Genetic variation in IL18R1 and IL18 genes and inteferon γ ELISPOT response to smallpox vaccination: An unexpected relationship

Journal of Infectious Diseases

Volumn 208, Issue 9, 2013, Pages 1422-1430

  Ovsyannikova, Inna G ^a   Haralambieva, Iana H ^a   Kennedy, Richard B ^a   O'byrne, Megan M ^a   Pankratz, V Shane ^a   Poland, Gregory A ^a  

^a MAYO CLINIC   (United States)

Author keywords

African Americans; enzyme linked immunospot assay; european continental ancestry group; genetic predisposition to disease; genetic variation; haplotypes; interferon gamma; interleukin 18; interleukin 18 receptor alpha subunit; Polymorphism; single nucleotide; smallpox vaccine; vaccinia virus; viral vaccines

Indexed keywords

GAMMA INTERFERON; INTERLEUKIN 10; INTERLEUKIN 18; INTERLEUKIN 18 RECEPTOR ALPHA; INTERLEUKIN 2 RECEPTOR BETA; INTERLEUKIN 6; NEUTRALIZING ANTIBODY; SMALLPOX VACCINE;

ADAPTIVE IMMUNITY; ADULT; ALLELE; ANTIBODY TITER; ARTICLE; CELLULAR IMMUNITY; COHORT ANALYSIS; CYTOKINE PRODUCTION; DOSE RESPONSE; ENZYME LINKED IMMUNOSPOT ASSAY; GENE; GENE LOCUS; GENETIC ASSOCIATION; GENETIC VARIABILITY; HAPLOTYPE; HUMAN; IL10 GENE; IL18 GENE; IL18R1 GENE; IL2RB GENE; IL6 GENE; NORMAL HUMAN; PRIORITY JOURNAL; SINGLE DRUG DOSE; SINGLE NUCLEOTIDE POLYMORPHISM; SMALLPOX; TNFRS1A GENE; VACCINATION; VACCINIA VIRUS;

AFRICAN-AMERICANS; ENZYME-LINKED IMMUNOSPOT ASSAY; EUROPEAN CONTINENTAL ANCESTRY GROUP; GENETIC PREDISPOSITION TO DISEASE; GENETIC VARIATION; HAPLOTYPES; INTERFERON-GAMMA; INTERLEUKIN-18; INTERLEUKIN-18 RECEPTOR ALPHA SUBUNIT; POLYMORPHISM; SINGLE NUCLEOTIDE; SMALLPOX VACCINE; VACCINIA VIRUS; VIRAL VACCINES;

ADAPTIVE IMMUNITY; ADOLESCENT; ADULT; ANTIBODIES, NEUTRALIZING; ANTIBODIES, VIRAL; ENZYME-LINKED IMMUNOSORBENT ASSAY; GENETIC ASSOCIATION STUDIES; HAPLOTYPES; HUMANS; INTERFERON-GAMMA; INTERLEUKIN-18; INTERLEUKIN-18 RECEPTOR ALPHA SUBUNIT; INTRONS; POLYMORPHISM, SINGLE NUCLEOTIDE; PROMOTER REGIONS, GENETIC; SEQUENCE ANALYSIS, DNA; SMALLPOX VACCINE; VACCINATION; VACCINIA; YOUNG ADULT;

EID: 84885413277     PISSN: 00221899     EISSN: None     Source Type: Journal    
DOI: 10.1093/infdis/jit341     Document Type: Article

References (24)

1. Frey SE, Couch RB, Tacket CO, et al. Clinical responses to undiluted and diluted smallpox vaccine. N Engl J Med 2002; 346:1265-74
2. Belshe RB, Newman FK, Frey SE, et al. Dose-Dependent neutralizingantibody responses to vaccinia. J Infect Dis 2004; 189:493-7
3. Rock MT, Yoder SM, Talbot TR, Edwards KM, Crowe JE Jr. Cellular immune responses to diluted and undiluted Aventis Pasteur smallpox vaccine. J Infect Dis 2006; 194:435-43
4. Rock MT, Yoder SM, Talbot TR, Edwards KM, Crowe JE Jr. Adverse events after smallpox immunizations are associated with alterations in systemic cytokine levels. J Infect Dis 2004; 189:1401-10
5. Kennedy RB, Ovsyannikova IG, Pankratz VS, et al. Gender effects on humoral immune responses to smallpox vaccine. Vaccine 2009; 27:3319-23
6. Ovsyannikova IG, Vierkant RA, Pankratz VS, Jacobson RM, Poland GA. Human leukocyte antigen genotypes in the genetic control of adaptive immune responses to smallpox vaccine. J Infect Dis 2011; 203:1546-55
7. Haralambieva IH, Ovsyannikova IG, Dhiman N, et al. Common SNPs/ haplotypes in IL18R1 and IL18 genes are associated with variations in humoral immunity to smallpox vaccination in Caucasians and African-Americans. J Infect Dis 2011; 204:433-41
8. Ovsyannikova IG, Haralambieva IH, Kennedy RB, et al. Impact of cytokine and cytokine receptor gene polymorphisms on cellular immunity after smallpox vaccination. Gene 2012; 510:59-65
9. Umlauf BJ, Ovsyannikova IG, Haralambieva IH, et al. Correlations between vaccinia-specific immune responses within a cohort of armed forces members. Viral Immunol 2011; 24:415-20
10. Kennedy RB, Ovsyannikova IG, Pankratz VS, et al. Genome-wide genetic associations with IFN gamma response to smallpox vaccine. Hum Genet 2012; 131:1433-51
11. Stanley SL Jr., Frey SE, Taillon-Miller P, et al. The immunogenetics of smallpox vaccination. J Infect Dis 2007; 196:212-9
12. Ovsyannikova IG, Kennedy RB, O'Byrne M, Jacobson RM, Pankratz VS, Poland GA. Genome-wide association study of antibody response to smallpox vaccine. Vaccine 2012; 30:4182-9
13. Umlauf BJ, Pinsky NA, Ovsyannikova IG, Poland GA. Detection of vaccinia virus-specific IFNγ and IL-10 secretion from human PBMCs and CD8+ T cells by ELISPOT. In: Kalyuzhny AE, ed. Handbook of ELISPOT: Methods and protocols, methods in molecular biology. Vol 792. Springer Science+Business Media, New York, 2012: 199-218
14. Storey JD. A direct approach to false discovery rates. J R Statist Soc B 2002; 64:479-98
15. Storey JD, Tibshirani R. Statistical significance for genomewide studies. Proc Natl Acad Sci U S A 2003; 100:9440-5
16. Zaykin DV, Westfall PH, Young SS, Karnoub MA, Wagner MJ, Ehm MG. Testing association of statistically inferred haplotypes with discrete and continuous traits in samples of unrelated individuals. Hum Hered 2002; 53:79-91
17. Nakanishi K, Yoshimoto T, Tsutsui H, Okamura H. Interleukin-18 is a unique cytokine that stimulates both Th1 and Th2 responses depending on its cytokine milieu. Cytokine Growth Factor Rev 2001; 12:53-72
18. Poland GA, Ovsyannikova IG, Jacobson RM, Smith DI. Heterogeneity in vaccine immune response: The role of immunogenetics and the emerging field of vaccinomics. Clin Pharmacol Ther 2007; 82: 653-64
19. Xu D, Chan WL, Leung BP, et al. Selective expression and functions of interleukin 18 receptor on T helper (Th) type 1 but not Th2 cells. J Exp Med 1998; 188:1485-92
20. Reading PC, Smith GL. Vaccinia virus interleukin-18-binding protein promotes virulence by reducing gamma interferon production and natural killer and T-cell activity. J Virol 2003; 77:9960-8
21. Zhernakova A, Festen EM, Franke L, et al. Genetic analysis of innate immunity in Crohn's disease and ulcerative colitis identifies two susceptibility loci harboring CARD9 and IL18RAP. Am J Hum Genet 2008; 82:1202-10
22. Shirts BH, Wood J, Yolken RH, Nimgaonkar VL. Comprehensive evaluation of positional candidates in the IL-18 pathway reveals suggestive associations with schizophrenia and herpes virus seropositivity. Am J Med Genet B Neuropsychiatr Genet 2008; 147: 343-50
23. Zhu G, Whyte MK, Vestbo J, et al. Interleukin 18 receptor 1 gene polymorphisms are associated with asthma. Eur J Hum Genet 2008; 16:1083-90
24. He M, Cornelis MC, Kraft P, et al. Genome-wide association study identifies variants at the IL18-BCO2 locus associated with interleukin-18 levels. Arterioscler Thromb Vasc Biol 2010; 30:885-90