Metabolite differences in the lenticular nucleus in type 2 diabetes mellitus shown by proton MR spectroscopy

American Journal of Neuroradiology

Volumn 34, Issue 9, 2013, Pages 1692-1696

  Lin, Y ^a   Zhou, J ^b   Sha, L ^a   Li, Y ^a   Qu, X ^a   Liu, L ^a   Chen, H ^a   An, Z ^a   Wang, Y ^a   Sun, C ^a  

^a DALIAN MEDICAL UNIVERSITY   (China)

^b ZHEJIANG UNIVERSITY SCHOOL OF MEDICINE   (China)

Author keywords

[No Author keywords available]

Indexed keywords

GLYCOSYLATED HEMOGLOBIN; LACTIC ACID;

ADULT; AGED; ARTICLE; BASAL GANGLION; BRAIN CORTEX; BRAIN METABOLISM; CLINICAL ARTICLE; CONTROLLED STUDY; DISEASE DURATION; FEMALE; GLUCOSE BLOOD LEVEL; HUMAN; LENTICULAR NUCLEUS; MALE; NEUTRON ACTIVATION ANALYSIS; NON INSULIN DEPENDENT DIABETES MELLITUS; PROTON NUCLEAR MAGNETIC RESONANCE; THALAMUS; WHITE MATTER;

AGED; AGED, 80 AND OVER; ASPARTIC ACID; BIOLOGICAL MARKERS; CHOLINE; CORPUS STRIATUM; CREATINE; DIABETES MELLITUS, TYPE 2; FEMALE; HUMANS; MAGNETIC RESONANCE SPECTROSCOPY; MALE; MIDDLE AGED; PROTONS; REPRODUCIBILITY OF RESULTS; SENSITIVITY AND SPECIFICITY; THALAMUS; TISSUE DISTRIBUTION;

EID: 84885411456     PISSN: 01956108     EISSN: 1936959X     Source Type: Journal    
DOI: 10.3174/ajnr.A3492     Document Type: Article

References (21)

1. Ross B, Bluml S. Magnetic resonance spectroscopy of the human brain. Anat Rec 2001;265:54-84
2. Miller BL. A review of chemical issues in 1H NMR spectroscopy: N-acetyl-L-aspartate, creatine and choline. NMR Biomed 1991;4:47-52
3. Geissler A, Frund R, Scholmerich J, et al. Alterations of cerebral metabolism in patients with diabetes mellitus studied by proton magnetic resonance spectroscopy. Exp Clin Endocrinol Diabetes 2003;111:421-27
4. Kario K, Ishikawa J, Hoshide S, et al. Diabetic brain damage in hypertension: role of renin-angiotensin system. Hypertension 2005;45:887-93
5. Kreis R, Ross BD. Cerebral metabolic disturbances in patients with subacute and chronic diabetes mellitus: detection with proton MR spectroscopy. Radiology 1992;184:123-30
6. Biessels GJ, Braun KP, De Graaf RA, et al. Cerebral metabolism in streptozotocin-diabetic rats: an in vivo magnetic resonance spectroscopy study. Diabetologia 2001;44:346-53
7. Sahin I, Alkan A, Keskin L, et al. Evaluation of in vivo cerebral metabolism on proton magnetic resonance spectroscopy in patients with impaired glucose tolerance and type 2 diabetes mellitus. J Diabetes Complications 2008;22:254-60
8. Modi S, Bhattacharya M, Sekhri T, et al. Assessmentof the metabolic profile in type 2 diabetes mellitus and hypothyroidism through proton MR spectroscopy. Magn Reson Imaging 2008;26:420-25
9. Higa M, Kaneko Y, Inokuchi T. Two cases of hyperglycemic chorea in diabetic patients. Diabet Med 2004;21:196-98
10. Lai PH, Chen PC, Chang MH, et al. In vivo proton MR spectroscopy of chorea-ballismus in diabetes mellitus. Neuroradiology 2001;43:525-31
11. Expert Committee on the Diagnosis and Classification of Diabetes Mellitus. Report of the Expert Committee on the Diagnosis and Classification of Diabetes Mellitus. Diabetes Care 2000;23(suppl 1):S4-19
12. Ajilore O, Haroon E, Kumaran S, et al. Measurement of brain metabolites in patients with type 2 diabetes and major depression using proton magnetic resonance spectroscopy. Neuropsychopharmacology 2007;32:1224-31
13. Keymel S, Heinen Y, Balzer J, et al. Characterization of macro-and microvascular function and structure inpatients with type 2 diabetes mellitus. Am J Cardiovasc Dis 2011;1:68-75
14. Jones RL, Peterson CM. Hematologic alterations in diabetes mellitus. Am J Med 1981;70:339-52
15. Djuricic B, Olson SR, Assaf HM, et al. Formation of free choline in brain tissue during in vitro energy deprivation. J Cereb Blood Flow Metab 1991;11:308-13
16. Scremin OU, Jenden DJ. Focal ischemia enhances choline output and decreases acetylcholine output from rat cerebral cortex. Stroke 1989;20:92-95
17. Blüml S, Seymour KJ, Ross BD. Developmental changes in cholineand ethanolamine-containing compounds measured with protondecoupled (31) P MRS in in vivo human brain. Magn Reson Med 1999;42:643-54
18. Mäkimattila S, Malmberg-Ceder K, Hakkinen AM, et al. Brain metabolic alterations in patients with type 1 diabetes-hyperglycemiainduced injury. J Cereb Blood Flow Metab 2004;24:1393-99
19. Tiehuis A, Van Der Meer F, Mali W, et al. MRspectroscopyof cerebral white matter in type 2 diabetes; no association with clinical variables and cognitive performance. Neuroradiology 2010;52:155-61
20. Li L, Holscher C. Common pathological processes in Alzheimer disease and type 2 diabetes: a review. Brain Res Rev 2007;56:384-402
21. Saunders DE. MR spectroscopy in stroke. Br Med Bull 2000;56:334-45