegylated interferon alfa-2a for HBeAg-negative patients. J Viral Hepat. 2011;18:580-6.
    • (2011) J Viral Hepat , vol.18 , pp. 580-586
    • Moucari, R.1    Boyer, N.2    Ripault, M.P.3    Castelnau, C.4    Mackiewicz, V.5    Dauvergne, A.6
  • 45
    • 84879636610 scopus 로고    scopus 로고
    • Entecavir and interferon-α sequential therapy in Japanese patients with hepatitis B e antigen-positive chronic hepatitis B
    • doi: 10.1007/s00535-012-0645-5
    • Enomoto M, Nishiguchi S, Tamori A, Kobayashi S, Sakaguchi H, Shiomi S, et al. Entecavir and interferon-α sequential therapy in Japanese patients with hepatitis B e antigen-positive chronic hepatitis B. J Gastroenterol 2012. doi: 10.1007/s00535-012-0645-5.
    • (2012) J Gastroenterol
    • Enomoto, M.1    Nishiguchi, S.2    Tamori, A.3    Kobayashi, S.4    Sakaguchi, H.5    Shiomi, S.6
  • 46
    • 84857371402 scopus 로고    scopus 로고
    • Safety and efficacy of two-step peginterferon α-2a treatment in patients of chronic hepatitis B with acute exacerbation
    • 22329370 10.1111/j.1365-2893.2011.01469.x
    • Chen CC, Wang PC, Chang HW, Chen CF. Safety and efficacy of two-step peginterferon α-2a treatment in patients of chronic hepatitis B with acute exacerbation. J Viral Hepat. 2012;19:161-72.
    • (2012) J Viral Hepat , vol.19 , pp. 161-172
    • Chen, C.C.1    Wang, P.C.2    Chang, H.W.3    Chen, C.F.4
  • 47
    • 84863393007 scopus 로고    scopus 로고
    • Combination of hepatitis B viral antigens and DNA for prediction of relapse after discontinuation of nucleos(t)ide analogs in patients with chronic hepatitis B
    • 22103237 10.1111/j.1872-034X.2011.00910.x 1:CAS:528:DC%2BC38XjvVaksrs%3D
    • Matsumoto A, Tanaka E, Suzuki Y, Kobayashi M, Tanaka Y, Shinkai N, et al. Combination of hepatitis B viral antigens and DNA for prediction of relapse after discontinuation of nucleos(t)ide analogs in patients with chronic hepatitis B. Hepatol Res. 2012;42:139-49.
    • (2012) Hepatol Res , vol.42 , pp. 139-149
    • Matsumoto, A.1    Tanaka, E.2    Suzuki, Y.3    Kobayashi, M.4    Tanaka, Y.5    Shinkai, N.6
  • 48
    • 84865129672 scopus 로고    scopus 로고
    • Anti-hepatitis B virus therapy: To stop, or not to stop: Has the question been solved?
    • 22882339 10.1111/j.1872-034X.2012.01001.x
    • Kozuka R, Enomoto M, Morikawa H, Tamori A, Kawada N. Anti-hepatitis B virus therapy: to stop, or not to stop: has the question been solved? Hepatol Res. 2012;42:946-7.
    • (2012) Hepatol Res , vol.42 , pp. 946-947
    • Kozuka, R.1    Enomoto, M.2    Morikawa, H.3    Tamori, A.4    Kawada, N.5
  • 49
    • 77954409307 scopus 로고    scopus 로고
    • Guidelines for the treatment of chronic hepatitis and cirrhosis due to hepatitis B virus infection for the fiscal year 2008 in Japan
    • 20156295 10.1111/j.1872-034X.2009.00633.x
    • Kumada H, Okanoue T, Onji M, Moriwaki H, Izumi N, Tanaka E, et al. Guidelines for the treatment of chronic hepatitis and cirrhosis due to hepatitis B virus infection for the fiscal year 2008 in Japan. Hepatol Res. 2010;40:1-7.
    • (2010) Hepatol Res , vol.40 , pp. 1-7
    • Kumada, H.1    Okanoue, T.2    Onji, M.3    Moriwaki, H.4    Izumi, N.5    Tanaka, E.6
  • 50
    • 66149115173 scopus 로고    scopus 로고
    • Long-term monitoring shows hepatitis B virus resistance to entecavir in nucleoside-naïve patients is rare through 5 years of therapy
    • 19280622 10.1002/hep.22841 1:CAS:528:DC%2BD1MXlslKmurw%3D
    • Tenney DJ, Rose RE, Baldick CJ, Pokornowski KA, Eggers BJ, Fang J, et al. Long-term monitoring shows hepatitis B virus resistance to entecavir in nucleoside-naïve patients is rare through 5 years of therapy. Hepatology. 2009;49:1503-14.
    • (2009) Hepatology , vol.49 , pp. 1503-1514
    • Tenney, D.J.1    Rose, R.E.2    Baldick, C.J.3    Pokornowski, K.A.4    Eggers, B.J.5    Fang, J.6
  • 51
    • 79952227475 scopus 로고    scopus 로고
    • No resistance to tenofovir disoproxil fumarate detected after up to 144 weeks of therapy in patients monoinfected with chronic hepatitis B virus
    • 21374657 10.1002/hep.24078 1:CAS:528:DC%2BC3MXkt1Clsbc%3D
    • Snow-Lampart A, Chappell B, Curtis M, Zhu Y, Myrick F, Schawalder J, et al. No resistance to tenofovir disoproxil fumarate detected after up to 144 weeks of therapy in patients monoinfected with chronic hepatitis B virus. Hepatology. 2011;53:763-73.
    • (2011) Hepatology , vol.53 , pp. 763-773
    • Snow-Lampart, A.1    Chappell, B.2    Curtis, M.3    Zhu, Y.4    Myrick, F.5    Schawalder, J.6
  • 52
    • 84861865262 scopus 로고    scopus 로고
    • Adding pegylated interferon to a current nucleos(t)ide therapy leads to HBsAg seroconversion in a subgroup of patients with chronic hepatitis B
    • 22365367 10.1016/j.jcv.2012.01.024 1:CAS:528:DC%2BC38XkvFWitbY%3D
    • Kittner JM, Sprinzl MF, Grambihler A, Weinmann A, Schattenberg JM, Galle PR, et al. Adding pegylated interferon to a current nucleos(t)ide therapy leads to HBsAg seroconversion in a subgroup of patients with chronic hepatitis B. J Clin Virol. 2012;54:93-5.
    • (2012) J Clin Virol , vol.54 , pp. 93-95
    • Kittner, J.M.1    Sprinzl, M.F.2    Grambihler, A.3    Weinmann, A.4    Schattenberg, J.M.5    Galle, P.R.6


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.